Angela M. Grimes

Works (11)

Updated: July 24th, 2023 21:16

2003 journal article

The effect of UVB irradiation on ferritin subunit synthesis, ferritin assembly and Fe metabolism in cultured canine lens epithelial cells

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 77(4), 440–445.

By: J. Harned*, A. Grimes* & M. McGahan

TL;DR: It was hypothesized and then determined that newly synthesized chains did not assemble into functional holoferritin, and this study provides a cautionary note regarding the conclusions of such studies in the absence of data indicating assembly of functional ferritin molecules. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Transferrin in after-cataract and as a survival factor for lens epithelium

EXPERIMENTAL EYE RESEARCH, 66(2), 207–215.

By: M. Davidson n, J. Harned n, A. Grimes n, G. Duncan*, I. Wormstone* & M. McGahan n

author keywords: transferrin; after-cataract; human; rabbit; lens; epithelial cells; growth factors
MeSH headings : Animals; Cataract / pathology; Cataract Extraction; Cell Division; Cell Survival; Cells, Cultured; Epithelial Cells / metabolism; Humans; Lens Capsule, Crystalline / metabolism; Lens Capsule, Crystalline / pathology; Lens, Crystalline / metabolism; Lens, Crystalline / pathology; Postoperative Period; Rabbits; Recurrence; Transferrin / biosynthesis; Transferrin / metabolism
TL;DR: Tf acts as a survival factor for lens epithelia and its synthesis is up-regulated in after-cataract lens sacs, suggesting that Tf may play an important role in the pathogenesis of lens epithelial cell proliferation and after-Cataract formation following cataract surgery. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Mechanisms by which ascorbic acid increases ferritin levels in cultured lens epithelial cells

EXPERIMENTAL EYE RESEARCH, 64(3), 413–421.

By: M. Goralska n, J. Harned n, A. Grimes n, L. Fleisher n & M. McGahan n

author keywords: ascorbic acid; ferritin; lens; cataract
MeSH headings : Animals; Ascorbic Acid / metabolism; Ascorbic Acid / pharmacology; Base Sequence; Blotting, Northern; Cells, Cultured; DNA / metabolism; Deferoxamine / pharmacology; Dithiothreitol / pharmacology; Dogs; Epithelium / drug effects; Epithelium / metabolism; Ferric Compounds / metabolism; Ferritins / biosynthesis; Ferritins / drug effects; Ferritins / genetics; Hydrogen Peroxide / pharmacology; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Molecular Sequence Data; Oxidation-Reduction; Protein Biosynthesis; Protein Synthesis Inhibitors / pharmacology; RNA, Messenger / drug effects; RNA, Messenger / metabolism
TL;DR: The ability of ascorbic acid to increase ferritin concentration in lens epithelial cells could provide an additional protective mechanism for this antioxidant vitamin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1996 journal article

Hemoglobin exacerbates the ocular inflammatory response to endotoxin

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 234(10), 643–647.

By: M. McGahan n, A. Grimes n & L. Fleisher n

TL;DR: It is likely that hemoglobinic Fe is responsible for the increased infiltration of white cells caused by the co-injection of autologous hemaglobin and endotoxin, which was increased 15-fold. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1995 journal article

IRON UPTAKE BY CULTURED LENS EPITHELIAL-CELLS

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 233(6), 354–359.

By: M. Mcgahan n, A. Grimes n, M. Nasisse n & L. Fleisher n

MeSH headings : 2,2'-Dipyridyl / pharmacology; Animals; Ascorbic Acid / pharmacology; Biological Transport / drug effects; Cataract / metabolism; Cataract / pathology; Cells, Cultured; Dogs; Epithelium / metabolism; Iron / metabolism; Iron Radioisotopes; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Receptors, Transferrin / metabolism; Transferrin / metabolism
TL;DR: The reduction of Fe uptake by the subcultured and cataract cell lines probably reflects a decrease in transferrin receptor expression and in the activity of an alternative pathway for Fe transferrin uptake occurring over time. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1994 journal article

REGULATION OF FERRITIN LEVELS IN CULTURED LENS EPITHELIAL-CELLS

EXPERIMENTAL EYE RESEARCH, 59(5), 551–555.

