Works (165)

Updated: March 2nd, 2024 11:05

2023 article

A computational study of droplet-spray formation from pressurized metered dose inhalers with applications to drug deposition in a human lung-airway model

Sridhar, K., Chari, S., & Kleinstreuer, C. (2023, March 16). AEROSOL SCIENCE AND TECHNOLOGY.

By: K. Sridhar n, S. Chari n & C. Kleinstreuer

co-author countries: United States of America 🇺🇸
author keywords: Jonathan P; Reid
Source: Web Of Science
Added: May 1, 2023

2022 journal article

An effective PBPK model predicting dissolved drug transfer from a representative nasal cavity to the blood stream

JOURNAL OF AEROSOL SCIENCE, 160.

By: S. Dave n, C. Kleinstreuer n & S. Chari n

co-author countries: United States of America 🇺🇸
author keywords: Intranasal drugs; Hybrid CFPD-PBPK model; Disposition of inhaled drugs; Pharmacokinetic modeling; Drug concentrations in the blood stream
Source: Web Of Science
Added: March 7, 2022

2022 journal article

Analysis of improved oral drug delivery with different helical stream inhalation modes

COMPUTERS IN BIOLOGY AND MEDICINE, 141.

By: A. Gurumurthy n & C. Kleinstreuer

co-author countries: United States of America 🇺🇸
author keywords: Pulmonary drug delivery; Polydisperse particle distribution; Subject-specific upper lung airway geometry; Helical drug-aerosol streams; Swirl number; Angled helical injection; Radially positioned helical injection; Lobe-specific drug targeting
MeSH headings : Administration, Inhalation; Aerosols; Drug Delivery Systems; Lung; Metered Dose Inhalers; Particle Size; Rivers
Source: Web Of Science
Added: February 7, 2022

2022 journal article

Effects of subject-variability on nasally inhaled drug deposition, uptake, and clearance

JOURNAL OF AEROSOL SCIENCE, 165.

By: S. Chari n, K. Sridhar n & C. Kleinstreuer

co-author countries: United States of America 🇺🇸
author keywords: Nasal geometric variabilities; CF-PD analysis With updated OpenFOAM; solver; Inhaled drug-aerosol transport and uptake; Mucus layer dynamics; Mucociliary clearance; Dissolution and absorption of three generic; drugs
Source: Web Of Science
Added: July 5, 2022

2021 journal article

Comparison of micron- and nano-particle transport in the human nasal cavity with a focus on the olfactory region

COMPUTERS IN BIOLOGY AND MEDICINE, 128.

By: S. Vachhani n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Nasal cavities; Olfactory bulb; Nanoparticles; Micron-particles; Drug deposition
MeSH headings : Administration, Inhalation; Computer Simulation; Drug Delivery Systems; Humans; Models, Biological; Nasal Cavity; Particle Size
Source: Web Of Science
Added: February 1, 2021

2021 journal article

Computational analysis of a 3D mucociliary clearance model predicting nasal drug uptake

JOURNAL OF AEROSOL SCIENCE, 155.

By: S. Chari n, K. Sridhar n, R. Walenga* & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Mucociliary clearance; Nasal drug dissolution and absorption; CFD analysis of inhaled drug-aerosol transport; and uptake; Mucus layer dynamics; 3D modeling
Source: Web Of Science
Added: June 10, 2021

2021 book

Essentials of Engineering Thermodynamics: Principles and Applications

New York: McGraw-Hill Education.

By: C. Kleinstreuer

Source: NC State University Libraries
Added: November 13, 2023

2021 journal article

Helical fluid-particle flow dynamics for controlling micron-particle deposition in a representative human upper lung-airway model

JOURNAL OF AEROSOL SCIENCE, 151.

By: A. Gurumurthy n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Helical air-particle inlet streams; Micron-particle deposition; Human upper respiratory tract; Drug-delivery applications; Open-FOAM software
Source: Web Of Science
Added: December 21, 2020

2021 journal article

Improving Pulmonary Nanotherapeutics Using Helical Aerosol Streams: An In Silico Study

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 143(11).

By: A. Gurumurthy n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: helical drug-aerosol streams; nanoparticles; human upper respiratory tract; improved drug delivery; CFD; openfoam
MeSH headings : Hydrodynamics
Source: Web Of Science
Added: October 18, 2021

2021 article

Numerical analysis of enhanced nano-drug delivery to the olfactory bulb

Vachhani, S., & Kleinstreuer, C. (2021, July 24). AEROSOL SCIENCE AND TECHNOLOGY.

By: S. Vachhani n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Yannis Drossinos
Source: Web Of Science
Added: August 23, 2021

2020 journal article

High-temperature effects on the mucus layers in a realistic human upper airway model

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 163.

By: N. Kulkarni n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Mucus layer; High temperature; Mass transfer; Evaporation
Source: Web Of Science
Added: January 4, 2021

2019 journal article

A new collision model for ellipsoidal particles in shear flow

JOURNAL OF COMPUTATIONAL PHYSICS, 376, 1028–1050.

By: N. Saini n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Collision model; Ellipsoidal particle interaction; Discrete element method; Dynamic sphere generation
Source: Web Of Science
Added: December 10, 2018

2019 journal article

Heterogeneous blood flow in microvessels with applications to nanodrug transport and mass transfer into tumor tissue

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, 18(1), 99–110.

By: Z. Xu n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Computer simulation; Cell-free layer; Nanodrug delivery; Extravasation
MeSH headings : Antineoplastic Agents / therapeutic use; Biological Transport; Diffusion; Drug Delivery Systems; Hematocrit; Hemorheology; Humans; Microvessels / physiology; Nanoparticles / chemistry; Neoplasms / drug therapy; Regional Blood Flow / physiology; Reproducibility of Results
Source: Web Of Science
Added: February 25, 2019

2019 journal article

Mice-to-men comparison of inhaled drug-aerosol deposition and clearance

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 260, 82–94.

By: A. Kolanjiyil n, C. Kleinstreuer n, N. Kleinstreuer*, W. Pham* & R. Sadikot*

co-author countries: United States of America 🇺🇸
author keywords: Lung deposition; Mouse lung model; Human lung model; Dose extrapolation; Pharmacokinetics
MeSH headings : Administration, Inhalation; Aerosols / administration & dosage; Animals; Computer Simulation; Female; Humans; Hydrodynamics; Lung / anatomy & histology; Lung / physiology; Male; Mice; Models, Biological; Pulmonary Ventilation / physiology
Source: Web Of Science
Added: February 11, 2019

2019 journal article

Modeling Airflow and Particle Deposition in a Human Acinar Region

COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2019.

By: A. Kolanjiyil n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
MeSH headings : Acinar Cells / physiology; Computer Simulation; Humans; Imaging, Three-Dimensional; Models, Anatomic; Models, Biological; Particulate Matter / pharmacokinetics; Pulmonary Alveoli / anatomy & histology; Pulmonary Alveoli / physiology; Respiration; Respiratory Mechanics / physiology
Source: Web Of Science
Added: February 11, 2019

2019 review

Recent advances in modeling and simulation of nanofluid flows-Part I: Fundamentals and theory

[Review of ]. PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS, 790, 1–48.

By: O. Mahian*, L. Kolsi*, M. Amani*, P. Estelle*, G. Ahmadi*, C. Kleinstreuer n, J. Marshalli, M. Siavashi* ...

co-author countries: Australia 🇦🇺 China 🇨🇳 France 🇫🇷 Iran (Islamic Republic of) 🇮🇷 Pakistan 🇵🇰 Romania 🇷🇴 Saudi Arabia 🇸🇦 Thailand 🇹🇭 Tunisia 🇹🇳 United States of America 🇺🇸
author keywords: Nanofluids; Thermophysical properties; Dynamics of nanoparticles; Physical models
Source: Web Of Science
Added: March 18, 2019

2019 review

Recent advances in modeling and simulation of nanofluid flows-Part II: Applications

[Review of ]. PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS, 791, 1–59.

co-author countries: United Arab Emirates 🇦🇪 Australia 🇦🇺 China 🇨🇳 France 🇫🇷 Iran (Islamic Republic of) 🇮🇷 Pakistan 🇵🇰 Romania 🇷🇴 Saudi Arabia 🇸🇦 Thailand 🇹🇭 Tunisia 🇹🇳 United States of America 🇺🇸
author keywords: Nanofluids; Physical models; 3D modeling; CFD techniques
Source: Web Of Science
Added: March 18, 2019

2018 journal article

An in silico inter-subject variability study of extra-thoracic morphology effects on inhaled particle transport and deposition

JOURNAL OF AEROSOL SCIENCE, 123, 185–207.

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Individualized pulmonary drug delivery; Health risk assessment; Precise treatment; Computational fluid-particle dynamics (CFPD); Inter-subject variability; Virtual population study
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Convective mass and heat transfer enhancement of nanofluid streams in bifurcating microchannels

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 125, 1212–1229.

By: S. Chari n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Microchannel mixing; Heat transfer; Pulsatile flow; Geometry optimization; Empirical correlation
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Direct nanodrug delivery for tumor targeting subject to shear-augmented diffusion in blood flow

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 56(11), 1949–1958.

By: Z. Xu n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Nanodrug delivery; Red blood cell interaction; Liver tumor targeting; Shear-induced diffusion; Computer simulations
MeSH headings : Computer Simulation; Diffusion; Drug Delivery Systems / methods; Humans; Hydrodynamics; Nanoparticles / administration & dosage; Neoplasms / drug therapy; Particle Size; Pharmaceutical Preparations / administration & dosage; Regional Blood Flow / physiology
Source: Web Of Science
Added: November 5, 2018

2018 journal article

Effects of thermal airflow and mucus-layer interaction on hygroscopic droplet deposition in a simple mouth–throat model

Aerosol Science and Technology, 52(8), 900–912.

