D. Keith Williams, Jr.

Works (9)

Updated: July 12th, 2023 21:15

2010 journal article

Binding site on human immunoglobulin G for the affinity ligand HWRGWV

Journal of Molecular Recognition, 23(3), 271–282.

By: H. Yang, P. Gurgel, D. Williams, B. Bobay, J. Cavanagh, D. Muddiman , R. Carbonell

Source: NC State University Libraries
Added: August 6, 2018

2009 article

Absolute Quantification of C-Reactive Protein in Human Plasma Derived from Patients with Epithelial Ovarian Cancer Utilizing Protein Cleavage Isotope Dilution Mass Spectrometry

Williams, D. K., & Muddiman, D. C. (2009, January 6). Journal of Proteome Research, Vol. 8, pp. 1085–1090.

By: D. Williams n & D. Muddiman n 

author keywords: absolute quantification; C-reactive protein; ovarian cancer; single reaction monitoring
MeSH headings : Amino Acid Sequence; C-Reactive Protein / chemistry; C-Reactive Protein / metabolism; Chromatography, Liquid / methods; Female; Humans; Isotope Labeling / methods; Mass Spectrometry / methods; Molecular Sequence Data; Ovarian Neoplasms / blood; Ovarian Neoplasms / chemistry; Peptides / chemistry; Peptides / genetics; Peptides / metabolism; Reproducibility of Results
topics (OpenAlex): Advanced Proteomics Techniques and Applications; Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies
TL;DR: Interestingly, the PC-IDMS method provided concentration values that were approximately 10x the concentration reported by the ELISA method, which demonstrated that the method of detection is an important consideration when determining reference ranges of a particular analyte. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 article

Evaluation of the ALiPHAT method for PC-IDMS and correlation of limits-of-detection with nonpolar surface area

Williams, D. K., Comins, D. L., Whitten, J. L., & Muddiman, D. C. (2009, August 11). Journal of the American Society for Mass Spectrometry, Vol. 20, pp. 2006–2012.

By: D. Williams n, D. Comins n, J. Whitten n  & D. Muddiman n 

MeSH headings : Alkylation; Amino Acid Sequence; Calibration; Carbon Isotopes / chemistry; Chromatography, High Pressure Liquid / methods; Humans; Hydrophobic and Hydrophilic Interactions; Isotope Labeling / methods; Laminin / analysis; Laminin / chemistry; Male; Mass Spectrometry / methods; Nitrogen Isotopes / chemistry; Oligopeptides / analysis; Oligopeptides / chemistry; Prostate-Specific Antigen / chemistry; Reference Standards; Trypsin / analysis; Trypsin / chemistry
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Advanced Proteomics Techniques and Applications; Identification and Quantification in Food
TL;DR: While an increase in hydrophobicity was found to aid in decreasing LOD to an extent, beyond a certain hydrophOBicity, the number of decreases in LOD was observed, the authors observed a decrease. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 article

Utilizing artificial neural networks in matlab to achieve parts-per-billion mass measurement accuracy with a fourier transform ion cyclotron resonance mass spectrometer

Williams, D. K., Kovach, A. L., Muddiman, D. C., & Hanck, K. W. (2009, March 12). Journal of the American Society for Mass Spectrometry, Vol. 20, pp. 1303–1310.

By: D. Williams n, A. Kovach n, D. Muddiman n  & K. Hanck n

MeSH headings : Fourier Analysis; Linear Models; Mass Spectrometry / methods; Models, Theoretical; Neural Networks, Computer; Reproducibility of Results; Sensitivity and Specificity
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Advanced Chemical Sensor Technologies
TL;DR: Artificial neural network calibration in conjunction with automatic gain control (AGC) is utilized in these experiments to formally account for the differences in total ion population in the ICR cell between the external calibration spectra and experimental spectra. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

Calibration laws based on multiple linear regression applied to matrix‐assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry

Williams, D. K., Jr., Chadwick, M. A., Williams, T. I., & Muddiman, D. C. (2008, June 19). Journal of Mass Spectrometry, Vol. 43, pp. 1659–1663.

