Alison Anne Motsinger-Reif
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Works (170)
Updated: August 13th, 2023 21:16
2023 journal article
MKX-AS1 Gene Expression Associated with Variation in Drug Response to Oxaliplatin and Clinical Outcomes in Colorectal Cancer Patients
PHARMACEUTICALS, 16(5).
author keywords: precision medicine; colorectal cancer; pharmacogenomics; oxaliplatin; lncRNA's; antisense
doi.org (publisher)
Sources: Web Of Science, ORCID
Added: May 19, 2023
2023 journal article
Pharmacogenomic Analyses Implicate B Cell Developmental Status and MKL1 as Determinants of Sensitivity toward Anti-CD20 Monoclonal Antibody Therapy
CELLS, 12(12).
author keywords: rituximab (Rituxan (R)); ofatumumab (Arzerra (R),& nbsp;Kesimpta (R)); obinutuzumab (Gazyva (R)); CD20 (MS4A1); MKL1 (MRTFA); TGFB1
Sources: Web Of Science, ORCID
Added: June 8, 2023
2023 journal article
RYK Gene Expression Associated with Drug Response Variation of Temozolomide and Clinical Outcomes in Glioma Patients
PHARMACEUTICALS, 16(5).
author keywords: GWAS; chemotherapy; sensitivity; resistance; glioma; drug response; temozolomide; knockdown; overexpression; pharmacogenomics; gene expression; RYK
Sources: Web Of Science, ORCID
Added: May 12, 2023
2022 journal article
Clomifene and Assisted Reproductive Technology in Humans Are Associated with Sex-Specific Offspring Epigenetic Alterations in Imprinted Control Regions
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(18).
author keywords: differentially methylated regions; adverse offspring outcomes; infertility
MeSH headings : Child; Clomiphene; DNA Methylation; Female; Genomic Imprinting; Humans; Male; Reproductive Techniques, Assisted / adverse effects; Retrospective Studies
Sources: Web Of Science, ORCID
Added: October 3, 2022
2022 journal article
Comparison of National Vulnerability Indices Used by the Centers for Disease Control and Prevention for the COVID-19 Response
Public Health Reports, 137(4), 803–812.
author keywords: COVID-19; vulnerability; social vulnerability index; GIS; geographic information systems
MeSH headings : COVID-19 / epidemiology; COVID-19 / prevention & control; Centers for Disease Control and Prevention, U.S.; Humans; Pandemics / prevention & control; Public Health; United States / epidemiology
Sources: Web Of Science, ORCID, Crossref
Added: May 6, 2022
2022 journal article
Correlation Analysis of Variables From the Atherosclerosis Risk in Communities Study
FRONTIERS IN PHARMACOLOGY, 13.
author keywords: cluster analysis; systems biology; meta-analysis as topic; ARIC; cardiovascular disease
Source: Web Of Science
Added: August 8, 2022
2022 article
Genomic map of candidate human imprint control regions: the imprintome
Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). EPIGENETICS, Vol. 6.
author keywords: Epigenetics; genomic imprinting; foetal origins; whole genome; methylation; imprint control regions
MeSH headings : Adult; Humans; Genomic Imprinting; DNA Methylation; Chromosome Mapping; Alleles; Genomics
Sources: Web Of Science, ORCID
Added: July 11, 2022
2022 journal article
The AGMK1-9T7 cell model of neoplasia: Evolution of DNA copy-number aberrations and miRNA expression during transition from normal to metastatic cancer cells
PLOS ONE, 17(10).
MeSH headings : Animals; Humans; Chlorocebus aethiops; MicroRNAs / genetics; MicroRNAs / metabolism; Neoplasms / genetics; Carcinogenesis / genetics; DNA Copy Number Variations / genetics; Chromosome Aberrations; Neoplasms, Second Primary / genetics; DNA; Gene Expression Regulation, Neoplastic; Gene Expression Profiling
Source: Web Of Science
Added: February 27, 2023
2022 article
ToxPi*GIS Toolkit: creating, viewing, and sharing integrative visualizations for geospatial data using ArcGIS
Fleming, J., Marvel, S. W., Supak, S., Motsinger-Reif, A. A., & Reif, D. M. (2022, April 26). JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, Vol. 4.
author keywords: Visual analytics; Geographic information systems; Data integration
MeSH headings : Humans; Geographic Information Systems; COVID-19
Sources: Web Of Science, ORCID
Added: May 10, 2022
2021 journal article
Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome‐Wide Interaction Meta‐Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies
Clinical Pharmacology & Therapeutics, 110(3), 723–732.
MeSH headings : Black or African American / genetics; Aged; Antihypertensive Agents / therapeutic use; Blood Pressure / drug effects; Blood Pressure / genetics; Cardiovascular Diseases / chemically induced; Cardiovascular Diseases / genetics; Cardiovascular System / drug effects; Drug-Related Side Effects and Adverse Reactions / etiology; Drug-Related Side Effects and Adverse Reactions / genetics; Female; Genome-Wide Association Study / methods; Humans; Hypertension / drug therapy; Hypertension / genetics; Male; Middle Aged; Pharmacogenomic Testing / methods; Polymorphism, Single Nucleotide / genetics
Sources: Web Of Science, ORCID, Crossref
Added: August 23, 2021
2021 article
Extending the lymphoblastoid cell line model for drug combination pharmacogenomics
Green, A. J., Anchang, B., Akhtari, F. S., Reif, D. M., & Motsinger-Reif, A. (2021, May 28). PHARMACOGENOMICS, Vol. 22.
author keywords: combination treatment; drug response; LCLs; omics; synergism
MeSH headings : Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cell Line, Tumor / drug effects; Humans; Lymphocytes / drug effects; Pharmacogenomic Testing / methods
Sources: Web Of Science, ORCID
Added: May 29, 2021
2021 journal article
High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs
PLOS GENETICS, 17(8).
Ed(s): F. Vazquez
MeSH headings : Antineoplastic Agents / pharmacology; Biomarkers, Pharmacological / analysis; Cell Line, Tumor; Genome-Wide Association Study / methods; High-Throughput Screening Assays / methods; Humans; NAD(P)H Dehydrogenase (Quinone) / drug effects; NAD(P)H Dehydrogenase (Quinone) / genetics; NAD(P)H Dehydrogenase (Quinone) / metabolism
Sources: Web Of Science, ORCID
Added: August 27, 2021
2021 journal article
In vitro iatrogenic hemolysis of canine packed red blood cells during various rapid transfusion techniques
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 31(1), 25–31.
author keywords: canine; coagulation; hemoglobin; trauma
MeSH headings : Animals; Blood Preservation / veterinary; Blood Transfusion / methods; Blood Transfusion / veterinary; Dogs; Erythrocytes / physiology; Hemolysis; Iatrogenic Disease / veterinary; Prospective Studies
Source: Web Of Science
Added: November 16, 2020
2021 journal article
Knockoff boosted tree for model-free variable selection
BIOINFORMATICS, 37(7), 976–983.
MeSH headings : Algorithms; Computer Simulation; Genome; Machine Learning
Source: Web Of Science
Added: June 21, 2021
2021 journal article
Prediction of synergistic drug combinations using PCA-initialized deep learning
BIODATA MINING, 14(1).
author keywords: Deep learning; Cancer treatment; Drug combination treatment; Feedforward neural network; Machine learning; XGBoost; Random Forests; Elastic net
Source: Web Of Science
Added: November 8, 2021
2021 journal article
Race and smoking status associated with paclitaxel drug response in patient-derived lymphoblastoid cell lines
PHARMACOGENETICS AND GENOMICS, 31(2), 48–52.
author keywords: dose-response; lymphoblastoid cell lines; paclitaxel; patient-derived cell lines; pharmacogenomics; smoking
MeSH headings : Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Breast Neoplasms / pathology; Cell Line, Tumor; Cell Survival / drug effects; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm / genetics; Female; Humans; Middle Aged; Paclitaxel / adverse effects; Paclitaxel / pharmacology; Pharmacogenetics; Racial Groups / genetics; Smoking / adverse effects; Smoking / genetics
Source: Web Of Science
Added: May 10, 2021
2021 personal communication
The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning
Marvel, S. W., House, J. S., Wheeler, M., Song, K., Zhou, Y.-H., Wright, F. A., … Reif, D. M. (2021, January).
MeSH headings : COVID-19 / epidemiology; Data Visualization; Health Status Indicators; Humans; Machine Learning; Models, Statistical; Vulnerable Populations
Sources: Web Of Science, ORCID
Added: March 22, 2021
2020 journal article
Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(12), 7409–7419.
MeSH headings : Animals; Biomarkers; Dogs; Environmental Monitoring; Humans; Organophosphates; Silicones
Source: Web Of Science
Added: July 13, 2020
2020 journal article
Genetic and environmental risk for lymphoma in boxer dogs
JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(5), 2068–2077.
author keywords: canine; detoxification; exposure; lymphosarcoma
MeSH headings : Animals; Dog Diseases / genetics; Dogs; Genetic Predisposition to Disease; Genotype; Lymphoma / genetics; Lymphoma / veterinary; Risk Factors
Source: Web Of Science
Added: August 3, 2020
2020 journal article
Low-Dose Silver Nanoparticle Surface Chemistry and Temporal Effects on Gene Expression in Human Liver Cells
SMALL, 16(21).
author keywords: nanotoxicity; silver nanoparticles; transcriptomics
MeSH headings : Gene Expression / drug effects; Hepatocytes / drug effects; Humans; Metal Nanoparticles / chemistry; Silver; Surface Properties; Time Factors
Sources: Web Of Science, ORCID
Added: April 14, 2020
2020 journal article
Nonlinear Dose-Response Modeling of High-Throughput Screening Data Using an Evolutionary Algorithm
DOSE-RESPONSE, 18(2).
author keywords: evolutionary algorithm; hillslope model; parameter estimation; nonlinear regression; model selection
Source: Web Of Science
Added: June 15, 2020
2020 journal article
The influence of packed cell volume versus plasma proteins on thromboelastographic variables in canine blood
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 30(4), 418–425.
