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Michael G. Gonda

Works (3)

Updated: July 5th, 2023 15:54

2013 journal article

Changes in chondrocyte gene expression following in vitro impaction of porcine articular cartilage in an impact injury model

JOURNAL OF ORTHOPAEDIC RESEARCH, 31(3), 385–391.

By: M. Ashwell  n, M. Gonda n, K. Gray n, C. Maltecca n , . Audrey T. O'Nan, J. Cassady n, P. Mente n

Contributors: M. Ashwell  n, M. Gonda n, K. Gray n, C. Maltecca n , . A.T. O'Nan n, J. Cassady n, P. Mente n

author keywords: articular cartilage; chondrocyte; gene expression; joint injury; osteoarthritis
MeSH headings : Animals; Cartilage, Articular / cytology; Cartilage, Articular / physiology; Chondrocytes / physiology; Female; Knee Injuries / genetics; Knee Injuries / physiopathology; Knee Joint / cytology; Knee Joint / physiology; Models, Genetic; Organ Culture Techniques; Osteoarthritis, Knee / genetics; Osteoarthritis, Knee / physiopathology; Patella / cytology; Patella / physiology; Real-Time Polymerase Chain Reaction; Sus scrofa; Transcriptome / physiology
topics (OpenAlex): Lower Extremity Biomechanics and Pathologies; Tendon Structure and Treatment; Osteoarthritis Treatment and Mechanisms
TL;DR: Ten of the 17 genes were differentially expressed with col1a1 most significantly up‐regulated in the impacted samples, suggesting impacted chondrocytes may have reverted to a fibroblast‐like phenotype. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 journal article

Gene expression profiling of chondrocytes from a porcine impact injury model

OSTEOARTHRITIS AND CARTILAGE, 16(8), 936–946.

By: M. Ashwell  n, A. O'Nan n, M. Gonda n & P. Mente n

author keywords: gene expression; chondrocyte; impact injury model; osteoarthritis
MeSH headings : Animals; Cells, Cultured / metabolism; Chondrocytes / metabolism; Disease Models, Animal; Gene Expression; Gene Expression Profiling / methods; Knee Joint / metabolism; Osteoarthritis / genetics; Osteoarthritis / metabolism; Phenotype; Polymerase Chain Reaction; Swine; Wounds, Nonpenetrating / genetics; Wounds, Nonpenetrating / metabolism
topics (OpenAlex): Osteoarthritis Treatment and Mechanisms; Knee injuries and reconstruction techniques; Lower Extremity Biomechanics and Pathologies
TL;DR: Results using this porcine impact injury model have contributed further evidence that damaged chondrocytes may de-differentiate into fibroblast-like cells and proliferate in an attempt to repair themselves and provide a more complete story about the fate of chondROcytes in articular cartilage following an injury. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Identification of a QTL on BTA20 affecting susceptibility to Mycobacterium avium ssp paratuberculosis infection in US Holsteins

ANIMAL GENETICS, 38(4), 389–396.

By: M. Gonda*, B. Kirkpatrick *, G. Shook * & M. Collins *

author keywords: dairy cattle; Johne's disease; Mycobacterium paratuberculosis; quantitative trait loci
MeSH headings : Animals; Cattle; Cattle Diseases / genetics; Chromosome Mapping; Genetic Markers; Genetic Predisposition to Disease; Genotype; Microsatellite Repeats; Mycobacterium avium subsp. paratuberculosis / isolation & purification; Paratuberculosis / genetics; Quantitative Trait Loci; United States
topics (OpenAlex): Mycobacterium research and diagnosis; Plant Disease Resistance and Genetics; Cancer-related molecular mechanisms research
TL;DR: Evidence for the presence of a QTL segregating within families on BTA20 was found and eight chromosomal regions putatively linked with susceptibility to M. paratuberculosis infection were identified using a Z-test. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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