Douglas D. Young

Works (32)

Updated: July 16th, 2023 21:15
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2015 journal article

Optically triggered immune response through photocaged oligonucleotides

TETRAHEDRON LETTERS, 56(23), 3639–3642.

By: J. Govan n, D. Young n, M. Lively* & A. Deiters n

author keywords: Oligonucleotide synthesis; Light-activation; Photocaged nucleotides; Immune response; Toll-like receptors
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Heterotaxin: A TGF-beta Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus Embryos

CHEMISTRY & BIOLOGY, 18(2), 252–263.

By: M. Dush n, A. McIver n, M. Parr n, D. Young n, J. Fisher n, D. Newman n, P. Sannes n, M. Hauck n, A. Deiters n, N. Nascone-Yoder n

MeSH headings : Animals; Cell Line; Drug Evaluation, Preclinical; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Humans; Intracellular Space / drug effects; Intracellular Space / metabolism; Neovascularization, Physiologic / drug effects; Phenotype; Pyridines / chemistry; Pyridines / pharmacology; Signal Transduction / drug effects; Stereoisomerism; Structure-Activity Relationship; Transforming Growth Factor beta / metabolism; Xenopus laevis
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Light Regulation of Protein Dimerization and Kinase Activity in Living Cells Using Photocaged Rapamycin and Engineered FKBP

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(3), 420–423.

By: A. Karginov *, Y. Zou*, D. Shirvanyants n, P. Kota  n, N. Dokholyan *, D. Young*, K. Hahn *, A. Deiters*

MeSH headings : Dimerization; Focal Adhesion Protein-Tyrosine Kinases / metabolism; HEK293 Cells; Humans; Light; Models, Molecular; Molecular Dynamics Simulation; Sirolimus / chemistry; Tacrolimus Binding Proteins / chemistry; Tacrolimus Binding Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Activation and Deactivation of DNAzyme and Antisense Function with Light for the Photochemical Regulation of Gene Expression in Mammalian Cells

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(17), 6183–6193.

By: D. Young n, M. Lively n & A. Deiters n

MeSH headings : Base Sequence; Cell Line; DNA / chemistry; DNA / metabolism; DNA, Catalytic / metabolism; DNA, Catalytic / radiation effects; Enzyme Activation; Gene Expression / radiation effects; Gene Expression Regulation; Humans; Light; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides, Antisense / metabolism; Oligodeoxyribonucleotides, Antisense / radiation effects; Photochemical Processes; RNA / metabolism
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Photocaged T7 RNA Polymerase for the Light Activation of Transcription and Gene Function in Pro- and Eukaryotic Cells

CHEMBIOCHEM, 11(7), 972–977.

By: C. Chou n, D. Young n & A. Deiters n

author keywords: amino acids; caged proteins; light activation; polymerases; RNA
MeSH headings : Catalytic Domain; Cell Line; DNA-Directed RNA Polymerases / genetics; DNA-Directed RNA Polymerases / metabolism; Escherichia coli / enzymology; Humans; Luciferases / genetics; Luciferases / metabolism; Models, Molecular; Photochemical Processes; Transcriptional Activation; Tyrosine / chemistry; Ultraviolet Rays; Viral Proteins / genetics; Viral Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Site-Specific Incorporation of Fluorotyrosines into Proteins in Escherichia coli by Photochemical Disguise

BIOCHEMISTRY, 49(8), 1557–1559.

By: B. Wilkins*, S. Marionni*, D. Young n, J. Liu *, Y. Wang *, M. Di Salvo *, A. Deiters n, T. Cropp *

MeSH headings : Escherichia coli / genetics; Escherichia coli / metabolism; Escherichia coli Proteins / chemistry; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Molecular Structure; Protein Engineering / methods; Protein Structure, Secondary; Tyrosine / analogs & derivatives; Tyrosine / chemical synthesis; Tyrosine / chemistry; Tyrosine / metabolism
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(23), 7976–7981.