MeSH headings : Animals; Blood Coagulation Tests / veterinary; Blood Proteins / physiology; Cell Size; Dogs / blood; Female; Fibrinogen / metabolism; Hematocrit / veterinary; Male; Thrombelastography / veterinary
Sources: Web Of Science, ORCID
Added: July 13, 2020
2020 journal article
Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(3), 897–906.
author keywords: Asthma; food allergy; invariant natural killer T cells; metabolomics; metabolites; secondary bile acids; sphingolipids; tryptophan
MeSH headings : Asthma / blood; Biomarkers / blood; Child; Child, Preschool; Female; Food Hypersensitivity / blood; Humans; Male; Metabolome; Metabolomics / methods; Pilot Projects
Source: Web Of Science
Added: April 27, 2020
2019 journal article
A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes: Results From the ACCORD and BARI 2D Studies
DIABETES, 68(8), 1649–1662.
MeSH headings : Aged; Alleles; Chromosomes, Human, Pair 2; Databases, Genetic; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / epidemiology; Diabetes Mellitus, Type 2 / genetics; Diabetic Neuropathies / genetics; Female; Gene Frequency; Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Incidence; Male; Middle Aged; Polymorphism, Single Nucleotide; Prevalence
Source: Web Of Science
Added: August 12, 2019
2019 journal article
Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome
Alzheimer's & Dementia, 15(1), 76–92.
author keywords: Metabolomics; Metabolome; Lipidomics; Alzheimer's disease; Gut microbiome; Gut-liver-brain axis; Atlas for Alzheimer; Genetic variants; Immunity; Inflammation
MeSH headings : Aged; Alzheimer Disease / microbiology; Alzheimer Disease / physiopathology; Bile Acids and Salts / blood; Bile Acids and Salts / metabolism; Cognitive Dysfunction / metabolism; Dysbiosis; Female; Gastrointestinal Microbiome; Humans; Liver / metabolism; Male; Metabolome
Source: Crossref
Added: February 21, 2020
2019 article
Bile acids targeted metabolomics and medication classification data in the ADNI1 and ADNIGO/2 cohorts
St John-Williams, L., Mahmoudiandehkordi, S., Arnold, M., Massaro, T., Blach, C., Kastenmueller, G., … Kaddurah-Daouk, R. (2019, October 17). SCIENTIFIC DATA, Vol. 6.
MeSH headings : Aged; Aged, 80 and over; Alzheimer Disease / metabolism; Bile Acids and Salts / blood; Disease Progression; Female; Humans; Male; Metabolomics
Source: Web Of Science
Added: November 11, 2019
2019 journal article
Cheminformatics approach to exploring and modeling trait-associated metabolite profiles
JOURNAL OF CHEMINFORMATICS, 11.
author keywords: Metabolomics; Data mining; Cheminformatics; Molecular fragmentation; Statistics; Visualization; Chemical structure
Source: Web Of Science
Added: July 15, 2019
2019 journal article
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
NATURE COMMUNICATIONS, 10.
MeSH headings : ADAM17 Protein / antagonists & inhibitors; Antineoplastic Combined Chemotherapy Protocols / pharmacology; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Benchmarking; Biomarkers, Tumor / genetics; Cell Line, Tumor; Computational Biology / methods; Computational Biology / standards; Datasets as Topic; Drug Antagonism; Drug Resistance, Neoplasm / drug effects; Drug Resistance, Neoplasm / genetics; Drug Synergism; Genomics / methods; Humans; Molecular Targeted Therapy / methods; Mutation; Neoplasms / drug therapy; Neoplasms / genetics; Pharmacogenetics / methods; Pharmacogenetics / standards; Phosphatidylinositol 3-Kinases / genetics; Phosphoinositide-3 Kinase Inhibitors; Treatment Outcome
Source: Web Of Science
Added: July 1, 2019
2019 journal article
Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking
EPIGENOMICS, 11(13), 1487–1500.
author keywords: cigarette smoking; epigenetics; infant; maternal exposure; methylation
MeSH headings : Adult; Cohort Studies; CpG Islands; DNA Methylation; Epigenesis, Genetic; Epigenomics / methods; Female; Humans; Infant, Newborn; Maternal Exposure / adverse effects; Pregnancy; Prenatal Exposure Delayed Effects / epidemiology; Prenatal Exposure Delayed Effects / genetics; Tobacco Smoking / epidemiology; Tobacco Smoking / genetics
Source: Web Of Science
Added: December 9, 2019
2019 journal article
Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex
CHROMOSOME RESEARCH, 27(3), 179–202.
author keywords: Histiocytic sarcoma; Chromothripsis; MMP9; Aurora kinase; Dendritic cell sarcoma
MeSH headings : Animals; Chromosome Disorders; DNA Copy Number Variations / genetics; Dog Diseases / diagnosis; Dog Diseases / genetics; Dogs; Gene Expression Profiling; Genome / genetics; Histiocytic Disorders, Malignant / diagnosis; Histiocytic Disorders, Malignant / genetics; Histiocytic Disorders, Malignant / veterinary; Humans; Immunohistochemistry / methods; Matrix Metalloproteinase 9 / metabolism; Spindle Apparatus / pathology
Source: Web Of Science
Added: September 30, 2019
2019 journal article
Identifying individual risk rare variants using protein structure guided local tests (POINT)
PLOS COMPUTATIONAL BIOLOGY, 15(2).
MeSH headings : Angiopoietin-Like Protein 4 / genetics; Cholesterol Ester Transfer Proteins / genetics; Computational Biology / methods; Computer Simulation; Genetic Association Studies / methods; Genetic Predisposition to Disease / genetics; Genetic Variation / genetics; Humans; Models, Genetic; Proprotein Convertase 9 / genetics; Protein Structure, Tertiary; Risk Factors; Sequence Analysis, DNA / methods
Source: Web Of Science
Added: March 25, 2019
2019 journal article
Long-term incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy
JOURNAL OF VETERINARY INTERNAL MEDICINE, 33(6), 2572–2586.
author keywords: cancer; chronic kidney disease; epidemiology; mortality; survival
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / mortality; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / mortality; Cats; Female; Incidence; Male; Retrospective Studies; Risk Factors
Source: Web Of Science
Added: October 28, 2019
2019 journal article
Synergistic Chemotherapy Drug Response Is a Genetic Trait in Lymphoblastoid Cell Lines
FRONTIERS IN GENETICS, 10.
author keywords: synergy; heritability; chemotherapy; lymphoblastoid cell lines; linkage mapping
Sources: Web Of Science, ORCID
Added: December 2, 2019
2019 article
Untargeted Metabolomic Profiling Identifies Disease-Specific Pathways in Food Allergy and Asthma
Crestani, E., Leirer, J., Motsinger-Reif, A., Phipatanakul, W., Kaddurah-Daouk, R., & Chatila, T. A. (2019, February). JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol. 143, pp. AB255–AB255.
Source: Web Of Science
Added: February 25, 2019
2018 journal article
Gene expression and linkage analysis implicate as a mediator of rituximab resistance
PHARMACOGENOMICS JOURNAL, 18(3), 467–473.
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Antibodies, Monoclonal / administration & dosage; Antibodies, Monoclonal / adverse effects; Antibodies, Monoclonal / genetics; Antigens, CD20 / drug effects; Antigens, CD20 / immunology; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm / drug effects; Drug Resistance, Neoplasm / genetics; Female; Gene Expression Regulation, Neoplastic / drug effects; Genetic Linkage; Genome, Human / genetics; Humans; Leukemia, Lymphocytic, Chronic, B-Cell / complications; Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell / genetics; Male; Proto-Oncogene Proteins c-cbl / genetics; Rituximab / administration & dosage; Rituximab / adverse effects
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Gene set analysis methods: A systematic comparison
Biodata Mining, 11.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Genetic Tools for Coronary Risk Assessment in Type 2 Diabetes: A Cohort Study From the ACCORD Clinical Trial
DIABETES CARE, 41(11), 2404–2413.
MeSH headings : Aged; Cohort Studies; Coronary Artery Disease / diagnosis; Coronary Artery Disease / genetics; Coronary Artery Disease / prevention & control; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / diagnosis; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / genetics; Diabetic Angiopathies / diagnosis; Diabetic Angiopathies / genetics; Diabetic Angiopathies / prevention & control; Female; Fenofibrate / administration & dosage; Genetic Association Studies; Genetic Markers; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Molecular Diagnostic Techniques; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Simvastatin / administration & dosage
Source: Web Of Science
Added: November 5, 2018
2018 journal article
Genetic variants in CPA6 and PRPF31 are associated with variation in response to metformin in individuals with type 2 diabetes
Diabetes, 67(7), 1428–1440.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
International collaborative study to assess cardiovascular risk and evaluate long-term health in cats with preclinical hypertrophic cardiomyopathy and apparently healthy cats: The REVEAL Study
Journal of Veterinary Internal Medicine, 32(3), 930–943.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Modulation of GLP-1 Levels by a Genetic Variant That Regulates the Cardiovascular Effects of Intensive Glycemic Control in ACCORD
DIABETES CARE, 41(2), 348–355.
MeSH headings : Aged; Blood Glucose / genetics; Blood Glucose / metabolism; Diabetes Mellitus, Type 2 / blood; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / genetics; Diabetic Angiopathies / blood; Diabetic Angiopathies / genetics; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Glucagon-Like Peptide 1 / blood; Humans; Hypoglycemic Agents / therapeutic use; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Pharmacogenetic Analysis of the Model-Based Pharmacokinetics of Five Anti-HIV Drugs: How Does This Influence the Effect of Aging?
CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 11(2), 226–236.
MeSH headings : ATP Binding Cassette Transporter, Subfamily B / genetics; Adult; Age Factors; Aged; Aging / genetics; Anti-HIV Agents / administration & dosage; Anti-HIV Agents / pharmacokinetics; Anti-HIV Agents / therapeutic use; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; Cytochrome P-450 CYP2B6 / genetics; Drug Combinations; Drug Therapy, Combination / methods; Female; Frail Elderly; HIV Infections / drug therapy; HIV Infections / genetics; Humans; Male; Middle Aged; Multidrug Resistance-Associated Proteins / genetics; Pharmacogenomic Testing / methods; Prospective Studies; Young Adult
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 7(8), 525–533.
