Kyungsil Yoon

Works (2)

Updated: July 5th, 2023 15:55

2007 article

Genetic Ablation of CCAAT/Enhancer Binding Protein α in Epidermis Reveals Its Role in Suppression of Epithelial Tumorigenesis

Loomis, K. D., Zhu, S., Yoon, K., Johnson, P. F., & Smart, R. C. (2007, July 15). Cancer Research, Vol. 67, pp. 6768–6776.

By: K. Loomis n, S. Zhu*, K. Yoon*, P. Johnson * & R. Smart n 

MeSH headings : Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-alpha / genetics; Cell Differentiation; Cell Proliferation; Epidermis / metabolism; Epithelial Cells / metabolism; Gene Expression Regulation, Neoplastic; Keratinocytes / cytology; Mice; Mice, Inbred BALB C; Mice, Knockout; Mutation; NIH 3T3 Cells; ras Proteins / metabolism
topics (OpenAlex): Genomics and Chromatin Dynamics; Retinoids in leukemia and cellular processes; Cancer-related Molecular Pathways
TL;DR: C/EBPalpha is dispensable for epidermal homeostasis and provides genetic evidence that C/EB Palpha is a suppressor of epithelial tumorigenesis, as well as proposed to block cell cycle progression through inhibition of E2F activity. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 article

Decreased survival of C/EBPβ-deficient keratinocytes is due to aberrant regulation of p53 levels and function

Yoon, K., Zhu, S., Ewing, S. J., & Smart, R. C. (2006, July 10). Oncogene, Vol. 26, pp. 360–367.

By: K. Yoon n, S. Zhu  n, S. Ewing n & R. Smart n 

author keywords: apoptosis; p53; C/EBP beta; keratinocytes
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / physiology; Carcinogens / toxicity; Cell Survival; Epidermis / drug effects; Epidermis / metabolism; Epidermis / pathology; Female; Gene Expression Regulation, Neoplastic; Immunoenzyme Techniques; In Situ Nick-End Labeling; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins c-bcl-2 / metabolism; Proto-Oncogene Proteins c-mdm2 / metabolism; Proto-Oncogene Proteins p21(ras) / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
topics (OpenAlex): Cancer-related Molecular Pathways; Ubiquitin and proteasome pathways; Cell death mechanisms and regulation
TL;DR: The results demonstrate that altered keratinocyte survival in C/EBPβ−/− mice results from aberrant regulation of p53 protein and function and indicate C/ EBPβ has a role in the negative regulation ofp53 protein levels in response to carcinogen-induced stress. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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