Cellular Uptake of Gold Nanoparticles Passivated with BSA−SV40 Large T Antigen Conjugates
Ryan, J. A., Overton, K. W., Speight, M. E., Oldenburg, C. N., Loo, L. N., Robarge, W., … Feldheim, D. L. (2007, October 31). Analytical Chemistry, Vol. 79, pp. 9150–9159.
MeSH headings : Antigens, Polyomavirus Transforming / metabolism; Cell Nucleus / metabolism; Gold / chemistry; HeLa Cells; Humans; Metal Nanoparticles; Reproducibility of Results; Serum Albumin, Bovine / metabolism; Subcellular Fractions / metabolism
topics (OpenAlex): Gold and Silver Nanoparticles Synthesis and Applications; Advanced biosensing and bioanalysis techniques; RNA Interference and Gene Delivery
TL;DR:
The ICP-OES and nuclear fractionation techniques reported here are valuable tools that can add important quantitative information to optical and electron imaging methods such as VEC-DIC and transmission electron microscopy regarding the fate of nanoparticles in cells.
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