Works (32)
Updated: July 16th, 2023 21:15
2015 journal article
Optically triggered immune response through photocaged oligonucleotides
TETRAHEDRON LETTERS, 56(23), 3639–3642.
author keywords: Oligonucleotide synthesis; Light-activation; Photocaged nucleotides; Immune response; Toll-like receptors
TL;DR:
Synthetic photocaged CpGs via site-specific incorporation of nitropiperonyloxymethyl (NPOM)-caged thymidine residues enable the optical control of TLR9 function and thereby provide light-activation of an immune response.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Heterotaxin: A TGF-beta Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus Embryos
CHEMISTRY & BIOLOGY, 18(2), 252–263.
MeSH headings : Animals; Cell Line; Drug Evaluation, Preclinical; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Humans; Intracellular Space / drug effects; Intracellular Space / metabolism; Neovascularization, Physiologic / drug effects; Phenotype; Pyridines / chemistry; Pyridines / pharmacology; Signal Transduction / drug effects; Stereoisomerism; Structure-Activity Relationship; Transforming Growth Factor beta / metabolism; Xenopus laevis
TL;DR:
A small molecule screen for left-right asymmetry phenotypes in Xenopus embryos is performed and a pyridine analog, heterotaxin, is discovered, which disrupts both cardiovascular and digestive organ laterality and inhibits TGF-β-dependent left- right asymmetric gene expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Activation and Deactivation of DNAzyme and Antisense Function with Light for the Photochemical Regulation of Gene Expression in Mammalian Cells
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(17), 6183–6193.
MeSH headings : Base Sequence; Cell Line; DNA / chemistry; DNA / metabolism; DNA, Catalytic / metabolism; DNA, Catalytic / radiation effects; Enzyme Activation; Gene Expression / radiation effects; Gene Expression Regulation; Humans; Light; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides, Antisense / metabolism; Oligodeoxyribonucleotides, Antisense / radiation effects; Photochemical Processes; RNA / metabolism
TL;DR:
The application of light-activated and light-deactivated antisense agents to the regulation of gene function in mammalian cells represents the first example of gene silencing antisense agent that can be turned on and turned off in mammalian tissue culture.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Light Regulation of Protein Dimerization and Kinase Activity in Living Cells Using Photocaged Rapamycin and Engineered FKBP
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(3), 420–423.
MeSH headings : Dimerization; Focal Adhesion Protein-Tyrosine Kinases / metabolism; HEK293 Cells; Humans; Light; Models, Molecular; Molecular Dynamics Simulation; Sirolimus / chemistry; Tacrolimus Binding Proteins / chemistry; Tacrolimus Binding Proteins / metabolism
TL;DR:
A new system for light-induced protein dimerization in living cells is developed using a photocaged analogue of rapamycin together with an engineered Rapamycin binding domain and focal adhesion kinase as a target, which demonstrated successful light-mediated regulation of protein interaction and localization in live cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Photocaged T7 RNA Polymerase for the Light Activation of Transcription and Gene Function in Pro- and Eukaryotic Cells
CHEMBIOCHEM, 11(7), 972–977.
author keywords: amino acids; caged proteins; light activation; polymerases; RNA
MeSH headings : Catalytic Domain; Cell Line; DNA-Directed RNA Polymerases / genetics; DNA-Directed RNA Polymerases / metabolism; Escherichia coli / enzymology; Humans; Luciferases / genetics; Luciferases / metabolism; Models, Molecular; Photochemical Processes; Transcriptional Activation; Tyrosine / chemistry; Ultraviolet Rays; Viral Proteins / genetics; Viral Proteins / metabolism
TL;DR:
The ability to achieve spatiotemporal regulation of orthogonal RNA synthesis enables the precise dissection and manipulation of a wide range of cellular events, including gene function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Site-Specific Incorporation of Fluorotyrosines into Proteins in Escherichia coli by Photochemical Disguise
BIOCHEMISTRY, 49(8), 1557–1559.