MeSH headings : Adult; Central Nervous System Stimulants / pharmacokinetics; Female; Humans; Male; Methylphenidate / pharmacokinetics; Prospective Studies; Young Adult
Source: NC State University Libraries
Added: October 16, 2018
2018 journal article
Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 7(1).
author keywords: blood pressure; lipid metabolites; metabolomics; pharmacogenetics; thiazide diuretics
MeSH headings : Adult; Blood Pressure; Female; Genomics; Humans; Hydrochlorothiazide / therapeutic use; Hypertension / drug therapy; Lipid Metabolism; Male; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Nitriles; Pharmacogenetics; Prognosis; Serine C-Palmitoyltransferase / genetics; Siloxanes; Sodium Chloride Symporter Inhibitors / therapeutic use; Sphingolipids / metabolism; Treatment Outcome
Source: Web Of Science
Added: August 6, 2018
2018 journal article
The influence of Neanderthal alleles on cytotoxic response
PEERJ, 6.
author keywords: Neanderthal alleles; Cytotoxic response; Pharmacogenomics; Toxicogenomics; Dose responses; Neanderthal ancestry; Lymphoblastoid cell lines; Anti-cancer drugs; Environmental chemicals; Single nucleotide polymorphisms
Source: Web Of Science
Added: November 5, 2018
2017 review
An introduction to terminology and methodology of chemical synergy-perspectives from across disciplines
[Review of ]. Frontiers in Pharmacology, 8.
Source: NC State University Libraries
Added: August 6, 2018
2017 article
Assessment of potential miRNA biomarkers of VERO-cell tumorigenicity in a new line (AGMK1-9T7) of African green monkey kidney cells
Teferedegne, B., Rotroff, D. M., Macauley, J., Foseh, G., Lewis, G., Motsinger-Rief, A., & Lewis, A. M., Jr. (2017, October 4). VACCINE, Vol. 35, pp. 5503–5509.
author keywords: African green monkey kidney (AGMK1-9T7) cells; Neoplastic development; Immortalization, transformation; Tumorigenic phenotype microRNA
MeSH headings : Animals; Biomarkers / metabolism; Carcinogenesis / genetics; Carcinogenesis / pathology; Cell Line; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / pathology; Chlorocebus aethiops; Female; Humans; Kidney / pathology; Mice, Nude; MicroRNAs / genetics; Neoplasms / genetics; Neoplasms / pathology; Vero Cells / pathology
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Association of breed and histopathological grade in canine mast cell tumours
VETERINARY AND COMPARATIVE ONCOLOGY, 15(3), 829–839.
author keywords: Boxer; dog; epidemiology; genetics; MCT; Pug
MeSH headings : Age Factors; Animals; Dog Diseases / etiology; Dog Diseases / pathology; Dogs; Female; Male; Mastocytosis, Cutaneous / etiology; Mastocytosis, Cutaneous / pathology; Mastocytosis, Cutaneous / veterinary; Retrospective Studies; Risk Factors; Sex Factors; Skin Neoplasms / etiology; Skin Neoplasms / pathology; Skin Neoplasms / veterinary; Species Specificity
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Common and rare genetic markers of lipid variation in subjects with type 2 diabetes from the ACCORD clinical trial
PeerJ, 5.
Source: NC State University Libraries
Added: August 6, 2018
2017 article
Common genetic variants in neurobeachin (nbea) are associated with metformin drug response in individuals with type 2 diabetes in the accord clinical trial
Clinical Pharmacology & Therapeutics, Vol. 101, pp. S9–9.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Data descriptor: Targeted metabolomics and medication classification data from participants in the ADNI1 cohort
Scientific Data, 4.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
GUT DERIVED BILE ACID METABOLITES CORRELATE WITH STRUCTURAL AND FUNCTIONAL NEUROIMAGING MEASURES IN ALZHEIMER’S DISEASE
Alzheimer's & Dementia, 13(7), P543–P544.
Source: Crossref
Added: February 21, 2020
2017 journal article
Genetic Variants in HSD17B3 , SMAD3 , and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes
Clinical Pharmacology & Therapeutics, 103(4), 712–721.
MeSH headings : Aldehyde Reductase / genetics; Animals; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / genetics; Diabetes Mellitus, Type 2 / metabolism; Dyslipidemias / blood; Dyslipidemias / complications; Dyslipidemias / drug therapy; Dyslipidemias / genetics; Female; Fenofibrate / administration & dosage; Fenofibrate / pharmacokinetics; Gene Expression Profiling / methods; Genome-Wide Association Study; Humans; Hypolipidemic Agents / administration & dosage; Hypolipidemic Agents / pharmacokinetics; Lipid Metabolism / drug effects; Lipid Metabolism / genetics; Male; Mice; Middle Aged; Pharmacogenomic Testing / methods; Signal Transduction / drug effects; Smad3 Protein / genetics; beta Karyopherins / genetics
Source: Crossref
Added: February 21, 2020
2017 journal article
Metabolic network failures in Alzheimer's disease: A biochemical road map
Alzheimers & Dementia, 13(9), 965–984.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Metabolic network failures in Alzheimer's disease: A biochemical road map
Alzheimer's & Dementia, 13(9), 965–984.
author keywords: Metabolomics; Metabonomics; Pharmacometabolomics; Pharmacometabonomics; Biomarkers; Serum; Metabolism; Systems biology; Biochemical networks; Precision medicine; Alzheimer's disease; Dementia; Branched-chain amino acids; Sphingomyelins; Phospholipids; Acylcarnitines
MeSH headings : Aged; Aged, 80 and over; Aging / blood; Alzheimer Disease / blood; Alzheimer Disease / cerebrospinal fluid; Alzheimer Disease / complications; Alzheimer Disease / diagnostic imaging; Amino Acids / blood; Amyloid beta-Peptides / metabolism; Aniline Compounds / metabolism; Cognitive Dysfunction / blood; Cognitive Dysfunction / diagnostic imaging; Cognitive Dysfunction / etiology; Cohort Studies; Cross-Sectional Studies; Fasting; Female; Humans; Male; Metabolic Diseases / blood; Metabolic Diseases / cerebrospinal fluid; Metabolic Diseases / diagnostic imaging; Metabolic Diseases / etiology; Metabolic Networks and Pathways / physiology; Metabolomics / methods; Peptide Fragments / metabolism; Phosphatidylcholines / blood; Phosphatidylcholines / metabolism; Sphingomyelins / blood; Thiazoles / metabolism; tau Proteins / cerebrospinal fluid
Source: Crossref
Added: February 21, 2020
2017 journal article
Targeted metabolomics and medication classification data from participants in the ADNI1 cohort
Scientific Data, 4(1).
MeSH headings : Alzheimer Disease / drug therapy; Alzheimer Disease / genetics; Alzheimer Disease / metabolism; Cognitive Dysfunction; Cohort Studies; Humans; Metabolomics; Neuroimaging
Source: Crossref
Added: February 21, 2020
2017 journal article
The Effect of Heart Disease on Anesthetic Complications During Routine Dental Procedures in Dogs
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 53(4), 206–213.
MeSH headings : Anesthesia / adverse effects; Anesthesia / veterinary; Animals; Case-Control Studies; Dental Prophylaxis / veterinary; Dog Diseases / etiology; Dogs; Heart Diseases / complications; Heart Diseases / veterinary; Intraoperative Complications / etiology; Intraoperative Complications / veterinary; Retrospective Studies; Risk Factors
Source: Web Of Science
Added: August 6, 2018
2017 journal article
The steroid metabolome in women with premenstrual dysphoric disorder during GnRH agonist-induced ovarian suppression: effects of estradiol and progesterone addback
Translational Psychiatry, 7(8), e1193–e1193.
MeSH headings : Adult; Cross-Over Studies; Desoxycorticosterone / blood; Estradiol / analogs & derivatives; Estradiol / blood; Estradiol / pharmacology; Estrone / blood; Female; Humans; Leuprolide / pharmacology; Metabolome / drug effects; Middle Aged; Pregnanediol / blood; Pregnanolone / blood; Premenstrual Dysphoric Disorder / metabolism; Progesterone / pharmacology; Young Adult
Sources: Crossref, NC State University Libraries
Added: August 6, 2018
2017 journal article
Thromboelastographic monitoring of the effect of unfractionated heparin in healthy dogs
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 27(1), 71–81.
author keywords: anticoagulation monitoring; anti-Xa; canine; RapidTEG; thrombosis
MeSH headings : Animals; Anticoagulants / administration & dosage; Anticoagulants / pharmacology; Blood Coagulation / drug effects; Dogs; Female; Heparin / administration & dosage; Heparin / pharmacology; Injections, Subcutaneous / veterinary; Male; Partial Thromboplastin Time / veterinary; Prospective Studies; Reference Values; Thrombelastography / veterinary
Source: Web Of Science
Added: August 6, 2018
2016 journal article
A European spectrum of pharmacogenomic biomarkers: Implications for clinical pharmacogenomics
PLoS One, 11(9).
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
A comparison of DMET Plus microarray and genome-wide technologies by assessing population substructure
PHARMACOGENETICS AND GENOMICS, 26(4), 147–153.
author keywords: admixture; Affymetrix; cryptic relatedness; DMET Plus; inbreeding coefficients; metabolism; pharmacogenomics; population stratification; principal component analysis; transporters
Source: Web Of Science
Added: August 6, 2018
2016 journal article
A genetic response score for hydrochlorothiazide use insights from genomics and metabolomics integration
Hypertension, 68(3), 621-.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
A genome-wide study of lipid response to fenofibrate in Caucasians: A combined analysis of the GOLDN and ACCORD studies
Pharmacogenetics and Genomics, 26(7), 324–333.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial
PHARMACOGENOMICS JOURNAL, 16(3), 243–248.
