Li Na Loo

Works (5)

Updated: July 29th, 2023 21:16

2010 journal article

The Red clover necrotic mosaic virus Capsid as a Multifunctional Cell Targeting Plant Viral Nanoparticle

BIOCONJUGATE CHEMISTRY, 22(1), 67–73.

By: D. Lockney n, R. Guenther n, L. Loo n, W. Overton  n, R. Antonelli n, J. Clark  n, M. Hu n, C. Luft n, S. Lommel n, S. Franzen n 

MeSH headings : Amino Acid Sequence; Biological Availability; Biological Transport; Capsid / chemistry; Capsid / metabolism; Doxorubicin / chemistry; Doxorubicin / pharmacokinetics; Fluorescent Dyes / chemistry; HeLa Cells; Humans; Models, Molecular; Nanoparticles / chemistry; Peptides / chemistry; Peptides / metabolism; Plants / virology; Protein Conformation; Surface Properties; Tombusviridae
TL;DR: It is shown that targeting peptides (less than 16 amino acids) can be conjugated to the capsid using the heterobifunctional chemical linker sulfosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (Sulfo-SMCC). (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Cellular uptake of gold nanoparticles passivated with BSA-SV40 large T antigen conjugates

ANALYTICAL CHEMISTRY, 79(23), 9150–9159.

By: J. Ryan n, K. Overton  n, M. Speight n, C. Oldenburg n, L. Loo n, W. Robarge n, S. Franzen n , D. Feldheim n

MeSH headings : Antigens, Polyomavirus Transforming / metabolism; Cell Nucleus / metabolism; Gold / chemistry; HeLa Cells; Humans; Metal Nanoparticles; Reproducibility of Results; Serum Albumin, Bovine / metabolism; Subcellular Fractions / metabolism
TL;DR: The ICP-OES and nuclear fractionation techniques reported here are valuable tools that can add important quantitative information to optical and electron imaging methods such as VEC-DIC and transmission electron microscopy regarding the fate of nanoparticles in cells. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Encapsidation of nanoparticles by Red Clover Necrotic Mosaic Virus

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 129(36), 11111–11117.

By: L. Loo n, R. Guenther n, S. Lommel n & S. Franzen n 

MeSH headings : Biocompatible Materials; Capsid / physiology; Capsid Proteins / genetics; Capsid Proteins / metabolism; Cobalt / chemistry; Ferric Compounds / chemistry; Gold / chemistry; Nanoparticles / chemistry; Nanotechnology; Quantum Dots; Tombusviridae / physiology; Virus Assembly
TL;DR: Covalent linkage of the OAS to nanoparticles directs RNA-dependent encapsidation and demonstrates that foreign cargo can be packaged into RCNMV virions. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Infusion of dye molecules into Red clover necrotic mosaic virus

CHEMICAL COMMUNICATIONS, (1), 88–90.

By: L. Loo n, R. Guenther n, S. Lommel n & S. Franzen n 

MeSH headings : Capsid Proteins / chemistry; Capsid Proteins / metabolism; Coloring Agents / analysis; Coloring Agents / metabolism; Doxorubicin / metabolism; Microscopy, Electron, Transmission; Tombusviridae / chemistry; Tombusviridae / metabolism; Tombusviridae / ultrastructure
TL;DR: The Red clover necrotic mosaic virus capsid is utilized to package and release molecules through reversible depletion and re-addition of divalent cations. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Controlled encapsidation of gold nanoparticles by a viral protein shell

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128(14), 4502–4503.

By: L. Loo n, R. Guenther n, V. Basnayake n, S. Lommel n & S. Franzen n 

MeSH headings : Capsid Proteins / chemistry; Capsid Proteins / genetics; DNA, Viral / chemistry; DNA, Viral / genetics; Gold / chemistry; Metal Nanoparticles / chemistry; Microscopy, Electron, Transmission; RNA, Viral / chemistry; RNA, Viral / genetics; Tombusviridae / chemistry; Tombusviridae / genetics
TL;DR: Covalent linkage of the OAS to Au functions as a trigger for specific encapsidation and demonstrates that foreign cargo can be packaged into Red clover necrotic mosaic virus virions. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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