Douglas D. Young

Works (32)

Updated: April 25th, 2025 12:44

2015 article

Optically triggered immune response through photocaged oligonucleotides

Govan, J. M., Young, D. D., Lively, M. O., & Deiters, A. (2015, February 3). Tetrahedron Letters.

By: J. Govan n, D. Young n, M. Lively* & A. Deiters n

author keywords: Oligonucleotide synthesis; Light-activation; Photocaged nucleotides; Immune response; Toll-like receptors
topics (OpenAlex): Photochromic and Fluorescence Chemistry; Nanoplatforms for cancer theranostics; Photodynamic Therapy Research Studies
TL;DR: Synthetic photocaged CpGs via site-specific incorporation of nitropiperonyloxymethyl (NPOM)-caged thymidine residues enable the optical control of TLR9 function and thereby provide light-activation of an immune response. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 article

Heterotaxin: A TGF-β Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus Embryos

Dush, M. K., McIver, A. L., Parr, M. A., Young, D. D., Fisher, J., Newman, D. R., … Nascone-Yoder, N. (2011, February 1). Chemistry & Biology, Vol. 18, pp. 252–263.

By: M. Dush n, A. McIver n, M. Parr n, D. Young n, J. Fisher n, D. Newman n, P. Sannes n, M. Hauck n, A. Deiters n, N. Nascone-Yoder n 

MeSH headings : Animals; Cell Line; Drug Evaluation, Preclinical; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Humans; Intracellular Space / drug effects; Intracellular Space / metabolism; Neovascularization, Physiologic / drug effects; Phenotype; Pyridines / chemistry; Pyridines / pharmacology; Signal Transduction / drug effects; Stereoisomerism; Structure-Activity Relationship; Transforming Growth Factor beta / metabolism; Xenopus laevis
topics (OpenAlex): Congenital heart defects research; Developmental Biology and Gene Regulation
TL;DR: A small molecule screen for left-right asymmetry phenotypes in Xenopus embryos is performed and a pyridine analog, heterotaxin, is discovered, which disrupts both cardiovascular and digestive organ laterality and inhibits TGF-β-dependent left- right asymmetric gene expression. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 article

Activation and Deactivation of DNAzyme and Antisense Function with Light for the Photochemical Regulation of Gene Expression in Mammalian Cells

Young, D. D., Lively, M. O., & Deiters, A. (2010, April 14). Journal of the American Chemical Society.

By: D. Young n, M. Lively n & A. Deiters n

MeSH headings : Base Sequence; Cell Line; DNA / chemistry; DNA / metabolism; DNA, Catalytic / metabolism; DNA, Catalytic / radiation effects; Enzyme Activation; Gene Expression / radiation effects; Gene Expression Regulation; Humans; Light; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides, Antisense / metabolism; Oligodeoxyribonucleotides, Antisense / radiation effects; Photochemical Processes; RNA / metabolism
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; DNA and Nucleic Acid Chemistry; Photochromic and Fluorescence Chemistry
TL;DR: The application of light-activated and light-deactivated antisense agents to the regulation of gene function in mammalian cells represents the first example of gene silencing antisense agent that can be turned on and turned off in mammalian tissue culture. (via Semantic Scholar)
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Source: Web Of Science
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2010 article

Light Regulation of Protein Dimerization and Kinase Activity in Living Cells Using Photocaged Rapamycin and Engineered FKBP

Karginov, A. V., Zou, Y., Shirvanyants, D., Kota, P., Dokholyan, N. V., Young, D. D., … Deiters, A. (2010, December 16). Journal of the American Chemical Society.

By: A. Karginov  n, Y. Zou n, D. Shirvanyants n, P. Kota  n, N. Dokholyan  n, D. Young n, K. Hahn  n, A. Deiters n

MeSH headings : Dimerization; Focal Adhesion Protein-Tyrosine Kinases / metabolism; HEK293 Cells; Humans; Light; Models, Molecular; Molecular Dynamics Simulation; Sirolimus / chemistry; Tacrolimus Binding Proteins / chemistry; Tacrolimus Binding Proteins / metabolism
topics (OpenAlex): Photochromic and Fluorescence Chemistry; Click Chemistry and Applications; Neurobiology and Insect Physiology Research
TL;DR: A new system for light-induced protein dimerization in living cells is developed using a photocaged analogue of rapamycin together with an engineered Rapamycin binding domain and focal adhesion kinase as a target, which demonstrated successful light-mediated regulation of protein interaction and localization in live cells. (via Semantic Scholar)
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Source: Web Of Science
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2010 article

Photocaged T7 RNA Polymerase for the Light Activation of Transcription and Gene Function in Pro‐ and Eukaryotic Cells

Chou, C., Young, D. D., & Deiters, A. (2010, March 20). ChemBioChem.

