Works (2)

Updated: July 5th, 2023 15:57

2007 journal article

Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation


By: S. Nordone n, G. Ignacio n, L. Su*, G. Sempowski*, D. Golenbock*, L. Li*, G. Dean n

MeSH headings : Cell Line; HIV Infections / immunology; HIV Infections / virology; HIV-1 / physiology; Humans; Interleukin-1 / biosynthesis; Interleukin-6 / biosynthesis; Lipopolysaccharides / immunology; NF-kappa B / metabolism; Toll-Like Receptor 2 / metabolism; Toll-Like Receptor 4 / metabolism; Toll-Like Receptor 9 / metabolism; Virus Replication
TL;DR: It is suggested that although several TLR can upregulate NF-kappaB in HIV-1-infected cells, upregulation of NF-KappaB alone is insufficient to activate the viral LTR, and the possibility that TLR4 signaling pathways may be altered during chronic HIV- 1 infection is raised. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Toll-like receptor expression in feline lymphoid tissues


By: G. Ignacio n, S. Nordone n, K. Howard n & G. Dean n

author keywords: toll-like receptors; feline; feline immunodeficiency virus; innate immunity
MeSH headings : Animals; Base Sequence; Cat Diseases / genetics; Cat Diseases / immunology; Cats / genetics; Cats / immunology; Cell Line; Cloning, Molecular; DNA Primers / genetics; Gene Expression; Immunodeficiency Virus, Feline / pathogenicity; Lentivirus Infections / genetics; Lentivirus Infections / immunology; Lentivirus Infections / veterinary; Lymphocyte Subsets / immunology; Lymphoid Tissue / immunology; Membrane Glycoproteins / genetics; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Cell Surface / genetics; Tissue Distribution; Toll-Like Receptors
TL;DR: Results demonstrate that tissue distribution of TLRs is associated with the immunological role of a particular tissue, that lymphocytes may also express these 'innate immune' receptors, and that FIV infection can alter TLR expression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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