MeSH headings : Escherichia coli / genetics; Escherichia coli / metabolism; Escherichia coli Proteins / chemistry; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Molecular Structure; Protein Engineering / methods; Protein Structure, Secondary; Tyrosine / analogs & derivatives; Tyrosine / chemical synthesis; Tyrosine / chemistry; Tyrosine / metabolism
TL;DR:
This work genetically encoded the unnatural amino acids o-nitrobenzyl-2-fluorotyrosine, -3-fluorschmidtine, and -2,6-difluorotYrosine in Escherichia coli, effectively preventing global incorporation of fluorotyosine into proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(23), 7976–7981.
MeSH headings : Apoptosis / drug effects; Base Sequence; Carcinoma, Hepatocellular / drug therapy; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / pathology; Enoxacin / pharmacology; HeLa Cells; Hepatitis C / drug therapy; Hepatitis C / genetics; Humans; Liver Neoplasms / drug therapy; Liver Neoplasms / genetics; Liver Neoplasms / pathology; MicroRNAs / antagonists & inhibitors; MicroRNAs / genetics; MicroRNAs / metabolism; Oligonucleotides, Antisense / genetics; Oligonucleotides, Antisense / pharmacology; Virus Replication / drug effects; Virus Replication / genetics
TL;DR:
The authors' small molecule inhibitors reduce viral replication in liver cells and represent a new approach to the treatment of HCV infections and small molecule activation of miR-122 in liver cancer cells selectively induced apoptosis through caspase activation, thus having implications in cancer chemotherapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
A Light-Activated DNA Polymerase
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 48(32), 5950–5953.
author keywords: DNA polymerases; mutagenesis; non-natural amino acids; photoactivation; polymerase chain reaction
MeSH headings : Catalytic Domain; Mutation; Nitrobenzenes / chemistry; Photolysis; Polymerase Chain Reaction; Taq Polymerase / chemistry; Taq Polymerase / metabolism; Tyrosine / chemistry; Ultraviolet Rays
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Development of a Robust and High Throughput Method for Profiling N-Linked Glycans Derived from Plasma Glycoproteins by NanoLC-FTICR Mass Spectrometry
JOURNAL OF PROTEOME RESEARCH, 8(7), 3764–3770.
MeSH headings : Biomarkers, Tumor / metabolism; Blood Proteins / chemistry; Chromatography, Liquid / methods; Detergents / pharmacology; Glycoproteins / chemistry; Humans; Mass Spectrometry / methods; Microwaves; Peptides / chemistry; Polysaccharides / chemistry; Proteome; Proteomics / methods; Spectroscopy, Fourier Transform Infrared / methods; Time Factors
TL;DR:
A step-by-step protocol describing a method for N-linked glycan profiling of plasma glycoproteins by nanoflow liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Light-Activated Cre Recombinase as a Tool for the Spatial and Temporal Control of Gene Function in Mammalian Cells
ACS CHEMICAL BIOLOGY, 4(6), 441–445.
MeSH headings : Binding Sites; Biocatalysis / radiation effects; Cells, Cultured; Cloning, Molecular; DNA / chemistry; DNA / metabolism; Genetic Engineering / methods; Humans; Integrases / chemistry; Integrases / metabolism; Models, Molecular; Nitrobenzenes / chemistry; Nitrobenzenes / pharmacology; Recombination, Genetic / radiation effects; Time Factors; Ultraviolet Rays
TL;DR:
Tight spatio-temporal control over DNA recombination is achieved by the installation of a light-responsive o-nitrobenzyl caging group directly in the catalytic site of Cre, inhibiting its activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Open-Vessel Microwave-Mediated [2+2+2]-Cyclotrimerization Reactions
SYNTHESIS-STUTTGART, (22), 3785–3790.
