Sarah H. MacKenzie

Works (8)

Updated: July 5th, 2023 15:46
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2016 journal article

Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(41), E6080–E6088.

By: J. Maciag n, S. Mackenzie n, M. Tucker n, J. Schipper n, P. Swartz n & A. Clark n

co-author countries: United States of America đŸ‡ºđŸ‡¸
author keywords: allostery; conformational selection; saturation mutagenesis; protein solvation; protein structure
MeSH headings : Allosteric Regulation; Allosteric Site; Amino Acid Substitution; Caspase 3 / chemistry; Caspase 3 / genetics; Caspase 3 / metabolism; Catalytic Domain; Crystallography, X-Ray; Enzyme Activation; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Mutagenesis; Protein Binding; Protein Conformation; Protein Multimerization; Quantitative Structure-Activity Relationship; Solubility; Water / chemistry
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Modifying Caspase-3 Activity by Altering Allosteric Networks

BIOCHEMISTRY, 53(48), 7582–7595.

By: C. Cade n, P. Swartz n, S. MacKenzie n & A. Clark n

co-author countries: United States of America đŸ‡ºđŸ‡¸
MeSH headings : Allosteric Site / genetics; Amino Acid Substitution; Caspase 3 / chemistry; Caspase 3 / genetics; Caspase 3 / metabolism; Crystallography, X-Ray; Humans; Kinetics; Models, Molecular; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Protein Conformation; Protein Multimerization; Protein Structure, Quaternary; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Redesigning the procaspase-8 dimer interface for improved dimerization

Protein Science, 23(4), 442–453.

By: C. Ma, S. MacKenzie & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Lengthening the Intersubunit Linker of Procaspase 3 Leads to Constitutive Activation

BIOCHEMISTRY, 52(36), 6219–6231.

By: S. MacKenzie n, J. Schipper n, E. England n, M. Thomas n, K. Blackburn n, P. Swartz n, A. Clark n

co-author countries: United States of America đŸ‡ºđŸ‡¸
MeSH headings : Apoptosis / physiology; Caspase 3 / chemistry; Caspase 3 / genetics; Caspase 3 / metabolism; Caspase Inhibitors / pharmacology; Catalytic Domain; Enzyme Activation; Enzyme Precursors / chemistry; Models, Chemical; Models, Molecular; Molecular Dynamics Simulation; Protein Conformation; Protein Multimerization
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Slow folding and assembly of a procaspase-3 interface variant

Biochemistry, 52(20), 3415–3427.

By: S. MacKenzie & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

A bifunctional allosteric site in the dimer interface of procaspase-3

BIOPHYSICAL CHEMISTRY, 159(1), 100–109.

By: J. Schipper n, S. MacKenzie n, A. Sharma n & A. Clark n

co-author countries: United States of America đŸ‡ºđŸ‡¸
author keywords: Caspase; Apoptosis; Allosteric activator; Drug design; Cancer therapy
MeSH headings : Allosteric Site; Caspase 3 / chemistry; Caspase 3 / metabolism; Enzyme Activation / drug effects; Humans; Models, Molecular; Protein Binding; Protein Multimerization; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 review

The potential for caspases in drug discovery

[Review of ]. Current Opinion in Drug Discovery & Development, 13(5), 568–576.

By: S. MacKenzie, J. Schipper & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2008 review

Targeting cell death in tumors by activating Caspases

[Review of ]. Current Cancer Drug Targets, 8(2), 98–109.

By: S. MacKenzie & A. Clark

Source: NC State University Libraries
Added: August 6, 2018