Michael G. Gonda

Works (3)

Updated: July 5th, 2023 15:54

2012 article

Changes in chondrocyte gene expression following in vitro impaction of porcine articular cartilage in an impact injury model

Ashwell, M. S., Gonda, M. G., Gray, K., Maltecca, C., O'Nan, A. T., Cassady, J. P., & Mente, P. L. (2012, October 1). Journal of Orthopaedic Research®, Vol. 31, pp. 385–391.

By: M. Ashwell n , M. Gonda n, K. Gray n, C. Maltecca n , A. O'Nan n, J. Cassady n, P. Mente n

Contributors: M. Ashwell n , M. Gonda n, K. Gray n, C. Maltecca n , . A.T. O'Nan n, J. Cassady n, P. Mente n

author keywords: articular cartilage; chondrocyte; gene expression; joint injury; osteoarthritis
MeSH headings : Animals; Cartilage, Articular / cytology; Cartilage, Articular / physiology; Chondrocytes / physiology; Female; Knee Injuries / genetics; Knee Injuries / physiopathology; Knee Joint / cytology; Knee Joint / physiology; Models, Genetic; Organ Culture Techniques; Osteoarthritis, Knee / genetics; Osteoarthritis, Knee / physiopathology; Patella / cytology; Patella / physiology; Real-Time Polymerase Chain Reaction; Sus scrofa; Transcriptome / physiology
topics (OpenAlex): Lower Extremity Biomechanics and Pathologies; Tendon Structure and Treatment; Osteoarthritis Treatment and Mechanisms
TL;DR: Ten of the 17 genes were differentially expressed with col1a1 most significantly up‐regulated in the impacted samples, suggesting impacted chondrocytes may have reverted to a fibroblast‐like phenotype. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 article

Gene expression profiling of chondrocytes from a porcine impact injury model

Ashwell, M. S., O'Nan, A. T., Gonda, M. G., & Mente, P. L. (2008, February 15). Osteoarthritis and Cartilage, Vol. 16, pp. 936–946.

By: M. Ashwell n , A. O'Nan n, M. Gonda n & P. Mente n

author keywords: gene expression; chondrocyte; impact injury model; osteoarthritis
MeSH headings : Animals; Cells, Cultured / metabolism; Chondrocytes / metabolism; Disease Models, Animal; Gene Expression; Gene Expression Profiling / methods; Knee Joint / metabolism; Osteoarthritis / genetics; Osteoarthritis / metabolism; Phenotype; Polymerase Chain Reaction; Swine; Wounds, Nonpenetrating / genetics; Wounds, Nonpenetrating / metabolism
topics (OpenAlex): Osteoarthritis Treatment and Mechanisms; Knee injuries and reconstruction techniques; Lower Extremity Biomechanics and Pathologies
TL;DR: Results using this porcine impact injury model have contributed further evidence that damaged chondrocytes may de-differentiate into fibroblast-like cells and proliferate in an attempt to repair themselves and provide a more complete story about the fate of chondROcytes in articular cartilage following an injury. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 article

Identification of a QTL on BTA20 affecting susceptibility toMycobacterium aviumssp.paratuberculosisinfection in US Holsteins

Gonda, M. G., Kirkpatrick, B. W., Shook, G. E., & Collins, M. T. (2007, July 6). Animal Genetics.

By: M. Gonda*, B. Kirkpatrick *, G. Shook * & M. Collins *

author keywords: dairy cattle; Johne's disease; Mycobacterium paratuberculosis; quantitative trait loci
MeSH headings : Animals; Cattle; Cattle Diseases / genetics; Chromosome Mapping; Genetic Markers; Genetic Predisposition to Disease; Genotype; Microsatellite Repeats; Mycobacterium avium subsp. paratuberculosis / isolation & purification; Paratuberculosis / genetics; Quantitative Trait Loci; United States
topics (OpenAlex): Mycobacterium research and diagnosis; Plant Disease Resistance and Genetics; Cancer-related molecular mechanisms research
TL;DR: Evidence for the presence of a QTL segregating within families on BTA20 was found and eight chromosomal regions putatively linked with susceptibility to M. paratuberculosis infection were identified using a Z-test. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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