author keywords: [2+2+2] cyclotrimerization; alkynes; microwave; bicyclic compounds; transition metal catalysis
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Photochemical Regulation of Restriction Endonuclease Activity
CHEMBIOCHEM, 10(10), 1612–1616.
author keywords: cage compounds; DNA cleavage; DNA enzymes; photochemistry
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Base Sequence; Benzodioxoles / chemistry; DNA / chemistry; DNA / radiation effects; DNA Cleavage; DNA Restriction Enzymes / genetics; DNA Restriction Enzymes / metabolism; Deoxyribonuclease BamHI / genetics; Deoxyribonuclease BamHI / metabolism; Deoxyribonuclease EcoRI / genetics; Deoxyribonuclease EcoRI / metabolism; Deoxyribonucleases, Type II Site-Specific / genetics; Deoxyribonucleases, Type II Site-Specific / metabolism; Substrate Specificity; Thymidine / analogs & derivatives; Thymidine / chemistry; Ultraviolet Rays
TL;DR:
Photolabile protecting groups have been installed on DNA substrates and have been demonstrated to inhibit restriction endonuclease activity until removed by UV light irradiation, but these groups do not appear to dramatically affect initial binding of the enzyme to the DNA substrate, but rather prevent recognition of the specific cleavage site.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Restriction enzyme-free mutagenesis via the light regulation of DNA polymerization
Nucleic Acids Research, 37(8).
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
The effect of microwave irradiation on DNA hybridization
ORGANIC & BIOMOLECULAR CHEMISTRY, 7(12), 2506–2508.
MeSH headings : Base Sequence; DNA / chemistry; DNA / genetics; DNA / radiation effects; Microwaves; Nucleic Acid Denaturation / radiation effects; Nucleic Acid Hybridization / radiation effects; Spectrometry, Fluorescence; Transition Temperature
TL;DR:
Observations indicate a specific interaction of microwaves with DNA, and have important implications in the chemical or enzymatic processing of DNA under microwave heating.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
A general approach to triphenylenes and azatriphenylenes: total synthesis of dehydrotylophorine and tylophorine
CHEMICAL COMMUNICATIONS, (39), 4750–4752.
MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Alkaloids / radiation effects; Aza Compounds / chemical synthesis; Aza Compounds / chemistry; Aza Compounds / radiation effects; Chrysenes / chemical synthesis; Chrysenes / chemistry; Chrysenes / radiation effects; Cyclization; Indolizines / chemical synthesis; Indolizines / chemistry; Indolizines / radiation effects; Microwaves; Molecular Structure; Phenanthrenes / chemical synthesis; Phenanthrenes / chemistry; Phenanthrenes / radiation effects; Stereoisomerism
TL;DR:
A convergent and flexible synthesis of substituted triphenylenes, azatriphenylene, and the cytotoxic alkaloids dehydrotylophorine and tylophOrine has been developed.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Gene Silencing in Mammalian Cells with Light-Activated Antisense Agents
ChemBioChem, 9(18), 2937–2940.
author keywords: Antisense agents; caged compounds; DNA; gene regulation; RNA
MeSH headings : Animals; Base Sequence; Gene Silencing; Genes, Reporter; Light; Luciferases, Renilla / chemistry; Mice; NIH 3T3 Cells; Oligonucleotides, Antisense / chemistry; Oligonucleotides, Antisense / metabolism; Oligonucleotides, Antisense / radiation effects; Phosphorothioate Oligonucleotides / chemistry; Phosphorothioate Oligonucleotides / metabolism; Transfection
TL;DR:
Detailed knowledge of the external regulation of gene func-tion is a fundamental necessity in order to annotate sequencedgenomes and to understand biological processes in single cells and multicellular organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Light-activation of gene function in mammalian cells via ribozymes
Chem. Commun., (5), 568–570.
