D. R. Georgianna

Works (8)

Updated: July 5th, 2023 15:54

2010 journal article

Detection of alternative splice variants at the proteome level in Aspergillus flavus

Journal of Proteome Research, 9(3), 1209–1217.

By: K. Chang, D. Georgianna, S. Heber, G. Payne & D. Muddiman

Source: NC State University Libraries
Added: August 6, 2018

2009 article

Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters

GEORGIANNA, D. R. Y. A. N., FEDOROVA, N. A. T. A. L. I. E. D., BURROUGHS, J. A. M. E. S. L., DOLEZAL, A. N. D. R. E. A. L., BOK, J. I. N. W. O. O., HOROWITZ‐BROWN, S. I. G. A. L., … PAYNE, G. A. R. Y. A. (2009, November 4). Molecular Plant Pathology.

By: D. Georgianna n, N. Fedorova*, J. Burroughs  n, A. Dolezal n, J. Bok *, S. Horowitz‐Brown*, C. Woloshuk *, Y. Jiujiang*, N. Keller *, G. Payne n

MeSH headings : Aflatoxins / chemistry; Aflatoxins / metabolism; Aspergillus flavus / enzymology; Aspergillus flavus / genetics; Aspergillus flavus / metabolism; Cluster Analysis; Fungal Proteins / genetics; Fungal Proteins / metabolism; Gene Expression Regulation, Fungal; Genes, Fungal / genetics; Hydrogen-Ion Concentration; Indoles / chemistry; Indoles / metabolism; Multigene Family / genetics; Reverse Transcriptase Polymerase Chain Reaction; Temperature; Transcription, Genetic; Zea mays / microbiology
topics (OpenAlex): Mycotoxins in Agriculture and Food; Fungal and yeast genetics research; Microbial Natural Products and Biosynthesis
TL;DR: Aflatoxin and CPA were found to have unique regulation, but are sufficiently similar that they would be expected to co-occur in substrates colonized with A. flavus. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 article

Genetic regulation of aflatoxin biosynthesis: From gene to genome

Georgianna, D. R., & Payne, G. A. (2008, November 8). Fungal Genetics and Biology.

By: D. Georgianna n & G. Payne n

author keywords: Aflatoxin; Aspergillus; Genomics; Secondary metabolism
MeSH headings : Aflatoxins / biosynthesis; Aspergillus / genetics; Aspergillus / metabolism; Fungal Proteins / genetics; Fungal Proteins / metabolism; Gene Expression Regulation, Fungal; Genome, Fungal; Signal Transduction; Transcription, Genetic
topics (OpenAlex): Mycotoxins in Agriculture and Food; Plant Pathogens and Fungal Diseases; Plant Disease Resistance and Genetics
TL;DR: Aflatoxins are notorious toxic secondary metabolites known for their impacts on human and animal health, and their effects on the marketability of key grain and nut crops, and new and emerging information garnered from structural and functional genomics are highlighted. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 article

Temperature-Dependent Regulation of Proteins in Aspergillus flavus: Whole Organism Stable Isotope Labeling by Amino Acids

Georgianna, D. R., Hawkridge, A. M., Muddiman, D. C., & Payne, G. A. (2008, June 5). Journal of Proteome Research, Vol. 7, pp. 2973–2979.

By: D. Georgianna n, A. Hawkridge n, D. Muddiman n  & G. Payne n

author keywords: SILAC; mass spectrometry; proteomics; Aspergillus flavus; aflatoxin
MeSH headings : Aflatoxins / biosynthesis; Amino Acids / metabolism; Arginine / metabolism; Aspergillus flavus / metabolism; Carbon Isotopes; Chromatography, Liquid; Culture Media; Fungal Proteins / biosynthesis; Fungal Proteins / genetics; Gene Expression Regulation, Fungal; Isotope Labeling; Oligonucleotide Array Sequence Analysis; Tandem Mass Spectrometry; Temperature
topics (OpenAlex): Mycotoxins in Agriculture and Food; Advanced Proteomics Techniques and Applications; Fungal and yeast genetics research
TL;DR: The utility of this procedure in quantifying changes in protein expression in response to environmental stimuli is shown, and the first reported labeling of a multicellular free-living prototroph using the SILAC procedure to compare (13)C(6)-arginine-labeled samples to (12)C (6-arginines-labeling samples for quantitative proteomics is reported. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

Top-Down Identification and Quantification of Stable Isotope Labeled Proteins from Aspergillus flavus Using Online Nano-Flow Reversed-Phase Liquid Chromatography Coupled to a LTQ-FTICR Mass Spectrometer

Collier, T. S., Hawkridge, A. M., Georgianna, D. R., Payne, G. A., & Muddiman, D. C. (2008, May 31). Analytical Chemistry, Vol. 80, pp. 4994–5001.

