E. S. Welf

Works (5)

Updated: July 5th, 2023 15:49

2012 article

Stochastic dynamics of membrane protrusion mediated by the DOCK180/Rac pathway in migrating cells (vol 3, pg 30, 2010)

Cellular and Molecular Bioengineering, Vol. 5, pp. 514–516.

By: E. Welf & J. Haugh 

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

In Chemotaxing Fibroblasts, Both High-Fidelity and Weakly Biased Cell Movements Track the Localization of PI3K Signaling

BIOPHYSICAL JOURNAL, 100(8), 1893–1901.

By: A. Melvin n, E. Welf n, Y. Wang *, D. Irvine * & J. Haugh n 

MeSH headings : Alginates / chemistry; Animals; Cell Surface Extensions / drug effects; Cell Surface Extensions / metabolism; Chemotaxis / drug effects; Dose-Response Relationship, Drug; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / enzymology; Glucuronic Acid / chemistry; Hexuronic Acids / chemistry; Mice; Microspheres; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Platelet-Derived Growth Factor / chemistry; Platelet-Derived Growth Factor / pharmacology; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction / drug effects; Stochastic Processes
TL;DR: It is shown that persistent and properly aligned (i.e., high-fidelity) fibroblast migration does indeed correlate with polarized PI3K signaling; accordingly, this behavior is seen only under conditions of high gradient steepness and a certain range of PDGF concentrations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Directional Persistence of Cell Migration Coincides with Stability of Asymmetric Intracellular Signaling

BIOPHYSICAL JOURNAL, 98(1), 67–75.

By: M. Weiger n, S. Ahmed n, E. Welf n & J. Haugh n 

MeSH headings : Animals; Cell Movement / physiology; Computer Simulation; Mice; Models, Biological; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases; Signal Transduction / physiology
TL;DR: Analysis of phosphoinositide 3-kinase signaling in randomly migrating fibroblasts shows that hot spots of intense signaling coincide with localized cell protrusion and endure with characteristic lifetimes that correspond to those of cell migration persistence, and shows that distant hot spots are dynamically and stochastically coupled. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Stochastic Dynamics of Membrane Protrusion Mediated by the DOCK180/Rac Pathway in Migrating Cells

CELLULAR AND MOLECULAR BIOENGINEERING, 3(1), 30–39.

By: E. Welf n & J. Haugh n 

author keywords: Integrins; Focal adhesions; Signal transduction; Paxillin; Src-family kinases; Myosin
TL;DR: It is shown that this “buffering of inhibition” mechanism, coupled with the core protrusion cycle, is capable of tuning the frequencies of protrusion and adhesion maturation events. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Stochastic Model of Integrin-Mediated Signaling and Adhesion Dynamics at the Leading Edges of Migrating Cells

PLOS COMPUTATIONAL BIOLOGY, 6(2).

By: M. Cirit n, M. Krajcovic n, C. Choi*, E. Welf n, A. Horwitz* & J. Haugh n 

Ed(s): A. Asthagiri

MeSH headings : Animals; CHO Cells; Cell Adhesion / physiology; Cell Movement / physiology; Cell Surface Extensions / metabolism; Computational Biology / methods; Computer Simulation; Cricetinae; Cricetulus; Extracellular Matrix / metabolism; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Integrins / metabolism; Models, Biological; Myosins / metabolism; Paxillin / genetics; Paxillin / metabolism; Signal Transduction / physiology; Stochastic Processes; rac GTP-Binding Proteins / metabolism
TL;DR: This work has formulated a quantitative model of leading edge dynamics combining mechanistic and phenomenological elements and studied its features through classical bifurcation analysis and stochastic simulation, showing that the qualitative behavior of the model is most sensitive to parameters characterizing the influence of stable adhesion and myosin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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