2007 journal article

The role of p38 mitogen-activated kinase (MAPK) in the mechanism regulating cyclooxygenase gene expression in equine leukocytes


By: R. Eckert n, L. Neuder n, J. Bell n, J. Trujillo n & S. Jones n

author keywords: other animals; endotoxin shock; lipopolysaccharide; inflammation
MeSH headings : Animals; Cells, Cultured; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Enzyme Activation; Epoprostenol / metabolism; Gene Expression Regulation, Enzymologic; Horses / blood; Horses / genetics; Imidazoles / pharmacology; Leukocytes / metabolism; Prostaglandins / genetics; Prostaglandins / metabolism; Pyridines / pharmacology; RNA, Messenger / metabolism; Time Factors; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR: It is concluded that p 38 MAPK is essential for LPS-induced COX-2 expression suggesting that p38 MAPK are a potential target for anti-inflammatory therapy during equine endotoxemia. (via Semantic Scholar)
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Added: August 6, 2018

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