MeSH headings : Adenosine Triphosphatases / genetics; Antineoplastic Combined Chemotherapy Protocols / adverse effects; Carboplatin / adverse effects; Cation Transport Proteins / genetics; Copper-Transporting ATPases; Docetaxel; Female; Gastrointestinal Diseases / chemically induced; Gastrointestinal Diseases / diagnosis; Gastrointestinal Diseases / genetics; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Kaplan-Meier Estimate; NAV1.8 Voltage-Gated Sodium Channel / genetics; Ovarian Neoplasms / drug therapy; Ovarian Neoplasms / mortality; Pharmacogenetics; Pharmacogenomic Variants / genetics; Phenotype; Polymorphism, Single Nucleotide; Proportional Hazards Models; Risk Factors; Scotland; Severity of Illness Index; Taxoids / adverse effects; Time Factors; Treatment Outcome; Vascular Endothelial Growth Factor A / genetics
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Comprehensive genomic characterization of five canine lymphoid tumor cell lines
BMC Veterinary Research, 12.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Eigenvector metabolite analysis reveals dietary effects on the association among metabolite correlation patterns, gene expression, and phenotypes
METABOLOMICS, 12(11).
author keywords: Eigenvector metabolite analysis; Linkage analyses; Environment; Enrichment analyses
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 review
Embracing integrative multiomics approaches
[Review of ]. International Journal of Genomics.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
GENETIC INFLUENCE ON LEVELS OF TARGETED METABOLITES ASSOCIATED WITH ALZHEIMER’S DISEASE
Alzheimer's & Dementia, 12(7), P164–P165.
Source: Crossref
Added: August 28, 2020
2016 journal article
Genetic predictors of cardiovascular mortality during intensive glycemic control in type 2 diabetes: Findings from the ACCORD clinical trial
Diabetes Care, 39(11), 1915–1924.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Genome-wide association study in immunocompetent patients with delayed hypersensitivity to sulfonamide antimicrobials
PLoS One, 11(6).
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
INDICES OF PLASMALOGEN BIOSYNTHESIS IN ADNI-1 BASELINE SERUM SAMPLES: ASSOCIATION WITH PROGRESSION TO DEMENTIA IN SUBJECTS WITH MILD COGNITIVE IMPAIRMENT
Alzheimer's & Dementia, 12(7), P879–P880.
Source: Crossref
Added: February 24, 2020
2016 journal article
Incorporating concomitant medications into genome-wide analyses for the study of complex disease and drug response
Frontiers in Genetics, 7.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero
BMC Genomics, 17.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants
Translational Psychiatry, 6(9), e894–e894.
MeSH headings : Adult; Arginine / metabolism; Citrulline / metabolism; Depressive Disorder, Major / drug therapy; Depressive Disorder, Major / metabolism; Depressive Disorder, Treatment-Resistant / drug therapy; Depressive Disorder, Treatment-Resistant / metabolism; Excitatory Amino Acid Antagonists / therapeutic use; Female; Glutamic Acid / metabolism; Humans; Indoleacetic Acids / metabolism; Infusions, Intravenous; Ketamine / therapeutic use; Male; Metabolomics; Methionine / metabolism; Middle Aged; Ornithine / metabolism; Phenotype; Phospholipids / metabolism; Tryptophan / metabolism; Urea / metabolism
Sources: Crossref, NC State University Libraries
Added: August 6, 2018
2016 journal article
Pharmacometabolomic assessment of metformin in non-diabetic, African Americans
Frontiers in Pharmacology, 7.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
THE ALZHEIMER’S METABOLOME: RELATIONSHIP TO PATHOLOGICAL MARKERS AND COGNITIVE DECLINE IN THE ALZHEIMER’S DISEASE NEUROIMAGING INITIATIVE (ADNI)
Alzheimer's & Dementia, 12(7), P164.
Source: Crossref
Added: August 28, 2020
2016 journal article
Use of RNA-seq to identify cardiac genes and gene pathways differentially expressed between dogs with and without dilated cardiomyopathy
AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(7), 693–699.
MeSH headings : Animals; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / metabolism; Cardiomyopathy, Dilated / veterinary; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Down-Regulation; Female; Gene Expression; Heart Ventricles; Male; Myocardium / metabolism; RNA / genetics; Up-Regulation
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
Nature Genetics, 48(9), 1055–1059.
MeSH headings : Blood Glucose / analysis; Body Mass Index; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / genetics; Genome-Wide Association Study; Glucose Transporter Type 2 / genetics; Glycated Hemoglobin / analysis; Humans; Hypoglycemic Agents / therapeutic use; Metformin / therapeutic use; Polymorphism, Single Nucleotide / genetics; Quantitative Trait, Heritable; White People
Source: Crossref
Added: February 24, 2020
2016 journal article
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
Nature Genetics, 48(9), 1055-.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
alpha-Hydroxybutyric Acid Is a Selective Metabolite Biomarker of Impaired Glucose Tolerance
DIABETES CARE, 39(6), 988–995.
MeSH headings : Adult; Biomarkers / metabolism; Blood Glucose / metabolism; Cohort Studies; Fasting; Female; Glucose Intolerance / metabolism; Glucose Tolerance Test; Humans; Hydroxybutyrates / metabolism; Male; Metabolomics; Middle Aged; Multivariate Analysis; Oleic Acid / metabolism; Prediabetic State / metabolism; Prospective Studies
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Accuracy of SNPs to predict risk of HLA alleles associated with drug-induced hypersensitivity events across racial groups
PHARMACOGENOMICS, 16(8), 817–824.
author keywords: drug-induced hypersensitivity; HLA; human leukocyte antigen; pharmacogenetics; pharmacogenomics; risk mitigation
MeSH headings : Black or African American / genetics; Alleles; Asian People / genetics; Drug Hypersensitivity / genetics; Drug Hypersensitivity / pathology; Genotype; HLA-B Antigens / genetics; HLA-DQ alpha-Chains / genetics; Hispanic or Latino / genetics; Humans; Polymorphism, Single Nucleotide / genetics; White People
Source: Web Of Science
Added: August 6, 2018
2015 journal article
An investigation of gene-gene interactions in dose-response studies with Bayesian nonparametrics
Biodata Mining, 8.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Canine urothelial carcinoma: genomically aberrant and comparatively relevant
Chromosome Research, 23(2), 311–331.
author keywords: Canine; Urothelial carcinoma; Transitional cell carcinoma; Cytogenetics; Chromosome aberration; Array comparative genomic hybridization; Comparative oncology
MeSH headings : Animals; Biopsy; Carcinoma / veterinary; Chromosome Aberrations; Comparative Genomic Hybridization; Computational Biology / methods; DNA Copy Number Variations; Dogs; Female; Genetic Loci; Genomics / methods; Humans; In Situ Hybridization, Fluorescence; Male; Urologic Neoplasms / veterinary
Sources: Web Of Science, Crossref
Added: August 6, 2018
2015 journal article
Comparative cytogenetic characterization of primary canine melanocytic lesions using array CGH and fluorescence in situ hybridization
CHROMOSOME RESEARCH, 23(2), 171–186.
author keywords: Canine; Oral melanoma; Cytogenetics; Array; Comparative genomic hybridization
MeSH headings : Animals; Chromosome Aberrations; Cluster Analysis; Comparative Genomic Hybridization; Computational Biology; DNA Copy Number Variations; Dogs; Female; Humans; In Situ Hybridization, Fluorescence; Male; Melanoma / genetics; Melanoma / metabolism; Melanoma / pathology; Mouth Neoplasms / genetics; Mouth Neoplasms / pathology; Penetrance; Skin Neoplasms
Sources: Web Of Science, ORCID
Added: August 6, 2018
2015 journal article
Evaluating the role of admixture in cancer therapy via in vitro drug response and multivariate genome-wide associations
PHARMACOGENOMICS, 16(13), 1451–1463.
author keywords: admixture; cancer; Caucasian; cytotoxicity; drug; genome-wide association study; GWAS; hispanic; in vitro; lymphoblastoid cell lines
MeSH headings : Black or African American; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cell Line, Tumor; Cohort Studies; Ethnicity; Genetic Variation; Genome-Wide Association Study; Hispanic or Latino; Humans; Multivariate Analysis; Neoplasms / drug therapy; Neoplasms / genetics; Pharmacogenetics; Treatment Outcome; White People
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Genome-wide assessment of recurrent genomic imbalances in canine leukemia identifies evolutionarily conserved regions for subtype differentiation
Chromosome Research, 23(4), 681–708.
author keywords: Leukemia; Canine; Chromosome; Comparative genomic hybridization; Comparative genomics
MeSH headings : Algorithms; Animals; Cell Transformation, Neoplastic / genetics; Chromosome Aberrations; Chromosome Mapping; Cluster Analysis; Comparative Genomic Hybridization; Conserved Sequence; DNA Copy Number Variations; Disease Models, Animal; Dogs; Evolution, Molecular; Female; Gene Dosage; Genome-Wide Association Study; Genomic Library; Genomics; Humans; In Situ Hybridization, Fluorescence; Leukemia / diagnosis; Leukemia / genetics; Leukemia / metabolism; Male
Sources: Web Of Science, Crossref
Added: August 6, 2018
2015 journal article
Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain
PeerJ, 3.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Pharmacometabolomic Assessments of Atenolol and Hydrochlorothiazide Treatment Reveal Novel Drug Response Phenotypes
CPT: Pharmacometrics & Systems Pharmacology, 4(11), 669–679.
Source: Crossref
Added: February 24, 2020
2015 journal article
Population-Based in Vitro Hazard and Concentration-Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study
ENVIRONMENTAL HEALTH PERSPECTIVES, 123(5), 458–466.