MeSH headings : Cell Line; Gene Expression / radiation effects; Humans; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; RNA, Messenger / metabolism; Toyocamycin / chemistry; Toyocamycin / radiation effects; Ultraviolet Rays
TL;DR:
A ribozyme based gene control element enabled the spatio-temporal regulation of gene function in mammalian cell culture with light.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Light-regulated RNA-small molecule interactions
CHEMBIOCHEM, 9(8), 1225–1228.
author keywords: aptamer; light; riboswitch; RNA; spiropyran
MeSH headings : Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / isolation & purification; Benzopyrans / chemistry; Indoles / chemistry; Light; Molecular Structure; Nitro Compounds / chemistry; Photochemistry; Pyrimidinones / chemistry; RNA / chemistry; Substrate Specificity; Surface Plasmon Resonance
TL;DR:
The development of light-regulated processes represents a noninvasive means to exert a high level of spatial and temporal control over a chemical or biological system and allows for the irreversible activation or deactivation of the system under study, thus limiting the scope of its utility.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Microwave activation of enzymatic catalysis
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(31), 10048-+.
MeSH headings : Carboxylesterase / metabolism; Catalysis; Enzymes / metabolism; Hot Temperature; Kinetics; Microwaves; Pyrococcus furiosus / enzymology; Sulfolobus solfataricus / enzymology; Thermotoga maritima / enzymology; alpha-Galactosidase / metabolism; beta-Glucosidase / metabolism
TL;DR:
This is the first illustration of a specific microwave effect in enzymatic catalysis, used to regulate biocatalysis, in a microwave reactor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Microwave-assisted synthesis of unnatural amino acids
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(20), 5478–5480.
author keywords: microwave; microwave synthesis; amino acid; unnatural amino acid; peptide synthesis; protein synthesis; unnatural amino acid; mutagenesis
MeSH headings : Amino Acids / chemical synthesis; Chemistry, Pharmaceutical / methods; Drug Design; Magnetic Resonance Spectroscopy; Microwaves; Models, Chemical; Mutagenesis; Peptides / chemistry; Proteins / chemistry; Temperature
TL;DR:
Microwave irradiation has been proven to be a useful tool in the rapid assembly of racemic unnatural amino acids in only two steps and its commercial availability and the high yields and high purities of the final amino acid products.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Small-molecule inhibitors of microRNA miR-21 function
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47(39), 7482–7484.
author keywords: antitumor agents; cell-based assays; inhibitors; medicinal chemistry; microRNA
MeSH headings : Gene Expression; Genes, Reporter / genetics; HeLa Cells; Humans; MicroRNAs / antagonists & inhibitors; MicroRNAs / genetics; Molecular Structure
TL;DR:
A cellular screen is reported for miRNA pathway inhibitors and the first small molecule modifiers of miRNA function, which are likely to be important tools to elucidate the detailed mechanisms of mi RNA function and provide lead structures for the development of new therapeutics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Synthesis of Anthracene and Azaanthracene Fluorophores via [2+2+2] Cyclotrimerization Reactions
ORGANIC LETTERS, 10(20), 4661–4664.
MeSH headings : Anthracenes / chemical synthesis; Anthracenes / chemistry; Aza Compounds / chemical synthesis; Aza Compounds / chemistry; Benzene / chemistry; Cell Line; Cyclization; Fluorescent Dyes / chemical synthesis; Fluorescent Dyes / chemistry; Humans; Molecular Structure; Pyridines / chemistry
TL;DR:
A highly convergent [2-2+2] cyclotrimerization approach to anthracenes and 2-azaanthracenes has been developed that allows for the facile introduction of the anthracene moiety on alkyne and nitrile bearing molecules and the rapid construction of compound arrays.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
A general approach to chemo- and regioselective cyclotrimerization reactions
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46(27), 5187–5190.
author keywords: cycloaddition; heterocycles; microwave synthesis; solid-phase synthesis; transition metals
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Light-triggered polymerase chain reaction
CHEMICAL COMMUNICATIONS, (4), 462–464.
