Sarah Jane Ewing

Works (1)

Updated: July 5th, 2023 21:15

2008 journal article

C/EBP beta represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19(Arf)

CELL DEATH AND DIFFERENTIATION, 15(11), 1734–1744.

By: S. Ewing n, S. Zhu n, F. Zhu n, J. House n  & R. Smart n 

Contributors: S. Ewing n, S. Zhu n, F. Zhu n, J. House n  & R. Smart n 

author keywords: apoptosis; p53; C/EBP beta; p19(Arf); DNA damage; keratinocytes
MeSH headings : Animals; Apoptosis / drug effects; CCAAT-Enhancer-Binding Protein-beta / deficiency; CCAAT-Enhancer-Binding Protein-beta / metabolism; Carcinogens / toxicity; Cell Survival / drug effects; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; Cyclophosphamide / administration & dosage; Cyclophosphamide / pharmacology; DNA Damage; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Injections, Intraperitoneal; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Mice; Oncogene Protein p21(ras) / metabolism; Protein Processing, Post-Translational / drug effects; Repressor Proteins / metabolism; Transcriptional Activation / drug effects; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
TL;DR: Results suggest that inhibition of C/EBPβ may be a target for cancer cotherapy to increase the efficacy of alkylating chemotherapeutic agents and suggest that p19Arf represses p53 to promote cell survival downstream of DNA damage. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

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