By: T. Collier n, A. Hawkridge n, D. Georgianna n, G. Payne n & D. Muddiman n 

MeSH headings : Arginine / chemistry; Arginine / metabolism; Aspergillus flavus / chemistry; Aspergillus flavus / metabolism; Carbon Radioisotopes / chemistry; Chromatography, Liquid / methods; Fourier Analysis; Fungal Proteins / analysis; Fungal Proteins / chemistry; Fungal Proteins / metabolism; Isotope Labeling; Tandem Mass Spectrometry / methods
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Metabolomics and Mass Spectrometry Studies
TL;DR: The qualitative and quantitative top-down characterization of proteins derived from SILAC-labeled Aspergillus flavus is described using nanoflow reversed-phase liquid chromatography directly coupled to a linear ion trap Fourier transform ion cyclotron resonance mass spectrometer (nLC-LTQ-FTICR-MS). (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 article

Improved protocols for functional analysis in the pathogenic fungus Aspergillus flavus

He, Z.-M., Price, M. S., OBrian, G. R., Georgianna, D. R., & Payne, G. A. (2007, November 26). BMC Microbiology.

By: Z. He  n, M. Price n, G. OBrian n, D. Georgianna n & G. Payne n

MeSH headings : Antifungal Agents / pharmacology; Aspergillus flavus / genetics; Blotting, Southern; Drug Resistance, Fungal / genetics; Genes, Fungal; Genetic Complementation Test; Mutagenesis; Mutagenesis, Insertional; Orotic Acid / analogs & derivatives; Orotic Acid / metabolism; Phleomycins / pharmacology; Polymerase Chain Reaction / methods; Protoplasts; Spores, Fungal / genetics; Transformation, Genetic; Uracil / biosynthesis
topics (OpenAlex): Mycotoxins in Agriculture and Food; Fungal and yeast genetics research; Plant Pathogens and Fungal Diseases
TL;DR: The phleomycin resistance as a new positive selectable marker for genetic transformation of A. flavus allows strains to be transformed without having to generate an auxotrophic mutation, which is time consuming and may result in undesirable mutations. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 article

The effect of elevated temperature on gene transcription and aflatoxin biosynthesis

OBrian, G. R., Georgianna, D. R., Wilkinson, J. R., Yu, J., Abbas, H. K., Bhatnagar, D., … Payne, G. A. (2007, March 1). Mycologia.

By: G. OBrian n, D. Georgianna n, J. Wilkinson*, J. Yu *, H. Abbas *, D. Bhatnagar, T. Cleveland *, W. Nierman, G. Payne n

author keywords: AFLR; biosynthesis; micro-arrays
MeSH headings : Aflatoxins / biosynthesis; Aflatoxins / genetics; Aspergillus flavus / genetics; Aspergillus flavus / physiology; DNA-Binding Proteins / genetics; Fungal Proteins / genetics; Gene Expression Profiling; Gene Expression Regulation, Fungal; Hot Temperature; Polymerase Chain Reaction; Transcription Factors / genetics
topics (OpenAlex): Mycotoxins in Agriculture and Food; Plant Pathogens and Fungal Diseases; Fungal and yeast genetics research
TL;DR: Data indicate that the failure of A. flavus to produce aflatoxin at 37 C is not due to lack of transcription of aflR or aflS, and that AFLR is nonfunctional at high temperatures, suggesting that the factor(s) sensing the elevated temperatures must be acute. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 article

What can comparative genomics tell us about species concepts in the genus Aspergillus?

Rokas, A., Payne, G., Fedorova, N. D., Baker, S. E., Machida, M., Yu, J., … Nierman, W. C. (2007, January 1). Studies in Mycology, pp. 11–17.

By: A. Rokas *, G. Payne n, N. Fedorova*, S. Baker *, M. Machida*, J. Yu*, D. Georgianna n, R. Dean n  ...

author keywords: comparative genomics; genetic diversity; genome sequences; identification of species boundaries
topics (OpenAlex): Plant Pathogens and Fungal Diseases; Antifungal resistance and susceptibility; Mycotoxins in Agriculture and Food
TL;DR: It is argued that genomic data can aid Aspergillus taxonomy by serving as a source of novel and unprecedented amounts of comparative data, as a resource for the development of additional diagnostic tools, and finally as a knowledge database about the biological differences between strains and species. (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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