By: M. Mcgahan n, J. Harned n, A. Grimes n & L. Fleisher n

author keywords: IRON; FERRITIN; LENS EPITHELIAL CELLS; PEROXIDE; FREE RADICALS; ASCORBIC ACID
MeSH headings : Animals; Cells, Cultured; Chelating Agents / pharmacology; Deferoxamine / pharmacology; Dogs; Enzyme-Linked Immunosorbent Assay; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ferritins / metabolism; Hemin / pharmacology; Lens, Crystalline / cytology; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism
TL;DR: Regulation of ferritin levels may represent a mechanism by which the lens epithelium is protected from oxidative damage, and in pathological circumstances, the iron content and redox state of the aqueous humor is dramatically altered and may affect the steady state levels of Ferritin within the lens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1994 personal communication

TRANSFERRIN INHIBITS THE OCULAR INFLAMMATORY RESPONSE

MCGAHAN, M. C., GRIMES, A. M., & FLEISHER, L. N. (1994, April).

By: M. Mcgahan, A. Grimes* & L. Fleisher*

MeSH headings : Animals; Eye Proteins / metabolism; Leukocyte Count / drug effects; Rats; Transferrin / therapeutic use; Uveitis / prevention & control; Xanthine Oxidase
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1991 journal article

EFFECTS OF COPPER DEPLETION AND D-PENICILLAMINE TREATMENT ON THE OCULAR INFLAMMATORY RESPONSE

AGENTS AND ACTIONS, 34(3-4), 405–409.

By: M. Mcgahan n, L. Fleisher n & A. Grimes n

MeSH headings : Animals; Antioxidants; Aqueous Humor / metabolism; Ceruloplasmin / metabolism; Copper / deficiency; Copper / metabolism; Endophthalmitis / metabolism; Endophthalmitis / pathology; Free Radicals; Penicillamine / pharmacology; Rabbits
TL;DR: Rabbits placed on a copper (Cu)-deficient diet for four weeks had lower plasma Cu concentration, ferroxidase activity, and antioxidant activity than rabbits fed an identical Cu-adequate basel diet and it is likely that ceruloplasmin plays a protective role in the intraocular inflammatory response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1991 journal article

SELENIUM CONCENTRATION IN OCULAR-TISSUES AND FLUIDS

OPHTHALMIC RESEARCH, 23(1), 45–50.

By: M. Mcgahan n & A. Grimes*

author keywords: SELENIUM; AQUEOUS HUMOR; LENS; IRIS; RETINA; CORNEA
MeSH headings : Animals; Aqueous Humor / chemistry; Brain Chemistry; Eye / chemistry; Kidney / chemistry; Organ Size; Rabbits; Selenium / analysis; Selenium / blood; Spectrophotometry, Atomic
TL;DR: A simple, precise method for the analysis of selenium (Se) in ocular fluids and tissues using electrothermal atomic absorption spectroscopy is presented and it is likely that the difference in Se concentration between plasma and aqueous humor reflects the relative distribution of protein between these fluids. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1989 journal article

CLINICAL SIGNS OF ACUTE OCULAR INFLAMMATORY RESPONSE TO ENDOTOXIN ARE NOT ALTERED BY INCREASING ANTIOXIDANT POTENCY OF INTRAOCULAR FLUIDS

INFLAMMATION, 13(4), 393–400.

By: M. Mcgahan n, L. Fleisher n & A. Grimes n

MeSH headings : Animals; Antioxidants; Aqueous Humor / metabolism; Ceruloplasmin / metabolism; Copper / blood; Copper / pharmacology; Endotoxins / toxicity; Rabbits; Transferrin / metabolism; Uveitis / physiopathology
TL;DR: Increased intraocular fluid antioxidant activity did not affect the acute anterior segment response to endotoxin, and it is possible that the time course and resolution of the response is altered by changes in extracellular fluid antioxidants activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1989 journal article

Ferroxidase activity increases dramatically in the aqueous humor during the ocular inflammatory response

Ophthalmic Research, 21, 221–225.

By: M. McGahan n, A. Grimes n & L. Fleisher*

MeSH headings : Animals; Aqueous Humor / enzymology; Ceruloplasmin / analysis; Ceruloplasmin / metabolism; Copper / analysis; Copper / blood; Endophthalmitis / enzymology; Endotoxins; Escherichia coli / metabolism; Proteins / analysis; Rabbits; Spectrophotometry, Atomic; Time Factors; Vitreous Body
TL;DR: Plasma copper transport protein ceruloplasmin (plasma ferroxidase) entered the inflamed aqueous humor from plasma through disrupted blood ocular barriers and would facilitate the removal of potentially damaging, free radical generating Fe+2.2. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

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