2013 journal article

Characterization of metabolites of genotoxic 4,4 '-aminoalkoxyazobenzene dyes

DYES AND PIGMENTS, 99(2), 496–501.

By: H. Freeman*, E. Jeong* & L. Claxton*

author keywords: Diaminoalkoxyazobenzene dyes; Metabolites; N-dehydroxyethylation; O-deacetylation; Reductive cleavage
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Synthesis and mutagenic properties of 4,4'-diamino-p-terphenyl and 4,4'-diamino-p-quaterphenyl

COLORATION TECHNOLOGY, 123(1), 34–38.

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Synthesis and mutagenic properties of direct dyes from 4,4'-diamino-p-terphenyl and 4,4'-diamino-p-quaterphenyl

COLORATION TECHNOLOGY, 123(1), 39–45.

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Evaluation of new 2,2 '-dimethyl-5,5 '-dipropoxybenzidine- and 3,3 '-dipropoxybenzidine-based direct dye analogs for mutagenic activity by use of the Salmonella/mammalian mutagenicity assay

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 603(2), 173–185.

By: J. Bae n, H. Freeman n, S. Warren* & L. Claxton*

author keywords: direct dyes; mutagenicity; Salmonella assay; benzidine analogs
MeSH headings : Animals; Azo Compounds / toxicity; Benzidines / toxicity; Coloring Agents / toxicity; Cricetinae; Male; Microsomes, Liver / drug effects; Mutagenicity Tests; Mutation / drug effects; Rats; Rats, Sprague-Dawley; Salmonella typhimurium / drug effects; Structure-Activity Relationship
TL;DR: The results of this study suggest that although benzidine analogs are potential replacements for benzidine, there is a need to understand which mutagenic products are produced when reductive metabolism is present and whether or not metal complexes of these dyes aremutagenic. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1991 journal article

Color, yes; cancer, no

Chemtech, 21(7), 438.

By: H. Freeman, J. Esancy, L. Claxton & M. Esancy

Source: NC State University Libraries
Added: August 6, 2018

1990 journal article

AN APPROACH TO THE DESIGN OF NONMUTAGENIC AZO DYES - ANALOGS OF THE MUTAGEN CI DIRECT BLACK 17

DYES AND PIGMENTS, 13(1), 55–70.

By: H. Freeman n, J. Esancy n & L. Claxton*

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1990 review

THE EFFECT OF ALKOXY SUBSTITUENTS ON THE MUTAGENICITY OF SOME AMINOAZOBENZENE DYES AND THEIR REDUCTIVE-CLEAVAGE PRODUCTS

[Review of ]. MUTATION RESEARCH, 238(1), 1–22.

By: J. Esancy n, H. Freeman n & L. Claxton*

MeSH headings : Azo Compounds / toxicity; Chemical Phenomena; Chemistry; Coloring Agents / toxicity; Mutagenicity Tests; Mutagens; Oxidation-Reduction; Salmonella typhimurium / genetics; p-Aminoazobenzene / analogs & derivatives; p-Aminoazobenzene / toxicity
TL;DR: The results from the latter aspect of this study suggest that the mutagenicity of aminoazobenzene dyes can not be accounted for solely from the properties of their reductive-cleavage products. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1990 review

THE EFFECT OF ALKOXY SUBSTITUENTS ON THE MUTAGENICITY OF SOME PHENYLENEDIAMINE-BASED DISAZO DYES

[Review of ]. MUTATION RESEARCH, 238(1), 23–38.

By: J. Esancy n, H. Freeman n & L. Claxton*

MeSH headings : Azo Compounds / toxicity; Chemical Phenomena; Chemistry; Coloring Agents / toxicity; Mutagenicity Tests; Mutagens; Phenylenediamines / toxicity; Salmonella typhimurium / genetics
TL;DR: Comparison of the mutagenicity of the disazo dyes with their potential reductive-cleavage products suggests that (1) the reductive/reduction products are not solely responsible for the mutagonicity ofThe disazoDyes, and (2) significant reductive -cleavage of the Disazo dye is not taking place in the standard Salmonella assay. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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