By: D. Young n, C. Connelly n, C. Grohmann n & A. Deiters n

MeSH headings : Apoptosis / drug effects; Base Sequence; Carcinoma, Hepatocellular / drug therapy; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / pathology; Enoxacin / pharmacology; HeLa Cells; Hepatitis C / drug therapy; Hepatitis C / genetics; Humans; Liver Neoplasms / drug therapy; Liver Neoplasms / genetics; Liver Neoplasms / pathology; MicroRNAs / antagonists & inhibitors; MicroRNAs / genetics; MicroRNAs / metabolism; Oligonucleotides, Antisense / genetics; Oligonucleotides, Antisense / pharmacology; Virus Replication / drug effects; Virus Replication / genetics
Source: Web Of Science
Added: August 6, 2018

2009 journal article

A Light-Activated DNA Polymerase

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 48(32), 5950–5953.

By: C. Chou n, D. Young n & A. Deiters n

author keywords: DNA polymerases; mutagenesis; non-natural amino acids; photoactivation; polymerase chain reaction
MeSH headings : Catalytic Domain; Mutation; Nitrobenzenes / chemistry; Photolysis; Polymerase Chain Reaction; Taq Polymerase / chemistry; Taq Polymerase / metabolism; Tyrosine / chemistry; Ultraviolet Rays
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Development of a Robust and High Throughput Method for Profiling N-Linked Glycans Derived from Plasma Glycoproteins by NanoLC-FTICR Mass Spectrometry

JOURNAL OF PROTEOME RESEARCH, 8(7), 3764–3770.

By: M. Bereman n, D. Young n, A. Deiters n & D. Muddiman n 

MeSH headings : Biomarkers, Tumor / metabolism; Blood Proteins / chemistry; Chromatography, Liquid / methods; Detergents / pharmacology; Glycoproteins / chemistry; Humans; Mass Spectrometry / methods; Microwaves; Peptides / chemistry; Polysaccharides / chemistry; Proteome; Proteomics / methods; Spectroscopy, Fourier Transform Infrared / methods; Time Factors
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Light-Activated Cre Recombinase as a Tool for the Spatial and Temporal Control of Gene Function in Mammalian Cells

ACS CHEMICAL BIOLOGY, 4(6), 441–445.

By: W. Edwards n, D. Young n & A. Deiters n

MeSH headings : Binding Sites; Biocatalysis / radiation effects; Cells, Cultured; Cloning, Molecular; DNA / chemistry; DNA / metabolism; Genetic Engineering / methods; Humans; Integrases / chemistry; Integrases / metabolism; Models, Molecular; Nitrobenzenes / chemistry; Nitrobenzenes / pharmacology; Recombination, Genetic / radiation effects; Time Factors; Ultraviolet Rays
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Light-activation of gene function in mammalian cells via ribozymes

Chem. Commun., (5), 568–570.

By: D. Young n, R. Garner n, J. Yoder n  & A. Deiters n

MeSH headings : Cell Line; Gene Expression / radiation effects; Humans; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; RNA, Messenger / metabolism; Toyocamycin / chemistry; Toyocamycin / radiation effects; Ultraviolet Rays
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2009 journal article

Open-Vessel Microwave-Mediated [2+2+2]-Cyclotrimerization Reactions

SYNTHESIS-STUTTGART, (22), 3785–3790.

By: D. Young*, J. Teske* & A. Deiters*

author keywords: [2+2+2] cyclotrimerization; alkynes; microwave; bicyclic compounds; transition metal catalysis
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Photochemical Regulation of Restriction Endonuclease Activity

CHEMBIOCHEM, 10(10), 1612–1616.

By: D. Young n, J. Govan n, M. Lively* & A. Deiters n

author keywords: cage compounds; DNA cleavage; DNA enzymes; photochemistry
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Base Sequence; Benzodioxoles / chemistry; DNA / chemistry; DNA / radiation effects; DNA Cleavage; DNA Restriction Enzymes / genetics; DNA Restriction Enzymes / metabolism; Deoxyribonuclease BamHI / genetics; Deoxyribonuclease BamHI / metabolism; Deoxyribonuclease EcoRI / genetics; Deoxyribonuclease EcoRI / metabolism; Deoxyribonucleases, Type II Site-Specific / genetics; Deoxyribonucleases, Type II Site-Specific / metabolism; Substrate Specificity; Thymidine / analogs & derivatives; Thymidine / chemistry; Ultraviolet Rays
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Restriction enzyme-free mutagenesis via the light regulation of DNA polymerization

Nucleic Acids Research, 37(8).