By: X. Chen*, C. Kleinstreuer n, W. Zhong*, Y. Feng* & X. Zhou*

co-author countries: China 🇨🇳 United States of America 🇺🇸
Source: Crossref
Added: August 28, 2020

2018 book

Modern Fluid Dynamics

By: K. Clement

Source: Crossref
Added: February 5, 2022

2018 journal article

Subject-variability effects on micron particle deposition in human nasal cavities

JOURNAL OF AEROSOL SCIENCE, 115, 12–28.

By: H. Calmet*, C. Kleinstreuer n, G. Houzeaux*, A. Kolanjiyil n, O. Lehmkuhl*, E. Olivares*, M. Vazquez*

co-author countries: Spain 🇪🇸 United States of America 🇺🇸
author keywords: Nasal cavities; Particle transport/deposition; Computational fluid-particle dynamics
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Computational analysis of aerosol-dynamics in a human whole-lung airway model

JOURNAL OF AEROSOL SCIENCE, 114, 301–316.

By: A. Kolanjiyil n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Whole-lung airway model; Particle deposition; Lung air-particle dynamics; Local and total lung depositions; Actual breathing modes; Alveolar region
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Computationally efficient analysis of particle transport and deposition in a human whole-lung-airway model. Part II: Dry powder inhaler application

Computers in Biology and Medicine, 84, 247–253.

By: A. Kolanjiyil n, C. Kleinstreuer n & R. Sadikot*

co-author countries: United States of America 🇺🇸
author keywords: Lung; Airflow; Whole lung-airway modeling; Computational fluid-particle dynamics (CF-PD); Particle deposition; Pharmaceutical aerosols; Dry powder inhaler (DPI); Curcumin
MeSH headings : Administration, Inhalation; Aerosols / administration & dosage; Aerosols / pharmacokinetics; Computer Simulation; Curcumin / administration & dosage; Curcumin / pharmacokinetics; Dry Powder Inhalers; Humans; Hydrodynamics; Lung / metabolism; Lung / physiology; Models, Biological; Particle Size
Source: Crossref
Added: February 24, 2020

2017 journal article

Numerical investigation of the interaction, transport and deposition of multicomponent droplets in a simple mouth-throat model

JOURNAL OF AEROSOL SCIENCE, 105, 108–127.

By: X. Chen*, Y. Feng*, W. Zhong* & C. Kleinstreuer n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Multicomponent droplet inhalation; droplet-vapor interaction; airway-wall condition; hygroscopic growth; deposition efficiency
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Computational transport, phase change and deposition analysis of inhaled multicomponent droplet-vapor mixtures in an idealized human upper lung model

JOURNAL OF AEROSOL SCIENCE, 96, 96–123.

By: Y. Feng n, C. Kleinstreuer n, N. Castro* & A. Rostami*

co-author countries: United States of America 🇺🇸
author keywords: Hygroscopic droplet growth; Multi-component droplet-vapor interaction modeling; Multi-component mixture plus discrete-droplet (MCM-DD) model; Inhaled droplet-reduction (IDR) method; Electronic cigarettes
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Computationally efficient analysis of particle transport and deposition in a human whole-lung-airway model. Part I: Theory and model validation

COMPUTERS IN BIOLOGY AND MEDICINE, 79, 193–204.

By: A. Kolanjiyil n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Lung; Airflow; Whole lung airway modeling; Computational fluid dynamics; Particle deposition
MeSH headings : Computational Biology; Computer Simulation; Humans; Hydrodynamics; Lung / physiology; Models, Biological; Respiratory Mechanics / physiology; Respiratory Transport / physiology; Trachea / physiology
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Experimental-computational study of fibrous particle transport and deposition in a bifurcating lung model

PARTICUOLOGY, 28, 102–113.

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Lung aerosol dynamics; Image-processing method; Fiber deposition data; Computer simulations; Deposited fiber orientations
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Laminar/turbulent airflow and microsphere deposition in a patient-specific airway geometry using an open-source solver

INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING AND TECHNOLOGY, 22(2), 145–161.

By: M. Vaish n, C. Kleinstreuer n, A. Kolanjiyil n, N. Saini n & N. Pillalamarri*

co-author countries: United States of America 🇺🇸
author keywords: OpenFOAM solver; patient-specific geometry and idealised configuration; modified eddy interaction model; microsphere transport and deposition; practical Stokes number range
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Solid Tumor Embolotherapy in Hepatic Arteries with an Anti-reflux Catheter System

ANNALS OF BIOMEDICAL ENGINEERING, 44(4), 1036–1046.

By: Z. Xu n, S. Jernigan n, C. Kleinstreuer n & G. Buckner n

co-author countries: United States of America 🇺🇸
author keywords: Liver cancer; Transient particle-hemodynamics; Embolization; Particle-reflux; Infusion-stop point; Excessive particle capture
MeSH headings : Blood Pressure; Carcinoma, Hepatocellular / therapy; Catheters; Embolization, Therapeutic; Hemodynamics; Hepatic Artery / physiology; Humans; Liver Neoplasms / therapy; Microspheres; Models, Biological
Source: Web Of Science
Added: August 6, 2018

2015 journal article

A Lagrangian Approach for Calculating Microsphere Deposition in a One-Dimensional Lung-Airway Model

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 137(9).

By: M. Vaish n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: lung-equivalent trumpet model; OPENFOAM solver; radial force function; microsphere transport; total lung deposition
MeSH headings : Air; Humans; Lung / metabolism; Microspheres; Models, Biological
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Computationally Efficient Fluid-Particle Dynamics Simulations of Arterial Systems

COMMUNICATIONS IN COMPUTATIONAL PHYSICS, 17(2), 401–423.

By: T. Umbarkar n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: 1-D modeling; skewed representative velocity profile; fluid-structure interaction; particle tracking
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Evaporation and condensation of multicomponent electronic cigarette droplets and conventional cigarette smoke particles in an idealized G3-G6 triple bifurcating unit

JOURNAL OF AEROSOL SCIENCE, 80, 58–74.

By: Y. Feng n, C. Kleinstreuer n & A. Rostami*

co-author countries: United States of America 🇺🇸
author keywords: Electronic cigarette (EC); Conventional cigarette smoke particles (CSPs); Multicomponent droplets; Deposition; Droplet-vapor interaction modeling; Multicomponent Mixture plus Discrete; Droplet (MM-DD) model
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Computationally Efficient Particle Release Map Determination for Direct Tumor-Targeting in a Representative Hepatic Artery System

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 136(1).

By: E. Childress n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: drug-particle transport; tumor-targeting; computational efficiency
MeSH headings : Antineoplastic Agents / administration & dosage; Computer Simulation; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Hepatic Artery / physiology; Humans; Infusions, Intra-Arterial; Microspheres; Models, Cardiovascular; Pulsatile Flow
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Concentration photovoltaic-thermal energy co-generation system using nanofluids for cooling and heating

ENERGY CONVERSION AND MANAGEMENT, 87, 504–512.

By: Z. Xu n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Co-generation; Concentration photovoltaic-thermal (CPV/T) system; Nanofluid thermal conductivity; System efficiencies
Source: Web Of Science
Added: August 6, 2018

2014 conference paper

DDPM-DEM simulations of particulate flows in human tracheobronchial airways

Proceedings of the ASME International Mechanical Engineering Congress and Exposition, 2013, vol 3B.

By: Y. Feng n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Impact of Fluid-Structure Interaction on Direct Tumor-Targeting in a Representative Hepatic Artery System

ANNALS OF BIOMEDICAL ENGINEERING, 42(3), 461–474.

By: E. Childress n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Optimal tumor-targeting; Drug particles; Fluid-particle dynamics; Fluid-structure interaction; Rigid-wall assumption
MeSH headings : Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Computer Simulation; Drug Delivery Systems; Hemorheology; Hepatic Artery / physiopathology; Humans; Liver Neoplasms / blood supply; Liver Neoplasms / drug therapy; Liver Neoplasms / physiopathology; Models, Cardiovascular
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Micron-particle transport, interactions and deposition in triple lung-airway bifurcations using a novel modeling approach

JOURNAL OF AEROSOL SCIENCE, 71, 1–15.

By: Y. Feng n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Dense discrete phase model (DDPM); Discrete element method (DEM); Lung aerosol dynamics; Triple bifurcations; Particle-particle interactions; Model combination criteria
Source: Web Of Science
Added: August 6, 2018

2013 review

A review of entropy generation in nanofluid flow

[Review of ]. INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 65, 514–532.

By: O. Mahian*, A. Kianifar*, C. Kleinstreuer n, M. Al-Nimr*, I. Pop*, A. Sahin*, S. Wongwises*

co-author countries: Iran (Islamic Republic of) 🇮🇷 Jordan 🇯🇴 Romania 🇷🇴 Saudi Arabia 🇸🇦 Thailand 🇹🇭 United States of America 🇺🇸
author keywords: Nanofluid flow; Thermophysical property; Entropy generation
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Analysis of non-spherical particle transport in complex internal shear flows

PHYSICS OF FLUIDS, 25(9).

By: Y. Feng n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2013 review

Computational Analysis of Non-Spherical Particle Transport and Deposition in Shear Flow With Application to Lung Aerosol Dynamics-A Review

[Review of ]. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 135(2).

By: C. Kleinstreuer n & Y. Feng n

co-author countries: United States of America 🇺🇸
author keywords: lung-aerosol dynamics; nonspherical particles; particle transport and deposition
MeSH headings : Aerosols; Biological Transport; Biomechanical Phenomena; Humans; Hydrodynamics; Lung / metabolism; Lung / physiology; Mechanical Phenomena
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Critical Invalidation of Temperature Dependence of Nanofluid Thermal Conductivity Enhancement

JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME, 135(5).

