Andrew D. Wallace

Works (15)

Updated: July 5th, 2023 15:53

2020 journal article

Role of long non-coding RNA in DEET- and fipronil-mediated alteration of transcripts associated with Phase I and Phase II xenobiotic metabolism in human primary hepatocytes

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 167.

By: R. Lawrie n, R. Mitchell n, A. Dhammi n, A. Wallace n, E. Hodgson n & R. Roe n 

author keywords: Long non-coding RNA; DEET; Fipronil; Xenobiotic metabolism; Environmental chemicals; Cytochrome P450
MeSH headings : DEET; Hepatocytes; Humans; Insect Repellents; Pyrazoles; RNA, Long Noncoding
TL;DR: The impact of two environmental chemicals used in and around homes, the insect repellent DEET and the phenylpyrazole insecticide fipronil, and the role of altered lncRNAs associated with xenobiotic induction, human diseases and chemical mixtures is discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2020

2017 journal article

Differential Expression Profile of lncRNAs from Primary Human Hepatocytes Following DEET and Fipronil Exposure

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(10).

By: R. Mitchell n, A. Wallace n, E. Hodgson n & R. Roe n 

author keywords: DEET; fipronil; long non-coding RNA; lncRNA; primary liver cells; epigenetics; RNA-Seq; transcriptomics; Zika virus; human hepatocytes
MeSH headings : Cells, Cultured; DEET / pharmacology; Epigenomics / methods; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Pyrazoles / pharmacology; RNA, Long Noncoding / genetics; Zika Virus / genetics
TL;DR: This initial analysis links several of the dysregulated lncRNAs to processes and pathways critical to proper cellular function, such as the innate and adaptive immune response and the p53 signaling pathway. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Impact of Environmental Chemicals on the Transcriptome of Primary Human Hepatocytes: Potential for Health Effects

Journal of Biochemical and Molecular Toxicology, 30(8), 375–395.

By: R. Mitchell n, A. Dhammi n, A. Wallace n, E. Hodgson n & R. Roe n 

author keywords: DEET; Fipronil; Gene expression; Human hepatocytes; RNA-Seq; Endocrine System; P450
MeSH headings : Chromosome Mapping; DEET / toxicity; Drug Combinations; Genome, Human; Hepatocytes / cytology; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Insect Repellents / toxicity; Insecticides / toxicity; Molecular Sequence Annotation; Primary Cell Culture; Pyrazoles / toxicity; Sequence Analysis, RNA; Transcriptome / drug effects
TL;DR: The overall treatment responses, specific pathways, and individual transcripts affected were discussed at different levels of fold‐change and changes found in transcript levels in response to treatments will require further research to understand their importance in overall cellular, organ, and organismic function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2013 journal article

Human Variation and Risk Assessment: Microarray and Other Studies Utilizing Human Hepatocytes and Human Liver Subcellular Preparations

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 28(1), 1–10.

By: E. Hodgson n, A. Wallace n, R. Shah*, K. Choi n & H. Joo n

author keywords: Cytotoxicity; Human Hepatocytes; Human Variation; Microarrays; RNAseq; Toxicant Metabolism; Toxicant Interactions
MeSH headings : Enzyme Activation; Enzyme Inhibitors / pharmacology; Genetic Variation; Hepatocytes / enzymology; Hepatocytes / metabolism; Humans; Liver / metabolism; Oligonucleotide Array Sequence Analysis; Risk Assessment; Subcellular Fractions / metabolism
TL;DR: This review summarizes the use of primary human hepatocytes and hepatocyte subcellular preparations for the investigation of the metabolism and metabolic interactions of environmental chemicals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

DNA methylation alterations in response to pesticide exposure in vitro

Environmental and Molecular Mutagenesis, 53(7), 542–549.

By: X. Zhang, A. Wallace, P. Du, W. Kibbe, N. Jafari, H. Xie, S. Lin, A. Baccarelli, M. Soares, L. Hou

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Genome-wide study of DNA methylation alterations in response to diazinon exposure in vitro

Environmental Toxicology and Pharmacology, 34(3), 959–968.

By: X. Zhang, A. Wallace, P. Du, S. Lin, A. Baccarelli, H. Jiang, N. Jafari, Y. Zheng ...

Source: NC State University Libraries
Added: August 6, 2018

2012 review

Toxic endpoints in the study of human exposure to environmental chemicals

[Review of ]. Toxicology and human environments, 112, 89–115.

By: A. Wallace

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor

Toxicology and Applied Pharmacology, 245(3), 335–343.

By: R. Casabar, P. Das, G. DeKrey, C. Gardiner, Y. Cao, R. Rose, A. Wallace

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Human variation in CYP-specific chlorpyrifos metabolism

TOXICOLOGY, 276(3), 184–191.

