Rachel N. Murrell

Works (7)

Updated: July 5th, 2023 15:55

2011 journal article

Brevetoxin 2 alters expression of apoptotic, DNA damage, and cytokine genes in Jurkat cells

Human & Experimental Toxicology, 30(3), 182–191.

By: R. Murrell & J. Gibson

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Brevetoxins 2, 3, 6, and 9 show variability in potency and cause significant induction of DNA damage and apoptosis in Jurkat E6-1 cells

ARCHIVES OF TOXICOLOGY, 83(11), 1009–1019.

By: R. Murrell n & J. Gibson n

MeSH headings : Apoptosis / drug effects; Caspases / drug effects; Caspases / metabolism; Cell Proliferation / drug effects; Comet Assay; DNA Damage / drug effects; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Jurkat Cells; Marine Toxins / administration & dosage; Marine Toxins / toxicity; Mutagenicity Tests; Mutagens / administration & dosage; Mutagens / toxicity; Oxocins / administration & dosage; Oxocins / toxicity; Time Factors
TL;DR: The conclusions are that brevetoxins affect cell proliferation in a dose-dependent fashion, are genotoxic, and cause cell death through an apoptotic mechanism. (via Semantic Scholar)
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14. Life Below Water (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Effects of storage, RNA extraction, genechip type, and donor sex on gene expression profiling of human whole blood

CLINICAL CHEMISTRY, 53(6), 1038–1045.

By: S. Kim *, D. Dix*, K. Thompson *, R. Murrell n, J. Schmid*, J. Gallagher*, J. Rockett*

MeSH headings : Adult; Cluster Analysis; Female; Gene Expression Profiling / instrumentation; Humans; Male; Oligonucleotide Array Sequence Analysis / instrumentation; Principal Component Analysis; RNA / blood; RNA / isolation & purification; Sex Factors
TL;DR: Sample storage and extraction methods and interindividual differences, particularly donor sex, affect GEP of human whole blood. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Effect of conazole fungicides on reproductive development in the female rat

Reproductive Toxicology (Elmsford, N.Y.), 22(4), 647–658.

By: J. Rockett, M. Narotsky, K. Thompson, I. Thillainadarajah, C. Blystone, A. Goetz, H. Ren, D. Best ...

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Gene expression in head hair follicles plucked from men and women

Annals of Clinical and Laboratory Science, 36(2), 115–126.

By: S. Kim, D. Dix, K. Thompson, R. Murrell, J. Schmid, J. Gallagher, J. Rockett

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Metabolism of myclobutanil and triadimefon by human and rat cytochrome P450 enzymes and liver microsomes

XENOBIOTICA, 36(9), 793–806.

By: H. Barton *, J. Tang *, Y. Sey*, J. Stanko*, R. Murrell n, J. Rockett*, D. Dix*

author keywords: myclobutanil; triadimefon; cytochrome P450 (CYP); CYP2C; CYP3A
MeSH headings : Animals; Binding, Competitive / drug effects; Cytochrome P-450 CYP2B1 / metabolism; Female; Fungicides, Industrial / chemistry; Fungicides, Industrial / metabolism; Fungicides, Industrial / pharmacology; Half-Life; Humans; Isoenzymes / metabolism; Kinetics; Male; Microsomes, Liver / drug effects; Microsomes, Liver / metabolism; Nitriles / chemistry; Nitriles / metabolism; Nitriles / pharmacology; Organ Size / drug effects; Rats; Rats, Sprague-Dawley; Time Factors; Triazoles / chemistry; Triazoles / metabolism; Triazoles / pharmacology
TL;DR: Estimated hepatic clearances suggest that CYP induction may have limited impact in vivo, and CYP enzymes important for the metabolization of these two triazoles are identified. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 journal article

Metabolomic evaluation of rat liver and testis to characterize the toxicity of triazole fungicides

METABOLOMICS, 2(2), 63–73.

By: D. Ekman *, H. Keun *, C. Eads*, C. Furnish*, J. Rockett* & D. Dix*

author keywords: myclobutanil; triadimefon; metabolomics; metabonomics; triazoles; NMR
TL;DR: The results of this study support the possible application of a metabolomics approach to assessing the toxicity of triazole fungicides and identifying biomarkers of exposure and/or effect. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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