By: K. Han*, W. Lee*, C. Kleinstreuer n & J. Koo*

co-author countries: Korea (Republic of) 🇰🇷 United States of America 🇺🇸
author keywords: transient hot-wire method; thermal conductivity; nanofluids; natural convection
Source: Web Of Science
Added: August 6, 2018

2013 review

Lung Deposition Analyses of Inhaled Toxic Aerosols in Conventional and Less Harmful Cigarette Smoke: A Review

[Review of ]. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 10(9), 4454–4485.

By: C. Kleinstreuer n & Y. Feng n

co-author countries: United States of America 🇺🇸
author keywords: conventional or less harmful cigarettes; aerosol toxicology; cigarette smoke droplet; vapor deposition; second-hand smoke; impact analysis; computational fluid-particle dynamics
MeSH headings : Aerosols; Humans; Inhalation Exposure; Lung / metabolism; Smoke / adverse effects; Tobacco; Tobacco Products / toxicity; Vulnerable Populations
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Nanoparticle Mass Transfer From Lung Airways to Systemic Regions-Part I: Whole-Lung Aerosol Dynamics

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 135(12).

By: A. Kolanjiyil n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: computational fluid-particle dynamics; multicompartment modeling; nanoparticle kinetics; nanoparticle deposition; toxic nanoparticles; nanodrugs
MeSH headings : Aerosols; Humans; Inhalation; Lung / metabolism; Lung / physiology; Models, Biological; Nanoparticles / chemistry; Particle Size; Pulmonary Alveoli / metabolism; Reproducibility of Results; Tissue Distribution
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Nanoparticle Mass Transfer From Lung Airways to Systemic Regions-Part II: Multi-Compartmental Modeling

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 135(12).

By: A. Kolanjiyil n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: multicompartment modeling; animal test data; model validations; nanoparticle bio-kinetics; temporal accumulations; human organs
MeSH headings : Animals; Body Weight; Humans; Hydrodynamics; Inhalation; Lung / metabolism; Lung / physiology; Models, Biological; Nanoparticles; Organ Specificity; Rats; Tissue Distribution
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Experimental Microsphere Targeting in a Representative Hepatic Artery System

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 59(1), 198–204.

By: A. Richards n, C. Kleinstreuer n, A. Kennedy, E. Childress n & G. Buckner n

co-author countries: United States of America 🇺🇸
author keywords: Computational fluid-particle dynamics; hepatic artery (HA); liver tumor; radioembolization (RE)
MeSH headings : Animals; Blood Flow Velocity / physiology; Blood Physiological Phenomena; Brachytherapy / instrumentation; Computer Simulation; Drug Carriers / chemistry; Hepatic Artery / physiopathology; Humans; Microspheres; Models, Cardiovascular; Motion; Radiopharmaceuticals / chemistry; Rheology / methods
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Size-change and deposition of conventional and composite cigarette smoke particles during inhalation in a subject-specific airway model

JOURNAL OF AEROSOL SCIENCE, 46, 34–52.

By: Z. Zhang n, C. Kleinstreuer n & S. Hyun*

co-author countries: United States of America 🇺🇸
author keywords: Respiratory deposition; Cigarette smoke particles; Subject-specific human upper airways; Computational analysis; Potential reduced exposure tobacco products
Source: Web Of Science
Added: August 6, 2018

2012 article

Thermal Nanofluid Property Model With Application to Nanofluid Flow in a Parallel Disk System-Part II: Nanofluid Flow Between Parallel Disks

Feng, Y., & Kleinstreuer, C. (2012, May). JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME, Vol. 134.

By: Y. Feng n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: nanofluid flow; augmented heat transfer; parallel disk system
Source: Web Of Science
Added: August 6, 2018

2012 article

Thermal Nanofluid Property Model With Application to Nanofluid Flow in a Parallel-Disk System-Part I: A New Thermal Conductivity Model for Nanofluid Flow

Kleinstreuer, C., & Feng, Y. (2012, May). JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME, Vol. 134.

By: C. Kleinstreuer n & Y. Feng n

co-author countries: United States of America 🇺🇸
author keywords: nanofluids; thermal conductivity enhancement; new theory; data comparisons
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Vapor deposition during cigarette smoke inhalation in a subject-specific human airway model

JOURNAL OF AEROSOL SCIENCE, 53, 40–60.

By: Z. Zhang n, C. Kleinstreuer n & Y. Feng n

co-author countries: United States of America 🇺🇸
author keywords: Cigarette smoke; Respiratory vapor mass transfer and deposition; Transient puffing and inhalation; Subject-specific human upper airways; Computational analysis; Quantitative data sets for toxicologists
Source: Web Of Science
Added: August 6, 2018

2011 journal article

A Relation Between Near-Wall Particle-Hemodynamics and Onset of Thrombus Formation in Abdominal Aortic Aneurysms

ANNALS OF BIOMEDICAL ENGINEERING, 39(7), 2010–2026.

By: C. Basciano*, C. Kleinstreuer n, S. Hyun* & E. Finol*

co-author countries: United States of America 🇺🇸
author keywords: Patient-specific AAA; Computational analysis; ILT onset criteria
MeSH headings : Animals; Aorta, Abdominal / pathology; Aorta, Abdominal / physiopathology; Aortic Aneurysm, Abdominal / complications; Aortic Aneurysm, Abdominal / physiopathology; Blood Platelets; Computer Simulation; Humans; Leukocytes; Models, Cardiovascular; Shear Strength; Thrombosis / etiology; Thrombosis / physiopathology
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Airflow analysis in the alveolar region using the lattice-Boltzmann method

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 49(4), 441–451.

By: Z. Li* & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
MeSH headings : Humans; Inhalation / physiology; Models, Biological; Pulmonary Alveoli / anatomy & histology; Pulmonary Alveoli / physiology; Respiratory Mechanics / physiology; Rheology
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Analysis of Multi-Layer Immiscible Fluid Flow in a Microchannel

JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME, 133(11).

By: J. Li n, P. Sheeran n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: immiscible fluids; multilayer viscosities; non-newtonian fluids; pressure-driven flow; electroosmotic flow; microchannel entrance effects
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Computational analysis of airflow and nanoparticle deposition in a combined nasal-oral-tracheobronchial airway model

JOURNAL OF AEROSOL SCIENCE, 42(3), 174–194.

By: Z. Zhang n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Breathing routes; Computational analysis; Laminar-to-turbulent airflow; Nanoparticle deposition efficiencies; Downstream resistances; Mass transfer correlation
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Deposition of naphthalene and tetradecane vapors in models of the human respiratory system

INHALATION TOXICOLOGY, 23(1), 44–57.

By: Z. Zhang n & C. Kleinstreuer*

co-author countries: United States of America 🇺🇸
author keywords: Computational analysis; toxic vapor deposition; lung airway model
MeSH headings : Absorption; Alkanes / toxicity; Computer Simulation; Humans; Hydrocarbons / toxicity; Inhalation Exposure / adverse effects; Male; Middle Aged; Models, Biological; Naphthalenes / toxicity; Respiratory System / metabolism; Trachea / metabolism
Source: Web Of Science
Added: August 6, 2018

2011 review

Experimental and theoretical studies of nanofluid thermal conductivity enhancement: a review

[Review of ]. NANOSCALE RESEARCH LETTERS, 6.

By: C. Kleinstreuer n & Y. Feng n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Impact analysis of natural convection on thermal conductivity measurements of nanofluids using the transient hot-wire method

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 54(15-16), 3448–3456.

By: S. Hong*, Y. Kang*, C. Kleinstreuer n & J. Koo*

co-author countries: Korea (Republic of) 🇰🇷 United States of America 🇺🇸
author keywords: Transient hot-wire method (THWM); Thermal conductivity; Natural convection; Nanofluids
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Laminar-to-turbulent fluid-nanoparticle dynamics simulations: Model comparisons and nanoparticle-deposition applications

International Journal for Numerical Methods in Biomedical Engineering, 27(12), 1930–1950.

By: Z. Zhang n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: laminar-to-turbulent flow; nanoparticle deposition; computer simulation; human upper airways
Source: Crossref
Added: February 24, 2020

2011 journal article

Optimal Drug-Aerosol Delivery to Predetermined Lung Sites

JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME, 133(1).

By: C. Kleinstreuer n & Z. Zhang n

co-author countries: United States of America 🇺🇸
author keywords: subject-specific lung airways; air-particle flow; computer simulation results; inhaler devices; optimal drug-aerosol targeting; smart inhaler system
Source: Web Of Science
Added: August 6, 2018

2010 article

Airflow and Particle Transport in the Human Respiratory System

ANNUAL REVIEW OF FLUID MECHANICS, Vol. 42, pp. 301–334.

By: C. Kleinstreuer n & Z. Zhang*

co-author countries: United States of America 🇺🇸
author keywords: human respiratory air-way models; experimental observations and computer simulations; laminar/turbulent airflow structures; dilute suspensions of nanomaterial; solid particles or droplets; inhaled/exhaled aerosol transport and deposition
Source: Web Of Science
Added: August 6, 2018

2010 journal article

COMPUTER MODELING OF YTTRIUM-90-MICROSPHERE TRANSPORT IN THE HEPATIC ARTERIAL TREE TO IMPROVE CLINICAL OUTCOMES

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 76(2), 631–637.

