Rachel N. Murrell

Works (7)

Updated: July 5th, 2023 15:55

2011 journal article

Brevetoxin 2 alters expression of apoptotic, DNA damage, and cytokine genes in Jurkat cells

Human & Experimental Toxicology, 30(3), 182–191.

By: R. Murrell & J. Gibson

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Brevetoxins 2, 3, 6, and 9 show variability in potency and cause significant induction of DNA damage and apoptosis in Jurkat E6-1 cells

ARCHIVES OF TOXICOLOGY, 83(11), 1009–1019.

By: R. Murrell n & J. Gibson n

MeSH headings : Apoptosis / drug effects; Caspases / drug effects; Caspases / metabolism; Cell Proliferation / drug effects; Comet Assay; DNA Damage / drug effects; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Jurkat Cells; Marine Toxins / administration & dosage; Marine Toxins / toxicity; Mutagenicity Tests; Mutagens / administration & dosage; Mutagens / toxicity; Oxocins / administration & dosage; Oxocins / toxicity; Time Factors
TL;DR: The conclusions are that brevetoxins affect cell proliferation in a dose-dependent fashion, are genotoxic, and cause cell death through an apoptotic mechanism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Effects of storage, RNA extraction, genechip type, and donor sex on gene expression profiling of human whole blood

CLINICAL CHEMISTRY, 53(6), 1038–1045.

By: S. Kim *, D. Dix*, K. Thompson *, R. Murrell n, J. Schmid*, J. Gallagher*, J. Rockett*

MeSH headings : Adult; Cluster Analysis; Female; Gene Expression Profiling / instrumentation; Humans; Male; Oligonucleotide Array Sequence Analysis / instrumentation; Principal Component Analysis; RNA / blood; RNA / isolation & purification; Sex Factors
TL;DR: Sample storage and extraction methods and interindividual differences, particularly donor sex, affect GEP of human whole blood. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Effect of conazole fungicides on reproductive development in the female rat

Reproductive Toxicology (Elmsford, N.Y.), 22(4), 647–658.

By: J. Rockett, M. Narotsky, K. Thompson, I. Thillainadarajah, C. Blystone, A. Goetz, H. Ren, D. Best ...

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Gene expression in head hair follicles plucked from men and women

Annals of Clinical and Laboratory Science, 36(2), 115–126.

By: S. Kim, D. Dix, K. Thompson, R. Murrell, J. Schmid, J. Gallagher, J. Rockett

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Metabolism of myclobutanil and triadimefon by human and rat cytochrome P450 enzymes and liver microsomes

XENOBIOTICA, 36(9), 793–806.

By: H. Barton *, J. Tang *, Y. Sey*, J. Stanko*, R. Murrell n, J. Rockett*, D. Dix*

author keywords: myclobutanil; triadimefon; cytochrome P450 (CYP); CYP2C; CYP3A
MeSH headings : Animals; Binding, Competitive / drug effects; Cytochrome P-450 CYP2B1 / metabolism; Female; Fungicides, Industrial / chemistry; Fungicides, Industrial / metabolism; Fungicides, Industrial / pharmacology; Half-Life; Humans; Isoenzymes / metabolism; Kinetics; Male; Microsomes, Liver / drug effects; Microsomes, Liver / metabolism; Nitriles / chemistry; Nitriles / metabolism; Nitriles / pharmacology; Organ Size / drug effects; Rats; Rats, Sprague-Dawley; Time Factors; Triazoles / chemistry; Triazoles / metabolism; Triazoles / pharmacology
TL;DR: Estimated hepatic clearances suggest that CYP induction may have limited impact in vivo, and CYP enzymes important for the metabolization of these two triazoles are identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Metabolomic evaluation of rat liver and testis to characterize the toxicity of triazole fungicides

METABOLOMICS, 2(2), 63–73.

By: D. Ekman *, H. Keun *, C. Eads*, C. Furnish*, J. Rockett* & D. Dix*

author keywords: myclobutanil; triadimefon; metabolomics; metabonomics; triazoles; NMR
TL;DR: The results of this study support the possible application of a metabolomics approach to assessing the toxicity of triazole fungicides and identifying biomarkers of exposure and/or effect. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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