MeSH headings : Cell Line, Tumor; Genome-Wide Association Study / methods; Genotype; Humans; Risk Assessment; Toxicity Tests / methods
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Relative Quantification and Higher-Order Modeling of the Plasma Glycan Cancer Burden Ratio in Ovarian Cancer Case-Control Samples
JOURNAL OF PROTEOME RESEARCH, 14(10), 4394–4401.
author keywords: N-linked glycosylation; INLIGHT; ovarian cancer; relative quantification; cancer biomarker; human plasma
MeSH headings : Biomarkers, Tumor / blood; Carbohydrate Sequence; Case-Control Studies; Chromatography, Liquid / methods; Female; Fucose / blood; Glycosylation; Humans; Hydrazines / chemistry; Molecular Sequence Data; Neoplasm Staging; Ovarian Neoplasms / blood; Ovarian Neoplasms / diagnosis; Ovarian Neoplasms / pathology; Polysaccharides / blood; Sialic Acids / blood; Staining and Labeling / methods; Tandem Mass Spectrometry / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
A novel canine model of immune thrombocytopenia: has immune thrombocytopenia (ITP) gone to the dogs?
British Journal of Haematology, 167(1), 110–120.
author keywords: immune thrombocytopenia; canine; interleukin-8; animal model
MeSH headings : Animals; Antibodies, Monoclonal / administration & dosage; Antibodies, Monoclonal / adverse effects; Antibodies, Monoclonal / immunology; Blood Platelets / immunology; Blood Platelets / metabolism; Cytokines / blood; Cytokines / metabolism; Disease Models, Animal; Dogs; Hemorrhage / immunology; Phenotype; Platelet Count; Purpura, Thrombocytopenic, Idiopathic / blood; Purpura, Thrombocytopenic, Idiopathic / diagnosis; Purpura, Thrombocytopenic, Idiopathic / immunology
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2014 journal article
An adaptive permutation approach for genome-wide association study: Evaluation and recommendations for use
Biodata Mining, 7.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Bayesian neural networks for detecting epistasis in genetic association studies
BMC Bioinformatics, 15.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Canine hereditary ataxia in Old English Sheepdogs and Gordon Setters is associated with a defect in the autophagy gene encoding RAB24
PLoS Genetics, 10(2).
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Evaluation of thromboelastography for prediction of clinical bleeding in thrombocytopenic dogs after total body irradiation and hematopoietic cell transplantation
AMERICAN JOURNAL OF VETERINARY RESEARCH, 75(5), 425–432.
MeSH headings : Animals; Bone Marrow Transplantation / veterinary; Cohort Studies; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dogs; Hemorrhage / diagnosis; Hemorrhage / physiopathology; Hemorrhage / veterinary; Hemostasis / physiology; Kaolin; Lymphoma / physiopathology; Lymphoma / veterinary; Male; Platelet Count / veterinary; Prospective Studies; Thrombelastography / methods; Thrombelastography / veterinary; Thrombocytopenia / physiopathology; Thrombocytopenia / veterinary; Whole-Body Irradiation / veterinary
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Genetic heterogeneity beyond CYP2C8*3 does not explain differential sensitivity to paclitaxel-induced neuropathy
BREAST CANCER RESEARCH AND TREATMENT, 145(1), 245–254.
author keywords: Paclitaxel; Pharmacogenetics; Breast cancer; Chemotherapy-induced peripheral neuropathy; ABCG1; Affymetrix DMET (TM) plus; CYP2C8; Race
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines
PHARMACOGENOMICS, 15(2), 137–146.
author keywords: chemotherapeutics; genome-wide association study; lymphoblastoid cell lines
MeSH headings : Antineoplastic Agents / administration & dosage; Biomarkers, Pharmacological / metabolism; Cell Line, Tumor; Chromosome Mapping; Genome-Wide Association Study; Genotype; Histone Deacetylases / genetics; Humans; Pharmacogenetics; Repressor Proteins / genetics
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma
CHROMOSOME RESEARCH, 22(3), 305–319.
author keywords: canine; chromosome; hemangiosarcoma; comparative genomic hybridization (CGH)
MeSH headings : Animals; Breeding; Comparative Genomic Hybridization; DNA Copy Number Variations / genetics; Dog Diseases / genetics; Dogs; Gene Amplification; Gene Expression Profiling; Genetic Heterogeneity; Genome; Hemangiosarcoma / genetics; Hemangiosarcoma / veterinary; Penetrance; Vascular Endothelial Growth Factor A / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Lymphoblastoid Cell Lines Models of Drug Response: Successes and Lessons from this Pharmacogenomic Model
CURRENT MOLECULAR MEDICINE, 14(7), 833–840.
author keywords: Cytotoxics; genetic association mapping; genome wide association analysis; lymphoplastoid cell lines; pharmacogenomics
MeSH headings : Cell Line, Transformed; Cost-Benefit Analysis; Genome-Wide Association Study / economics; Genome-Wide Association Study / methods; Humans; Lymphocytes / drug effects; Lymphocytes / metabolism; Models, Biological; Models, Genetic; Pharmacogenetics / economics; Pharmacogenetics / methods; Polymorphism, Single Nucleotide; RNA Interference; Reproducibility of Results; Translational Research, Biomedical / economics; Translational Research, Biomedical / methods
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013
Equine Veterinary Journal, 47(3), 279–284.
author keywords: horse; large colon volvulus; strangulation; pelvic flexure; surgery
MeSH headings : Animals; Biopsy; Colon / pathology; Hemorrhage / pathology; Hemorrhage / veterinary; Horse Diseases / surgery; Horses; Intestinal Volvulus / pathology; Intestinal Volvulus / surgery; Intestinal Volvulus / veterinary; Logistic Models; Retrospective Studies
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2014 journal article
PGxClean: a quality control GUI for the Affymetrix DMET chip and other candidate gene studies with non-biallelic alleles
Biodata Mining, 7.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Positive association between a glutathione-S-transferase polymorphism and lymphoma in dogs
VETERINARY AND COMPARATIVE ONCOLOGY, 12(3), 227–236.
author keywords: cancer risk; canine; carcinogens; glutathione; lymphosarcoma; polymorphisms
MeSH headings : Animals; Case-Control Studies; Dog Diseases / enzymology; Dog Diseases / genetics; Dogs; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genotype; Glutathione Transferase / genetics; Glutathione Transferase / metabolism; Lymphoma / enzymology; Lymphoma / genetics; Lymphoma / veterinary; Point Mutation; Polymorphism, Genetic
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Prevalence of onychectomy in cats presented for veterinary care near Raleigh, NC and educational attitudes toward the procedure
Veterinary Anaesthesia and Analgesia, 41(1), 48–53.
author keywords: cat; declaw; education; onychectomy; pain; sterilization
MeSH headings : Animals; Cats / surgery; Education, Veterinary; Female; Hoof and Claw / surgery; Male; North Carolina; Surgical Procedures, Operative / education; Surgical Procedures, Operative / veterinary
Sources: Web Of Science, Crossref
Added: August 6, 2018
2014 journal article
Relationship Between Mechanical Thresholds and Limb Use in Dogs With Coxofemoral Joint OA-Associated Pain and the Modulating Effects of Pain Alleviation From Total Hip Replacement on Mechanical Thresholds
VETERINARY SURGERY, 43(5), 542–548.
MeSH headings : Animals; Arthroplasty, Replacement, Hip / veterinary; Coccyx; Dog Diseases / physiopathology; Dog Diseases / surgery; Dogs; Female; Femur; Gait; Hip Joint / physiopathology; Joint Instability / physiopathology; Joint Instability / veterinary; Male; Pain Measurement / veterinary; Prospective Studies; Recovery of Function
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Single-Nucleotide Polymorphism Data Support the General Unrelatedness of the Males in the Agricultural Health Study
Cancer Epidemiology Biomarkers & Prevention, 23(10), 2192–2195.
MeSH headings : Agriculture; Case-Control Studies; Cohort Studies; Consanguinity; Gene-Environment Interaction; Humans; Male; Occupational Exposure; Polymorphism, Single Nucleotide; Principal Component Analysis; Research Design
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2014 journal article
VH1-44 gene usage defines a subset of canine B-cell lymphomas associated with better patient survival
Veterinary Immunology and Immunopathology, 157(3-4), 125–130.
author keywords: Immunoglobulin heavy chain variable region (VH); B-cell lymphoma; Diffuse large B-cell lymphoma; Survival; VH1-44
MeSH headings : Animals; Dog Diseases / genetics; Dog Diseases / immunology; Dog Diseases / mortality; Dogs / immunology; Humans; Immunoglobulin Heavy Chains / genetics; Immunoglobulin Variable Region / genetics; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / immunology; Lymphoma, B-Cell / mortality; Lymphoma, B-Cell / veterinary
Sources: Web Of Science, Crossref
Added: August 6, 2018
2013 journal article
Alfaxalone anesthesia in bullfrogs (Lithobates catesbeiana) by injection or immersion
Journal of Zoo and Wildlife Medicine, 44(4), 965–971.
author keywords: Alfaxalone; Alfaxan (R); anesthesia; bullfrogs; immersion; intramuscular
MeSH headings : Anesthetics / administration & dosage; Anesthetics / pharmacology; Animals; Drug Administration Routes; Pregnanediones / administration & dosage; Pregnanediones / pharmacology; Rana catesbeiana
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2013 journal article
Alterations in metabolic pathways and networks in Alzheimer’s disease
Translational Psychiatry, 3(4), e244–e244.
author keywords: Alzheimer's disease; metabolomics; partial network reconstruction; pathway analysis
MeSH headings : Aged; Aged, 80 and over; Alzheimer Disease / cerebrospinal fluid; Alzheimer Disease / metabolism; Biomarkers / cerebrospinal fluid; Case-Control Studies; Chromatography, Liquid; Cognitive Dysfunction / cerebrospinal fluid; Cognitive Dysfunction / metabolism; Female; Humans; Male; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Neuropsychological Tests; Prospective Studies
Sources: Crossref, NC State University Libraries
Added: August 6, 2018
2013 journal article
CYP2C8*3 increases risk of neuropathy in breast cancer patients treated with paclitaxel
ANNALS OF ONCOLOGY, 24(6), 1472–1478.
author keywords: chemotherapy-induced peripheral neuropathy; cytochrome P450 2C8*3; paclitaxel; pharmacogenetics; race
MeSH headings : Adult; Black or African American / genetics; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic / therapeutic use; Aryl Hydrocarbon Hydroxylases / genetics; Breast Neoplasms / drug therapy; Breast Neoplasms / enzymology; Breast Neoplasms / genetics; Cohort Studies; Cytochrome P-450 CYP2C8; Female; Genetic Variation / genetics; Humans; Middle Aged; Paclitaxel / adverse effects; Paraneoplastic Polyneuropathy / chemically induced; Paraneoplastic Polyneuropathy / enzymology; Paraneoplastic Polyneuropathy / genetics; Risk Factors; Treatment Outcome; White People / genetics; Young Adult
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Differentially expressed microRNAs and affected biological pathways revealed by modulated modularity clustering (MMC) analysis of human preeclamptic and IUGR placentas
Placenta, 34(7), 599–605.
author keywords: Placenta; Preeclampsia; IUGR; MiR-194; MiR-149
MeSH headings : Down-Regulation; Female; Fetal Growth Retardation / genetics; Fetal Growth Retardation / metabolism; Humans; MicroRNAs / biosynthesis; Placenta / metabolism; Pre-Eclampsia / genetics; Pre-Eclampsia / metabolism; Pregnancy; Transcriptome
Sources: Web Of Science, Crossref
Added: August 6, 2018
2013 journal article
Gene Profiling of Canine B-Cell Lymphoma Reveals Germinal Center and Postgerminal Center Subtypes with Different Survival Times, Modeling Human DLBCL
Cancer Research, 73(16), 5029–5039.