By: A. Kennedy n, C. Kleinstreuer n, C. Basciano n & W. Dezarn*

co-author countries: United States of America 🇺🇸
author keywords: Hepatic artery system; Y-90-microspheres; Computer modeling; Blood flow; Particle transport
MeSH headings : Computer Simulation; Embolization, Therapeutic / methods; Hepatic Artery / anatomy & histology; Hepatic Artery / physiology; Humans; Liver / blood supply; Liver Circulation / physiology; Liver Neoplasms / blood supply; Liver Neoplasms / radiotherapy; Microspheres; Models, Cardiovascular; Yttrium Radioisotopes / pharmacokinetics; Yttrium Radioisotopes / therapeutic use
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Computer Modeling of Controlled Microsphere Release and Targeting in a Representative Hepatic Artery System

ANNALS OF BIOMEDICAL ENGINEERING, 38(5), 1862–1879.

By: C. Basciano n, C. Kleinstreuer n, A. Kennedy*, W. Dezarn* & E. Childress n

co-author countries: United States of America 🇺🇸
author keywords: Computational fluid-particle dynamics; Yttrium-90 particle transport; Transient particle-hemodynamics; Non-Newtonian fluid; Drug-targeting methodology
MeSH headings : Animals; Computer Simulation; Drug Delivery Systems / methods; Hemodynamics / physiology; Hepatic Artery / physiology; Liver / blood supply; Liver Neoplasms / drug therapy; Liver Neoplasms / radiotherapy; Microspheres; Yttrium / adverse effects
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Influence of aspect ratio on the dynamics of a freely moving circular disk

JOURNAL OF FLUID MECHANICS, 653, 463–487.

By: A. Shenoy* & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Nanofluid convective heat transfer in a parallel-disk system

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 53(21-22), 4619–4628.

By: Y. Feng n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Nanofluid; Convective heat transfer; Impinging-jet; Parallel disk; Entropy generation; Wall temperature control
Source: Web Of Science
Added: August 6, 2018

2009 journal article

An Adjustable Triple-Bifurcation Unit Model for Air-Particle Flow Simulations in Human Tracheobronchial Airways

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 131(2).

By: C. Kleinstreuer n & Z. Zhang n

co-author countries: United States of America 🇺🇸
author keywords: bifurcation; computational fluid dynamics; flow simulation; lung; nanoparticles; physiological models; pneumodynamics; turbulence
MeSH headings : Air; Bronchi / physiology; Computer Simulation; Humans; Lung / physiology; Models, Biological; Particle Size; Respiratory Mechanics; Trachea / physiology
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Comparison of analytical and CFD models with regard to micron particle deposition in a human 16-generation tracheobronchial airway model

JOURNAL OF AEROSOL SCIENCE, 40(1), 16–28.

By: Z. Zhang n, C. Kleinstreuer n & C. Kim*

co-author countries: United States of America 🇺🇸
author keywords: Human tracheobronchial airways; Computational analysis; Micron particle deposition; Deposition efficiency; Deposition fraction
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Invariant-Based Anisotropic Constitutive Models of the Healthy and Aneurysmal Abdominal Aortic Wall

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 131(2).

By: C. Basciano n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: ab initio calculations; biomechanics; blood vessels; diseases; elasticity; physiological models
MeSH headings : Anisotropy; Aorta, Abdominal / physiology; Aortic Aneurysm, Abdominal / physiopathology; Biomechanical Phenomena; Computer Simulation; Elasticity; Humans; Models, Cardiovascular; Nonlinear Dynamics
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Microfluidics analysis of nanoparticle mixing in a microchannel system

MICROFLUIDICS AND NANOFLUIDICS, 6(5), 661–668.

By: J. Li n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Microfluidics; Nanofluid; Micro-mixer; Heat and mass transfer; Nanodrug delivery
Source: Web Of Science
Added: August 6, 2018

2008 journal article

A new methodology for targeting drug-aerosols in the human respiratory system

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 51(23-24), 5578–5589.

By: C. Kleinstreuer n, Z. Zhang n, Z. Li n, W. Roberts n & C. Rojas*

co-author countries: United States of America 🇺🇸
author keywords: Drug-aerosol inhalers; Targeted drug-aerosol delivery; Methodology for smart inhaler system; Experimental verification of new methodology
Source: Web Of Science
Added: August 6, 2018

2008 journal article

A nonlinear effective thermal conductivity model for carbon nanotube and nanofiber suspensions

NANOTECHNOLOGY, 19(37).

By: J. Koo*, Y. Kang* & C. Kleinstreuer n

co-author countries: Korea (Republic of) 🇰🇷 United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Airflow and Nanoparticle Deposition in a 16-Generation Tracheobronchial Airway Model

ANNALS OF BIOMEDICAL ENGINEERING, 36(12), 2095–2110.

By: Z. Zhang n, C. Kleinstreuer n & C. Kim*

co-author countries: United States of America 🇺🇸
author keywords: Human tracheobronchial region; Computational analysis; Airflow; Nanoparticle deposition; Deposition efficiencies; Deposition correlations
MeSH headings : Algorithms; Bronchi / physiology; Computer Simulation; Humans; Models, Biological; Nanoparticles; Particle Size; Pulmonary Ventilation; Reproducibility of Results; Trachea / physiology
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Computational mechanics of Nitinol stent grafts

JOURNAL OF BIOMECHANICS, 41(11), 2370–2378.

By: C. Kleinstreuer n, Z. Li*, C. Basciano n, S. Seelecke n & M. Farber n

co-author countries: United States of America 🇺🇸
author keywords: stent; stent graft; abdominal aortic aneurysm; Nitinol; graft material; finite element analysis; computer simulations; wall stress and strain; crimp; fatigue; fracture
MeSH headings : Alloys; Computer Simulation; Models, Biological; Stents; Stress, Mechanical
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Dilute suspension flow with nanoparticle deposition in a representative nasal airway model

PHYSICS OF FLUIDS, 20(1).

By: H. Shi n, C. Kleinstreuer n & Z. Zhang n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2008 article

Discussion: "Effects of various parameters on nanotluid thermal conductivity" ( Jang, S.P., and Choi, S.D.S., 2007, ASME J. heat transfer, 129, pp. 617-623)

Kleinstreuer, C., & Li, J. (2008, February). JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME, Vol. 130.

By: C. Kleinstreuer n & J. Li n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Flow over a thin circular disk at low to moderate Reynolds numbers

JOURNAL OF FLUID MECHANICS, 605, 253–262.

By: A. Shenoy n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Microfluidics of nano-drug delivery

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 51(23-24), 5590–5597.

By: C. Kleinstreuer n, J. Li n & J. Koo*

co-author countries: Korea (Republic of) 🇰🇷 United States of America 🇺🇸
author keywords: Bio-MEMS; Drug delivery; Nanofluids; Microfluidics; Microchannel
Source: Web Of Science
Added: August 6, 2018

2008 review

Modeling airflow and particle transport/deposition in pulmonary airways

[Review of ]. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 163(1-3), 128–138.

By: C. Kleinstreuer n, Z. Zhang n & Z. Li n

co-author countries: United States of America 🇺🇸
author keywords: Pulmonary airways; Deposition enhancement factor; Tracheobronchial airways
MeSH headings : Aerosols; Computer Simulation; Humans; Models, Biological; Particle Size; Pulmonary Ventilation / physiology; Respiratory Transport / physiology
Source: Web Of Science
Added: August 6, 2018

2008 article

Targeted drug-aerosol delivery in the human respiratory system

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, Vol. 10, pp. 195–220.

By: C. Kleinstreuer n, Z. Zhang n & J. Donohue*

co-author countries: United States of America 🇺🇸
author keywords: nasal and lung airways; nano- and micro-size aerosols; transport/deposition; present and proposed inhaler devices; methodology of optimal drug-aerosol targeting; computer simulations; experimental evidence
MeSH headings : Aerosols / administration & dosage; Aerosols / pharmacokinetics; Animals; Computer Simulation; Drug Delivery Systems / methods; Humans; Models, Biological; Pharmaceutical Preparations / administration & dosage; Pharmacokinetics; Respiratory System / metabolism
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Thermal performance of nanofluid flow in microchannels

INTERNATIONAL JOURNAL OF HEAT AND FLUID FLOW, 29(4), 1221–1232.

By: J. Li* & C. Kleinstreuer*

author keywords: Brownian motion; micro-mixing; effective thermal conductivity; nanofluid flow; microchannel heat sinks
Source: Web Of Science
Added: August 6, 2018

2007 journal article

A comparison between different asymmetric abdominal aortic aneurysm morphologies employing computational fluid-structure interaction analysis

EUROPEAN JOURNAL OF MECHANICS B-FLUIDS, 26(5), 615–631.

By: Z. Li* & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: pulsatile 3-D blood flow; abdominal aortic aneurysms; AAA morphologies; maximum wall stress
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Combined inertial and gravitational deposition of microparticles in small model airways of a human respiratory system

JOURNAL OF AEROSOL SCIENCE, 38(10), 1047–1061.

By: C. Kleinstreuer n, Z. Zhang n & C. Kim*

co-author countries: United States of America 🇺🇸
author keywords: inertial impaction; gravitational sedimentation; micron particle deposition; small human airways; computational analysis; deposition efficiency; stokes number; fronde number; sedimentation parameter; deposition correlations
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Computational analyses of a pressurized metered dose inhaler and a new drug-aerosol targeting methodology

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG, 20(3), 294–309.

By: C. Kleinstreuer n, H. Shi* & Z. Zhang n

co-author countries: United States of America 🇺🇸
author keywords: computer simulation; droplet spray formation; pMDI performance; droplet transport/deposition; human upper airways; controlled air-particle stream; targeted drug-aerosol transport/deposition
MeSH headings : Aerosol Propellants / chemistry; Aerosols; Anti-Asthmatic Agents / administration & dosage; Anti-Asthmatic Agents / chemistry; Computer Simulation; Drug Delivery Systems / instrumentation; Equipment Design; Humans; Hydrocarbons, Fluorinated / chemistry; Inhalation Spacers; Metered Dose Inhalers; Models, Biological; Motion; Particle Size; Pressure; Reproducibility of Results; Respiratory System / anatomy & histology
Source: Web Of Science
Added: August 6, 2018

2007 review

Fluid-structure interaction analyses of stented abdominal aortic aneurysms

[Review of ]. Annual Review of Biomedical Engineering, 9, 169–204.

