Ren-Hua Chung

Works (6)

Updated: July 19th, 2023 21:15

2019 personal communication

Genetic loci determining total immunoglobulin E levels from birth through adulthood

Yao, T.-C., Chung, R.-H., Lin, C.-Y., Tsai, P.-C., Chang, W.-C., Yeh, K.-W., … Huang, J.-L. (2019, March).

By: T. Yao*, R. Chung*, C. Lin *, P. Tsai*, W. Chang *, K. Yeh*, M. Tsai *, S. Liao * ...

MeSH headings : Age Factors; Female; Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Immunoglobulin E / blood; Immunoglobulin E / immunology; Pregnancy
TL;DR: The whole metagenome profiling reveals skin microbiome‐dependent susceptibility to atopic dermatitis flare, and deep sequencing transcriptome analysis of murine wound healing: effects of a multicomponent, Multitarget Natural Product Therapy‐Tr14. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 11, 2019

2008 journal article

X-LRT: A likelihood approach to estimate genetic risks and test association with X-linked markers using a case-parents design

GENETIC EPIDEMIOLOGY, 32(4), 370–380.

By: L. Zhang n, E. Martin*, R. Chung*, Y. Li * & R. Morris *

author keywords: sex linked; maximum-likelihood estimation; confidence interval; hypothesis test; family-based design
MeSH headings : Algorithms; Biometry; Computer Simulation; Confidence Intervals; Epidemiologic Methods; Female; Genes, X-Linked; Genetic Diseases, X-Linked / epidemiology; Genetic Diseases, X-Linked / genetics; Genetic Markers; Haplotypes; Humans; Likelihood Functions; Male; Models, Genetic; Monoamine Oxidase / genetics; Parents; Parkinson Disease / enzymology; Parkinson Disease / genetics; Penetrance; Risk Factors; Siblings
TL;DR: A likelihood approach to estimate disease‐related marker relative risks and test genotype association using a case‐parents design and shows how efficiency with missing parental information can be improved with additional sibling genotype information. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Interpretation of simultaneous linkage and family-based association tests in genome screens

GENETIC EPIDEMIOLOGY, 31(2), 134–142.

By: R. Chung n, E. Hauser * & E. Martin *

author keywords: linkage analysis; family-based association analysis; correlation
MeSH headings : Alleles; Chromosome Mapping; Computer Simulation; Female; Genetic Markers; Genome, Human; Genotype; Humans; Linkage Disequilibrium / genetics; Male; Models, Genetic; Nuclear Family; Pedigree; Prevalence; Siblings; Statistical Distributions
TL;DR: It is concluded that when linkage and association tests are applied in the same data, the type I error rate of neither test will be affected and that power can be increased by applying tests conditionally. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

X-APL: An improved family-based test of association in the presence of linkage for the X chromosome

AMERICAN JOURNAL OF HUMAN GENETICS, 80(1), 59–68.

By: R. Chung*, R. Morris, L. Zhang*, Y. Li & E. Martin

MeSH headings : Chromosomes, Human, X / genetics; Family; Female; Genetic Diseases, X-Linked / genetics; Genetic Markers; Humans; Linkage Disequilibrium; Male; Monoamine Oxidase / genetics; Parkinson Disease / genetics; Pedigree; Siblings
TL;DR: A novel family-based test of association, X-APL, a modification of the test for association in the presence of linkage (APL) test that can use singleton or multiplex families and properly infers missing parental genotypes in linkage regions by considering identity-by-descent parameters for affected siblings. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

The APL test: Extension to general nuclear families and haplotypes and examination of its robustness

HUMAN HEREDITY, 61(4), 189–199.

By: R. Chung n, E. Hauser * & E. Martin *

author keywords: family-based association; linkage disequilibrium; haplotype analysis; rare alleles and rare haplotypes; Hardy-Weinberg disequilibrium
MeSH headings : Computer Simulation; Data Interpretation, Statistical; Gene Frequency; Haplotypes; Humans; Linkage Disequilibrium; Models, Genetic
TL;DR: This work presents a generalization of the APL model and examination of its robustness under a variety of non-standard scenarios, and evaluated general guidelines for the validity of APL with rare alleles and rare haplotypes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Interaction between the alpha-T catenin gene (VR22) and APOE in Alzheimer's disease

JOURNAL OF MEDICAL GENETICS, 42(10), 787–792.

By: E. Martin *, P. Bronson *, Y. Li *, N. Wall*, R. Chung n, D. Schmechel*, G. Small *, P. Xu* ...

MeSH headings : Aged; Aged, 80 and over; Alzheimer Disease / genetics; Apolipoproteins E / genetics; Female; Genetic Predisposition to Disease; Humans; Linkage Disequilibrium; Male; Polymorphism, Genetic; Polymorphism, Single Nucleotide; alpha Catenin / genetics
TL;DR: This study suggests that VR22 or a nearby gene influences susceptibility to Alzheimer’s disease, and the effect is dependent on APOE status. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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