Larry D. Claxton

Works (8)

Updated: July 5th, 2023 15:55

2013 article

Characterization of metabolites of genotoxic 4,4′-aminoalkoxyazobenzene dyes

Freeman, H. S., Jeong, E., & Claxton, L. D. (2013, June 15). Dyes and Pigments.

By: H. Freeman n, E. Jeong n & L. Claxton*

author keywords: Diaminoalkoxyazobenzene dyes; Metabolites; N-dehydroxyethylation; O-deacetylation; Reductive cleavage
topics (OpenAlex): Carcinogens and Genotoxicity Assessment; bioluminescence and chemiluminescence research; Effects and risks of endocrine disrupting chemicals
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Source: Web Of Science
Added: August 6, 2018

2007 article

Synthesis and mutagenic properties of 4,4′‐diamino‐p‐terphenyl and 4,4′‐diamino‐p‐quaterphenyl

Wang, J., Freeman, H. S., & Claxton, L. D. (2007, January 12). Coloration Technology.

By: J. Wang n, H. Freeman n & L. Claxton*

topics (OpenAlex): Synthesis and Biological Evaluation; Carcinogens and Genotoxicity Assessment; DNA and Nucleic Acid Chemistry
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Source: Web Of Science
Added: August 6, 2018

2007 article

Synthesis and mutagenic properties of direct dyes from 4,4′‐diamino‐p‐terphenyl and 4,4′‐diamino‐p‐quaterphenyl

Wang, J., Freeman, H. S., & Claxton, L. D. (2007, January 12). Coloration Technology.

By: J. Wang n, H. Freeman n & L. Claxton*

topics (OpenAlex): bioluminescence and chemiluminescence research; Dyeing and Modifying Textile Fibers; Dye analysis and toxicity
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Source: Web Of Science
Added: August 6, 2018

2006 article

Evaluation of new 2,2′-dimethyl-5,5′-dipropoxybenzidine- and 3,3′-dipropoxybenzidine-based direct dye analogs for mutagenic activity by use of the Salmonella/mammalian mutagenicity assay

Bae, J.-S., Freeman, H. S., Warren, S. H., & Claxton, L. D. (2006, January 19). Mutation Research/Genetic Toxicology and Environmental Mutagenesis.

By: J. Bae n, H. Freeman n, S. Warren * & L. Claxton*

author keywords: direct dyes; mutagenicity; Salmonella assay; benzidine analogs
MeSH headings : Animals; Azo Compounds / toxicity; Benzidines / toxicity; Coloring Agents / toxicity; Cricetinae; Male; Microsomes, Liver / drug effects; Mutagenicity Tests; Mutation / drug effects; Rats; Rats, Sprague-Dawley; Salmonella typhimurium / drug effects; Structure-Activity Relationship
topics (OpenAlex): Carcinogens and Genotoxicity Assessment; bioluminescence and chemiluminescence research; Effects and risks of endocrine disrupting chemicals
TL;DR: The results of this study suggest that although benzidine analogs are potential replacements for benzidine, there is a need to understand which mutagenic products are produced when reductive metabolism is present and whether or not metal complexes of these dyes aremutagenic. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1991 journal article

Color, yes; cancer, no

Chemtech, 21(7), 438.

By: H. Freeman, J. Esancy, L. Claxton & M. Esancy

Source: NC State University Libraries
Added: August 6, 2018

1990 article

An approach to the design of nonmutagenic azo dyes: analogs of the mutagen ci direct black 17

Freeman, H. S., Esancy, J. F., & Claxton, L. D. (1990, January 1). Dyes and Pigments.

By: H. Freeman n, J. Esancy n & L. Claxton*

topics (OpenAlex): Carcinogens and Genotoxicity Assessment; bioluminescence and chemiluminescence research; Effects and risks of endocrine disrupting chemicals
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6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1990 article

The effect of alkoxy substituents on the mutagenicity of some aminoazobenzene dyes and their reductive-cleavage products

Esancy, J. F., Freeman, H. S., & Claxton, L. D. (1990, January 1). Mutation Research/Reviews in Genetic Toxicology.

By: J. Esancy n, H. Freeman n & L. Claxton*

MeSH headings : Azo Compounds / toxicity; Chemical Phenomena; Chemistry; Coloring Agents / toxicity; Mutagenicity Tests; Mutagens; Oxidation-Reduction; Salmonella typhimurium / genetics; p-Aminoazobenzene / analogs & derivatives; p-Aminoazobenzene / toxicity
topics (OpenAlex): bioluminescence and chemiluminescence research; Carcinogens and Genotoxicity Assessment; Effects and risks of endocrine disrupting chemicals
TL;DR: The results from the latter aspect of this study suggest that the mutagenicity of aminoazobenzene dyes can not be accounted for solely from the properties of their reductive-cleavage products. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1990 article

The effect of alkoxy substituents on the mutagenicity of some phenylenediamine-based disazo dyes

Esancy, J. F., Freeman, H. S., & Claxton, L. D. (1990, January 1). Mutation Research/Reviews in Genetic Toxicology.

By: J. Esancy n, H. Freeman n & L. Claxton*

MeSH headings : Azo Compounds / toxicity; Chemical Phenomena; Chemistry; Coloring Agents / toxicity; Mutagenicity Tests; Mutagens; Phenylenediamines / toxicity; Salmonella typhimurium / genetics
topics (OpenAlex): Carcinogens and Genotoxicity Assessment; bioluminescence and chemiluminescence research; Effects and risks of endocrine disrupting chemicals
TL;DR: Comparison of the mutagenicity of the disazo dyes with their potential reductive-cleavage products suggests that (1) the reductive/reduction products are not solely responsible for the mutagonicity ofThe disazoDyes, and (2) significant reductive -cleavage of the Disazo dye is not taking place in the standard Salmonella assay. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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