MeSH headings : Adolescent; Animals; Child; Child, Preschool; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Disease Models, Animal; Dogs; Female; Gene Expression Profiling / methods; Germinal Center / metabolism; Germinal Center / pathology; Humans; Immunoglobulin Heavy Chains / genetics; Immunoglobulin Heavy Chains / metabolism; Interferon Regulatory Factors / genetics; Interferon Regulatory Factors / metabolism; Lymph Nodes / metabolism; Lymph Nodes / pathology; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / metabolism; Lymphoma, B-Cell / pathology; Lymphoma, Large B-Cell, Diffuse / genetics; Lymphoma, Large B-Cell, Diffuse / metabolism; Lymphoma, Large B-Cell, Diffuse / pathology; Male; Mutation; NF-kappa B / genetics; NF-kappa B / metabolism; Proto-Oncogene Proteins c-bcl-6; Transcriptome
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2013 journal article
Gene selection and cancer type classification of diffuse large-B-cell lymphoma using a bivariate mixture model for two-species data
Human Genomics, 7.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Genome-wide association studies in pharmacogenomics: Successes and lessons
Pharmacogenetics and Genomics, 23(8), 383–394.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Interview A discussion on genome-wide associations in pharmacogenomics
Pharmacogenomics, 14(4), 361–363.
Source: NC State University Libraries
Added: August 6, 2018
2013 article
Naturally occuring canine cancers: powerful models for stimulating pharmacogenomic advancement in human medicine
Rotroff, D. M., Thomas, R., Breen, M., & Motsinger-Reif, A. A. (2013, December). PHARMACOGENOMICS, Vol. 14, pp. 1929–1931.
author keywords: cancer; canine model; chemotherapy; clinical trials
MeSH headings : Animals; Disease Models, Animal; Dogs; Humans; Neoplasms / drug therapy; Neoplasms / pathology; Pharmacogenetics / methods
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction
Biodata Mining, 6.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT
PHARMACOGENETICS AND GENOMICS, 22(11), 796–802.
author keywords: genome-wide association studies; lymphoblastoid cell lines; MGMT; pharmacogenetics; temozolomide
MeSH headings : Antineoplastic Agents, Alkylating / pharmacology; Cell Line, Tumor; DNA Methylation; DNA Modification Methylases / genetics; DNA Repair Enzymes / genetics; Dacarbazine / analogs & derivatives; Dacarbazine / pharmacology; Gene Expression Regulation, Neoplastic; Genome, Human; Genome-Wide Association Study; Humans; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology; Temozolomide; Tumor Suppressor Proteins / genetics
Source: Web Of Science
Added: August 6, 2018
2012 journal article
A predictive model for Efavirenz dosing
Pharmacogenomics, 13(2), 137–138.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Assessing the utility of whole genome amplified DNA as a template for DMET Plus array
Clinical Chemistry and Laboratory Medicine, 50(8), 1329–1334.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
CYP2C8*3 predicts benefit/risk profile in breast cancer patients receiving neoadjuvant paclitaxel
BREAST CANCER RESEARCH AND TREATMENT, 134(1), 401–410.
author keywords: Paclitaxel; CYP2C8*3; Pharmacogenetics; Neoadjuvant breast cancer therapy; Clinical complete response
MeSH headings : ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics; Adult; Aged; Antineoplastic Agents, Phytogenic / adverse effects; Antineoplastic Agents, Phytogenic / pharmacology; Antineoplastic Agents, Phytogenic / therapeutic use; Aryl Hydrocarbon Hydroxylases / genetics; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Breast Neoplasms / pathology; Chemotherapy, Adjuvant; Cytochrome P-450 CYP2C8; Female; Gene Frequency; Genetic Association Studies; Haplotypes; Humans; Middle Aged; Multivariate Analysis; Neoadjuvant Therapy; Paclitaxel / adverse effects; Paclitaxel / pharmacology; Paclitaxel / therapeutic use; Polymorphism, Single Nucleotide; Tumor Burden / drug effects
Source: Web Of Science
Added: August 6, 2018
2012 article
Comparison of venous sampling methods for thromboelastography in clinically normal dogs
Walker, J. M., Hanel, R. M., Hansen, B. D., & Motsinger-Reif, A. A. (2012, December). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 73, pp. 1864–1870.
MeSH headings : Animals; Blood Platelets / physiology; Dogs / blood; Male; Phlebotomy / methods; Phlebotomy / veterinary; Thrombelastography / methods; Thrombelastography / veterinary
Source: Web Of Science
Added: August 6, 2018
2012 article
Effects of acepromazine maleate on platelet function assessed by use of adenosine diphosphate activated- and arachidonic acid-activated modified thromboelastography in healthy dogs
Conner, B. J., Hanel, R. M., Hansen, B. D., Motsinger-Reif, A. A., Asakawa, M., & Swanson, C. R. (2012, May). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 73, pp. 595–601.
MeSH headings : Acepromazine / administration & dosage; Acepromazine / adverse effects; Adenosine Diphosphate / chemistry; Animals; Arachidonic Acid / chemistry; Blood Platelets / drug effects; Blood Platelets / physiology; Cross-Over Studies; Dogs / physiology; Female; Hemostasis / drug effects; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / adverse effects; Injections, Intravenous / veterinary; Thrombelastography / methods; Thrombelastography / veterinary
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Evaluation of Polymorphisms in the Sulfonamide Detoxification Genes CYB5A and CYB5R3 in Dogs with Sulfonamide Hypersensitivity
JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(5), 1126–1133.
author keywords: Genotype; Idiosyncratic; Potentiated sulfonamide; Predisposition
MeSH headings : Animals; Cytochrome-B(5) Reductase / genetics; Cytochrome-B(5) Reductase / immunology; Cytochromes b5 / genetics; Cytochromes b5 / immunology; Dog Diseases / genetics; Dog Diseases / immunology; Dogs; Drug Hypersensitivity / etiology; Drug Hypersensitivity / genetics; Drug Hypersensitivity / immunology; Drug Hypersensitivity / veterinary; Female; Genotype; Liver / enzymology; Liver / immunology; Male; Polymorphism, Genetic; RNA / chemistry; RNA / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Sulfonamides / adverse effects
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity
PHARMACOGENETICS AND GENOMICS, 22(10), 733–740.
author keywords: cytochrome b(5); drug hypersensitivity; hydroxylamine; N-acetyltransferase; potentiated sulfonamides; sulfamethoxazole
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Arylamine N-Acetyltransferase / genetics; Child; Child, Preschool; Cytochrome-B(5) Reductase / genetics; Cytochrome-B(5) Reductase / metabolism; Cytochromes b5 / genetics; Drug Hypersensitivity / genetics; Female; Gene Frequency; Genetic Association Studies; Humans; Inactivation, Metabolic / genetics; Infant; Male; Middle Aged; Polymorphism, Genetic; Sulfonamides / pharmacokinetics
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Loss of Power in Two-Stage Residual-Outcome Regression Analysis in Genetic Association Studies
Genetic Epidemiology, n/a-n/a.
author keywords: loss of power; two-stage regression; degrees of freedom
MeSH headings : Bias; Female; Genetic Association Studies; Humans; Male; Regression Analysis
Source: Crossref
Added: February 24, 2020
2012 personal communication
Loss of power in two-stage residual-outcome regression analysis in genetic association studies
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Multivariate methods and software for association mapping in dose-response genome-wide association studies
Biodata Mining, 5.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Twice-Daily Application of HIV Microbicides Alters the Vaginal Microbiota
MBIO, 3(6).
MeSH headings : Administration, Intravaginal; Adolescent; Adult; Anti-Infective Agents / administration & dosage; Biota; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; DNA, Ribosomal / chemistry; DNA, Ribosomal / genetics; Female; HIV Infections / prevention & control; Human Experimentation; Humans; Metagenome / drug effects; Middle Aged; Placebos / administration & dosage; RNA, Ribosomal, 16S / genetics; Sequence Analysis, DNA; Vagina / microbiology; Young Adult
Source: Web Of Science
Added: August 6, 2018
2011 journal article
A Comparison of Multifactor Dimensionality Reduction and L-1-Penalized Regression to Identify Gene-Gene Interactions in Genetic Association Studies
STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY, 10(1).
author keywords: Multifactor Dimensionality Reduction (MDR); Lasso; gene-gene interactions
MeSH headings : Algorithms; Computer Simulation; Data Mining / methods; Epistasis, Genetic; Genetic Association Studies / statistics & numerical data; Humans; Monte Carlo Method; Multifactor Dimensionality Reduction / methods
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Characterization of Canine Osteosarcoma by Array Comparative Genomic Hybridization and RT-qPCR: Signatures of Genomic Imbalance in Canine Osteosarcoma Parallel the Human Counterpart
GENES CHROMOSOMES & CANCER, 50(11), 859–874.
