Works (1)
Updated: July 5th, 2023 15:55
2006 journal article
Frequent p53 and H-ras mutations in benzene- and ethylene oxide-induced mammary gland carcinomas from B6C3F1 mice
TOXICOLOGIC PATHOLOGY, 34(6), 752–762.
author keywords: p53; H-ras; benzene; ethylene oxide; mammary gland carcinoma; mice; carcinogen
MeSH headings : Animals; Benzene; Carcinogens; Codon; DNA Mutational Analysis; Ethylene Oxide; Exons; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Immunohistochemistry; Mammary Neoplasms, Animal / chemically induced; Mammary Neoplasms, Animal / genetics; Mammary Neoplasms, Animal / metabolism; Mammary Neoplasms, Animal / pathology; Mammary Neoplasms, Experimental / chemically induced; Mammary Neoplasms, Experimental / genetics; Mammary Neoplasms, Experimental / metabolism; Mammary Neoplasms, Experimental / pathology; Mice; Mutation; Polymerase Chain Reaction; Rodent Diseases / chemically induced; Rodent Diseases / genetics; Rodent Diseases / metabolism; Rodent Diseases / pathology; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
TL;DR:
The results demonstrate that p53 and H-ras mutations are relatively common in control and chemically induced mouse mammary carcinomas although both chemicals can alter the mutational spectra and more commonly induce concurrent mutations.
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