Doug H. Gebhard

Works (8)

Updated: July 5th, 2023 16:03

2000 journal article

Infection of a canine macrophage cell line with Leishmania infantum: determination of nitric oxide production and anti-leishmanial activity

VETERINARY PARASITOLOGY, 92(3), 181–189.

By: E. Pinelli *, D. Gebhard n, A. Mommaas*, M. Hoeij*, J. Langermans *, E. Ruitenberg*, V. Rutten *

author keywords: Leishmania infantum; macrophage cell line; NO; dog
MeSH headings : Animals; Arginine / metabolism; Cell Line; Dog Diseases / immunology; Dog Diseases / parasitology; Dogs; Enzyme Inhibitors / pharmacology; Interferon-gamma / metabolism; Interleukin-2 / metabolism; Leishmania infantum / immunology; Leishmaniasis, Visceral / immunology; Leishmaniasis, Visceral / veterinary; Macrophage Activation / drug effects; Macrophages / immunology; Macrophages / parasitology; Macrophages / ultrastructure; Microscopy, Electron; NG-Nitroarginine Methyl Ester / pharmacology; Nitric Oxide / biosynthesis; Tumor Necrosis Factor-alpha / metabolism
TL;DR: It is observed that activation of 030-D cells by incubation with a supernatant derived from a Leishmania-specific T cell line containing IFN-gamma, TNF-alpha and interleukin-2 (IL-2) resulted in enhanced nitric oxide (NO) production by these cells, which play an important role in the anti-leishmanial activity of these canine macrophages. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1999 journal article

Progressive expansion of an L-selectin-negative CD8 cell with anti-feline immunodeficiency virus (FIV) suppressor function in the circulation of FIV-infected cats

JOURNAL OF INFECTIOUS DISEASES, 180(5), 1503–1513.

By: D. Gebhard n, J. Dow n, T. Childers n, J. Alvelo n, M. Tompkins n & W. Tompkins n

MeSH headings : Animals; CD8-Positive T-Lymphocytes / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Immunodeficiency Virus, Feline / immunology; Immunophenotyping; Integrins / metabolism; L-Selectin / analysis; Leukocytes, Mononuclear / immunology; Lymph Nodes / immunology; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Regulatory / immunology
TL;DR: The progressive expansion of the CD8alpha+betaloCD62L- effector subset cells in FIV-infected cats parallels that seen in human immunodeficiency virus (HIV)-infected patients, suggesting that failure in homeostatic mechanisms regulating lymphocyte activation or trafficking (or both) may be a consequence of both HIV and FIV infections. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1998 journal article

The CD8(+) cell phenotype mediating antiviral activity in feline immunodeficiency virus-infected cats is characterized by reduced surface expression of the CD8 beta chain

JOURNAL OF INFECTIOUS DISEASES, 178(4), 968–977.

By: J. Bucci n, D. Gebhard n, T. Childers n, R. English n, M. Tompkins n & W. Tompkins n

MeSH headings : Acute Disease; Animals; Antibody Specificity; CD8 Antigens / biosynthesis; CD8 Antigens / immunology; CD8-Positive T-Lymphocytes / immunology; Carrier State; Cats; Down-Regulation; Feline Acquired Immunodeficiency Syndrome / immunology; Flow Cytometry; Immunity, Cellular; Immunodeficiency Virus, Feline / isolation & purification; Phenotype
TL;DR: Flow cytometric analysis of peripheral blood mononuclear cells with anti-CD8 beta chain monoclonal antibody 117 revealed that the CD8 alpha + beta lo phenotype expanded throughout the asymptomatic infection, constituting 80%-90% of the CD 8 beta + cells in long-term-infected cats. (via Semantic Scholar)
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Source: Web Of Science
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1997 journal article

Auto IgG anti-IgE and IgG x IgE immune complex presence and effects on ELISA-based quantitation of IgE in canine atopic dermatitis, demodectic acariasis and helminthiasis.

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 60(1-2), 33–46.

By: B. Hammerberg n, D. Bevier n, D. DeBoer *, T. Olivry n , S. Orton n, D. Gebhard n, S. Vaden n 

Contributors: B. Hammerberg n, D. Bevier n, D. DeBoer *, T. Olivry n , S. Orton n, D. Gebhard n, S. Vaden n 

author keywords: auto anti-IgE; ELISA; atopic; helminth; immune complexes; demodectic acariasis
MeSH headings : Animals; Antibodies, Anti-Idiotypic / blood; Antigen-Antibody Complex / blood; Ascariasis / immunology; Ascariasis / veterinary; Autoantibodies / blood; Dermatitis, Atopic / immunology; Dermatitis, Atopic / veterinary; Dog Diseases / immunology; Dogs; Enzyme-Linked Immunosorbent Assay; Helminthiasis, Animal / immunology; Immunoglobulin E / blood; Immunoglobulin G / blood
TL;DR: The increase in detectable IgG anti-IgE after heating sera indicates that IgG x IgE immune complexes are normally present in most dogs; however, the increase over uncomplexed IgG against IgE was most pronounced in dogs manifesting atopic dermatitis and demodectic acariasis. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

1997 journal article

Immunophenotypic characterization of canine lymphoproliferative disorders

In Vivo (Athens, Greece), 11(2), 169–172.

By: D. Ruslander, D. Gebhard, M. Tompkins, C. Grindem & R. Page

Source: NC State University Libraries
Added: August 6, 2018

1997 conference paper

Investigation of homologous and heterologous avian blood transfusions

Proceedings Annual Conference of the Association of Avian Veterinarians, 227–278.

By: L. Degernes, M. Crosier, L. Harrison, D. Smith, P. Dennis & D. Gebhard

Source: NC State University Libraries
Added: August 6, 2018

1995 journal article

Canine IgE monoclonal antibody specific for a filarial antigen: Production by a canine x murine heterohybridoma using B cells from a clinically affected lymph node

Immunology (Oxford, England), 85(3), 429.

By: D. Gebhard, S. Orton, D. Edmiston, K. Nakagaki, D. Deboer & B. Hammerberg

Source: NC State University Libraries
Added: August 6, 2018

1992 journal article

IDENTIFICATION OF CANINE LYMPHOCYTE-T SUBSETS WITH MONOCLONAL-ANTIBODIES

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 33(3), 187–199.

By: D. Gebhard n & P. Carter n

MeSH headings : Animals; Antibodies, Monoclonal / biosynthesis; Antibodies, Monoclonal / immunology; Antigens, Surface / immunology; Bone Marrow / immunology; CD4-Positive T-Lymphocytes / immunology; Dogs / immunology; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Immunoglobulin Isotypes / immunology; Lymphoid Tissue / immunology; Mice; Mice, Inbred BALB C; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Regulatory / immunology
TL;DR: SDS-PAGE analysis of radiolabelled thymus cell lysates demonstrated that antibodies 1.140 and 4.78 react with canine lymphocyte populations that occur in proportions similar to lymphocytes expressing CD4 and CD8 like molecules in several primate and non-primate species. (via Semantic Scholar)
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