Andrew D. Wallace
Works (15)
Updated: July 5th, 2023 15:53
2020 journal article
Role of long non-coding RNA in DEET- and fipronil-mediated alteration of transcripts associated with Phase I and Phase II xenobiotic metabolism in human primary hepatocytes
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 167.
author keywords: Long non-coding RNA; DEET; Fipronil; Xenobiotic metabolism; Environmental chemicals; Cytochrome P450
MeSH headings : DEET; Hepatocytes; Humans; Insect Repellents; Pyrazoles; RNA, Long Noncoding
TL;DR:
The impact of two environmental chemicals used in and around homes, the insect repellent DEET and the phenylpyrazole insecticide fipronil, and the role of altered lncRNAs associated with xenobiotic induction, human diseases and chemical mixtures is discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 6, 2020
2017 journal article
Differential Expression Profile of lncRNAs from Primary Human Hepatocytes Following DEET and Fipronil Exposure
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(10).
author keywords: DEET; fipronil; long non-coding RNA; lncRNA; primary liver cells; epigenetics; RNA-Seq; transcriptomics; Zika virus; human hepatocytes
MeSH headings : Cells, Cultured; DEET / pharmacology; Epigenomics / methods; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Pyrazoles / pharmacology; RNA, Long Noncoding / genetics; Zika Virus / genetics
TL;DR:
This initial analysis links several of the dysregulated lncRNAs to processes and pathways critical to proper cellular function, such as the innate and adaptive immune response and the p53 signaling pathway.
(via Semantic Scholar)
www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Impact of Environmental Chemicals on the Transcriptome of Primary Human Hepatocytes: Potential for Health Effects
Journal of Biochemical and Molecular Toxicology, 30(8), 375–395.
author keywords: DEET; Fipronil; Gene expression; Human hepatocytes; RNA-Seq; Endocrine System; P450
MeSH headings : Chromosome Mapping; DEET / toxicity; Drug Combinations; Genome, Human; Hepatocytes / cytology; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Insect Repellents / toxicity; Insecticides / toxicity; Molecular Sequence Annotation; Primary Cell Culture; Pyrazoles / toxicity; Sequence Analysis, RNA; Transcriptome / drug effects
TL;DR:
The overall treatment responses, specific pathways, and individual transcripts affected were discussed at different levels of fold‐change and changes found in transcript levels in response to treatments will require further research to understand their importance in overall cellular, organ, and organismic function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2014 journal article
Human Variation and Risk Assessment: Microarray and Other Studies Utilizing Human Hepatocytes and Human Liver Subcellular Preparations
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 28(1), 1–10.
author keywords: Cytotoxicity; Human Hepatocytes; Human Variation; Microarrays; RNAseq; Toxicant Metabolism; Toxicant Interactions
MeSH headings : Enzyme Activation; Enzyme Inhibitors / pharmacology; Genetic Variation; Hepatocytes / enzymology; Hepatocytes / metabolism; Humans; Liver / metabolism; Oligonucleotide Array Sequence Analysis; Risk Assessment; Subcellular Fractions / metabolism
TL;DR:
This review summarizes the use of primary human hepatocytes and hepatocyte subcellular preparations for the investigation of the metabolism and metabolic interactions of environmental chemicals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
DNA methylation alterations in response to pesticide exposure in vitro
Environmental and Molecular Mutagenesis, 53(7), 542–549.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Genome-wide study of DNA methylation alterations in response to diazinon exposure in vitro
Environmental Toxicology and Pharmacology, 34(3), 959–968.