By: D. Young, H. Lusic, M. Lively & A. Deiters

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

The effect of microwave irradiation on DNA hybridization

ORGANIC & BIOMOLECULAR CHEMISTRY, 7(12), 2506–2508.

By: W. Edwards n, D. Young n & A. Deiters n

MeSH headings : Base Sequence; DNA / chemistry; DNA / genetics; DNA / radiation effects; Microwaves; Nucleic Acid Denaturation / radiation effects; Nucleic Acid Hybridization / radiation effects; Spectrometry, Fluorescence; Transition Temperature
Source: Web Of Science
Added: August 6, 2018

2008 journal article

A general approach to triphenylenes and azatriphenylenes: total synthesis of dehydrotylophorine and tylophorine

CHEMICAL COMMUNICATIONS, (39), 4750–4752.

By: A. McIver n, D. Young n & A. Deiters n

MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Alkaloids / radiation effects; Aza Compounds / chemical synthesis; Aza Compounds / chemistry; Aza Compounds / radiation effects; Chrysenes / chemical synthesis; Chrysenes / chemistry; Chrysenes / radiation effects; Cyclization; Indolizines / chemical synthesis; Indolizines / chemistry; Indolizines / radiation effects; Microwaves; Molecular Structure; Phenanthrenes / chemical synthesis; Phenanthrenes / chemistry; Phenanthrenes / radiation effects; Stereoisomerism
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Gene Silencing in Mammalian Cells with Light-Activated Antisense Agents

ChemBioChem, 9(18), 2937–2940.

By: D. Young n, H. Lusic n, M. Lively*, J. Yoder n  & A. Deiters n

author keywords: Antisense agents; caged compounds; DNA; gene regulation; RNA
MeSH headings : Animals; Base Sequence; Gene Silencing; Genes, Reporter; Light; Luciferases, Renilla / chemistry; Mice; NIH 3T3 Cells; Oligonucleotides, Antisense / chemistry; Oligonucleotides, Antisense / metabolism; Oligonucleotides, Antisense / radiation effects; Phosphorothioate Oligonucleotides / chemistry; Phosphorothioate Oligonucleotides / metabolism; Transfection
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2008 journal article

Light-regulated RNA-small molecule interactions

CHEMBIOCHEM, 9(8), 1225–1228.

By: D. Young* & A. Deiters*

author keywords: aptamer; light; riboswitch; RNA; spiropyran
MeSH headings : Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / isolation & purification; Benzopyrans / chemistry; Indoles / chemistry; Light; Molecular Structure; Nitro Compounds / chemistry; Photochemistry; Pyrimidinones / chemistry; RNA / chemistry; Substrate Specificity; Surface Plasmon Resonance
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Light-triggered polymerase chain reaction

CHEMICAL COMMUNICATIONS, (4), 462–464.

By: D. Young n, W. Edwards n, H. Lusic n, M. Lively* & A. Deiters n

MeSH headings : Base Sequence; DNA / chemistry; DNA Primers; Light; Photochemistry; Polymerase Chain Reaction / methods
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Microwave activation of enzymatic catalysis

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(31), 10048-+.

By: D. Young n, J. Nichols n, R. Kelly n  & A. Deiters n

MeSH headings : Carboxylesterase / metabolism; Catalysis; Enzymes / metabolism; Hot Temperature; Kinetics; Microwaves; Pyrococcus furiosus / enzymology; Sulfolobus solfataricus / enzymology; Thermotoga maritima / enzymology; alpha-Galactosidase / metabolism; beta-Glucosidase / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

Microwave-assisted synthesis of unnatural amino acids

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(20), 5478–5480.

By: D. Young n, J. Torres-Kolbus n & A. Deiters n

author keywords: microwave; microwave synthesis; amino acid; unnatural amino acid; peptide synthesis; protein synthesis; unnatural amino acid; mutagenesis
MeSH headings : Amino Acids / chemical synthesis; Chemistry, Pharmaceutical / methods; Drug Design; Magnetic Resonance Spectroscopy; Microwaves; Models, Chemical; Mutagenesis; Peptides / chemistry; Proteins / chemistry; Temperature
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Small-molecule inhibitors of microRNA miR-21 function

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47(39), 7482–7484.

