Kyungsil Yoon

Works (2)

Updated: July 5th, 2023 15:55

2007 journal article

Genetic ablation of CCAAT/Enhancer binding protein alpha in epidermis reveals its role in suppression of epithelial tumorigenesis

CANCER RESEARCH, 67(14), 6768–6776.

By: K. Loomis n, S. Zhu*, K. Yoon*, P. Johnson * & R. Smart n 

MeSH headings : Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-alpha / genetics; Cell Differentiation; Cell Proliferation; Epidermis / metabolism; Epithelial Cells / metabolism; Gene Expression Regulation, Neoplastic; Keratinocytes / cytology; Mice; Mice, Inbred BALB C; Mice, Knockout; Mutation; NIH 3T3 Cells; ras Proteins / metabolism
TL;DR: C/EBPalpha is dispensable for epidermal homeostasis and provides genetic evidence that C/EB Palpha is a suppressor of epithelial tumorigenesis, as well as proposed to block cell cycle progression through inhibition of E2F activity. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Decreased survival of C/EBP beta-deficient keratinocytes is due to aberrant regulation of p53 levels and function

ONCOGENE, 26(3), 360–367.

By: K. Yoon n, S. Zhu  n, S. Ewing n & R. Smart n 

author keywords: apoptosis; p53; C/EBP beta; keratinocytes
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / physiology; Carcinogens / toxicity; Cell Survival; Epidermis / drug effects; Epidermis / metabolism; Epidermis / pathology; Female; Gene Expression Regulation, Neoplastic; Immunoenzyme Techniques; In Situ Nick-End Labeling; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins c-bcl-2 / metabolism; Proto-Oncogene Proteins c-mdm2 / metabolism; Proto-Oncogene Proteins p21(ras) / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
TL;DR: The results demonstrate that altered keratinocyte survival in C/EBPβ−/− mice results from aberrant regulation of p53 protein and function and indicate C/ EBPβ has a role in the negative regulation ofp53 protein levels in response to carcinogen-induced stress. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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