By: C. Kleinstreuer n, Z. Li* & M. Farber*

co-author countries: United States of America 🇺🇸
MeSH headings : Aorta, Abdominal / physiopathology; Aorta, Abdominal / surgery; Aortic Aneurysm, Abdominal / physiopathology; Aortic Aneurysm, Abdominal / surgery; Blood Flow Velocity; Blood Pressure; Blood Vessel Prosthesis; Computer Simulation; Humans; Models, Cardiovascular; Stents; Surgery, Computer-Assisted / methods
Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Modeling of inertial particle transport and deposition in human nasal cavities with wall roughness

JOURNAL OF AEROSOL SCIENCE, 38(4), 398–419.

By: H. Shi n, C. Kleinstreuer n & Z. Zhang n

co-author countries: United States of America 🇺🇸
author keywords: human nasal cavity; inertial particle decomposition; computer analysis; wall roughness
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Particle deposition in the human tracheobronchial airways due to transient inspiratory flow patterns

JOURNAL OF AEROSOL SCIENCE, 38(6), 625–644.

By: Z. Li n, C. Kleinstreuer n & Z. Zhang n

co-author countries: United States of America 🇺🇸
author keywords: transient inhalation; laminar flow; turbulent flow; local flow pattern; micro-particle deposition; deposition fraction; drug-aerosol targeting
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Simulation and analysis of high-speed droplet spray dynamics

JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME, 129(5), 621–633.

By: H. Shi n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Simulation of airflow fields and microparticle deposition in realistic human lung airway models. Part I: Airflow patterns

EUROPEAN JOURNAL OF MECHANICS B-FLUIDS, 26(5), 632–649.

By: Z. Li n, C. Kleinstreuer n & Z. Zhang n

co-author countries: United States of America 🇺🇸
author keywords: asymmetric upper airways; transient 3-D airflow simulations; parabolic and realistic velocity inlet conditions; local velocity distributions
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Simulation of airflow fields and microparticle deposition in realistic human lung airway models. Part II: Particle transport and deposition

EUROPEAN JOURNAL OF MECHANICS B-FLUIDS, 26(5), 650–668.

By: Z. Li n, C. Kleinstreuer n & Z. Zhang n

co-author countries: United States of America 🇺🇸
author keywords: asymmetric upper airways; matching inlet Reynolds number; 3-D microparticle transport simulations; particle depositions and segmental correlations
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Analysis of biomechanical factors affecting stent-graft migration in an abdominal aortic aneurysm model

JOURNAL OF BIOMECHANICS, 39(12), 2264–2273.

By: Z. Li n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: stented abdominal aortic aneurysm; stent-graft migration; blood flow; stent-graft and aneurysm-wall interactions; computational parametric sensitivity analyses
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Computational analysis of type II endoleaks in a stented abdominal aortic aneurysm model

JOURNAL OF BIOMECHANICS, 39(14), 2573–2582.

By: Z. Li n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: abdominal aortic aneurysm; stent-graft; type II endoleaks; computational fluid-structure interaction analysis; sac pressure; wall stress; estimation of aneurysm-rupture risk; theoretical stent-graft migration
MeSH headings : Algorithms; Aorta, Abdominal / physiopathology; Aorta, Abdominal / surgery; Aortic Aneurysm, Abdominal / physiopathology; Aortic Aneurysm, Abdominal / surgery; Biomechanical Phenomena; Blood Flow Velocity / physiology; Blood Pressure / physiology; Blood Viscosity; Computer Simulation; Hematocrit; Humans; Models, Cardiovascular; Postoperative Complications / etiology; Postoperative Complications / physiopathology; Pressure; Stents / adverse effects; Stress, Mechanical; Vascular Surgical Procedures / adverse effects
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Effects of blood flow and vessel geometry on wall stress and rupture risk of abdominal aortic aneurysms

Journal of Medical Engineering & Technology, 30(5), 283–297.

By: Z. Li & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
MeSH headings : Aorta, Abdominal / physiopathology; Aortic Aneurysm, Abdominal / physiopathology; Blood Pressure; Computer Simulation; Hemorheology; Humans; Models, Cardiovascular; Regional Blood Flow; Stress, Mechanical
Source: Crossref
Added: February 24, 2020

2006 journal article

Effects of major endoleaks on a stented abdominal aortic aneurysm

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 128(1), 59–68.

By: Z. Li n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: abdominal aortic aneurysm; stent-graft; type I endoleaks; computational analysis; sac pressure; hypertension; aneurysm rupture risk; stent-graft migration; wall stress
MeSH headings : Aorta, Abdominal / physiopathology; Aorta, Abdominal / surgery; Aortic Aneurysm, Abdominal / complications; Aortic Aneurysm, Abdominal / physiopathology; Aortic Aneurysm, Abdominal / surgery; Blood Flow Velocity; Blood Loss, Surgical / prevention & control; Blood Pressure; Blood Vessel Prosthesis / adverse effects; Computer Simulation; Humans; Models, Cardiovascular; Postoperative Hemorrhage / etiology; Postoperative Hemorrhage / physiopathology; Shear Strength; Stents / adverse effects; Stress, Mechanical; Treatment Outcome
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Isotonic and hypertonic saline droplet deposition in a human upper airway model

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG, 19(2), 184–198.

By: Z. Zhang n, C. Kleinstreuer n & C. Kim*

co-author countries: United States of America 🇺🇸
author keywords: aerosol deposition; computational fluid-particle dynamics; droplet vaporization and hygroscopicity; isotonic and hypertonic saline droplets
MeSH headings : Administration, Inhalation; Humans; Humidity; Isotonic Solutions / pharmacokinetics; Lung / physiology; Models, Anatomic; Models, Biological; Particle Size; Respiratory Mechanics; Saline Solution, Hypertonic / pharmacokinetics; Thermodynamics; Volatilization; Wettability
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Laminar airflow and nanoparticle or vapor deposition in a human nasal cavity model

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 128(5), 697–706.

By: H. Shi n, C. Kleinstreuer n & Z. Zhang n

co-author countries: United States of America 🇺🇸
MeSH headings : Absorption; Aerosols / pharmacokinetics; Air Movements; Computer Simulation; Gases / pharmacokinetics; Humans; Male; Middle Aged; Models, Biological; Nanoparticles; Nasal Cavity / metabolism; Tissue Distribution
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Transport and uptake of MTBE and ethanol vapors in a human upper airway model

INHALATION TOXICOLOGY, 18(3), 169–184.

By: Z. Zhang n, C. Kleinstreuer n & C. Kim*

co-author countries: United States of America 🇺🇸
MeSH headings : Absorption; Biological Transport; Ethanol / pharmacokinetics; Humans; Methyl Ethers / pharmacokinetics; Mouth Mucosa / metabolism; Respiratory System / metabolism; Trachea / metabolism; Volatilization
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Water vapor transport and its effects on the deposition of hygroscopic droplets in a human upper airway model

AEROSOL SCIENCE AND TECHNOLOGY, 40(1), 1–16.

By: Z. Zhang n, C. Kleinstreuer n & C. Kim*

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2005 journal article

A new wall stress equation for aneurysm-rupture prediction

ANNALS OF BIOMEDICAL ENGINEERING, 33(2), 209–213.

By: Z. Li n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: Laplace structure equation; abdominal aortic aneurysm; semi-empirical wall stress equation; AAA-rupture prediction
MeSH headings : Animals; Aortic Aneurysm, Abdominal / pathology; Aortic Aneurysm, Abdominal / physiopathology; Aortic Rupture / pathology; Aortic Rupture / physiopathology; Blood Flow Velocity; Blood Pressure; Computer Simulation; Diagnosis, Computer-Assisted / methods; Elasticity; Humans; Models, Cardiovascular; Prognosis; Risk Assessment / methods; Risk Factors; Severity of Illness Index; Shear Strength; Stress, Mechanical
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Analysis of surface roughness effects on heat transfer in micro-conduits

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 48(13), 2625–2634.

By: J. Koo n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: thermal flow; microchannels; microtubes; computational analyses microscale parameters dimensionless temperature profiles; Nusselt numbers
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Blood flow and structure interactions in a stented abdominal aortic aneurysm model

MEDICAL ENGINEERING & PHYSICS, 27(5), 369–382.

By: Z. Li n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: fluid-structure interaction; stented abdominal aortic aneurysm; endovascular graft; sac pressure; wall stress; drag force; EVG migration
MeSH headings : Algorithms; Aorta, Abdominal; Aortic Aneurysm, Abdominal / diagnosis; Aortic Aneurysm, Abdominal / pathology; Aortic Rupture; Biophysical Phenomena; Biophysics; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Hemodynamics; Humans; Hypertension; Models, Anatomic; Models, Cardiovascular; Models, Statistical; Models, Theoretical; Pressure; Time Factors
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Comparison of micro- and nano-size particle depositions in a human upper airway model

JOURNAL OF AEROSOL SCIENCE, 36(2), 211–233.

By: Z. Zhang n, C. Kleinstreuer n, J. Donohue* & C. Kim*

co-author countries: United States of America 🇺🇸
author keywords: microparticle deposition; nanoparticle deposition; human upper airways; computational fluid-particle dynamics
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Computational analysis of biomechanical contributors to endovascular graft failure

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, 4(4), 221–234.

