Diana A. Saggese

Works (4)

Updated: July 5th, 2023 15:55

2008 journal article

Investigations with O-linked protein glycosylations by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry

JOURNAL OF MASS SPECTROMETRY, 43(9), 1215–1223.

By: T. Williams n , D. Saggese n, K. Toups n, J. Frahm n, H. An *, B. Li*, C. Lebrilla *, D. Muddiman n 

Contributors: T. Williams n , D. Saggese n, K. Toups n, J. Frahm n, H. An *, B. Li*, C. Lebrilla *, D. Muddiman n 

author keywords: Fourier transform ion cyclotron mass spectrometry (FT-ICR-MS); matrix-assisted laser desorption/ionization (MALDI); mucin; O-linked glycans; protein glycosylations
MeSH headings : Angiotensins / chemistry; Animals; Glycosylation; Mucins / chemistry; Oligosaccharides / chemistry; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectroscopy, Fourier Transform Infrared / methods; Swine; Tandem Mass Spectrometry / methods
TL;DR: A detailed examination of sample preparation and matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FT-ICR-MS) analysis of O-linked glycans globally cleaved from mucin glycoproteins is presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 journal article

Studying O-linked protein glycosylations in human plasma

JOURNAL OF PROTEOME RESEARCH, 7(6), 2562–2568.

By: T. Williams n , D. Saggese n & D. Muddiman n 

Contributors: T. Williams n , D. Saggese n & D. Muddiman n 

author keywords: protein O-glycosylations; plasma; epithelial ovarian cancer (EOC); matrix-assisted laser desorption/iozation (MALDI); Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR-MS)
MeSH headings : Blood Proteins / chemistry; Blood Proteins / metabolism; Borohydrides / chemistry; Dialysis / methods; Female; Glycosylation; Hexosamines / analysis; Hexoses / analysis; Hexuronic Acids / analysis; Humans; Middle Aged; Ovarian Neoplasms / blood; Polysaccharides / analysis; Polysaccharides / chemistry; Polysaccharides / isolation & purification; Pronase / metabolism; Solid Phase Extraction / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: The protocol here identifies O-linked carbohydrate patterns in EOC plasma glycoproteins through chemical cleavage and purification of these glycans through chemical Cleavage and Purification ofThese glycans are identified through carbohydrate pattern analysis with MALDI-FT-ICR-MS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2007 journal article

Effect of matrix crystal structure on ion abundance of carbohydrates by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 21(5), 807–811.

By: T. Williams n , D. Saggese n, R. Wilcox n, J. Martin n  & D. Muddiman n 

Contributors: T. Williams n , D. Saggese n, R. Wilcox n, J. Martin n  & D. Muddiman n 

MeSH headings : Acetylglucosamine / chemistry; Crystallization; Cyclotrons; Ions; N-Acetylneuraminic Acid / chemistry; Powder Diffraction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectroscopy, Fourier Transform Infrared
TL;DR: Sample preparation techniques for carbohydrate analysis using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) are explored, with particular emphasis on analyte/matrix co-crystallization procedures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2007 review

Epithelial ovarian cancer: Disease etiology, treatment, detection, and investigational gene, metabolite, and protein biomarkers

[Review of ]. JOURNAL OF PROTEOME RESEARCH, 6(8), 2936–2962.

By: T. Williams n , K. Toups n, D. Saggese n, K. Kalli n, W. Cliby  n & D. Muddiman n 

Contributors: T. Williams n , K. Toups n, D. Saggese n, K. Kalli n, W. Cliby  n & D. Muddiman n 

author keywords: biomarkers; epithelial ovarian cancer; proteomics; mass spectrometry; detection; treatments
MeSH headings : Biomarkers, Tumor / metabolism; Female; Humans; Neoplasms, Glandular and Epithelial / diagnosis; Neoplasms, Glandular and Epithelial / etiology; Neoplasms, Glandular and Epithelial / metabolism; Ovarian Neoplasms / diagnosis; Ovarian Neoplasms / etiology; Ovarian Neoplasms / metabolism
TL;DR: An introduction to ovarian cancer is offered, with particular emphasis on human epithelial ovarian cancer, and a survey of promising new protein, gene, and metabolite biomarkers on the horizon is provided. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

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