Rachael E. Eckert

Works (5)

Updated: August 2nd, 2023 21:14

2010 journal article

Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein Regulation of Human Neutrophil Migration

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 42(5), 586–594.

By: R. Eckert n, L. Neuder*, J. Park*, K. Adler* & S. Jones* 

author keywords: inflammation; adhesion; beta 2 integrin; actin
MeSH headings : Actins / metabolism; CD18 Antigens / metabolism; Cell Adhesion / drug effects; Cell Membrane / drug effects; Cell Membrane / metabolism; Cell Polarity / drug effects; Chemotactic Factors / pharmacology; Chemotaxis, Leukocyte / drug effects; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; N-Formylmethionine Leucyl-Phenylalanine / pharmacology; Neutrophils / cytology; Neutrophils / drug effects; Neutrophils / metabolism; Peptides / pharmacology; Tetradecanoylphorbol Acetate / pharmacology
TL;DR: Treating isolated human neutrophils with MANS significantly inhibited both their migration and beta2 integrin-dependent adhesion in response to N-formyl-methionyl-leucyl-phenylalanine (fMLF), IL-8, or leukotriene (LT)B(4). (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Role of p38 MAPK in LPS induced pro-inflammatory cytokine and chemokine gene expression in equine leukocytes

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 129(3-4), 192–199.

By: L. Neuder n, J. Keener n, R. Eckert n, J. Trujillo n & S. Jones n 

author keywords: Endotoxemia; LPS; p38 MAPK; Equine; Leukocytes; Inflammation
MeSH headings : Animals; Cells, Cultured; Chemokines / genetics; Chemokines / metabolism; Cytokines / genetics; Cytokines / metabolism; Gene Expression Regulation / physiology; Horses / blood; Horses / immunology; Horses / metabolism; Leukocytes / drug effects; Leukocytes / metabolism; Lipopolysaccharides / pharmacology; RNA, Messenger / metabolism; Signal Transduction / drug effects; Signal Transduction / physiology; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR: TNFalpha,IL-1beta, IL-6 and IL-8 are induced upon LPS stimulation of equine leukocytes and that this induction of gene expression is dependent on the p38 MAPK pathway, however, there are differences in the efficacy of the p 38 inhibitors tested here that may be explained by differences in specificity or potency. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

p38 mitogen-activated kinase (MAPK) is essential for equine neutrophil migration

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 129(3-4), 181–191.

By: R. Eckert*, Y. Sharief* & S. Jones* 

author keywords: Other animals; Inflammation; Laminitis
MeSH headings : Animals; CD18 Antigens / metabolism; Cell Adhesion; Cells, Cultured; Chemotaxis, Leukocyte / physiology; Dose-Response Relationship, Drug; Enzyme Inhibitors / pharmacology; Gene Expression Regulation / physiology; Horses / physiology; Imidazoles / pharmacology; Inflammation / metabolism; Leukotriene B4 / metabolism; Neutrophils / metabolism; Pyridines / pharmacology; p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR: Findings support a function for p38 MAPK in equine neutrophil migration and suggest the potential for the ability of p38MAPK inhibition to limit neutrophilic inflammation in the laminae during acute laminitis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Regulation of VASP serine 157 phosphorylation in human neutrophils after stimulation by a chemoattractant

JOURNAL OF LEUKOCYTE BIOLOGY, 82(5), 1311–1321.

By: R. Eckert n & S. Jones n 

author keywords: PK4; chemotaxis; fMLF
MeSH headings : Actins / metabolism; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2 / antagonists & inhibitors; Calcium-Calmodulin-Dependent Protein Kinase Type 2 / physiology; Cell Adhesion; Cell Adhesion Molecules / genetics; Cell Adhesion Molecules / metabolism; Cells, Cultured; Chemotaxis; Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases / physiology; Cyclic GMP / analogs & derivatives; Cyclic GMP / pharmacology; Cyclic GMP-Dependent Protein Kinases / antagonists & inhibitors; Cyclic GMP-Dependent Protein Kinases / physiology; Enzyme Inhibitors / pharmacology; Humans; Interleukin-8 / pharmacology; Leukotriene B4 / pharmacology; Microfilament Proteins / genetics; Microfilament Proteins / metabolism; N-Formylmethionine Leucyl-Phenylalanine / analogs & derivatives; N-Formylmethionine Leucyl-Phenylalanine / pharmacology; Neutrophils / drug effects; Neutrophils / metabolism; Phosphoproteins / genetics; Phosphoproteins / metabolism; Phosphorylation / drug effects; Platelet Activating Factor / pharmacology; Protein Kinase C / antagonists & inhibitors; Protein Kinase C / physiology; Serine / chemistry; Serine / genetics; Serine / metabolism; Signal Transduction; Tumor Necrosis Factor-alpha / pharmacology
TL;DR: The data show that chemoattractant stimulation of human neutrophils induces a rapid and transient PKA‐dependent VASP Ser 157 phosphorylation, andhesion does not appear to be an important regulator of the state of Vasodilator‐stimulated phosphoprotein. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

The role of p38 mitogen-activated kinase (MAPK) in the mechanism regulating cyclooxygenase gene expression in equine leukocytes

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 118(3-4), 294–303.

By: R. Eckert n, L. Neuder n, J. Bell n, J. Trujillo n & S. Jones n 

author keywords: other animals; endotoxin shock; lipopolysaccharide; inflammation
MeSH headings : Animals; Cells, Cultured; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Enzyme Activation; Epoprostenol / metabolism; Gene Expression Regulation, Enzymologic; Horses / blood; Horses / genetics; Imidazoles / pharmacology; Leukocytes / metabolism; Prostaglandins / genetics; Prostaglandins / metabolism; Pyridines / pharmacology; RNA, Messenger / metabolism; Time Factors; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR: It is concluded that p 38 MAPK is essential for LPS-induced COX-2 expression suggesting that p38 MAPK are a potential target for anti-inflammatory therapy during equine endotoxemia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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