MeSH headings : Animals; Bone Neoplasms / genetics; Bone Neoplasms / veterinary; Comparative Genomic Hybridization; Core Binding Factor Alpha 1 Subunit / genetics; DNA Copy Number Variations; Dog Diseases / genetics; Dogs; Female; Gene Dosage; Genomic Instability; Humans; In Situ Hybridization, Fluorescence; Male; Membrane Proteins / genetics; Osteosarcoma / genetics; Osteosarcoma / veterinary; PTEN Phosphohydrolase / genetics; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Tumor Suppressor Proteins / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
Genomic Profiling in CEPH Cell Lines Distinguishes between the Camptothecins and Indenoisoquinolines
MOLECULAR CANCER THERAPEUTICS, 10(10), 1839–1845.
MeSH headings : Antineoplastic Agents, Phytogenic / pharmacology; Camptothecin / pharmacology; Cell Line; Drug Evaluation, Preclinical / methods; Gene Expression Profiling; Genomics / methods; Humans; Isoquinolines / pharmacology; Oligonucleotide Array Sequence Analysis; Quantitative Trait Loci; Topoisomerase I Inhibitors / pharmacology
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Identification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigrees
PLoS One, 6(5).
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Insights into the inhibition of platelet activation by omega-3 polyunsaturated fatty acids: Beyond aspirin and clopidogrel
THROMBOSIS RESEARCH, 128(4), 335–340.
MeSH headings : Adult; Aspirin / administration & dosage; Aspirin / adverse effects; Bleeding Time; Blood Platelets / drug effects; Chi-Square Distribution; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fatty Acids, Omega-3 / administration & dosage; Fatty Acids, Omega-3 / adverse effects; Female; Hemorrhage / chemically induced; Humans; Male; Middle Aged; North Carolina; Pilot Projects; Platelet Aggregation / drug effects; Platelet Aggregation Inhibitors / administration & dosage; Platelet Aggregation Inhibitors / adverse effects; Platelet Function Tests; Predictive Value of Tests; Surface Properties; Ticlopidine / administration & dosage; Ticlopidine / adverse effects; Ticlopidine / analogs & derivatives; Time Factors
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer
British Journal of Cancer, 105(11), 1654–1662.
author keywords: MTHFR polymorphisms; 5-FU; mucositis; diarrhoea; rectal cancer; neoadjuvant chemoradiation
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic / administration & dosage; Antimetabolites, Antineoplastic / adverse effects; Antimetabolites, Antineoplastic / therapeutic use; Antineoplastic Combined Chemotherapy Protocols / adverse effects; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Camptothecin / administration & dosage; Camptothecin / adverse effects; Camptothecin / analogs & derivatives; Chemoradiotherapy, Adjuvant / adverse effects; Disease-Free Survival; Fluorouracil / administration & dosage; Fluorouracil / adverse effects; Genotype; Humans; Irinotecan; Methylenetetrahydrofolate Reductase (NADPH2) / genetics; Methylenetetrahydrofolate Reductase (NADPH2) / metabolism; Middle Aged; Pharmacogenetics / methods; Polymorphism, Genetic; Prospective Studies; Radiation-Sensitizing Agents / administration & dosage; Radiation-Sensitizing Agents / adverse effects; Rectal Neoplasms / enzymology; Rectal Neoplasms / genetics; Rectal Neoplasms / therapy; Treatment Outcome; Young Adult
Source: Crossref
Added: February 24, 2020
2011 journal article
Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior
BMC Cancer, 11.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Optimization of nonlinear dose- and concentration-response models utilizing evolutionary computation
Dose-Response, 9(3), 387–409.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Pharmacogenomic characterization of US FDA-approved cytotoxic drugs
PHARMACOGENOMICS, 12(10), 1407–1415.
author keywords: cancer; cell line; chemotherapy; cytotoxicity; pharmacogenetics; pharmacogenomic; QTL
MeSH headings : Antineoplastic Agents / pharmacology; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Approval; Genetic Linkage; Humans; Pharmacogenetics; Quantitative Trait Loci / genetics; United States; United States Food and Drug Administration
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Quality of reporting on randomised controlled trials of auriculotherapy for pain
ACUPUNCTURE IN MEDICINE, 29(2), 122–126.
MeSH headings : Auriculotherapy; Cluster Analysis; Guidelines as Topic; Humans; Pain Management; Peer Review, Research / standards; Principal Component Analysis; Publishing / standards; Quality Improvement; Randomized Controlled Trials as Topic / standards
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas
Leukemia & Lymphoma, 52(7), 1321–1335.
author keywords: Comparative genomic hybridization (CGH); canine; lymphoma; chromosome; microarray
MeSH headings : Aneuploidy; Animals; Breeding; Comparative Genomic Hybridization; Cyclin-Dependent Kinase Inhibitor p16 / genetics; DNA Copy Number Variations / genetics; Dogs; Gene Expression Regulation, Neoplastic; Genomics; Immunophenotyping; Lymphoma, Non-Hodgkin / genetics; Lymphoma, Non-Hodgkin / pathology
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2011 journal article
Shift work in nurses: Contribution of phenotypes and genotypes to adaptation
PLoS One, 6(4).
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
The Effect of Retrospective Sampling on Estimates of Prediction Error for Multifactor Dimensionality Reduction
Annals of Human Genetics, 75, 46–61.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways
PLACENTA, 32(2), 175–182.
author keywords: Placenta; Preeclampsia; Maternal hypertension; Sialic acid acetylesterase
MeSH headings : Acetylesterase / biosynthesis; Antigens, CD / biosynthesis; Endoglin; Female; Genome-Wide Association Study; Humans; Infant, Newborn; Inhibins / biosynthesis; Male; Pre-Eclampsia / etiology; Pre-Eclampsia / metabolism; Pregnancy; Protein Array Analysis; Receptors, Cell Surface / biosynthesis; Trophoblasts / physiology; Up-Regulation; Vascular Endothelial Growth Factor Receptor-1 / biosynthesis
Source: Web Of Science
Added: August 6, 2018
2010 journal article
A comparison of internal validation techniques for multifactor dimensionality reduction
BMC Bioinformatics, 11.
Source: NC State University Libraries
Added: August 6, 2018
2010 review
Auriculotherapy for Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
[Review of ]. JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 16(10), 1097–1108.
MeSH headings : Acupuncture, Ear; Analgesia; Humans; Pain Management; Pain Measurement; Perioperative Period; Randomized Controlled Trials as Topic
Source: Web Of Science
Added: August 6, 2018
2010 article
Discussion of a Genome-Wide Association Approach to Determine HIV-1 Set Point in African Americans
Motsinger-Reif, A. A. (2010, April 15). JOURNAL OF INFECTIOUS DISEASES, Vol. 201, pp. 1118–1120.
MeSH headings : Black or African American / genetics; Disease Susceptibility; Epitopes / genetics; Genome-Wide Association Study; HIV Infections / genetics; HIV-1; Humans; Polymorphism, Single Nucleotide / genetics
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Effect of CYP2B6, ABCB1, and CYP3A5 Polymorphisms on Efavirenz Pharmacokinetics and Treatment Response: An AIDS Clinical Trials Group Study
JOURNAL OF INFECTIOUS DISEASES, 202(5), 717–722.
MeSH headings : ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics; Alkynes; Anti-HIV Agents / pharmacokinetics; Anti-HIV Agents / therapeutic use; Aryl Hydrocarbon Hydroxylases / genetics; Benzoxazines / pharmacokinetics; Benzoxazines / therapeutic use; Black People; Cyclopropanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A / genetics; Female; HIV Infections / drug therapy; HIV Infections / ethnology; HIV Infections / genetics; Hispanic or Latino; Humans; Male; Oxidoreductases, N-Demethylating / genetics; Pharmacogenetics; Polymorphism, Single Nucleotide; Reverse Transcriptase Inhibitors / pharmacokinetics; Reverse Transcriptase Inhibitors / therapeutic use; Treatment Outcome; White People
Source: Web Of Science
Added: August 6, 2018
2010 chapter
Grammatical Evolution Decision Trees for Detecting Gene-Gene Interactions
In Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics (pp. 98–109).
Source: Crossref
Added: February 24, 2020
2010 conference paper
Grammatical evolution decision trees for detecting gene-gene interactions
Evolutionary computation, machine learning and data mining in bioinformatics, proceedings, 6023, 98–109.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Polymorphisms in IL-1 beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis
BMC Medical Genetics, 11.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups
BLOOD, 115(18), 3827–3834.
MeSH headings : Adult; Aged; Aged, 80 and over; Algorithms; Anticoagulants / administration & dosage; Asian People / genetics; Black People / genetics; Dose-Response Relationship, Drug; Female; Genotype; Haplotypes; Humans; Linkage Disequilibrium; Male; Middle Aged; Mixed Function Oxygenases / genetics; Pharmacogenetics; Polymorphism, Single Nucleotide / genetics; Racial Groups / genetics; Risk Factors; Vitamin K Epoxide Reductases; Warfarin / administration & dosage; White People / genetics
Source: Web Of Science
Added: August 6, 2018
2009 article
A Comparison of Analytical Methods for Genetic Association Studies (vol 32, pg 767, 2008)
Motsinger-Reif, A. A., Reif, D. M., Fanelli, T. J., & Ritchie, M. D. (2009, December). GENETIC EPIDEMIOLOGY, Vol. 33, pp. 751–751.