By: Z. Li n, C. Kleinstreuer n & M. Farber*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Aorta, Abdominal / injuries; Aorta, Abdominal / physiopathology; Aortic Aneurysm, Abdominal / complications; Aortic Aneurysm, Abdominal / physiopathology; Aortic Aneurysm, Abdominal / surgery; Biomechanical Phenomena / methods; Blood Flow Velocity / physiology; Blood Vessel Prosthesis / adverse effects; Computer Simulation; Elasticity; Equipment Failure Analysis; Humans; Mechanotransduction, Cellular; Models, Cardiovascular; Prosthesis Failure; Rupture; Shear Strength; Stress, Mechanical; Viscosity
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Computational models for simulating multicomponent aerosol evaporation in the upper respiratory airways

AEROSOL SCIENCE AND TECHNOLOGY, 39(2), 124–138.

By: P. Longest* & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Fluid-structure interaction effects on sac-blood pressure and wall stress in a stented aneurysm

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 127(4), 662–671.

By: Z. Li n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: stented aneurysm; computational fluid-structure interaction simulations; abdominal aortic aneurysm; sac pressure; wall stress
MeSH headings : Animals; Aorta, Abdominal / physiopathology; Aorta, Abdominal / surgery; Aortic Aneurysm, Abdominal / complications; Aortic Aneurysm, Abdominal / physiopathology; Aortic Aneurysm, Abdominal / surgery; Aortic Rupture / etiology; Aortic Rupture / physiopathology; Blood Flow Velocity; Blood Pressure; Blood Vessel Prosthesis; Computer Simulation; Humans; Models, Cardiovascular; Stents; Stress, Mechanical
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Laminar nanofluid flow in microheat-sinks

International Journal of Heat and Mass Transfer, 48(13), 2652–2661.

By: J. Koo & C. Kleinstreuer

Source: NC State University Libraries
Added: August 6, 2018

2005 article

Numerical simulation of wall shear stress and particle-based hemodynamic parameters in pre-cuffed and streamlined end-to-side anastomoses

Longest, P. W., Kleinstreuer, C., & Deanda, A. (2005, December). ANNALS OF BIOMEDICAL ENGINEERING, Vol. 33, pp. 1752–1766.

By: P. Longest*, C. Kleinstreuer n & A. Deanda*

co-author countries: United States of America 🇺🇸
author keywords: particle hemodynamics; hemodynamic wall parameters; near-wall residence time; femoropopliteal bypass; end-to-side anastomosis; intimal hyperplasia; pre-cuffed grafts; streamlined grafts
MeSH headings : Anastomosis, Surgical / adverse effects; Blood Vessel Prosthesis / adverse effects; Blood Vessel Prosthesis Implantation / adverse effects; Blood Vessels / physiopathology; Hemodynamics; Humans; Hyperplasia; Imaging, Three-Dimensional; Models, Cardiovascular; Nanostructures; Stress, Mechanical; Tunica Intima / pathology; Tunica Intima / physiopathology
Source: Web Of Science
Added: August 6, 2018

2004 journal article

A new thermal conductivity model for nanofluids

JOURNAL OF NANOPARTICLE RESEARCH, 6(6), 577–588.

By: J. Koo* & C. Kleinstreuer*

author keywords: nanofluids; effective thermal conductivity; apparent thermal conductivity; Brownian motion; interparticle potential; modeling and simulation
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Airflow structures and nano-particle deposition in a human upper airway model

JOURNAL OF COMPUTATIONAL PHYSICS, 198(1), 178–210.

By: Z. Zhang n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: inspiratory flow; nano-size particle deposition; human airways; computational fluid-particle dynamics simulation
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Computational analysis of wall roughness effects for liquid flow in micro-conduits

Journal of Fluids Engineering, 126(1), 09-.

By: C. Kleinstreuer & J. Koo

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Efficient computation of micro-particle dynamics including wall effects

COMPUTERS & FLUIDS, 33(4), 577–601.

By: P. Longest n, C. Kleinstreuer n & . Buchanan n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Interacting effects of uniform flow, plane shear, and near-wall proximity on the heat and mass transfer of respiratory aerosols

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 47(22), 4745–4759.

By: P. Longest* & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: droplet heat and mass transfer; respiratory aerosols; near-wall droplet evaporation; droplet Nusselt and Sherwood number correlations
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Nanoparticle transport and deposition in bifurcating tubes with different inlet conditions

PHYSICS OF FLUIDS, 16(7), 2199–2213.

By: H. Shi n, C. Kleinstreuer n, Z. Zhang n & C. Kim*

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Particle-hemodynamics simulations and design options for surgical reconstruction of diseased carotid artery bifurcations

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 126(2), 188–195.

By: S. Hyun*, C. Kleinstreuer n, P. Longest n & C. Chen n

co-author countries: United States of America 🇺🇸
MeSH headings : Blood Flow Velocity; Blood Pressure; Carotid Artery Diseases / physiopathology; Carotid Artery Diseases / surgery; Computer Simulation; Endarterectomy, Carotid; Hemorheology / methods; Humans; Models, Cardiovascular; Particle Size; Risk Assessment; Surgery, Computer-Assisted / methods
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Vaporizing Microdroplet Inhalation, Transport, and Deposition in a Human Upper Airway Model

Aerosol Science and Technology, 38(1), 36–49.

By: Z. Zhang, C. Kleinstreuer*, C. Kim & Y. Cheng

Source: Crossref
Added: February 24, 2020

2004 journal article

Vaporizing microdroplet inhalation, transport, and deposition in a human upper airway model

AEROSOL SCIENCE AND TECHNOLOGY, 38(1), 36–49.

By: Z. Zhang*, C. Kleinstreuer*, C. Kim & Y. Cheng

Source: Web Of Science
Added: August 6, 2018

2004 journal article

Viscous dissipation effects in microtubes and microchannels

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 47(14-16), 3159–3169.

By: J. Koo n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: viscous dissipation; microchannel; microtube; computational analyses; dimensionless groups; temperature distributions; friction factor
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Comparison of blood particle deposition models for non-parallel flow domains

JOURNAL OF BIOMECHANICS, 36(3), 421–430.

By: P. Longest n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: particle-hemodynamics; monocytes; platelets; deposition; adhesion; computational fluid-particle dynamics; near-wall residence time
MeSH headings : Animals; Blood Flow Velocity; Blood Platelets / physiology; Blood Vessels / physiology; Cell Adhesion / physiology; Computer Simulation; Hemorheology / methods; Humans; Models, Cardiovascular; Monocytes / physiology; Particle Size; Platelet Adhesiveness / physiology; Rheology / methods; Sensitivity and Specificity; Shear Strength; Stress, Mechanical
Source: Web Of Science
Added: August 6, 2018

2003 article

Computational thermodynamics analysis of vaporizing fuel droplets in the human upper airways

Zhang, Z., & Kleinstreuer, C. (2003, November). JSME INTERNATIONAL JOURNAL SERIES B-FLUIDS AND THERMAL ENGINEERING, Vol. 46, pp. 563–571.

By: Z. Zhang n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: liquid aerosol transport and deposition; JP-8 fuel; human airways; heat and mass transfer
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Hemodynamics simulation and identification of susceptible sites of atherosclerotic lesion formation in a model abdominal aorta

JOURNAL OF BIOMECHANICS, 36(8), 1185–1196.

By: . Buchanan n, C. Kleinstreuer n, S. Hyun* & G. Truskey*

co-author countries: United States of America 🇺🇸
author keywords: computational blood flow simulation; rabbit aorta; atherosclerotic model; hemodynamic wall parameters; monocyte deposition; experimental data comparisons
MeSH headings : Animals; Aorta, Abdominal / pathology; Aorta, Abdominal / physiopathology; Blood Flow Velocity; Blood Pressure; Cell Adhesion / physiology; Cell Aggregation / physiology; Cell Movement / physiology; Computer Simulation; Coronary Artery Disease / pathology; Coronary Artery Disease / physiopathology; Elasticity; Endothelium, Vascular / physiology; Hemorheology / methods; Models, Cardiovascular; Monocytes / physiology; Physical Conditioning, Animal / physiology; Pulsatile Flow / physiology; Rabbits; Shear Strength
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Laminar-to-turbulent fluid-particle flows in a human airway model

INTERNATIONAL JOURNAL OF MULTIPHASE FLOW, 29(2), 271–289.

By: C. Kleinstreuer n & Z. Zhang n

co-author countries: United States of America 🇺🇸
author keywords: computational gas-solid two-phase flow; internal laminar-to-turbulent flow modeling; micro-particle distributions; human oral airway
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Liquid flow in microchannels: experimental observations and computational analyses of microfluidics effects

JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 13(5), 568–579.

By: J. Koo n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Low-Reynolds-number turbulent flows in locally constricted conduits: A comparison study

AIAA JOURNAL, 41(5), 831–840.

By: Z. Zhang n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Numerical simulation of wall shear stress conditions and platelet localization in realistic end-to-side arterial anastomoses

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 125(5), 671–681.

By: P. Longest n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
MeSH headings : Anastomosis, Surgical; Animals; Arteries / physiopathology; Arteries / surgery; Blood Flow Velocity; Blood Pressure; Cell Movement; Computer Simulation; Hemorheology / methods; Humans; Models, Cardiovascular; Platelet Activation; Platelet Adhesiveness; Shear Strength; Surface Properties
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Particle hemodynamics analysis of Miller cuff arterial anastomosis

JOURNAL OF VASCULAR SURGERY, 38(6), 1353–1362.

By: P. Longest n, C. Kleinstreuer n & J. Archie n

co-author countries: United States of America 🇺🇸
MeSH headings : Anastomosis, Surgical / adverse effects; Anastomosis, Surgical / instrumentation; Blood Flow Velocity / physiology; Endothelium, Vascular / pathology; Endothelium, Vascular / physiopathology; Femoral Artery / physiopathology; Femoral Artery / surgery; Humans; Hyperplasia / etiology; Hyperplasia / physiopathology; Models, Cardiovascular; Popliteal Artery / physiopathology; Popliteal Artery / surgery; Shear Strength; Vascular Patency / physiology; Vascular Resistance / physiology
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Particle-hemodynamics modeling of the distal end-to-side femoral bypass: effects of graft caliber and graft-end cut

MEDICAL ENGINEERING & PHYSICS, 25(10), 843–858.