By: C. Chou n, D. Young n & A. Deiters n

author keywords: amino acids; caged proteins; light activation; polymerases; RNA
MeSH headings : Catalytic Domain; Cell Line; DNA-Directed RNA Polymerases / genetics; DNA-Directed RNA Polymerases / metabolism; Escherichia coli / enzymology; Humans; Luciferases / genetics; Luciferases / metabolism; Models, Molecular; Photochemical Processes; Transcriptional Activation; Tyrosine / chemistry; Ultraviolet Rays; Viral Proteins / genetics; Viral Proteins / metabolism
topics (OpenAlex): Photochromic and Fluorescence Chemistry; bioluminescence and chemiluminescence research; DNA and Nucleic Acid Chemistry
TL;DR: The ability to achieve spatiotemporal regulation of orthogonal RNA synthesis enables the precise dissection and manipulation of a wide range of cellular events, including gene function. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 article

Site-Specific Incorporation of Fluorotyrosines into Proteins in Escherichia coli by Photochemical Disguise

Wilkins, B. J., Marionni, S., Young, D. D., Liu, J., Wang, Y., Salvo, M. L. D., … Cropp, T. A. (2010, February 5). Biochemistry.

By: B. Wilkins *, S. Marionni*, D. Young n, J. Liu *, Y. Wang *, M. Salvo *, A. Deiters n, T. Cropp *

MeSH headings : Escherichia coli / genetics; Escherichia coli / metabolism; Escherichia coli Proteins / chemistry; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Molecular Structure; Protein Engineering / methods; Protein Structure, Secondary; Tyrosine / analogs & derivatives; Tyrosine / chemical synthesis; Tyrosine / chemistry; Tyrosine / metabolism
topics (OpenAlex): Click Chemistry and Applications; RNA and protein synthesis mechanisms; Chemical Synthesis and Analysis
TL;DR: This work genetically encoded the unnatural amino acids o-nitrobenzyl-2-fluorotyrosine, -3-fluorschmidtine, and -2,6-difluorotYrosine in Escherichia coli, effectively preventing global incorporation of fluorotyosine into proteins. (via Semantic Scholar)
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2010 article

Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma

Young, D. D., Connelly, C. M., Grohmann, C., & Deiters, A. (2010, May 19). Journal of the American Chemical Society.

By: D. Young n, C. Connelly n, C. Grohmann n & A. Deiters n

MeSH headings : Apoptosis / drug effects; Base Sequence; Carcinoma, Hepatocellular / drug therapy; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / pathology; Enoxacin / pharmacology; HeLa Cells; Hepatitis C / drug therapy; Hepatitis C / genetics; Humans; Liver Neoplasms / drug therapy; Liver Neoplasms / genetics; Liver Neoplasms / pathology; MicroRNAs / antagonists & inhibitors; MicroRNAs / genetics; MicroRNAs / metabolism; Oligonucleotides, Antisense / genetics; Oligonucleotides, Antisense / pharmacology; Virus Replication / drug effects; Virus Replication / genetics
topics (OpenAlex): MicroRNA in disease regulation; Circular RNAs in diseases; RNA modifications and cancer
TL;DR: The authors' small molecule inhibitors reduce viral replication in liver cells and represent a new approach to the treatment of HCV infections and small molecule activation of miR-122 in liver cancer cells selectively induced apoptosis through caspase activation, thus having implications in cancer chemotherapy. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 article

A Light‐Activated DNA Polymerase

Chou, C., Young, D. D., & Deiters, A. (2009, June 30). Angewandte Chemie International Edition.

