Dilek Kiper Dogutan

Works (5)

Updated: July 5th, 2023 15:55

2009 article

Imidazole metalloporphyrins as photosensitizers for photodynamic therapy: Role of molecular charge, central metal and hydroxyl radical production

Mroz, P., Bhaumik, J., Dogutan, D. K., Aly, Z., Kamal, Z., Khalid, L., … Hamblin, M. R. (2009, April 7). Cancer Letters, Vol. 282, pp. 63–76.

By: P. Mroz *, J. Bhaumik n, D. Dogutan n, Z. Aly*, Z. Kamal*, L. Khalid*, H. Kee*, D. Bocian * ...

author keywords: Structure function relationship; Photophysics; Phototoxicity; Metalloporphyrins; Apoptosis; Fluorescence microscopy; Reactive oxygen species; Hydroxyl radicals
MeSH headings : Adenocarcinoma / drug therapy; Adenocarcinoma / metabolism; Animals; Apoptosis / drug effects; Cell Line, Tumor; Colonic Neoplasms / drug therapy; Colonic Neoplasms / metabolism; HeLa Cells / drug effects; HeLa Cells / metabolism; Humans; Hydroxyl Radical / metabolism; Imidazoles / therapeutic use; Lysosomes / metabolism; Metalloporphyrins / chemical synthesis; Metalloporphyrins / chemistry; Metalloporphyrins / metabolism; Metalloporphyrins / therapeutic use; Mice; Microscopy, Fluorescence; Mitochondria / metabolism; Models, Molecular; Photochemotherapy / methods
topics (OpenAlex): Photodynamic Therapy Research Studies; Porphyrin and Phthalocyanine Chemistry; Nanoplatforms for cancer theranostics
TL;DR: The cationic Pd porphyrin has high potential as a photosensitizer and gives insights into characteristics for improved molecular designs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

Rational or Statistical Routes from 1-Acyldipyrromethanes to meso-Substituted Porphyrins. Distinct Patterns, Multiple Pyridyl Substituents, and Amphipathic Architectures

Dogutan, D. K., Ptaszek, M., & Lindsey, J. S. (2008, July 19). The Journal of Organic Chemistry, Vol. 73, pp. 6187–6201.

By: D. Dogutan n, M. Ptaszek n & J. Lindsey n 

MeSH headings : Magnesium / chemistry; Methane / analogs & derivatives; Methane / chemical synthesis; Methane / chemistry; Microwaves; Porphyrins / chemical synthesis; Pyrroles / chemical synthesis; Pyrroles / chemistry
topics (OpenAlex): Porphyrin and Phthalocyanine Chemistry; Supramolecular Chemistry and Complexes; Luminescence and Fluorescent Materials
TL;DR: The rational and statistical routes enable facile conversion of readily available 1-acyldipyrromethanes to diverse porphyrins bearing 1-4 meso substituents for which access is limited via other methods. (via Semantic Scholar)
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Added: August 6, 2018

2007 article

Direct Synthesis of Magnesium Porphine via 1-Formyldipyrromethane

Dogutan, D. K., Ptaszek, M., & Lindsey, J. S. (2007, May 23). The Journal of Organic Chemistry, Vol. 72, pp. 5008–5011.

By: D. Dogutan n, M. Ptaszek n & J. Lindsey n 

MeSH headings : Magnesium / chemistry; Metalloporphyrins / chemical synthesis; Metalloporphyrins / chemistry; Methane / analogs & derivatives; Methane / chemistry; Molecular Structure; Palladium / chemistry; Porphyrins / chemical synthesis; Porphyrins / chemistry; Pyrroles / chemistry; Zinc / chemistry
topics (OpenAlex): Porphyrin and Phthalocyanine Chemistry; Supramolecular Chemistry and Complexes; Asymmetric Synthesis and Catalysis
TL;DR: The reaction of 1-formyldipyrromethane in toluene at 115 degrees C containing DBU and MgBr2 in the presence of air affords the magnesium chelate Mg(II) porphine in 30-40% yield. (via Semantic Scholar)
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2007 article

New Route to ABCD-Porphyrins via Bilanes

Dogutan, D. K., Zaidi, S. H. H., Thamyongkit, P., & Lindsey, J. S. (2007, September 1). The Journal of Organic Chemistry, Vol. 72, pp. 7701–7714.

By: D. Dogutan n, S. Zaidi n, P. Thamyongkit n & J. Lindsey n 

MeSH headings : Magnesium / chemistry; Metalloporphyrins / chemical synthesis; Tetrapyrroles / chemistry
topics (OpenAlex): Porphyrin and Phthalocyanine Chemistry; Porphyrin Metabolism and Disorders; Metal-Catalyzed Oxygenation Mechanisms
TL;DR: The new route to ABCD-porphyrins retains the desirable features of the existing "2 + 2" (dipyrromethane + dipyrromETHane-1,9-dicarbinol) method, such as absence of scrambling, yet has significant advantages. (via Semantic Scholar)
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2006 article

Synthesis of hydrodipyrrins tailored for reactivity at the 1- and 9-positions

Kim, H.-J., Dogutan, D. K., Ptaszek, M., & Lindsey, J. S. (2006, November 2). Tetrahedron, Vol. 63, pp. 37–55.

By: H. Kim n, D. Dogutan n, M. Ptaszek n & J. Lindsey n 

author keywords: hydrodipyrrin; 1-pyrroline; pyrrole; hydroporphyrin
topics (OpenAlex): Porphyrin and Phthalocyanine Chemistry; Synthesis and Characterization of Pyrroles; Organic Chemistry Cycloaddition Reactions
TL;DR: Straightforward access to various hydrodipyrrins should facilitate development of syntheses of diverse hydroporphyrins. (via Semantic Scholar)
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Added: August 6, 2018

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