John West

Works (1)

Updated: July 5th, 2023 15:56

2006 journal article

Role of a conserved tripeptide in the endodomain of Sindbis virus glycoprotein E2 in virus assembly and function

JOURNAL OF GENERAL VIROLOGY, 87, 657–664.

By: J. West n & D. Brown n

MeSH headings : Acids; Amino Acid Sequence; Animals; Cell Fusion; Cell Line; Cricetinae; Molecular Sequence Data; Protein Structure, Tertiary / genetics; Protein Structure, Tertiary / physiology; Sindbis Virus / pathogenicity; Sindbis Virus / physiology; Viral Envelope Proteins / chemistry; Viral Envelope Proteins / genetics; Viral Envelope Proteins / physiology; Virulence; Virus Assembly
TL;DR: The loss of infectivity in the double mutant is accompanied by the loss of the ability to fuse cells after brief exposure to acid pH, which supports the idea that these residues are vital for production of infectious/functional virus; however, they are dispensable for assembly. (via Semantic Scholar)
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