Works (6)

Updated: July 5th, 2023 15:54

2011 journal article

Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid


By: M. Mohamadzadeh*, E. Pfeiler n, J. Brown*, M. Zadeh*, M. Gramarossa*, E. Managlia*, P. Bere*, B. Sarraj* ...

author keywords: antiinflammatory; lactobacilli; Toll-like receptor 2; innate immunity
MeSH headings : Animals; Autoimmunity / immunology; CD4-Positive T-Lymphocytes / immunology; Colitis / chemically induced; Colitis / immunology; Colitis / microbiology; DNA Primers / genetics; Dextran Sulfate / toxicity; Flow Cytometry; Fluorescent Antibody Technique; Gene Deletion; Gene Expression Regulation / immunology; Homeodomain Proteins / genetics; Interleukin-10 / genetics; Lactobacillus acidophilus / metabolism; Lipopolysaccharides / deficiency; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88 / genetics; Polymerase Chain Reaction; Teichoic Acids; Transferases (Other Substituted Phosphate Groups) / genetics
TL;DR: Directed alteration of cell surface components of L. acidophilus NCFM establishes a potential strategy for the treatment of inflammatory intestinal disorders and significantly mitigated dextran sulfate sodium and CD4+CD45RBhighT cell-induced colitis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Role of Transporter Proteins in Bile Tolerance of Lactobacillus acidophilus


By: E. Pfeiler n & T. Klaenhammer n

MeSH headings : Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacology; Bile / chemistry; Bile / metabolism; Ciprofloxacin / metabolism; Ciprofloxacin / pharmacology; Detergents / metabolism; Detergents / pharmacology; Gene Deletion; Genes, Bacterial; Lactobacillus acidophilus / drug effects; Lactobacillus acidophilus / physiology; Membrane Transport Proteins / genetics; Membrane Transport Proteins / metabolism; Microbial Viability; Taurocholic Acid / metabolism; Taurocholic Acid / pharmacology
TL;DR: These strains showed unique patterns of sensitivity to a variety of inhibitory compounds, as well as differential accumulations of ciprofloxacin and taurocholate. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 article

Analysis of the genome sequence of Lactobacillus gasseri ATCC 33323 reveals the molecular basis of an autochthonous intestinal organism

Azcarate-Peril, M. A., Altermann, E., Goh, Y. J., Tallon, R., Sanozky-Dawes, R. B., Pfeiler, E. A., … Klaenhammer, T. R. (2008, August). APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol. 74, pp. 4610–4625.

By: M. Azcarate-Peril n, E. Altermann n, Y. Goh n, R. Tallon n, R. Sanozky-Dawes n, E. Pfeiler n, S. O'Flaherty n, B. Buck n ...

MeSH headings : Adult; Bacterial Adhesion / genetics; Bacterial Adhesion / physiology; Bacterial Proteins / genetics; Child; DNA Primers; Gastrointestinal Tract / microbiology; Genes, Bacterial; Genome, Bacterial; Humans; Infant, Newborn; Intestines / microbiology; Lactobacillus / genetics; Lactobacillus / isolation & purification; Lactobacillus / pathogenicity; Open Reading Frames
TL;DR: The results from this study indicated high intraspecies variability from a genome encoding traits important for survival and retention in the gastrointestinal tract. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 article

Functional genomics of probiotic Lactobacilli

Klaenhammer, T. R., Altermann, E., Pfeiler, E., Buck, B. L., Goh, Y.-J., O'Flaherty, S., … Duong, T. (2008, September). JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol. 42, pp. S160–S162.

By: T. Klaenhammer n, E. Altermann n, E. Pfeiler n, B. Buck n, Y. Goh n, S. O'Flaherty n, R. Barrangou n, T. Duong n

author keywords: Lactobacillus acidophilus; Lactobacillus johnsonii; Lactobacillus plantarum; Lactobacillus gasseri; genomics; probiotic cultures; lactic acid bacteria
MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Evolution, Molecular; Genome, Bacterial; Genomics; Humans; Lactobacillus / classification; Lactobacillus / genetics; Lactobacillus / metabolism; Lactobacillus / physiology; Probiotics / metabolism; Species Specificity
TL;DR: A comparative genomic analysis of 4 completely sequenced Lactobacillus strains versus 25 lactic acid bacterial genomes present in the public database at thetime of analysis is conducted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Characterization of a novel bile-inducible operon encoding a two-component regulatory system in Lactobacillus acidophilus

JOURNAL OF BACTERIOLOGY, 189(13), 4624–4634.

By: E. Pfeiler n, M. Azcarate-Peril n & T. Klaenhammer n

MeSH headings : Bacterial Proteins / genetics; Base Sequence; Bile Acids and Salts / pharmacology; Gene Expression Regulation, Bacterial / drug effects; Gene Order; Genes, Bacterial / genetics; Lactobacillus acidophilus / drug effects; Lactobacillus acidophilus / genetics; Models, Genetic; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic / drug effects
TL;DR: Functional analysis of the effects of bile on the global transcriptional profile of lactobacillus acidophilus NCFM showed that the operon encoded proteins involved in both bile tolerance and bile sensitivity, indicating that the 2CRS plays a role in bileolerance and that theOperon it resides in is negatively controlled by the RR. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 review

The genomics of lactic acid bacteria

[Review of ]. TRENDS IN MICROBIOLOGY, 15(12), 546–553.

By: E. Pfeiler* & T. Klaenhammer*

MeSH headings : Dairy Products / microbiology; Genome, Bacterial; Gram-Positive Bacteria / classification; Gram-Positive Bacteria / genetics; Gram-Positive Bacteria / metabolism; Humans; Lactic Acid / biosynthesis; Lactic Acid / metabolism; Probiotics
TL;DR: A review of the genome sequencing of 20 lactic acid bacteria provides an expanded view of their genetic and metabolic capacities and enables researchers to perform functional and comparative genomic studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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