By: C. Chou n, D. Young n & A. Deiters n

author keywords: DNA polymerases; mutagenesis; non-natural amino acids; photoactivation; polymerase chain reaction
MeSH headings : Catalytic Domain; Mutation; Nitrobenzenes / chemistry; Photolysis; Polymerase Chain Reaction; Taq Polymerase / chemistry; Taq Polymerase / metabolism; Tyrosine / chemistry; Ultraviolet Rays
topics (OpenAlex): Photochromic and Fluorescence Chemistry; DNA and Nucleic Acid Chemistry; Advanced biosensing and bioanalysis techniques
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 article

Development of a Robust and High Throughput Method for Profiling N-Linked Glycans Derived from Plasma Glycoproteins by NanoLC−FTICR Mass Spectrometry

Bereman, M. S., Young, D. D., Deiters, A., & Muddiman, D. C. (2009, May 12). Journal of Proteome Research, Vol. 8, pp. 3764–3770.

By: M. Bereman n, D. Young n, A. Deiters n & D. Muddiman n 

MeSH headings : Biomarkers, Tumor / metabolism; Blood Proteins / chemistry; Chromatography, Liquid / methods; Detergents / pharmacology; Glycoproteins / chemistry; Humans; Mass Spectrometry / methods; Microwaves; Peptides / chemistry; Polysaccharides / chemistry; Proteome; Proteomics / methods; Spectroscopy, Fourier Transform Infrared / methods; Time Factors
topics (OpenAlex): Glycosylation and Glycoproteins Research; Carbohydrate Chemistry and Synthesis; Enzyme Structure and Function
TL;DR: A step-by-step protocol describing a method for N-linked glycan profiling of plasma glycoproteins by nanoflow liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) is presented. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 article

Light-Activated Cre Recombinase as a Tool for the Spatial and Temporal Control of Gene Function in Mammalian Cells

Edwards, W. F., Young, D. D., & Deiters, A. (2009, May 4). ACS Chemical Biology.

By: W. Edwards n, D. Young n & A. Deiters n

MeSH headings : Binding Sites; Biocatalysis / radiation effects; Cells, Cultured; Cloning, Molecular; DNA / chemistry; DNA / metabolism; Genetic Engineering / methods; Humans; Integrases / chemistry; Integrases / metabolism; Models, Molecular; Nitrobenzenes / chemistry; Nitrobenzenes / pharmacology; Recombination, Genetic / radiation effects; Time Factors; Ultraviolet Rays
topics (OpenAlex): Photochromic and Fluorescence Chemistry; Photoreceptor and optogenetics research; Light effects on plants
TL;DR: Tight spatio-temporal control over DNA recombination is achieved by the installation of a light-responsive o-nitrobenzyl caging group directly in the catalytic site of Cre, inhibiting its activity. (via Semantic Scholar)
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2009 article

Open-Vessel Microwave-Mediated [2+2+2]-Cyclotrimerization Reactions

Deiters, A., Young, D., & Teske, J. (2009, October 7). Synthesis.

By: A. Deiters*, D. Young* & J. Teske*

author keywords: [2+2+2] cyclotrimerization; alkynes; microwave; bicyclic compounds; transition metal catalysis
topics (OpenAlex): Catalytic Alkyne Reactions; Catalysis for Biomass Conversion
Source: Web Of Science
Added: August 6, 2018

2009 article

Photochemical Regulation of Restriction Endonuclease Activity

Young, D. D., Govan, J. M., Lively, M. O., & Deiters, A. (2009, June 16). ChemBioChem.

By: D. Young n, J. Govan n, M. Lively* & A. Deiters n

author keywords: cage compounds; DNA cleavage; DNA enzymes; photochemistry
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Base Sequence; Benzodioxoles / chemistry; DNA / chemistry; DNA / radiation effects; DNA Cleavage; DNA Restriction Enzymes / genetics; DNA Restriction Enzymes / metabolism; Deoxyribonuclease BamHI / genetics; Deoxyribonuclease BamHI / metabolism; Deoxyribonuclease EcoRI / genetics; Deoxyribonuclease EcoRI / metabolism; Deoxyribonucleases, Type II Site-Specific / genetics; Deoxyribonucleases, Type II Site-Specific / metabolism; Substrate Specificity; Thymidine / analogs & derivatives; Thymidine / chemistry; Ultraviolet Rays
topics (OpenAlex): Photochromic and Fluorescence Chemistry; bioluminescence and chemiluminescence research; Photoreceptor and optogenetics research
TL;DR: Photolabile protecting groups have been installed on DNA substrates and have been demonstrated to inhibit restriction endonuclease activity until removed by UV light irradiation, but these groups do not appear to dramatically affect initial binding of the enzyme to the DNA substrate, but rather prevent recognition of the specific cleavage site. (via Semantic Scholar)
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2009 journal article

Restriction enzyme-free mutagenesis via the light regulation of DNA polymerization

Nucleic Acids Research, 37(8).