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 journal article
Characterization of Conserved and Nonconserved Imprinted Genes in Swine
BIOLOGY OF REPRODUCTION, 81(5), 906–920.
author keywords: assisted reproductive technology; comparative genomic imprinting; epigenetics; gene regulation; genomic imprinting; parthenogenesis; placenta; swine parthenote
MeSH headings : Animals; Female; Fetus / anatomy & histology; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genomic Imprinting / genetics; Oligonucleotide Array Sequence Analysis; Organ Size; Parthenogenesis / genetics; Placenta / anatomy & histology; Polymorphism, Single Nucleotide; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; Staining and Labeling; Swine / genetics
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination
GENES AND IMMUNITY, 10(2), 112–119.
author keywords: smallpox; Random Forests; integrated analysis; genetic; proteomic; interactions
MeSH headings : Biomarkers / blood; Cytokines / blood; Cytokines / genetics; Decision Making, Computer-Assisted; Female; Humans; Inflammation / blood; Inflammation / chemically induced; Inflammation / genetics; Intercellular Adhesion Molecule-1 / blood; Intercellular Adhesion Molecule-1 / genetics; Male; Models, Biological; Polymorphism, Single Nucleotide; Proteomics / methods; Smallpox Vaccine / administration & dosage; Smallpox Vaccine / adverse effects; Vaccination
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 journal article
262: Molecular signatures of preeclampsia in human term placentas
American Journal of Obstetrics and Gynecology, 199(6), S84.
Source: Crossref
Added: February 24, 2020
2008 journal article
A Comparison of Analytical Methods for Genetic Association Studies
GENETIC EPIDEMIOLOGY, 32(8), 767–778.
author keywords: genetic association study; epistasis; multifactor dimensionality reduction; grammatical evolution neural networks; focused interaction testing framework
MeSH headings : Data Interpretation, Statistical; Epistasis, Genetic; Genetic Linkage; Genetic Techniques; Genome; Humans; Models, Genetic; Models, Statistical; Models, Theoretical; Neural Networks, Computer; Phenotype; Probability; Regression Analysis; Software
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 journal article
Comparison of approaches for machine-learning optimization of neural networks for detecting gene-gene interactions in genetic epidemiology
GENETIC EPIDEMIOLOGY, 32(4), 325–340.
author keywords: grammatical evolution neural networks; epistasis; genetic programming neural networks
MeSH headings : Artificial Intelligence; Data Interpretation, Statistical; Databases, Genetic; Epidemiologic Methods; Epistasis, Genetic; Genetic Predisposition to Disease; HIV Infections / epidemiology; HIV Infections / genetics; HIV Infections / immunology; Humans; Immunogenetics; Models, Genetic; Neural Networks, Computer; Pattern Recognition, Automated; Polymorphism, Single Nucleotide
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Genetic Basis for Adverse Events after Smallpox Vaccination
The Journal of Infectious Diseases, 198(1), 16–22.
MeSH headings : Adult; Female; Genetic Predisposition to Disease; Genotype; Humans; Interferon Regulatory Factor-1 / genetics; Interleukin-4 / genetics; Male; Methylenetetrahydrofolate Reductase (NADPH2) / genetics; Polymorphism, Single Nucleotide; Smallpox Vaccine / adverse effects; Vaccination / adverse effects
Sources: Crossref, ORCID
Added: May 14, 2019
2008 journal article
Hemochromatosis Gene Polymorphisms, Mitochondrial Haplogroups, and Peripheral Lipoatrophy during Antiretroviral Therapy
The Journal of Infectious Diseases, 197(6), 858–866.
Source: Crossref
Added: October 29, 2021
2007 journal article
A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction
Genetic Epidemiology, 31(4), 306–315.
MeSH headings : Algorithms; Epistasis, Genetic; Gene Frequency; Humans; Models, Genetic; Polymorphism, Single Nucleotide; Sample Size; Software
Source: Crossref
Added: October 29, 2021
2007 journal article
Complex gene–gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes
Neurogenetics, 8(1), 11–20.
author keywords: multiple sclerosis; multifactor dimensionality reduction; epistasis
MeSH headings : Case-Control Studies; Genotype; Humans; Inflammation / genetics; Models, Genetic; Multiple Sclerosis / genetics; Multiple Sclerosis / pathology; Proteins / genetics
Source: Crossref
Added: October 29, 2021
2007 journal article
Genetic heterogeneity is not as threatening as you might think
Genetic Epidemiology, 31(7), 797–800.
MeSH headings : Genetic Variation; Humans; Models, Genetic; Quantitative Trait Loci / genetics
Source: Crossref
Added: October 29, 2021
2007 journal article
Genetic programming neural networks: A powerful bioinformatics tool for human genetics
Applied Soft Computing, 7(1), 471–479.
author keywords: nueral networks; genetic programming; bioinformatics; epistasis; gene-gene interactions
Source: Crossref
Added: October 29, 2021
2007 journal article
Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: A validated genetic association study
Mitochondrion, 7(3), 204–210.
author keywords: mitochondrial enzyme; CPSI; pulmonary artery pressure
MeSH headings : Carbamoyl-Phosphate Synthase (Ammonia) / genetics; Cohort Studies; DNA / blood; DNA / genetics; DNA Primers; Down Syndrome / epidemiology; Female; Genetic Variation; Heart Defects, Congenital / surgery; Humans; Hypertension, Pulmonary / epidemiology; Infant; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Postoperative Complications / physiopathology; Reproducibility of Results
Source: Crossref
Added: October 29, 2021
2007 journal article
Human Genomic Association Studies: A Primer for the Infectious Diseases Specialist
The Journal of Infectious Diseases, 195(12), 1737–1744.
MeSH headings : Communicable Diseases / genetics; Genetic Linkage / genetics; Genome, Human / genetics; Genomics / methods; HIV Infections / drug therapy; HIV Infections / genetics; Haplotypes; Humans; Phenotype; Polymorphism, Single Nucleotide; Research Design
Source: Crossref
Added: October 29, 2021
2007 journal article
Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation
Heart Rhythm, 4(6), 743–749.
author keywords: atrial fibrillation; antiarrhythmic drugs; angiotensin-converting-enzyme; genetics
MeSH headings : Acetylcysteine / metabolism; Alleles; Anti-Arrhythmia Agents / pharmacology; Anti-Arrhythmia Agents / therapeutic use; Atrial Fibrillation / drug therapy; Atrial Fibrillation / genetics; Female; Gene Deletion; Genotype; Humans; Male; Middle Aged; Peptidyl-Dipeptidase A / genetics; Polymorphism, Genetic; Prospective Studies; Renin-Angiotensin System / drug effects
Source: Crossref
Added: October 29, 2021
2006 chapter
Comparison of Neural Network Optimization Approaches for Studies of Human Genetics
In F. Rothlauf (Ed.), Applications of Evolutionary Computing. EvoWorkshops 2006 (pp. 103–114).
Ed(s): F. Rothlauf
Source: Crossref
Added: October 29, 2021
2006 journal article
Drug Transporter and Metabolizing Enzyme Gene Variants and Nonnucleoside Reverse-Transcriptase Inhibitor Hepatotoxicity
Clinical Infectious Diseases, 43(6), 779–782.
MeSH headings : Adult; Alkynes; Anti-HIV Agents / adverse effects; Anti-HIV Agents / metabolism; Anti-HIV Agents / therapeutic use; Aryl Hydrocarbon Hydroxylases / genetics; Benzoxazines; Case-Control Studies; Chemical and Drug Induced Liver Injury; Cyclopropanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System / genetics; Female; Genes, MDR; Genetic Variation; Genotype; HIV Infections / drug therapy; HIV-1; Humans; Liver / drug effects; Liver Diseases / genetics; Liver Diseases / virology; Male; Nevirapine / adverse effects; Nevirapine / metabolism; Nevirapine / therapeutic use; Oxazines / adverse effects; Oxazines / metabolism; Oxazines / therapeutic use; Oxidoreductases, N-Demethylating / genetics; Reverse Transcriptase Inhibitors / adverse effects; Reverse Transcriptase Inhibitors / metabolism; Reverse Transcriptase Inhibitors / therapeutic use
Source: Crossref
Added: October 29, 2021
2006 journal article
Immunogenetics of CD4 Lymphocyte Count Recovery during Antiretroviral Therapy: An AIDS Clinical Trials Group Study
The Journal of Infectious Diseases, 194(8), 1098–1107.
MeSH headings : Adult; Antiretroviral Therapy, Highly Active; Apoptosis Regulatory Proteins / genetics; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes / cytology; Female; HIV Infections / blood; HIV Infections / drug therapy; HIV Infections / epidemiology; HIV Infections / genetics; Humans; Interleukin-2 / genetics; Male; Membrane Glycoproteins / genetics; Polymorphism, Genetic; Puerto Rico / epidemiology; Receptors, Interleukin-15; Receptors, Interleukin-2 / genetics; Retrospective Studies; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha / genetics; United States / epidemiology
Source: Crossref
Added: October 29, 2021
2006 journal article
Multifactor dimensionality reduction reveals gene–gene interactions associated with multiple sclerosis susceptibility in African Americans
Genes & Immunity, 7(4), 310–315.
MeSH headings : Black or African American / genetics; Case-Control Studies; Epistasis, Genetic; Female; Gene Deletion; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-5 Receptor alpha Subunit; Lipopolysaccharide Receptors / genetics; Male; Multifactorial Inheritance; Multiple Sclerosis / genetics; Multiple Sclerosis / immunology; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Receptors, Interleukin / genetics; Receptors, Interleukin-4 / genetics
Source: Crossref
Added: October 29, 2021
2006 journal article
The effect of reduction in cross-validation intervals on the performance of multifactor dimensionality reduction
Genetic Epidemiology, 30(6), 546–555.
author keywords: model validation; MDR; epistasis; gene-gene interactions
MeSH headings : Alzheimer Disease / genetics; Genetic Predisposition to Disease / genetics; Genotype; Humans; Models, Genetic; Multifactorial Inheritance; Polymorphism, Genetic; Risk Assessment / statistics & numerical data
Source: Crossref
Added: October 29, 2021
2005 chapter
Can Neural Network Constraints in GP Provide Power to Detect Genes Associated with Human Disease?
In F. Rothlauf (Ed.), Applications of Evolutionary Computing. EvoWorkshops 2005 (pp. 44–53).
Ed(s): F. Rothlauf
Source: Crossref
Added: October 29, 2021
