Christopher B. Whitehurst

Works (1)

Updated: July 5th, 2023 15:56

2006 journal article

Single and multiple deletions in the transmembrane domain of the Sindbis virus E2 glycoprotein identify a region critical for normal virus growth

VIROLOGY, 347(1), 199–207.

By: C. Whitehurst n, J. Willis  n, C. Sinodis n, R. Hernandez n & D. Brown n

author keywords: Sindis virus; E2 glycoprotein; transmembrane domain; virus assembly; compensatory mutations
MeSH headings : Amino Acid Sequence; Animals; Cell Line; Cricetinae; Models, Molecular; Molecular Sequence Data; Protein Structure, Tertiary; Sequence Deletion; Sindbis Virus / genetics; Sindbis Virus / growth & development; Sindbis Virus / physiology; Viral Envelope Proteins / chemistry; Viral Envelope Proteins / genetics; Virus Replication / genetics
TL;DR: Results suggest that the position of the deletion and the length of the C terminal region of the E2 transmembrane domain is vital for normal virus production, and deletion mutants resulting in decreased infectivity produce particles that appear to be processed and transported correctly suggesting a role involved in virus entry. (via Semantic Scholar)
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