By: D. Young, H. Lusic, M. Lively & A. Deiters

Source: NC State University Libraries
Added: August 6, 2018

2009 article

The effect of microwave irradiation on DNA hybridization

Edwards, W. F., Young, D. D., & Deiters, A. (2009, January 1). Organic & Biomolecular Chemistry.

By: W. Edwards n, D. Young n & A. Deiters n

MeSH headings : Base Sequence; DNA / chemistry; DNA / genetics; DNA / radiation effects; Microwaves; Nucleic Acid Denaturation / radiation effects; Nucleic Acid Hybridization / radiation effects; Spectrometry, Fluorescence; Transition Temperature
topics (OpenAlex): Microwave-Assisted Synthesis and Applications; DNA and Nucleic Acid Chemistry; Bacteriophages and microbial interactions
TL;DR: Observations indicate a specific interaction of microwaves with DNA, and have important implications in the chemical or enzymatic processing of DNA under microwave heating. (via Semantic Scholar)
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2008 article

A general approach to triphenylenes and azatriphenylenes: total synthesis of dehydrotylophorine and tylophorine

McIver, A., Young, D. D., & Deiters, A. (2008, January 1). Chemical Communications.

By: A. McIver n, D. Young n & A. Deiters n

MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Alkaloids / radiation effects; Aza Compounds / chemical synthesis; Aza Compounds / chemistry; Aza Compounds / radiation effects; Chrysenes / chemical synthesis; Chrysenes / chemistry; Chrysenes / radiation effects; Cyclization; Indolizines / chemical synthesis; Indolizines / chemistry; Indolizines / radiation effects; Microwaves; Molecular Structure; Phenanthrenes / chemical synthesis; Phenanthrenes / chemistry; Phenanthrenes / radiation effects; Stereoisomerism
topics (OpenAlex): Phytochemistry and biological activities of Ficus species; Phytochemical compounds biological activities; Carbohydrate Chemistry and Synthesis
TL;DR: A convergent and flexible synthesis of substituted triphenylenes, azatriphenylene, and the cytotoxic alkaloids dehydrotylophorine and tylophOrine has been developed. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Gene Silencing in Mammalian Cells with Light-Activated Antisense Agents

ChemBioChem, 9(18), 2937–2940.

By: D. Young n, H. Lusic n, M. Lively*, J. Yoder*  & A. Deiters n

author keywords: Antisense agents; caged compounds; DNA; gene regulation; RNA
MeSH headings : Animals; Base Sequence; Gene Silencing; Genes, Reporter; Light; Luciferases, Renilla / chemistry; Mice; NIH 3T3 Cells; Oligonucleotides, Antisense / chemistry; Oligonucleotides, Antisense / metabolism; Oligonucleotides, Antisense / radiation effects; Phosphorothioate Oligonucleotides / chemistry; Phosphorothioate Oligonucleotides / metabolism; Transfection
topics (OpenAlex): Photochromic and Fluorescence Chemistry; bioluminescence and chemiluminescence research; Advanced biosensing and bioanalysis techniques
TL;DR: Detailed knowledge of the external regulation of gene func-tion is a fundamental necessity in order to annotate sequencedgenomes and to understand biological processes in single cells and multicellular organisms. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2008 journal article

Light-activation of gene function in mammalian cells via ribozymes

Chem. Commun., (5), 568–570.

