Diana A. Saggese

Works (4)

Updated: July 5th, 2023 15:55

2008 article

Investigations with O‐linked protein glycosylations by matrix‐assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry

Williams, T. I., Saggese, D. A., Toups, K. L., Frahm, J. L., An, H. J., Li, B., … Muddiman, D. C. (2008, March 6). Journal of Mass Spectrometry, Vol. 43, pp. 1215–1223.

By: T. Williams n , D. Saggese n, K. Toups n, J. Frahm n, H. An *, B. Li*, C. Lebrilla *, D. Muddiman n 

Contributors: T. Williams n , D. Saggese n, K. Toups n, J. Frahm n, H. An *, B. Li*, C. Lebrilla *, D. Muddiman n 

author keywords: Fourier transform ion cyclotron mass spectrometry (FT-ICR-MS); matrix-assisted laser desorption/ionization (MALDI); mucin; O-linked glycans; protein glycosylations
MeSH headings : Angiotensins / chemistry; Animals; Glycosylation; Mucins / chemistry; Oligosaccharides / chemistry; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectroscopy, Fourier Transform Infrared / methods; Swine; Tandem Mass Spectrometry / methods
topics (OpenAlex): Glycosylation and Glycoproteins Research; Mass Spectrometry Techniques and Applications; RNA and protein synthesis mechanisms
TL;DR: A detailed examination of sample preparation and matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FT-ICR-MS) analysis of O-linked glycans globally cleaved from mucin glycoproteins is presented. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 article

Studying O-Linked Protein Glycosylations in Human Plasma

Williams, T. I., Saggese, D. A., & Muddiman, D. C. (2008, April 19). Journal of Proteome Research, Vol. 7, pp. 2562–2568.

By: T. Williams n , D. Saggese n & D. Muddiman n 

Contributors: T. Williams n , D. Saggese n & D. Muddiman n 

author keywords: protein O-glycosylations; plasma; epithelial ovarian cancer (EOC); matrix-assisted laser desorption/iozation (MALDI); Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR-MS)
MeSH headings : Blood Proteins / chemistry; Blood Proteins / metabolism; Borohydrides / chemistry; Dialysis / methods; Female; Glycosylation; Hexosamines / analysis; Hexoses / analysis; Hexuronic Acids / analysis; Humans; Middle Aged; Ovarian Neoplasms / blood; Polysaccharides / analysis; Polysaccharides / chemistry; Polysaccharides / isolation & purification; Pronase / metabolism; Solid Phase Extraction / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
topics (OpenAlex): Glycosylation and Glycoproteins Research; Galectins and Cancer Biology; Carbohydrate Chemistry and Synthesis
TL;DR: The protocol here identifies O-linked carbohydrate patterns in EOC plasma glycoproteins through chemical cleavage and purification of these glycans through chemical Cleavage and Purification ofThese glycans are identified through carbohydrate pattern analysis with MALDI-FT-ICR-MS. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2007 article

Effect of matrix crystal structure on ion abundance of carbohydrates by matrix‐assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry

Williams, T. I., Saggese, D. A., Wilcox, R. J., Martin, J. D., & Muddiman, D. C. (2007, February 5). Rapid Communications in Mass Spectrometry, Vol. 21, pp. 807–811.

By: T. Williams n , D. Saggese n, R. Wilcox n, J. Martin n  & D. Muddiman n 

Contributors: T. Williams n , D. Saggese n, R. Wilcox n, J. Martin n  & D. Muddiman n 

MeSH headings : Acetylglucosamine / chemistry; Crystallization; Cyclotrons; Ions; N-Acetylneuraminic Acid / chemistry; Powder Diffraction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectroscopy, Fourier Transform Infrared
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Metabolomics and Mass Spectrometry Studies
TL;DR: Sample preparation techniques for carbohydrate analysis using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) are explored, with particular emphasis on analyte/matrix co-crystallization procedures. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2007 article

Epithelial Ovarian Cancer:  Disease Etiology, Treatment, Detection, and Investigational Gene, Metabolite, and Protein Biomarkers

Williams, T. I., Toups, K. L., Saggese, D. A., Kalli, K. R., Cliby, W. A., & Muddiman, D. C. (2007, June 21). Journal of Proteome Research, Vol. 6, pp. 2936–2962.

By: T. Williams n , K. Toups n, D. Saggese n, K. Kalli n, W. Cliby  n & D. Muddiman n 

Contributors: T. Williams n , K. Toups n, D. Saggese n, K. Kalli n, W. Cliby  n & D. Muddiman n 

author keywords: biomarkers; epithelial ovarian cancer; proteomics; mass spectrometry; detection; treatments
MeSH headings : Biomarkers, Tumor / metabolism; Female; Humans; Neoplasms, Glandular and Epithelial / diagnosis; Neoplasms, Glandular and Epithelial / etiology; Neoplasms, Glandular and Epithelial / metabolism; Ovarian Neoplasms / diagnosis; Ovarian Neoplasms / etiology; Ovarian Neoplasms / metabolism
topics (OpenAlex): Ovarian cancer diagnosis and treatment; Cancer, Lipids, and Metabolism; RNA modifications and cancer
TL;DR: An introduction to ovarian cancer is offered, with particular emphasis on human epithelial ovarian cancer, and a survey of promising new protein, gene, and metabolite biomarkers on the horizon is provided. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

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