Dilek Kiper Dogutan

Works (5)

Updated: July 5th, 2023 15:55

2009 journal article

Imidazole metalloporphyrins as photosensitizers for photodynamic therapy: Role of molecular charge, central metal and hydroxyl radical production

CANCER LETTERS, 282(1), 63–76.

By: P. Mroz *, J. Bhaumik n, D. Dogutan n, Z. Aly*, Z. Kamal*, L. Khalid*, H. Kee*, D. Bocian * ...

author keywords: Structure function relationship; Photophysics; Phototoxicity; Metalloporphyrins; Apoptosis; Fluorescence microscopy; Reactive oxygen species; Hydroxyl radicals
MeSH headings : Adenocarcinoma / drug therapy; Adenocarcinoma / metabolism; Animals; Apoptosis / drug effects; Cell Line, Tumor; Colonic Neoplasms / drug therapy; Colonic Neoplasms / metabolism; HeLa Cells / drug effects; HeLa Cells / metabolism; Humans; Hydroxyl Radical / metabolism; Imidazoles / therapeutic use; Lysosomes / metabolism; Metalloporphyrins / chemical synthesis; Metalloporphyrins / chemistry; Metalloporphyrins / metabolism; Metalloporphyrins / therapeutic use; Mice; Microscopy, Fluorescence; Mitochondria / metabolism; Models, Molecular; Photochemotherapy / methods
TL;DR: The cationic Pd porphyrin has high potential as a photosensitizer and gives insights into characteristics for improved molecular designs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Rational or statistical routes from 1-acyldipyrromethanes to meso-substituted porphyrins. Distinct patterns, multiple pyridyl substituents, and amphipathic architectures

JOURNAL OF ORGANIC CHEMISTRY, 73(16), 6187–6201.

By: D. Dogutan n, M. Ptaszek n & J. Lindsey n 

MeSH headings : Magnesium / chemistry; Methane / analogs & derivatives; Methane / chemical synthesis; Methane / chemistry; Microwaves; Porphyrins / chemical synthesis; Pyrroles / chemical synthesis; Pyrroles / chemistry
TL;DR: The rational and statistical routes enable facile conversion of readily available 1-acyldipyrromethanes to diverse porphyrins bearing 1-4 meso substituents for which access is limited via other methods. (via Semantic Scholar)
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Added: August 6, 2018

2007 journal article

Direct synthesis of magnesium porphine via 1-formyldipyrromethane

JOURNAL OF ORGANIC CHEMISTRY, 72(13), 5008–5011.

By: D. Dogutan n, M. Ptaszek n & J. Lindsey n 

MeSH headings : Magnesium / chemistry; Metalloporphyrins / chemical synthesis; Metalloporphyrins / chemistry; Methane / analogs & derivatives; Methane / chemistry; Molecular Structure; Palladium / chemistry; Porphyrins / chemical synthesis; Porphyrins / chemistry; Pyrroles / chemistry; Zinc / chemistry
TL;DR: The reaction of 1-formyldipyrromethane in toluene at 115 degrees C containing DBU and MgBr2 in the presence of air affords the magnesium chelate Mg(II) porphine in 30-40% yield. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

New route to ABCD-porphyrins via bilanes

JOURNAL OF ORGANIC CHEMISTRY, 72(20), 7701–7714.

By: D. Dogutan n, S. Zaidi n, P. Thamyongkit n & J. Lindsey n 

MeSH headings : Magnesium / chemistry; Metalloporphyrins / chemical synthesis; Tetrapyrroles / chemistry
TL;DR: The new route to ABCD-porphyrins retains the desirable features of the existing "2 + 2" (dipyrromethane + dipyrromETHane-1,9-dicarbinol) method, such as absence of scrambling, yet has significant advantages. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Synthesis of hydrodipyrrins tailored for reactivity at the 1- and 9-positions

TETRAHEDRON, 63(1), 37–55.

By: H. Kim n, D. Dogutan n, M. Ptaszek n & J. Lindsey n 

author keywords: hydrodipyrrin; 1-pyrroline; pyrrole; hydroporphyrin
TL;DR: Straightforward access to various hydrodipyrrins should facilitate development of syntheses of diverse hydroporphyrins. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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