Works (7)
Updated: July 5th, 2023 15:54
2013 journal article
Developing Predictive Approaches to Characterize Adaptive Responses of the Reproductive Endocrine Axis to Aromatase Inhibition: II. Computational Modeling
TOXICOLOGICAL SCIENCES, 133(2), 234–247.
author keywords: endocrine disruptors; biological modeling; non-mammalian species; dose response; biomarkers
MeSH headings : Adaptation, Physiological / drug effects; Animal Testing Alternatives; Animals; Aromatase Inhibitors / toxicity; Computer Simulation; Cyprinidae / physiology; Dose-Response Relationship, Drug; Estradiol / blood; Estrogen Antagonists / toxicity; Fadrozole / toxicity; Female; Hypothalamo-Hypophyseal System / drug effects; Hypothalamo-Hypophyseal System / enzymology; Male; Ovary / drug effects; Ovary / enzymology; Predictive Value of Tests; Time Factors
TL;DR:
A computational model of the hypothalamic-pituitary-gonadal (HPG) axis in female fathead minnows is developed to predict dose-response and time-course behaviors for endocrine effects of the aromatase inhibitor, fadrozole (FAD).
(via Semantic Scholar)
open access via academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Developing predictive approaches to characterize adaptive responses of the reproductive endocrine axis to Aromatase inhibition: I. Data generation in a small fish model
Toxicological Sciences, 133(2), 225–233.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Mechanistic Computational Model of Steroidogenesis in H295R Cells: Role of Oxysterols and Cell Proliferation to Improve Predictability of Biochemical Response to Endocrine Active Chemical-Metyrapone
TOXICOLOGICAL SCIENCES, 123(1), 80–93.
author keywords: endocrine disrupting chemicals; mechanistic computational model; in vitro toxicology; metyrapone; H295R cells; steroid biosynthesis
MeSH headings : Adrenocortical Carcinoma / drug therapy; Adrenocortical Carcinoma / metabolism; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Cholesterol / analogs & derivatives; Cholesterol / metabolism; Computational Biology / methods; Endocrine Disruptors / toxicity; Enzyme Inhibitors / toxicity; Humans; Metyrapone / toxicity; Models, Theoretical; Predictive Value of Tests; Steroids / metabolism
TL;DR:
The improvement of the extended, more biologically realistic model to predict CHOL and steroid concentrations in H295R cells and medium and their dynamic biochemical response to the EAC, MET is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 conference paper
Predicting chemical impacts on vertebrate endocrine systems
Environmental Toxicology and Chemistry, 30(1), 39–51.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Computational model of steroidogenesis in humanH295R cells to predict biochemical response to endocrine-active chemicals: Model development for metyrapone
Environmental Health Perspectives, 118(2), 265–272.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Predicting Residential Air Exchange Rates from Questionnaires and Meteorology: Model Evaluation in Central North Carolina
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 44(24), 9349–9356.
MeSH headings : Air Movements; Air Pollutants / analysis; Air Pollution, Indoor / analysis; Air Pollution, Indoor / statistics & numerical data; Atmosphere / chemistry; Environmental Monitoring / methods; Forecasting; Meteorological Concepts; Models, Chemical; North Carolina; Particle Size; Seasons; Surveys and Questionnaires
TL;DR:
The capability of the LBL, LBLX, and SF models could help reduce the AER uncertainty in air pollution exposure models used to develop exposure metrics for health studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 journal article
MRI-guided thermal ablation therapy: Model and parameter estimates to predict cell death from MR thermometry images
ANNALS OF BIOMEDICAL ENGINEERING, 35(8), 1391–1403.
author keywords: cell death model; interventional MRI; laser thermal ablation; MR thermometry
MeSH headings : Animals; Brain; Brain Neoplasms / therapy; Cell Death / physiology; Laser Therapy; Magnetic Resonance Imaging / methods; Models, Theoretical; Rabbits; Temperature
TL;DR:
There is good evidence that iMRI temperature maps can be used with the model to predict therapeutic regions in real-time during treatment, and as compared to the critical temperature cell death model and the generalized Arrhenius model, the model typically predicted fewer FP and FN.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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