By: D. Young n, R. Garner n, J. Yoder n  & A. Deiters n

MeSH headings : Cell Line; Gene Expression / radiation effects; Humans; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; RNA, Messenger / metabolism; Toyocamycin / chemistry; Toyocamycin / radiation effects; Ultraviolet Rays
topics (OpenAlex): Photochromic and Fluorescence Chemistry; Photoreceptor and optogenetics research; Supramolecular Self-Assembly in Materials
TL;DR: A ribozyme based gene control element enabled the spatio-temporal regulation of gene function in mammalian cell culture with light. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2008 article

Light‐Regulated RNA–Small Molecule Interactions

Young, D. D., & Deiters, A. (2008, April 11). ChemBioChem.

By: D. Young n & A. Deiters n

author keywords: aptamer; light; riboswitch; RNA; spiropyran
MeSH headings : Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / isolation & purification; Benzopyrans / chemistry; Indoles / chemistry; Light; Molecular Structure; Nitro Compounds / chemistry; Photochemistry; Pyrimidinones / chemistry; RNA / chemistry; Substrate Specificity; Surface Plasmon Resonance
topics (OpenAlex): Photochromic and Fluorescence Chemistry; Advanced biosensing and bioanalysis techniques; Photoreceptor and optogenetics research
TL;DR: The development of light-regulated processes represents a noninvasive means to exert a high level of spatial and temporal control over a chemical or biological system and allows for the irreversible activation or deactivation of the system under study, thus limiting the scope of its utility. (via Semantic Scholar)
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Source: Web Of Science
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2008 article

Microwave Activation of Enzymatic Catalysis

Young, D. D., Nichols, J., Kelly, R. M., & Deiters, A. (2008, July 10). Journal of the American Chemical Society, Vol. 130, p. 10048-.

By: D. Young n, J. Nichols n, R. Kelly n  & A. Deiters n

MeSH headings : Carboxylesterase / metabolism; Catalysis; Enzymes / metabolism; Hot Temperature; Kinetics; Microwaves; Pyrococcus furiosus / enzymology; Sulfolobus solfataricus / enzymology; Thermotoga maritima / enzymology; alpha-Galactosidase / metabolism; beta-Glucosidase / metabolism
topics (OpenAlex): Microwave-Assisted Synthesis and Applications; Chemical Synthesis and Analysis; Asymmetric Hydrogenation and Catalysis
TL;DR: This is the first illustration of a specific microwave effect in enzymatic catalysis, used to regulate biocatalysis, in a microwave reactor. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

Microwave-assisted synthesis of unnatural amino acids

Young, D. D., Torres-Kolbus, J., & Deiters, A. (2008, September 11). Bioorganic & Medicinal Chemistry Letters.

By: D. Young n, J. Torres-Kolbus n & A. Deiters n

author keywords: microwave; microwave synthesis; amino acid; unnatural amino acid; peptide synthesis; protein synthesis; unnatural amino acid; mutagenesis
MeSH headings : Amino Acids / chemical synthesis; Chemistry, Pharmaceutical / methods; Drug Design; Magnetic Resonance Spectroscopy; Microwaves; Models, Chemical; Mutagenesis; Peptides / chemistry; Proteins / chemistry; Temperature
topics (OpenAlex): Chemical Synthesis and Analysis; Carbohydrate Chemistry and Synthesis; Microwave-Assisted Synthesis and Applications
TL;DR: Microwave irradiation has been proven to be a useful tool in the rapid assembly of racemic unnatural amino acids in only two steps and its commercial availability and the high yields and high purities of the final amino acid products. (via Semantic Scholar)
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2008 article

Small‐Molecule Inhibitors of MicroRNA miR‐21 Function

Gumireddy, K., Young, D. D., Xiong, X., Hogenesch, J. B., Huang, Q., & Deiters, A. (2008, August 19). Angewandte Chemie International Edition.

By: K. Gumireddy*, D. Young n, X. Xiong  n, J. Hogenesch *, Q. Huang* & A. Deiters n

author keywords: antitumor agents; cell-based assays; inhibitors; medicinal chemistry; microRNA
MeSH headings : Gene Expression; Genes, Reporter / genetics; HeLa Cells; Humans; MicroRNAs / antagonists & inhibitors; MicroRNAs / genetics; Molecular Structure
topics (OpenAlex): MicroRNA in disease regulation; RNA Interference and Gene Delivery; Advanced biosensing and bioanalysis techniques
TL;DR: A cellular screen is reported for miRNA pathway inhibitors and the first small molecule modifiers of miRNA function, which are likely to be important tools to elucidate the detailed mechanisms of mi RNA function and provide lead structures for the development of new therapeutics. (via Semantic Scholar)
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2008 article

Synthesis of Anthracene and Azaanthracene Fluorophores via [2+2+2] Cyclotrimerization Reactions

Zou, Y., Young, D. D., Cruz-Montanez, A., & Deiters, A. (2008, September 25). Organic Letters.