By: E. Croom n, A. Wallace n & E. Hodgson n

author keywords: Chlorpyrifos; CYP isoform; Desulfuration; Dearylation; Human liver microsomes; Organophosphorothioate pesticides
MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases / metabolism; Cell Line; Chlorpyrifos / metabolism; Chlorpyrifos / toxicity; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A / metabolism; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Humans; Insecticides / metabolism; Insecticides / toxicity; Isoenzymes / genetics; Isoenzymes / metabolism; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Oxidoreductases, N-Demethylating / metabolism; Substrate Specificity / drug effects; Substrate Specificity / physiology
TL;DR: Individual variations in CPO production may need to be considered in determining the risk of chlorpyrifos poisoning, and the combination of ketoconazole and ticlopidine inhibited the majority of TCP and CPO formation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Interactions of the crustacean nuclear receptors HR3 and E75 in the regulation of gene transcription

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 167(2), 268–278.

By: B. Hannas n, Y. Wang n, W. Baldwin *, Y. Li *, A. Wallace n & G. LeBlanc n 

author keywords: Daphnia pulex; Ecdysteroids; Endocrine disruptor; Nuclear receptors
TL;DR: The premise that HR3 is a major component of ecdysteroid signaling in some crustaceans and is under the negative regulatory control of E75 is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Lysine 419 targets human glucocorticoid receptor for proteasomal degradation

Steroids, 75(12), 1016–1023.

By: A. Wallace, Y. Cao, S. Chandramouleeswaran & J. Cidlowski

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Human hepatic CYP2B6 developmental expression: The impact of age and genotype

BIOCHEMICAL PHARMACOLOGY, 78(2), 184–190.

By: E. Croom n, J. Stevens*, R. Hines *, A. Wallace n & E. Hodgson n

author keywords: CYP450; Ontogeny; CYP2B6; CYP3A; Hepatic
MeSH headings : Adolescent; Age Factors; Aryl Hydrocarbon Hydroxylases / biosynthesis; Aryl Hydrocarbon Hydroxylases / chemistry; Aryl Hydrocarbon Hydroxylases / genetics; Child; Child, Preschool; Cytochrome P-450 CYP2B6; Female; Gene Expression Regulation, Developmental / physiology; Gene Expression Regulation, Enzymologic / physiology; Genotype; Humans; Infant; Male; Microsomes, Liver / enzymology; Oxidoreductases, N-Demethylating / biosynthesis; Oxidoreductases, N-Demethylating / chemistry; Oxidoreductases, N-Demethylating / genetics
TL;DR: Hepatic CYP2B6 protein levels were characterized in microsomal protein preparations isolated from a pediatric liver bank and showed consistency with different mechanisms controlling the ontogeny and constitutive expression of these enzymes and the lack of significant induction in the pediatric samples. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression

TOXICOLOGICAL SCIENCES, 103(2), 268–277.

By: B. Cooper n, T. Cho n, P. Thompson n  & A. Wallace n

author keywords: pregnane X receptor; CYP3A4; DEHP; MEHP; glucocorticoid
MeSH headings : Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-450 CYP3A / biosynthesis; Dexamethasone / pharmacology; Diethylhexyl Phthalate / analogs & derivatives; Diethylhexyl Phthalate / toxicity; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction / drug effects; Glucocorticoids / pharmacology; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Plasticizers / toxicity; Pregnane X Receptor; Rats; Receptors, Steroid / drug effects; Receptors, Steroid / metabolism; Transcription, Genetic / drug effects; Transfection
TL;DR: It is suggested that the magnitude of CYP3A4 induction by phthalates is dependent on the expression of PXR and may be significantly higher in the presence of glucocorticoids and may play a role in altered efficacy of pharmaceutical agents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

Unique transcription start sites and distinct promoter regions differentiate the pregnane X receptor (PXR) isoforms PXR 1 and PXR 2

DRUG METABOLISM AND DISPOSITION, 36(5), 923–929.

By: L. Tompkins*, T. Sit*  & A. Wallace*

Contributors: L. Tompkins*, T. Sit*  & A. Wallace*

MeSH headings : Cell Line, Tumor; Cytochrome P-450 CYP3A / genetics; Gene Expression; Humans; Liver / metabolism; Pregnane X Receptor; Promoter Regions, Genetic; Protein Isoforms / genetics; RNA, Messenger / metabolism; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid / genetics; Reverse Transcriptase Polymerase Chain Reaction; Transcription Initiation Site; Transfection
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Mechanisms of cytochrome P450 induction

Journal of Biochemical and Molecular Toxicology, 21(4), 176–181.

By: L. Tompkins & A. Wallace

Source: NC State University Libraries
Added: August 6, 2018

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