By: P. Longest n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: particle-hemodynamics; hemodynamic wall parameters; near-wall residence time; femoropopliteal bypass; end-to-side anastomosis; intimal hyperplasia
MeSH headings : Anastomosis, Surgical; Arteries / pathology; Blood Flow Velocity; Blood Platelets / metabolism; Blood Vessel Prosthesis; Femoral Artery / pathology; Femoral Vein / pathology; Humans; Hyperplasia; Models, Anatomic; Models, Cardiovascular; Models, Theoretical; Platelet Activation; Stress, Mechanical; Thrombosis
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Relation between near-wall residence times of monocytes and early lesion growth in the rabbit aorto-celiac junction

ANNALS OF BIOMEDICAL ENGINEERING, 31(1), 53–64.

By: P. Longest n, C. Kleinstreuer n, G. Truskey* & . Buchanan*

co-author countries: United States of America 🇺🇸
author keywords: atherosclerosis; particle hemodynamics; hemodynamic wall parameters; monocytes; adhesion; deposition; computational fluid dynamics; near-wall residence time
MeSH headings : Animals; Aorta, Abdominal / physiopathology; Arteriosclerosis / physiopathology; Blood Flow Velocity; Blood Physiological Phenomena; Blood Pressure; Celiac Artery / physiopathology; Cell Adhesion; Computer Simulation; Hemorheology / methods; Models, Cardiovascular; Monocytes; Particle Size; Rabbits; Shear Strength; Stress, Mechanical
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Species heat and mass transfer in a human upper airway model

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 46(25), 4755–4768.

By: Z. Zhang n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Targeted drug aerosol deposition analysis for a four-generation lung airway model with hemispherical tumors

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 125(2), 197–206.

By: C. Kleinstreuer n & Z. Zhang n

co-author countries: United States of America 🇺🇸
MeSH headings : Administration, Inhalation; Adsorption; Aerosols / administration & dosage; Aerosols / pharmacokinetics; Aerosols / therapeutic use; Bronchi / drug effects; Bronchi / metabolism; Bronchi / physiopathology; Bronchial Neoplasms / drug therapy; Bronchial Neoplasms / metabolism; Bronchial Neoplasms / physiopathology; Computer Simulation; Drug Delivery Systems / methods; Drug Therapy, Computer-Assisted / methods; Finite Element Analysis; Lung / drug effects; Lung / metabolism; Lung / physiopathology; Models, Biological; Particle Size; Pulsatile Flow; Rheology / methods; Sensitivity and Specificity
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Acoustic streaming induced by ultrasonic flexural vibrations and associated enhancement of convective heat transfer

JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 111(2), 875–883.

By: B. Loh n, S. Hyun n, P. Ro n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
MeSH headings : Acoustics; Hot Temperature; Models, Theoretical; Ultrasonics; Vibration
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Aerosol deposition efficiencies and upstream release positions for different inhalation modes in an upper bronchial airway model

AEROSOL SCIENCE AND TECHNOLOGY, 36(7), 828–844.

By: Z. Zhang, C. Kleinstreuer* & C. Kim

Source: Web Of Science
Added: August 6, 2018

2002 journal article

Aerosol transport and deposition in a triple bifurcation bronchial airway model with local tumors

INHALATION TOXICOLOGY, 14(11), 1111–1133.

By: Z. Zhang*, C. Kleinstreuer*, C. Kim* & A. Hickey*

co-author countries: United States of America 🇺🇸
MeSH headings : Administration, Inhalation; Aerosols / administration & dosage; Aerosols / pharmacokinetics; Airway Obstruction / pathology; Airway Obstruction / physiopathology; Biological Availability; Bronchi / metabolism; Computer Simulation; Humans; Models, Anatomic; Models, Biological; Neoplasms / metabolism; Neoplasms / pathology; Particle Size; Pulmonary Ventilation
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Cyclic micron-size particle inhalation and deposition in a triple bifurcation lung airway model

JOURNAL OF AEROSOL SCIENCE, 33(2), 257–281.

By: Z. Zhang*, C. Kleinstreuer n & C. Kim*

co-author countries: United States of America 🇺🇸
author keywords: cyclic inhalation; particle deposition; symmetric triple bifurcation; computational fluid-particle dynamics; simulations
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Gas-solid two-phase flow in a triple bifurcation lung airway model

INTERNATIONAL JOURNAL OF MULTIPHASE FLOW, 28(6), 1021–1046.

By: Z. Zhang*, C. Kleinstreuer* & C. Kim*

co-author countries: United States of America 🇺🇸
author keywords: large bronchial airways; aerosol transport and deposition; computational two-phase flow
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Micro-particle transport and deposition in a human oral airway model

JOURNAL OF AEROSOL SCIENCE, 33(12), 1635–1652.

By: Z. Zhang n, C. Kleinstreuer n & C. Kim*

co-author countries: United States of America 🇺🇸
author keywords: human oral airway; laminar-to-turbulent airflow; particle deposition; computational fluid-particle dynamics simulations
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Transient airflow structures and particle transport in a sequentially branching lung airway model

Physics of Fluids (Woodbury, N.Y.), 14(2), 862–880.

By: Z. Zhang* & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
Source: NC State University Libraries
Added: August 6, 2018

2001 article

'Effects of asymmetric branch flow rates on aerosol deposition in bifurcating airways', by Z. Zhang, C. Kleinstreuer and C. S. Kim - Response

JOURNAL OF MEDICAL ENGINEERING & TECHNOLOGY, Vol. 25, pp. 127–127.

By: C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2001 journal article

A New Near-wall Residence Time Model Applied to Three Arterio-venous Graft End-to-side Anastomoses

Computer Methods in Biomechanics and Biomedical Engineering, 4(5), 379–397.

By: P. Longest n, C. Kleinstreuer n & J. Buchanan n

co-author countries: United States of America 🇺🇸
Source: Crossref
Added: August 28, 2020

2001 journal article

Computational particle-hemodynamics analysis and geometric reconstruction after carotid endarterectomy

COMPUTERS IN BIOLOGY AND MEDICINE, 31(5), 365–384.

By: S. Hyun n, C. Kleinstreuer n & J. Archie n

co-author countries: United States of America 🇺🇸
author keywords: endarterectomized carotid artery; particle-hemodynamics simulations; indicator functions; surgical reconstruction geometries
MeSH headings : Carotid Stenosis / pathology; Carotid Stenosis / physiopathology; Carotid Stenosis / surgery; Computer Simulation; Endarterectomy, Carotid / adverse effects; Endarterectomy, Carotid / methods; Endarterectomy, Carotid / statistics & numerical data; Hemodynamics; Humans; Models, Cardiovascular; Postoperative Complications / prevention & control; Stroke / prevention & control
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Effect of particle inlet distributions on deposition in a triple bifurcation lung airway model

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG, 14(1), 13–29.

By: Z. Zhang* & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
author keywords: aerosol deposition; random particle release conditions; computational fluid-particle dynamics; deposition efficiencies
MeSH headings : Administration, Inhalation; Aerosols / administration & dosage; Aerosols / pharmacokinetics; Biological Availability; Computer Simulation; Humans; Lung / physiology; Models, Anatomic; Particle Size; Respiratory Mechanics; Respiratory Physiological Phenomena; Sensitivity and Specificity
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Effects of curved inlet tubes on air flow and particle deposition in bifurcating lung models

JOURNAL OF BIOMECHANICS, 34(5), 659–669.

By: Z. Zhang*, C. Kleinstreuer* & C. Kim*

co-author countries: United States of America 🇺🇸
author keywords: double airway bifurcations; bent parent tubes; uniform and parabolic inlet velocity profiles; aerosol transport and deposition; computational parametric sensitivity analyses
MeSH headings : Biomechanical Phenomena; Humans; Lung / anatomy & histology; Lung / physiology; Models, Anatomic; Models, Biological; Respiratory Mechanics
Source: Web Of Science
Added: August 6, 2018

2001 article

Flow structure and particle transport in a triple bifurcation airway model

Zhang, Z., Kleinstreuer, C., & Kim, C. S. (2001, June). JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME, Vol. 123, pp. 320–330.

By: Z. Zhang*, C. Kleinstreuer n & C. Kim*

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Flow structures and particle deposition patterns in double-bifurcation airway models. Part 1. Air flow fields

JOURNAL OF FLUID MECHANICS, 435, 25–54.

By: J. Comer n, C. Kleinstreuer n & Z. Zhang*

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Flow structures and particle deposition patterns in double-bifurcation airway models. Part 2. Aerosol transport and deposition

JOURNAL OF FLUID MECHANICS, 435, 55–80.

By: J. Comer n, C. Kleinstreuer* & C. Kim*

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Hemodynamic parameters and early intimal thickening in branching blood vessels

Critical Reviews in Biomedical Engineering, 29(1), 1–64.

By: C. Kleinstreuer*, S. Hyun n, J. Buchanan n, P. Longest n, J. Archie* & G. Truskey n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Arteriosclerosis / physiopathology; Biological Transport; Carotid Arteries / physiology; Carotid Arteries / physiopathology; Compliance; Endothelium, Vascular / pathology; Endothelium, Vascular / physiopathology; Hemodynamics; Humans; Hyperplasia; Hypertension / physiopathology; Models, Cardiovascular; Muscle, Smooth, Vascular / pathology; Muscle, Smooth, Vascular / physiopathology; Pulsatile Flow / physiology; Stress, Mechanical; Tunica Intima / pathology; Tunica Intima / physiopathology; Vascular Cell Adhesion Molecule-1 / metabolism
Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Numerical simulation of mixed convection heat and mass transfer in a human inhalation test chamber

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 44(12), 2247–2260.