By: K. Gumireddy*, D. Young n, X. Xiong  n, J. Hogenesch *, Q. Huang * & A. Deiters n

author keywords: antitumor agents; cell-based assays; inhibitors; medicinal chemistry; microRNA
MeSH headings : Gene Expression; Genes, Reporter / genetics; HeLa Cells; Humans; MicroRNAs / antagonists & inhibitors; MicroRNAs / genetics; Molecular Structure
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Synthesis of Anthracene and Azaanthracene Fluorophores via [2+2+2] Cyclotrimerization Reactions

ORGANIC LETTERS, 10(20), 4661–4664.

By: Y. Zou n, D. Young n, A. Cruz-Montanez n & A. Deiters n

MeSH headings : Anthracenes / chemical synthesis; Anthracenes / chemistry; Aza Compounds / chemical synthesis; Aza Compounds / chemistry; Benzene / chemistry; Cell Line; Cyclization; Fluorescent Dyes / chemical synthesis; Fluorescent Dyes / chemistry; Humans; Molecular Structure; Pyridines / chemistry
Source: Web Of Science
Added: August 6, 2018

2007 journal article

A general approach to chemo- and regioselective cyclotrimerization reactions

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46(27), 5187–5190.

By: D. Young* & A. Deiters*

author keywords: cycloaddition; heterocycles; microwave synthesis; solid-phase synthesis; transition metals
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Microwave-assisted solid-supported alkyne cyclotrimerization reactions for combinatorial chemistry

JOURNAL OF COMBINATORIAL CHEMISTRY, 9(5), 735–738.

By: D. Young n, L. Sripada n & A. Deiters n

MeSH headings : Alkynes / chemistry; Combinatorial Chemistry Techniques; Cyclization; Microwaves
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Photochemical DNA activation

ORGANIC LETTERS, 9(10), 1903–1906.

By: H. Lusic n, D. Young n, M. Lively n & A. Deiters n

MeSH headings : DNA, Catalytic / chemistry; DNA, Catalytic / metabolism; Molecular Sequence Data; Molecular Structure; Photochemistry; RNA / metabolism; Substrate Specificity
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Photochemical activation of protein expression in bacterial cells

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46(23), 4290–4292.

By: D. Young n & A. Deiters n

author keywords: bacterial cells; caged compounds; gene expression; photochemistry; proteins
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Photochemical control of biological processes

ORGANIC & BIOMOLECULAR CHEMISTRY, 5(7), 999–1005.

By: D. Young n & A. Deiters n

MeSH headings : Enzymes / genetics; Enzymes / radiation effects; Humans; Light; Molecular Conformation; Organic Chemicals / chemistry; Organic Chemicals / radiation effects; Photochemistry; Proteins / genetics; Proteins / radiation effects; Ultraviolet Rays
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Synthesis of indanones via solid-supported [2+2+2] cyclotrimerization

JOURNAL OF ORGANIC CHEMISTRY, 72(20), 7801–7804.

By: R. Senaiar n, J. Teske n, D. Young n & A. Deiters n

Source: Web Of Science
Added: August 6, 2018

2006 journal article

Photochemical hammerhead ribozyme activation

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(10), 2658–2661.

By: D. Young n & A. Deiters n

author keywords: caged compounds; genomics; photochemistry; ribozymes; RNA
MeSH headings : Base Sequence; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Nucleic Acid Conformation; Photochemistry; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; Ultraviolet Rays
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Pyridines via solid-supported [2+2+2] cyclotrimerization

Chemical Communications (Cambridge, England), (12), 1313–1315.

By: R. Senaiar n, D. Young n & A. Deiters n

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Solid-supported [2+2+2] cyclotrimerizations

CHEMISTRY-A EUROPEAN JOURNAL, 12(21), 5563–5568.

By: D. Young n, R. Senaiar n & A. Deiters n

author keywords: combinatorial chemistry; cyclotrimerization; homogeneous catalysis; solid-phase synthesis
Source: Web Of Science
Added: August 6, 2018