Works (1)
Updated: August 2nd, 2023 21:14
2007 journal article
The role of p38 mitogen-activated kinase (MAPK) in the mechanism regulating cyclooxygenase gene expression in equine leukocytes
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 118(3-4), 294–303.
author keywords: other animals; endotoxin shock; lipopolysaccharide; inflammation
MeSH headings : Animals; Cells, Cultured; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Enzyme Activation; Epoprostenol / metabolism; Gene Expression Regulation, Enzymologic; Horses / blood; Horses / genetics; Imidazoles / pharmacology; Leukocytes / metabolism; Prostaglandins / genetics; Prostaglandins / metabolism; Pyridines / pharmacology; RNA, Messenger / metabolism; Time Factors; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
It is concluded that p 38 MAPK is essential for LPS-induced COX-2 expression suggesting that p38 MAPK are a potential target for anti-inflammatory therapy during equine endotoxemia.
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Added: August 6, 2018
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