MeSH headings : Base Sequence; DNA / chemistry; DNA Primers; Light; Photochemistry; Polymerase Chain Reaction / methods
TL;DR:
Photochemical control of the polymerase chain reaction has been achieved through the incorporation of light-triggered nucleotides into DNA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Microwave-assisted solid-supported alkyne cyclotrimerization reactions for combinatorial chemistry
JOURNAL OF COMBINATORIAL CHEMISTRY, 9(5), 735–738.
MeSH headings : Alkynes / chemistry; Combinatorial Chemistry Techniques; Cyclization; Microwaves
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Photochemical DNA activation
ORGANIC LETTERS, 9(10), 1903–1906.
MeSH headings : DNA, Catalytic / chemistry; DNA, Catalytic / metabolism; Molecular Sequence Data; Molecular Structure; Photochemistry; RNA / metabolism; Substrate Specificity
TL;DR:
A new photocaged nucleoside was synthesized and incorporated into DNA with the use of standard synthesis conditions and Brief irradiation with nonphotodamaging UV light led to rapid decaging and almost quantitative restoration of DNAzyme activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Photochemical activation of protein expression in bacterial cells
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46(23), 4290–4292.
author keywords: bacterial cells; caged compounds; gene expression; photochemistry; proteins
TL;DR:
A light-inducible gene-expression system which can be used in bacterial cells, plants, and mammalian organisms is reported, based on the lactose (lac) repressor which binds to the lac operator ( lacO), thereby inhibiting RNA polymerase from performing gene transcription.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Synthesis of indanones via solid-supported [2+2+2] cyclotrimerization
JOURNAL OF ORGANIC CHEMISTRY, 72(20), 7801–7804.
TL;DR:
A new facile approach toward natural and unnatural indanones has been developed, featuring a solid-supported [2+2+3+2] cyclotrimerization as the key step.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Photochemical control of biological processes
ORGANIC & BIOMOLECULAR CHEMISTRY, 5(7), 999–1005.
MeSH headings : Enzymes / genetics; Enzymes / radiation effects; Humans; Light; Molecular Conformation; Organic Chemicals / chemistry; Organic Chemicals / radiation effects; Photochemistry; Proteins / genetics; Proteins / radiation effects; Ultraviolet Rays
TL;DR:
This report summarizes the advances made in recent years, focusing predominantly on the in vivo regulation of gene function using irradiation with UV light, using photocaging groups installed either on a small molecule modulator of biomolecular function or directly on a biological macromolecule itself.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Photochemical hammerhead ribozyme activation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(10), 2658–2661.
author keywords: caged compounds; genomics; photochemistry; ribozymes; RNA
MeSH headings : Base Sequence; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Nucleic Acid Conformation; Photochemistry; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; Ultraviolet Rays
TL;DR:
The light-activation of allosteric cis and trans acting ribozymes via decaging of a small organic molecule ligand is reported through an optimized N-caging group based on a nitrobenzyl core structure that can potentially be employed toward a light-induced control of gene function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Pyridines via solid-supported [2+2+2] cyclotrimerization
Chemical Communications (Cambridge, England), (12), 1313–1315.
TL;DR:
The formation of pyridines via a crossed [2 + 2 + 2] cycloaddition has been achieved on a solid-support for the first time.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Solid-supported [2+2+2] cyclotrimerizations
CHEMISTRY-A EUROPEAN JOURNAL, 12(21), 5563–5568.
author keywords: combinatorial chemistry; cyclotrimerization; homogeneous catalysis; solid-phase synthesis
TL;DR:
The transition-metal-catalyzed [2+2-2] cyclotrimerization of a diyne and an alkyne provides a convergent route to highly-substituted aromatic rings and enables rapid combinatorial access to diverse sets of carbo- and heterocyclic small-molecule arrays.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
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