Larry D. Claxton

Works (8)

Updated: July 5th, 2023 15:55

2013 journal article

Characterization of metabolites of genotoxic 4,4 '-aminoalkoxyazobenzene dyes

DYES AND PIGMENTS, 99(2), 496–501.

By: H. Freeman n, E. Jeong n & L. Claxton*

author keywords: Diaminoalkoxyazobenzene dyes; Metabolites; N-dehydroxyethylation; O-deacetylation; Reductive cleavage
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Source: Web Of Science
Added: August 6, 2018

2007 journal article

Synthesis and mutagenic properties of 4,4'-diamino-p-terphenyl and 4,4'-diamino-p-quaterphenyl

COLORATION TECHNOLOGY, 123(1), 34–38.

By: J. Wang n, H. Freeman n & L. D Claxton *

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Source: Web Of Science
Added: August 6, 2018

2007 journal article

Synthesis and mutagenic properties of direct dyes from 4,4'-diamino-p-terphenyl and 4,4'-diamino-p-quaterphenyl

COLORATION TECHNOLOGY, 123(1), 39–45.

By: J. Wang n, H. Freeman n & L. D Claxton *

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Source: Web Of Science
Added: August 6, 2018

2006 journal article

Evaluation of new 2,2 '-dimethyl-5,5 '-dipropoxybenzidine- and 3,3 '-dipropoxybenzidine-based direct dye analogs for mutagenic activity by use of the Salmonella/mammalian mutagenicity assay

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 603(2), 173–185.

By: J. Bae n, H. Freeman n, S. Warren * & L. Claxton*

author keywords: direct dyes; mutagenicity; Salmonella assay; benzidine analogs
MeSH headings : Animals; Azo Compounds / toxicity; Benzidines / toxicity; Coloring Agents / toxicity; Cricetinae; Male; Microsomes, Liver / drug effects; Mutagenicity Tests; Mutation / drug effects; Rats; Rats, Sprague-Dawley; Salmonella typhimurium / drug effects; Structure-Activity Relationship
TL;DR: The results of this study suggest that although benzidine analogs are potential replacements for benzidine, there is a need to understand which mutagenic products are produced when reductive metabolism is present and whether or not metal complexes of these dyes aremutagenic. (via Semantic Scholar)
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Source: Web Of Science
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1991 journal article

Color, yes; cancer, no

Chemtech, 21(7), 438.

By: H. Freeman, J. Esancy, L. Claxton & M. Esancy

Source: NC State University Libraries
Added: August 6, 2018

1990 journal article

AN APPROACH TO THE DESIGN OF NONMUTAGENIC AZO DYES - ANALOGS OF THE MUTAGEN CI DIRECT BLACK 17

DYES AND PIGMENTS, 13(1), 55–70.

By: H. Freeman n, J. Esancy n & L. Claxton*

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Source: Web Of Science
Added: August 6, 2018

1990 review

THE EFFECT OF ALKOXY SUBSTITUENTS ON THE MUTAGENICITY OF SOME AMINOAZOBENZENE DYES AND THEIR REDUCTIVE-CLEAVAGE PRODUCTS

[Review of ]. MUTATION RESEARCH, 238(1), 1–22.

By: J. Esancy n, H. Freeman n & L. Claxton*

MeSH headings : Azo Compounds / toxicity; Chemical Phenomena; Chemistry; Coloring Agents / toxicity; Mutagenicity Tests; Mutagens; Oxidation-Reduction; Salmonella typhimurium / genetics; p-Aminoazobenzene / analogs & derivatives; p-Aminoazobenzene / toxicity
TL;DR: The results from the latter aspect of this study suggest that the mutagenicity of aminoazobenzene dyes can not be accounted for solely from the properties of their reductive-cleavage products. (via Semantic Scholar)
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1990 review

THE EFFECT OF ALKOXY SUBSTITUENTS ON THE MUTAGENICITY OF SOME PHENYLENEDIAMINE-BASED DISAZO DYES

[Review of ]. MUTATION RESEARCH, 238(1), 23–38.

By: J. Esancy n, H. Freeman n & L. Claxton*

MeSH headings : Azo Compounds / toxicity; Chemical Phenomena; Chemistry; Coloring Agents / toxicity; Mutagenicity Tests; Mutagens; Phenylenediamines / toxicity; Salmonella typhimurium / genetics
TL;DR: Comparison of the mutagenicity of the disazo dyes with their potential reductive-cleavage products suggests that (1) the reductive/reduction products are not solely responsible for the mutagonicity ofThe disazoDyes, and (2) significant reductive -cleavage of the Disazo dye is not taking place in the standard Salmonella assay. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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