By: S. Hyun n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Aerosol transport and deposition in sequentially bifurcating airways

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 122(2), 152–158.

By: J. Comer n, C. Kleinstreuer n, S. Hyun n & C. Kim*

co-author countries: United States of America 🇺🇸
MeSH headings : Aerosols; Biomedical Engineering; Computer Simulation; Humans; Models, Anatomic; Models, Biological; Particle Size; Respiratory Mechanics; Respiratory Physiological Phenomena; Respiratory System / anatomy & histology
Source: Web Of Science
Added: August 6, 2018

2000 article

Computational analyses and design improvements of graft-to-vein anastomoses

CRITICAL REVIEWS IN BIOMEDICAL ENGINEERING, Vol. 28, pp. 141–147.

By: P. Longest n, C. Kleinstreuer n & P. Andreotti

co-author countries: United States of America 🇺🇸
author keywords: hemodialysis; graft failure; hemodynamic simulations; geometric designs
MeSH headings : Arteriovenous Shunt, Surgical / methods; Blood Flow Velocity; Computer Simulation; Hemodynamics; Humans; Models, Cardiovascular; Renal Dialysis / methods
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Computational haemodynamics analysis and comparison study of arterio-venous grafts

Journal of Medical Engineering & Technology, 24(3), 102–110.

By: P. Longest & C. Kleinstreuer

Source: NC State University Libraries
Added: August 6, 2018

2000 article

Computer simulation and geometric design of endarterectomized carotid artery bifurcations

CRITICAL REVIEWS IN BIOMEDICAL ENGINEERING, Vol. 28, pp. 53–59.

By: S. Hyun n, C. Kleinstreuer n & J. Archie*

co-author countries: United States of America 🇺🇸
author keywords: branching blood vessels; arterial diseases; particle-hemodynamics; numerical analysis
MeSH headings : Blood Flow Velocity; Carotid Arteries / anatomy & histology; Carotid Arteries / surgery; Computer Simulation; Endarterectomy, Carotid; Humans; Models, Cardiovascular
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Effects of asymmetric branch flow rates on aerosol deposition in bifurcating airways

Journal of Medical Engineering & Technology, 24(5), 192–202.

By: Z. Zhang, C. Kleinstreuer & C. Kim

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Hemodynamics analyses of arterial expansions with implications to thrombosis and restenosis

MEDICAL ENGINEERING & PHYSICS, 22(1), 13–27.

By: S. Hyun n, C. Kleinstreuer n & J. Archie n

co-author countries: United States of America 🇺🇸
author keywords: computational hemodynamics simulations; transient particle-hemodynamics; sudden and smooth expansions; arterial disease indicators; thrombosis; restenosis
MeSH headings : Arteries / pathology; Arteries / physiopathology; Carotid Artery, Common / pathology; Carotid Artery, Common / physiopathology; Endarterectomy, Carotid / adverse effects; Hemodynamics; Humans; Models, Cardiovascular; Postoperative Complications / etiology; Postoperative Complications / pathology; Postoperative Complications / physiopathology; Stress, Mechanical; Thrombosis / etiology; Thrombosis / pathology; Thrombosis / physiopathology
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Rheological effects on pulsatile hemodynamics in a stenosed tube

COMPUTERS & FLUIDS, 29(6), 695–724.

By: . Buchanan n, C. Kleinstreuer n & J. Comer n

co-author countries: United States of America 🇺🇸
author keywords: stenosis; transient flow; non-Newtonian fluids; particle residence times; hemodynamic wall parameter
Source: Web Of Science
Added: August 6, 2018

2000 article

Turbulent three-dimensional air flow and trace gas distribution in an inhalation test chamber

Longest, P. W., Kleinstreuer, C., & Kinsey, J. S. (2000, June). JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME, Vol. 122, pp. 403–411.

By: P. Longest n, C. Kleinstreuer n & J. Kinsey*

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Relation between non-uniform hemodynamics and sites of altered permeability and lesion growth at the rabbit aorto-celiac junction

ATHEROSCLEROSIS, 143(1), 27–40.

By: . Buchanan n, C. Kleinstreuer n, G. Truskey* & M. Lei*

co-author countries: United States of America 🇺🇸
author keywords: computational simulation; aorto-celiac junction; hemodynamic parameters; enhanced wall permeability; WBC uptake; atherosclerotic lesion growth
MeSH headings : Animals; Aorta, Abdominal / pathology; Aorta, Abdominal / physiopathology; Aorta, Thoracic / physiopathology; Arteriosclerosis / pathology; Arteriosclerosis / physiopathology; Blood Flow Velocity; Capillary Permeability; Celiac Artery / pathology; Celiac Artery / physiopathology; Computer Simulation; Hemorheology; Leukocytes / physiology; Models, Cardiovascular; Rabbits; Stress, Mechanical
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Analytical solution to flux enhancement in laminar concentrically stratified pipe flow of Bingham and Newtonian fluids

JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME, 120(3), 629–631.

By: C. Buchanan n, C. Kleinstreuer n & P. Longest n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Simulation of particle-hemodynamics in a partially occluded artery segment with implications to the initiation of microemboli and secondary stenoses

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 120(4), 446–454.

By: . Buchanan n & C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
MeSH headings : Algorithms; Arterial Occlusive Diseases / blood; Arterial Occlusive Diseases / complications; Arterial Occlusive Diseases / physiopathology; Humans; Models, Cardiovascular; Monocytes / physiology; Numerical Analysis, Computer-Assisted; Oscillometry; Platelet Count; Reproducibility of Results; Rheology; Stress, Mechanical; Thrombin / physiology; Thromboembolism / blood; Thromboembolism / etiology; Thromboembolism / physiopathology
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Computational design of a bypass graft that minimizes wall shear stress gradients in the region of the distal anastomosis

JOURNAL OF VASCULAR SURGERY, 25(4), 637–646.

By: M. Lei n, J. Archie & C. Kleinstreuer*

co-author countries: United States of America 🇺🇸
MeSH headings : Algorithms; Anastomosis, Surgical / adverse effects; Anastomosis, Surgical / methods; Arterial Occlusive Diseases / prevention & control; Arterial Occlusive Diseases / surgery; Arteries / pathology; Arteries / surgery; Arteriosclerosis / etiology; Computer Simulation; Constriction, Pathologic / prevention & control; Constriction, Pathologic / surgery; Hemodynamics; Hemorheology / classification; Humans; Hyperplasia; Models, Cardiovascular; Physical Exertion / physiology; Recurrence; Regional Blood Flow; Rest / physiology; Stress, Mechanical; Thrombosis / prevention & control; Tunica Intima / pathology
Source: Web Of Science
Added: August 6, 2018

1997 book

Engineering fluid dynamics: An interdisciplinary systems approach

By: C. Kleinstreuer n

co-author countries: United States of America 🇺🇸
Source: NC State University Libraries
Added: August 6, 2018

1997 article

Hemodynamic simulations and computer aided designs of graft-artery junctions

Lei, M., Kleinstreuer, C., & Archie, J. P. (1997, August). JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol. 119, pp. 343–348.

By: M. Lei n, C. Kleinstreuer n & J. Archie n

co-author countries: United States of America 🇺🇸
MeSH headings : Algorithms; Anastomosis, Surgical / adverse effects; Animals; Arteries / physiopathology; Blood Flow Velocity; Blood Vessel Prosthesis / adverse effects; Computer Simulation; Computer-Aided Design; Constriction, Pathologic / etiology; Constriction, Pathologic / physiopathology; Femoral Artery / physiology; Femoral Artery / surgery; Hemodynamics / physiology; Humans; Models, Cardiovascular; Recurrence; Stress, Mechanical; Vascular Patency
Source: Web Of Science
Added: August 6, 2018

journal article

Analysis and computer program for rupture-risk prediction of abdominal aortic aneurysms

Kleinstreuer, C., & Li, Z. H. Biomedical Engineering Online, 5.

By: C. Kleinstreuer & Z. Li

Source: NC State University Libraries
Added: August 6, 2018

book

Biofluid dynamics

Kleinstreuer, C. Boca Raton, FL: CRC/Taylor & Francis.

By: C. Kleinstreuer

Source: NC State University Libraries
Added: August 6, 2018

chapter

Computational analysis of enhanced cooling performance and pressure drop for nanofluid flow in microchannels

Kleinstreuer, C., Li, J., & Feng, Y. In E. M. W.J. Minkowycz, Sparrow, & J. P. Abraham (Eds.), Advanced in numerical heat transfer (pp. 250–273). Boca Raton: CRC Press/Taylor & Francis Group.

By: C. Kleinstreuer, J. Li & Y. Feng

Ed(s): E. W.J. Minkowycz, . Sparrow & J. Abraham

Source: NC State University Libraries
Added: August 6, 2018

journal article

Computational nanofluid flow and heat transfer in microchannels

Kleinstreuer, C. Handbook of Fluid Dynamics, 2nd Edition.

By: C. Kleinstreuer

Source: NC State University Libraries
Added: August 6, 2018

journal article

Entropy generation analysis for nanofluid flow in microchannels

Kleinstreuer, C. Journal of Heat Transfer, 132(12).

By: C. Kleinstreuer

Source: NC State University Libraries
Added: August 6, 2018

journal article

Microsystems and microfluidics

Kleinstreuer, C. Handbook of Fluid Dynamics, 2nd Edition.

By: C. Kleinstreuer

Source: NC State University Libraries
Added: August 6, 2018

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