@article{harbison_kumar_huang_mccoy_smith_mackay_2019, title={Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster}, volume={49}, ISSN={["1573-3297"]}, DOI={10.1007/s10519-018-9932-0}, abstractNote={Circadian rhythms influence physiological processes from sleep-wake cycles to body temperature and are controlled by highly conserved cycling molecules. Although the mechanistic basis of the circadian clock has been known for decades, the extent to which circadian rhythms vary in nature and the underlying genetic basis for that variation is not well understood. We measured circadian period (Ʈ) and rhythmicity index in the Drosophila Genetic Reference Panel (DGRP) and observed extensive genetic variation in both. Seven DGRP lines had sexually dimorphic arrhythmicity and one line had an exceptionally long Ʈ. Genome-wide analyses identified 584 polymorphisms in 268 genes. We observed differences among transcripts for nine genes predicted to interact among themselves and canonical clock genes in the long period line and a control. Mutations/RNAi knockdown targeting these genes also affected circadian behavior. Our observations reveal that complex genetic interactions influence high levels of variation in circadian phenotypes.}, number={1}, journal={BEHAVIOR GENETICS}, author={Harbison, Susan T. and Kumar, Shailesh and Huang, Wen and McCoy, Lenovia J. and Smith, Kirklin R. and Mackay, Trudy F. C.}, year={2019}, month={Jan}, pages={60–82} }
 @article{harbison_mccoy_mackay_2013, title={Genome-wide association study of sleep in Drosophila melanogaster}, volume={14}, journal={BMC Genomics}, author={Harbison, S. T. and McCoy, L. J. and Mackay, T. F. C.}, year={2013} }
 @article{de luca_klimentidis_casazza_chambers_cho_harbison_jumbo-lucioni_zhang_leips_fernandez_2010, title={A conserved role for syndecan family members in the regulation of whole-body energy metabolism}, volume={5}, number={6}, journal={PLoS One}, author={De Luca, M. and Klimentidis, Y. C. and Casazza, K. and Chambers, M. M. and Cho, R. and Harbison, S. T. and Jumbo-Lucioni, P. and Zhang, S. Y. and Leips, J. and Fernandez, J. R.}, year={2010} }
 @article{harbison_carbone_ayroles_stone_lyman_mackay_2009, title={Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep}, volume={41}, ISSN={["1546-1718"]}, DOI={10.1038/ng.330}, abstractNote={Sleep disorders are common in humans, and sleep loss increases the risk of obesity and diabetes. Studies in Drosophila have revealed molecular pathways and neural tissues regulating sleep; however, genes that maintain genetic variation for sleep in natural populations are unknown. Here, we characterized sleep in 40 wild-derived Drosophila lines and observed abundant genetic variation in sleep architecture. We associated sleep with genome-wide variation in gene expression to identify candidate genes. We independently confirmed that molecular polymorphisms in Catsup (Catecholamines up) are associated with variation in sleep and that P-element mutations in four candidate genes affect sleep and gene expression. Transcripts associated with sleep grouped into biologically plausible genetically correlated transcriptional modules. We confirmed co-regulated gene expression using P-element mutants. Quantitative genetic analysis of natural phenotypic variation is an efficient method for revealing candidate genes and pathways.}, number={3}, journal={NATURE GENETICS}, author={Harbison, Susan T. and Carbone, Mary Anna and Ayroles, Julien F. and Stone, Eric A. and Lyman, Richard F. and Mackay, Trudy F. C.}, year={2009}, month={Mar}, pages={371–375} }
 @article{harbison_sehgal_2009, title={Energy stores are not altered by long-term partial sleep deprivation in Drosophila melanogaster}, volume={4}, number={7}, journal={PLoS One}, author={Harbison, S. T. and Sehgal, A.}, year={2009} }
 @article{harbison_sehgal_2008, title={Quantitative genetic analysis of sleep in Drosophila melanogaster}, volume={178}, ISSN={["1943-2631"]}, DOI={10.1534/genetics.107.081232}, abstractNote={Abstract}, number={4}, journal={GENETICS}, author={Harbison, Susan T. and Sehgal, Amita}, year={2008}, month={Apr}, pages={2341–2360} }
 @article{huang_lyman_lyman_carbone_harbison_magwire_mackay, title={Spontaneous mutations and the origin and maintenance of quantitative genetic variation}, volume={5}, journal={Elife}, author={Huang, W. and Lyman, R. F. and Lyman, R. A. and Carbone, M. A. and Harbison, S. T. and Magwire, M. M. and Mackay, T. F. C.} }
 @misc{harbison_mackay_anholt, title={Understanding the neurogenetics of sleep: Progress from Drosophila}, volume={25}, number={6}, journal={Trends in Genetics}, author={Harbison, S. T. and Mackay, T. F. C. and Anholt, R. R. H.}, pages={262–269} }