Source: NC State University Libraries
Added: August 6, 2018
2012 review
Toxic endpoints in the study of human exposure to environmental chemicals
[Review of ]. Toxicology and human environments, 112, 89–115.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor
Toxicology and Applied Pharmacology, 245(3), 335–343.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Human variation in CYP-specific chlorpyrifos metabolism
TOXICOLOGY, 276(3), 184–191.
author keywords: Chlorpyrifos; CYP isoform; Desulfuration; Dearylation; Human liver microsomes; Organophosphorothioate pesticides
MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases / metabolism; Cell Line; Chlorpyrifos / metabolism; Chlorpyrifos / toxicity; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A / metabolism; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Humans; Insecticides / metabolism; Insecticides / toxicity; Isoenzymes / genetics; Isoenzymes / metabolism; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Oxidoreductases, N-Demethylating / metabolism; Substrate Specificity / drug effects; Substrate Specificity / physiology
TL;DR:
Individual variations in CPO production may need to be considered in determining the risk of chlorpyrifos poisoning, and the combination of ketoconazole and ticlopidine inhibited the majority of TCP and CPO formation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Interactions of the crustacean nuclear receptors HR3 and E75 in the regulation of gene transcription
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 167(2), 268–278.
author keywords: Daphnia pulex; Ecdysteroids; Endocrine disruptor; Nuclear receptors
TL;DR:
The premise that HR3 is a major component of ecdysteroid signaling in some crustaceans and is under the negative regulatory control of E75 is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Lysine 419 targets human glucocorticoid receptor for proteasomal degradation
Steroids, 75(12), 1016–1023.
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Human hepatic CYP2B6 developmental expression: The impact of age and genotype
BIOCHEMICAL PHARMACOLOGY, 78(2), 184–190.
author keywords: CYP450; Ontogeny; CYP2B6; CYP3A; Hepatic
MeSH headings : Adolescent; Age Factors; Aryl Hydrocarbon Hydroxylases / biosynthesis; Aryl Hydrocarbon Hydroxylases / chemistry; Aryl Hydrocarbon Hydroxylases / genetics; Child; Child, Preschool; Cytochrome P-450 CYP2B6; Female; Gene Expression Regulation, Developmental / physiology; Gene Expression Regulation, Enzymologic / physiology; Genotype; Humans; Infant; Male; Microsomes, Liver / enzymology; Oxidoreductases, N-Demethylating / biosynthesis; Oxidoreductases, N-Demethylating / chemistry; Oxidoreductases, N-Demethylating / genetics
TL;DR:
Hepatic CYP2B6 protein levels were characterized in microsomal protein preparations isolated from a pediatric liver bank and showed consistency with different mechanisms controlling the ontogeny and constitutive expression of these enzymes and the lack of significant induction in the pediatric samples.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression
TOXICOLOGICAL SCIENCES, 103(2), 268–277.
author keywords: pregnane X receptor; CYP3A4; DEHP; MEHP; glucocorticoid
MeSH headings : Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-450 CYP3A / biosynthesis; Dexamethasone / pharmacology; Diethylhexyl Phthalate / analogs & derivatives; Diethylhexyl Phthalate / toxicity; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction / drug effects; Glucocorticoids / pharmacology; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Plasticizers / toxicity; Pregnane X Receptor; Rats; Receptors, Steroid / drug effects; Receptors, Steroid / metabolism; Transcription, Genetic / drug effects; Transfection
TL;DR:
It is suggested that the magnitude of CYP3A4 induction by phthalates is dependent on the expression of PXR and may be significantly higher in the presence of glucocorticoids and may play a role in altered efficacy of pharmaceutical agents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 journal article
Unique transcription start sites and distinct promoter regions differentiate the pregnane X receptor (PXR) isoforms PXR 1 and PXR 2
DRUG METABOLISM AND DISPOSITION, 36(5), 923–929.
Contributors: L. Tompkins*, T. Sit* & *
MeSH headings : Cell Line, Tumor; Cytochrome P-450 CYP3A / genetics; Gene Expression; Humans; Liver / metabolism; Pregnane X Receptor; Promoter Regions, Genetic; Protein Isoforms / genetics; RNA, Messenger / metabolism; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid / genetics; Reverse Transcriptase Polymerase Chain Reaction; Transcription Initiation Site; Transfection
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2007 journal article
Mechanisms of cytochrome P450 induction
Journal of Biochemical and Molecular Toxicology, 21(4), 176–181.
Source: NC State University Libraries
Added: August 6, 2018
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.
