Hyun Joo

Works (7)

Updated: July 5th, 2023 15:57

2013 journal article

Human Variation and Risk Assessment: Microarray and Other Studies Utilizing Human Hepatocytes and Human Liver Subcellular Preparations

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 28(1), 1–10.

By: E. Hodgson n, A. Wallace n, R. Shah*, K. Choi n & H. Joo n

author keywords: Cytotoxicity; Human Hepatocytes; Human Variation; Microarrays; RNAseq; Toxicant Metabolism; Toxicant Interactions
MeSH headings : Enzyme Activation; Enzyme Inhibitors / pharmacology; Genetic Variation; Hepatocytes / enzymology; Hepatocytes / metabolism; Humans; Liver / metabolism; Oligonucleotide Array Sequence Analysis; Risk Assessment; Subcellular Fractions / metabolism
TL;DR: This review summarizes the use of primary human hepatocytes and hepatocyte subcellular preparations for the investigation of the metabolism and metabolic interactions of environmental chemicals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Human metabolism of atrazine

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 98(1), 73–79.

By: H. Joo n, K. Choi n & E. Hodgson n

author keywords: Atrazine; Human liver microsomes; Cytochrome P450; Human liver S9 fractions; Human metabolism; Phase I metabolism; Phase II metabolism; Glutathione conjugation; LC/MS/MS
TL;DR: Atrazine (ATZ) metabolism by human liver microsomes, cytochrome P450 (CYP) isoforms, and human liver S9 fractions, was investigated using HPLC/PDA and LC/MS/MS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Reduction in Metolachlor and Degradate Concentrations in Shallow Groundwater through Cover Crop Use

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 57(20), 9658–9667.

By: P. White *, T. Potter, D. Bosch, H. Joo*, B. Schaffer & R. Munoz-Carpena

author keywords: Metolachlor; metolachlor ethane sulfonic acid; groundwater; cover cropping; soil dissipation
MeSH headings : Acetamides / analysis; Acetamides / metabolism; Biodegradation, Environmental; Crops, Agricultural / metabolism; Environmental Restoration and Remediation / methods; Herbicides / analysis; Herbicides / metabolism; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / metabolism
TL;DR: It is demonstrated that integration of cover crops into agronomic systems in the region may yield water quality benefits by reducing herbicide inputs to groundwater. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Inhibition of fipronil and nonane metabolism in human liver microsomes and human cytochrome P450 isoforms by chlorpyrifos

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 21(2), 76–80.

By: H. Joo n, K. Choi n, R. Rose n & E. Hodgson n

author keywords: fipronil; nonane; human liver microsomes; cytochrome P450; CYP2B6; CYP3A4
MeSH headings : Alkanes / pharmacology; Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors; Aryl Hydrocarbon Hydroxylases / metabolism; Chlorpyrifos / pharmacology; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / metabolism; Enzyme Activation / drug effects; Female; Humans; Insecticides / pharmacology; Isoenzymes / antagonists & inhibitors; Isoenzymes / metabolism; Male; Microsomes, Liver / enzymology; Oxidoreductases, N-Demethylating / antagonists & inhibitors; Oxidoreductases, N-Demethylating / metabolism; Pyrazoles / pharmacology
TL;DR: In both co‐ and preincubation experiments, CPS significantly inhibited the metabolism of fipronil or nonane by HLM although CPS inhibited the metabolization of fIPronil more effectively than that of nonane. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Summer cover crops reduce atrazine leaching to shallow groundwater in southern Florida

JOURNAL OF ENVIRONMENTAL QUALITY, 36(5), 1301–1309.

By: T. Potter *, D. Bosch *, H. Joo n, B. Schaffer * & R. Munoz-Carpena *

MeSH headings : Atrazine / analysis; Atrazine / metabolism; Biodegradation, Environmental; Crotalaria; Environmental Monitoring; Florida; Herbicides / analysis; Herbicides / metabolism; Rain; Seasons; Soil / analysis; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / metabolism; Zea mays / growth & development
TL;DR: Groundwater data and laboratory study findings demonstrated a relatively small although potentially significant risk for leaching of atrazine and its dealkylated degradates to groundwater and that the use of a cover crop like Sunn Hemp during summer months may be an effective mitigation measure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Metabolism of chlorpyrifos and chlorpyrifos oxon by human hepatocytes

Journal of Biochemical and Molecular Toxicology, 20(6), 279–291.

By: K. Choi n, H. Joo n, R. Rose n & E. Hodgson

MeSH headings : Adult; Biotransformation; Chlorpyrifos / analogs & derivatives; Chlorpyrifos / analysis; Chlorpyrifos / chemistry; Chlorpyrifos / metabolism; Chlorpyrifos / toxicity; Chromatography, High Pressure Liquid; Female; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Male; Mass Spectrometry; Middle Aged; Subcellular Fractions
TL;DR: The results suggest that human liver plays an important role in detoxification, rather than activation, of CPS, and phase II‐related conjugates, including O‐ and S‐glucuronides, were identified in CPS‐treated human hepatocytes, although the O‐sulfate of TCP conjugate was found only when human liver S9 fractions were used as the enzyme source. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Accelerated soil dissipation of tebuconazole following multiple applications to peanut

JOURNAL OF ENVIRONMENTAL QUALITY, 34(4), 1205–1213.

By: T. Potter *, T. Strickland *, H. Joo n & A. Culbreath *

MeSH headings : Arachis; Environmental Monitoring; Kinetics; Soil; Soil Pollutants / analysis; Temperature; Triazoles / analysis; Triazoles / chemistry; Water
TL;DR: It is indicated that varying soil conditions (in particular, soil temperature and water content) may have an equal or greater impact on field dissipation rate than development of accelerated dissipation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

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