By: D. Williams n, M. Chadwick n, T. Williams n  & D. Muddiman n 

Contributors: D. Williams Jr. n, M. Chadwick n, T. Williams n  & D. Muddiman n 

author keywords: multiple linear regression; polypropylene glycol; calibration; matrix-assisted laser desorption/ionization (MALDI); Fourier transform ion cyclotron mass spectrometry (FT-ICR-MS); space-charge effects
MeSH headings : Calibration; Cyclotrons; Fourier Analysis; Linear Models; Mass Spectrometry / methods; Multivariate Analysis; Peptide Mapping / methods; Peptide Mapping / statistics & numerical data; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Metabolomics and Mass Spectrometry Studies
TL;DR: An evaluation of external mass calibration laws applied to MALDI-FT-ICR-MS is performed to achieve higher mass measurement accuracy (MMA) in Fourier transform ion cyclotron resonance mass spectrometry. (via Semantic Scholar)
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1. No Poverty (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 article

Synthesis, characterization, and application of lodoacetamide derivatives utilized for the ALiPHAT strategy

Journal of the American Chemical Society, Vol. 130, p. 2122-.

By: D. Williams, C. Meadows, I. Bori, A. Hawkridge, D. Comins & D. Muddiman 

topics (OpenAlex):
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2007 article

Dual Electrospray Ion Source for Electron-Transfer Dissociation on a Hybrid Linear Ion Trap−Orbitrap Mass Spectrometer

D. Keith Williams, McAlister, G. C., Good, D. M., Coon, J. J., & Muddiman, D. C. (2007, September 15). Analytical Chemistry, Vol. 79, pp. 7916–7919.

By: . D. Keith Williams n, G. McAlister n, D. Good n, J. Coon  n & D. Muddiman n 

MeSH headings : Electrons; Ions; Molecular Structure; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Advanced Proteomics Techniques and Applications
TL;DR: The stability of the ETD anion population is demonstrated and the ability to identify several c- and z-type product ions from multiply protonated peptide cations is demonstrated. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 article

Parts-Per-Billion Mass Measurement Accuracy Achieved through the Combination of Multiple Linear Regression and Automatic Gain Control in a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer

Williams, D. K., & Muddiman, D. C. (2007, June 1). Analytical Chemistry, Vol. 79, pp. 5058–5063.

By: D. Williams n & D. Muddiman n 

MeSH headings : Automation; Calibration; Cyclotrons / instrumentation; Ions; Mass Spectrometry / instrumentation; Mass Spectrometry / methods; Regression Analysis; Reproducibility of Results; Sensitivity and Specificity
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Metabolomics and Mass Spectrometry Studies
TL;DR: Calibrated multiple linear regression calibration is used to account for both differences in total ion population in the ICR cell as well as relative ion abundance of a given species, which affords mean MMA values at the parts-per-billion (ppb) level. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 article

Sub parts-per-million mass measurement accuracy of intact proteins and product ions achieved using a dual electrospray ionization quadrupole fourier transform ion cyclotron resonance mass spectrometer

Williams, D. K., Hawkridge, A. M., & Muddiman, D. C. (2006, September 19). Journal of the American Society for Mass Spectrometry, Vol. 18, pp. 1–7.

By: D. Williams n, A. Hawkridge n & D. Muddiman n 

MeSH headings : Amino Acid Sequence; Calibration; Cyclotrons; Ions; Melitten / chemistry; Molecular Sequence Data; Nanotechnology; Polymers / chemistry; Propylene Glycols / chemistry; Proteomics; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Spectroscopy, Fourier Transform Infrared / instrumentation; Spectroscopy, Fourier Transform Infrared / methods; Tandem Mass Spectrometry; Ubiquitin / chemistry
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Advanced Proteomics Techniques and Applications; Analytical Chemistry and Chromatography
TL;DR: While external calibration of protein fragments resulted in absolute MMA greater than 16 ppm, internal standardization significantly improved upon the MMA of both the intact proteins and their products ions which ranged from −2.0 ppm to 1.1 ppm. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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