Katalin Eszter Borbas

Works (10)

Updated: July 5th, 2023 15:56

2015 journal article

Hydrophilic bioconjugatable trans-AB-porphyrins and peptide conjugates

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 19(5), 663–678.

By: T. Sahin n, P. Vairaprakash  n, K. Borbas  n, T. Balasubramanian n & J. Lindsey n 

author keywords: water-soluble; manganese; dipyrromethane; molecular design; facial encumbrance
TL;DR: Porphyrins bearing a single bioconjugatable group and a single water-solubilization motif in a trans-AB-architecture provide a compact design of value for studies in diverse disciplines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

In Vitro Photodynamic Therapy and Quantitative Structure-Activity Relationship Studies with Stable Synthetic Near-Infrared-Absorbing Bacteriochlorin Photosensitizers

JOURNAL OF MEDICINAL CHEMISTRY, 53(10), 4018–4027.

By: Y. Huang, P. Mroz*, T. Zhiyentayev, S. Sharma *, T. Balasubramanian, C. Ruzie*, M. Krayer*, D. Fan* ...

MeSH headings : Cell Death / drug effects; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Infrared Rays; Photochemotherapy; Photosensitizing Agents / chemistry; Photosensitizing Agents / metabolism; Photosensitizing Agents / pharmacology; Porphyrins / chemistry; Porphyrins / metabolism; Porphyrins / pharmacology; Quantitative Structure-Activity Relationship; Quantum Theory
TL;DR: Testing of 12 new stable synthetic bacteriochlorins for PDT activity described, which possess a variety of peripheral substituents and are very potent in killing cancer cells in vitro after illumination, gives them great potential as photosensitizers for treatment of cancer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Stable synthetic bacteriochlorins overcome the resistance of melanoma to photodynamic therapy

FASEB JOURNAL, 24(9), 3160–3170.

By: P. Mroz*, Y. Huang *, A. Szokalska*, T. Zhiyentayev*, S. Janjua*, A. Nifli*, M. Sherwood*, C. Ruzie n ...

author keywords: multidrug resistance; melanosomes; electron microscopy
MeSH headings : Animals; Cell Line, Tumor; Male; Melanoma / drug therapy; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Molecular Structure; Photochemotherapy / methods; Porphyrins / chemical synthesis; Porphyrins / chemistry; Porphyrins / therapeutic use
TL;DR: The extent of melanin contribution to melanoma resistance to PDT was investigated in a set of melanoma cell lines that markedly differ in the levels of pigmentation;3 new bacteriochlorins successfully overcame the resistance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

A compact water-soluble porphyrin bearing an iodoacetamido bioconjugatable site

ORGANIC & BIOMOLECULAR CHEMISTRY, 6(1), 187–194.

By: K. Borbas  n, H. Kee*, D. Holten * & J. Lindsey n 

MeSH headings : Amines / chemistry; Carboxylic Acids / chemistry; Magnetic Resonance Spectroscopy; Porphyrins / chemistry; Solubility; Spectrometry, Fluorescence; Water / chemistry
TL;DR: The synthesis of three new water-soluble trans-AB-porphyrins is reported, where each porphyrin bears a diphosphonate-terminated swallowtail group and an amino, acetamido, or iodoacetamido group, and the amine affords considerable versatility for functionalization. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Design, synthesis, and photophysical characterization of water-soluble chlorins

JOURNAL OF ORGANIC CHEMISTRY, 73(8), 3145–3158.

By: K. Borbas  n, V. Chandrashaker n, C. Muthiah n, H. Kee n, D. Holten  n & J. Lindsey n 

MeSH headings : Molecular Structure; Photochemistry; Porphyrins / chemical synthesis; Porphyrins / chemistry; Solubility; Spectrophotometry; Water / chemistry
TL;DR: The use of chlorins as photosensitizers or fluorophores in a range of biological applications requires facile provisions for imparting high water solubility, which makes these compounds suitable for a wide range of biomedical applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Soluble precipitable porphyrins for use in targeted molecular brachytherapy

NEW JOURNAL OF CHEMISTRY, 32(3), 436–451.

By: Z. Yao n, K. Borbas  n & J. Lindsey n 

TL;DR: A class of porphyrin–alkyldiphosphates that are soluble in aqueous solution and that are rendered insoluble upon removal of the two phosphate groups are examined and found to exhibit satisfactory solubility in water. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Swallowtail bacteriochlorins. Lipophilic absorbers for the near-infrared

ORGANIC LETTERS, 10(10), 1931–1934.

By: K. Borbas  n, C. Ruzie & J. Lindsey n 

MeSH headings : Drug Stability; Molecular Structure; Porphyrins / chemical synthesis; Porphyrins / chemistry; Spectroscopy, Near-Infrared / methods; Stereoisomerism
TL;DR: A de novo route has been exploited to prepare synthetic bacteriochlorins that bear a geminal dimethyl group in each pyrroline ring for stability and a symmetrically branched 1,5-dimethoxypentyl group attached to every pyrrole ring for solubility in lipophilic media. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Near IR-emitting DNA-probes exploiting stepwise energy transfer processes

Dalton Transactions (Cambridge, England : 2003), (38), 4352–4358.

By: A. Bodi, K. Borbas & J. Bruce

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Bioconjugatable porphyrins bearing a compact swallowtail motif for water solubility

BIOCONJUGATE CHEMISTRY, 17(3), 638–653.

By: K. Borbas *, P. Mroz*, M. Hamblin * & J. Lindsey* 

MeSH headings : Flow Cytometry; Humans; Immunoglobulin G / chemistry; Immunoglobulin G / metabolism; Jurkat Cells; Molecular Structure; Porphyrins / chemical synthesis; Porphyrins / chemistry; Solubility; Spectrum Analysis; Water / chemistry
TL;DR: Covalent attachment was carried out in aqueous solution with the unprotected porphyrin diphosphonate and a monoclonal antibody against the T-cell receptor CD3epsilon and the resulting conjugate performed comparably to a commercially available fluorescein isothiocyanate-labeled antibody with Jurkat cells in flow cytometry and fluorescence microscopy assays. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Masked imidazolyl-dipyrromethanes in the synthesis of imidazole-substituted porphyrins

JOURNAL OF ORGANIC CHEMISTRY, 71(23), 8807–8817.

By: J. Bhaumik n, Z. Yao n, K. Borbas  n, M. Taniguchi n  & J. Lindsey n 

Contributors: J. Bhaumik n, Z. Yao n, K. Borbas n, M. Taniguchi n  & J. Lindsey n 

MeSH headings : Imidazoles / chemistry; Molecular Conformation; Porphyrins / chemical synthesis; Porphyrins / chemistry; Pyrroles / chemistry; Stereoisomerism
TL;DR: This work establishes the foundation for the rational synthesis of a variety of porphyrins containing imidazole units by using the 2-(trimethylsilyl)ethoxymethyl (SEM) group at the imdazole pyrrolic nitrogen and a dialkylboron motif. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

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