Jennifer L. Frahm

Works (4)

Updated: July 5th, 2023 21:18

2008 journal article

Investigations with O-linked protein glycosylations by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry

JOURNAL OF MASS SPECTROMETRY, 43(9), 1215–1223.

By: T. Williams n , D. Saggese n, K. Toups n, J. Frahm n, H. An *, B. Li*, C. Lebrilla *, D. Muddiman n 

Contributors: T. Williams n , D. Saggese n, K. Toups n, J. Frahm n, H. An *, B. Li*, C. Lebrilla *, D. Muddiman n 

author keywords: Fourier transform ion cyclotron mass spectrometry (FT-ICR-MS); matrix-assisted laser desorption/ionization (MALDI); mucin; O-linked glycans; protein glycosylations
MeSH headings : Angiotensins / chemistry; Animals; Glycosylation; Mucins / chemistry; Oligosaccharides / chemistry; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectroscopy, Fourier Transform Infrared / methods; Swine; Tandem Mass Spectrometry / methods
TL;DR: A detailed examination of sample preparation and matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FT-ICR-MS) analysis of O-linked glycans globally cleaved from mucin glycoproteins is presented. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2007 journal article

Achieving augmented limits of detection for peptides with hydrophobic alkyl tags

ANALYTICAL CHEMISTRY, 79(11), 3989–3995.

By: J. Frahm n, I. Bori n, D. Comins n, A. Hawkridge n & D. Muddiman n 

MeSH headings : Acetates / chemistry; Alkylation; Amides / chemical synthesis; Amides / chemistry; Amino Acid Sequence; Chlorides / chemistry; Hydrophobic and Hydrophilic Interactions; Iodine / chemistry; Molecular Sequence Data; Peptides / analysis; Peptides / chemistry; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry
TL;DR: The results demonstrate the feasibility of the octylcarboxyamidomethyl modification to improve limits of detection for cysteine-containing peptides with hydrophobic alkyl tags. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Understanding the influence of post-excite radius and axial confinement on quantitative proteomic measurements using Fourier transform ion cyclotron resonance mass spectrometry

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 21(7), 1196–1204.

By: J. Frahm n, C. Capo Velez* & D. Muddiman n 

MeSH headings : Artifacts; Cyclotrons; Ions; Peptide Mapping / methods; Proteome / analysis; Proteome / chemistry; Reproducibility of Results; Sensitivity and Specificity; Sequence Analysis, Protein / methods; Spectrometry, Mass, Electrospray Ionization / methods; Spectroscopy, Fourier Transform Infrared / methods
TL;DR: To adequately assess the multiple parameters in the large dataset, a multiplicative quality factor is developed that encompasses the total ion abundance, as well as the accuracy and the precision of abundance ratios, which allows facile determination of optimal instrument parameters for quantitative measurements. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Accessible proteomics space and its implications for peak capacity for zero-, one- and two-dimensional separations coupled with FT-ICR and TOF mass spectrometry

JOURNAL OF MASS SPECTROMETRY, 41(3), 281–288.

By: J. Frahm n, B. Howard n, S. Heber n  & D. Muddiman n 

MeSH headings : Biotechnology / instrumentation; Biotechnology / methods; Electrophoresis, Gel, Two-Dimensional; Fourier Analysis; Mass Spectrometry; Peptides / analysis; Proteomics / instrumentation; Proteomics / methods
TL;DR: The results indicate that reverse-phase-nanoHPLC (RP-nHPLC) separation coupled with FT-ICR MS offers an order of magnitude improvement in peak capacity over RP- nHPLC separation coupling with TOF MS, and the addition of an orthogonal separation method, strong cation exchange (SCX), for 2D LC-MS demonstrates an additional 10-fold improvement inpeak capacity over 1D LC -MS methods. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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