By: Y. Zou n, D. Young n, A. Cruz-Montanez n & A. Deiters n

MeSH headings : Anthracenes / chemical synthesis; Anthracenes / chemistry; Aza Compounds / chemical synthesis; Aza Compounds / chemistry; Benzene / chemistry; Cell Line; Cyclization; Fluorescent Dyes / chemical synthesis; Fluorescent Dyes / chemistry; Humans; Molecular Structure; Pyridines / chemistry
topics (OpenAlex): Chemical Synthesis and Analysis; Click Chemistry and Applications; Catalytic Cross-Coupling Reactions
TL;DR: A highly convergent [2-2+2] cyclotrimerization approach to anthracenes and 2-azaanthracenes has been developed that allows for the facile introduction of the anthracene moiety on alkyne and nitrile bearing molecules and the rapid construction of compound arrays. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 article

A General Approach to Chemo‐ and Regioselective Cyclotrimerization Reactions

Young, D. D., & Deiters, A. (2007, May 25). Angewandte Chemie International Edition.

By: D. Young n & A. Deiters n

author keywords: cycloaddition; heterocycles; microwave synthesis; solid-phase synthesis; transition metals
topics (OpenAlex): Catalytic Alkyne Reactions; Synthesis and Biological Evaluation
Source: Web Of Science
Added: August 6, 2018

2007 article

Light-triggered polymerase chain reaction

Young, D. D., Edwards, W. F., Lusic, H., Lively, M. O., & Deiters, A. (2007, November 14). Chemical Communications.

By: D. Young n, W. Edwards n, H. Lusic n, M. Lively* & A. Deiters n

MeSH headings : Base Sequence; DNA / chemistry; DNA Primers; Light; Photochemistry; Polymerase Chain Reaction / methods
topics (OpenAlex): Photochromic and Fluorescence Chemistry; DNA and Nucleic Acid Chemistry; Click Chemistry and Applications
TL;DR: Photochemical control of the polymerase chain reaction has been achieved through the incorporation of light-triggered nucleotides into DNA. (via Semantic Scholar)
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2007 article

Microwave-Assisted Solid-Supported Alkyne Cyclotrimerization Reactions for Combinatorial Chemistry

Young, D. D., Sripada, L., & Deiters, A. (2007, July 21). Journal of Combinatorial Chemistry.

By: D. Young n, L. Sripada n & A. Deiters n

MeSH headings : Alkynes / chemistry; Combinatorial Chemistry Techniques; Cyclization; Microwaves
topics (OpenAlex): Catalytic Alkyne Reactions; Multicomponent Synthesis of Heterocycles; Microwave-Assisted Synthesis and Applications
Source: Web Of Science
Added: August 6, 2018

2007 article

Photochemical Activation of Protein Expression in Bacterial Cells

Young, D. D., & Deiters, A. (2007, April 25). Angewandte Chemie International Edition.

By: D. Young n & A. Deiters n

author keywords: bacterial cells; caged compounds; gene expression; photochemistry; proteins
MeSH headings : Bacteria / growth & development; Bacteria / metabolism; Gene Expression Regulation, Enzymologic / radiation effects; Molecular Conformation; Photochemistry; Ultraviolet Rays; beta-Galactosidase / chemistry; beta-Galactosidase / genetics; beta-Galactosidase / radiation effects
topics (OpenAlex): Photochromic and Fluorescence Chemistry; bioluminescence and chemiluminescence research; Photoreceptor and optogenetics research
TL;DR: A light-inducible gene-expression system which can be used in bacterial cells, plants, and mammalian organisms is reported, based on the lactose (lac) repressor which binds to the lac operator ( lacO), thereby inhibiting RNA polymerase from performing gene transcription. (via Semantic Scholar)
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2007 article

Photochemical DNA Activation

Lusic, H., Young, D. D., Lively, M. O., & Deiters, A. (2007, April 21). Organic Letters.

