Jennifer C. Trujillo

Works (1)

Updated: July 5th, 2023 15:50

2008 journal article

Role of p38 MAPK in LPS induced pro-inflammatory cytokine and chemokine gene expression in equine leukocytes

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 129(3-4), 192–199.

By: L. Neuder n, J. Keener n, R. Eckert n, J. Trujillo n & S. Jones n 

author keywords: Endotoxemia; LPS; p38 MAPK; Equine; Leukocytes; Inflammation
MeSH headings : Animals; Cells, Cultured; Chemokines / genetics; Chemokines / metabolism; Cytokines / genetics; Cytokines / metabolism; Gene Expression Regulation / physiology; Horses / blood; Horses / immunology; Horses / metabolism; Leukocytes / drug effects; Leukocytes / metabolism; Lipopolysaccharides / pharmacology; RNA, Messenger / metabolism; Signal Transduction / drug effects; Signal Transduction / physiology; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR: TNFalpha,IL-1beta, IL-6 and IL-8 are induced upon LPS stimulation of equine leukocytes and that this induction of gene expression is dependent on the p38 MAPK pathway, however, there are differences in the efficacy of the p 38 inhibitors tested here that may be explained by differences in specificity or potency. (via Semantic Scholar)
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