Kyungsil Yoon

Works (2)

Updated: July 5th, 2023 15:55

2007 journal article

Genetic ablation of CCAAT/Enhancer binding protein alpha in epidermis reveals its role in suppression of epithelial tumorigenesis

CANCER RESEARCH, 67(14), 6768–6776.

By: K. Loomis n, S. Zhu*, K. Yoon*, P. Johnson * & R. Smart n 

MeSH headings : Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-alpha / genetics; Cell Differentiation; Cell Proliferation; Epidermis / metabolism; Epithelial Cells / metabolism; Gene Expression Regulation, Neoplastic; Keratinocytes / cytology; Mice; Mice, Inbred BALB C; Mice, Knockout; Mutation; NIH 3T3 Cells; ras Proteins / metabolism
TL;DR: C/EBPalpha is dispensable for epidermal homeostasis and provides genetic evidence that C/EB Palpha is a suppressor of epithelial tumorigenesis, as well as proposed to block cell cycle progression through inhibition of E2F activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Decreased survival of C/EBP beta-deficient keratinocytes is due to aberrant regulation of p53 levels and function

ONCOGENE, 26(3), 360–367.

By: K. Yoon n, S. Zhu  n, S. Ewing n & R. Smart n 

author keywords: apoptosis; p53; C/EBP beta; keratinocytes
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / physiology; Carcinogens / toxicity; Cell Survival; Epidermis / drug effects; Epidermis / metabolism; Epidermis / pathology; Female; Gene Expression Regulation, Neoplastic; Immunoenzyme Techniques; In Situ Nick-End Labeling; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins c-bcl-2 / metabolism; Proto-Oncogene Proteins c-mdm2 / metabolism; Proto-Oncogene Proteins p21(ras) / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
TL;DR: The results demonstrate that altered keratinocyte survival in C/EBPβ−/− mice results from aberrant regulation of p53 protein and function and indicate C/ EBPβ has a role in the negative regulation ofp53 protein levels in response to carcinogen-induced stress. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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