By: H. Lusic n, D. Young n, M. Lively n & A. Deiters n

MeSH headings : DNA, Catalytic / chemistry; DNA, Catalytic / metabolism; Molecular Sequence Data; Molecular Structure; Photochemistry; RNA / metabolism; Substrate Specificity
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; DNA and Nucleic Acid Chemistry; Photochromic and Fluorescence Chemistry
TL;DR: A new photocaged nucleoside was synthesized and incorporated into DNA with the use of standard synthesis conditions and Brief irradiation with nonphotodamaging UV light led to rapid decaging and almost quantitative restoration of DNAzyme activity. (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 article

Synthesis of Indanones via Solid-Supported [2+2+2] Cyclotrimerization

Senaiar, R. S., Teske, J. A., Young, D. D., & Deiters, A. (2007, September 1). The Journal of Organic Chemistry.

By: R. Senaiar n, J. Teske n, D. Young n & A. Deiters n

topics (OpenAlex): Synthesis and biological activity; Synthesis of Indole Derivatives; Synthesis of Organic Compounds
TL;DR: A new facile approach toward natural and unnatural indanones has been developed, featuring a solid-supported [2+2+3+2] cyclotrimerization as the key step. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: Web Of Science
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2006 article

Photochemical control of biological processes

Young, D. D., & Deiters, A. (2006, December 20). Organic & Biomolecular Chemistry.

By: D. Young n & A. Deiters n

MeSH headings : Enzymes / genetics; Enzymes / radiation effects; Humans; Light; Molecular Conformation; Organic Chemicals / chemistry; Organic Chemicals / radiation effects; Photochemistry; Proteins / genetics; Proteins / radiation effects; Ultraviolet Rays
topics (OpenAlex): Photochromic and Fluorescence Chemistry; bioluminescence and chemiluminescence research; Click Chemistry and Applications
TL;DR: This report summarizes the advances made in recent years, focusing predominantly on the in vivo regulation of gene function using irradiation with UV light, using photocaging groups installed either on a small molecule modulator of biomolecular function or directly on a biological macromolecule itself. (via Semantic Scholar)
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2006 article

Photochemical hammerhead ribozyme activation

Young, D. D., & Deiters, A. (2006, March 3). Bioorganic & Medicinal Chemistry Letters.

By: D. Young n & A. Deiters n

author keywords: caged compounds; genomics; photochemistry; ribozymes; RNA
MeSH headings : Base Sequence; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Nucleic Acid Conformation; Photochemistry; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; Ultraviolet Rays
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; RNA and protein synthesis mechanisms; Molecular Junctions and Nanostructures
TL;DR: The light-activation of allosteric cis and trans acting ribozymes via decaging of a small organic molecule ligand is reported through an optimized N-caging group based on a nitrobenzyl core structure that can potentially be employed toward a light-induced control of gene function. (via Semantic Scholar)
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2006 article

Pyridines via solid-supported [2 + 2 + 2] cyclotrimerization

Senaiar, R. S., Young, D. D., & Deiters, A. (2006, January 1). Chemical Communications.

By: R. Senaiar n, D. Young n & A. Deiters n

topics (OpenAlex): Chemical Synthesis and Analysis; Cyclopropane Reaction Mechanisms; Catalytic Alkyne Reactions
TL;DR: The formation of pyridines via a crossed [2 + 2 + 2] cycloaddition has been achieved on a solid-support for the first time. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2006 article

Solid‐Supported [2+2+2] Cyclotrimerizations

Young, D. D., Senaiar, R. S., & Deiters, A. (2006, June 6). Chemistry - A European Journal.

By: D. Young n, R. Senaiar n & A. Deiters n

author keywords: combinatorial chemistry; cyclotrimerization; homogeneous catalysis; solid-phase synthesis
topics (OpenAlex): Synthetic Organic Chemistry Methods; Catalytic Alkyne Reactions; Microbial Natural Products and Biosynthesis
TL;DR: The transition-metal-catalyzed [2+2-2] cyclotrimerization of a diyne and an alkyne provides a convergent route to highly-substituted aromatic rings and enables rapid combinatorial access to diverse sets of carbo- and heterocyclic small-molecule arrays. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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