Works (171)

Updated: January 22nd, 2024 08:12

2024 journal article

Guided optimization of ToxPi model weights using a Semi-Automated approach

COMPUTATIONAL TOXICOLOGY, 29.

By: J. Fleming n, J. House*, J. Chappel n, A. Motsinger-Reif* & D. Reif*

co-author countries: United States of America 🇺🇸
author keywords: Machine learning; Feature weighting; Exposure assessment; Chemical toxicity; Ordinal regression; Genetic algorithm
Sources: Web Of Science, ORCID
Added: January 16, 2024

2023 journal article

MKX-AS1 Gene Expression Associated with Variation in Drug Response to Oxaliplatin and Clinical Outcomes in Colorectal Cancer Patients

PHARMACEUTICALS, 16(5).

By: R. Gonzalez*, G. Small*, A. Green n, F. Akhtari*, A. Motsinger-Reif*, J. Quintanilha, T. Havener*, D. Reif*, H. McLeod*, T. Wiltshire*

co-author countries: United States of America 🇺🇸
author keywords: precision medicine; colorectal cancer; pharmacogenomics; oxaliplatin; lncRNA's; antisense
Sources: Web Of Science, ORCID
Added: May 19, 2023

2023 journal article

Pharmacogenomic Analyses Implicate B Cell Developmental Status and MKL1 as Determinants of Sensitivity toward Anti-CD20 Monoclonal Antibody Therapy

CELLS, 12(12).

By: G. Small*, F. Akhtari*, A. Green n, T. Havener*, M. Sikes n, J. Quintanhila, R. Gonzalez*, D. Reif* ...

co-author countries: United States of America 🇺🇸
author keywords: rituximab (Rituxan (R)); ofatumumab (Arzerra (R),& nbsp;Kesimpta (R)); obinutuzumab (Gazyva (R)); CD20 (MS4A1); MKL1 (MRTFA); TGFB1
Sources: Web Of Science, ORCID
Added: June 8, 2023

2023 journal article

RYK Gene Expression Associated with Drug Response Variation of Temozolomide and Clinical Outcomes in Glioma Patients

PHARMACEUTICALS, 16(5).

By: R. Gonzalez*, G. Small*, A. Green n, F. Akhtari*, T. Havener*, J. Quintanilha, A. Cipriani*, D. Reif* ...

co-author countries: United States of America 🇺🇸
author keywords: GWAS; chemotherapy; sensitivity; resistance; glioma; drug response; temozolomide; knockdown; overexpression; pharmacogenomics; gene expression; RYK
Sources: Web Of Science, ORCID
Added: May 12, 2023

2022 journal article

Clomifene and Assisted Reproductive Technology in Humans Are Associated with Sex-Specific Offspring Epigenetic Alterations in Imprinted Control Regions

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(18).

By: D. Lloyd n, H. Skinner n, R. Maguire n, S. Murphy*, A. Motsinger-Reif*, C. Hoyo n, J. House n

co-author countries: United States of America 🇺🇸
author keywords: differentially methylated regions; adverse offspring outcomes; infertility
MeSH headings : Child; Clomiphene; DNA Methylation; Female; Genomic Imprinting; Humans; Male; Reproductive Techniques, Assisted / adverse effects; Retrospective Studies
Sources: Web Of Science, ORCID
Added: October 3, 2022

2022 journal article

Comparison of National Vulnerability Indices Used by the Centers for Disease Control and Prevention for the COVID-19 Response

Public Health Reports, 137(4), 803–812.

By: A. Wolkin*, S. Collier*, J. House*, D. Reif n, A. Motsinger-Reif*, L. Duca*, J. Sharpe*

co-author countries: United States of America 🇺🇸
author keywords: COVID-19; vulnerability; social vulnerability index; GIS; geographic information systems
MeSH headings : COVID-19 / epidemiology; COVID-19 / prevention & control; Centers for Disease Control and Prevention, U.S.; Humans; Pandemics / prevention & control; Public Health; United States / epidemiology
Sources: Web Of Science, ORCID, Crossref
Added: May 6, 2022

2022 journal article

Correlation Analysis of Variables From the Atherosclerosis Risk in Communities Study

FRONTIERS IN PHARMACOLOGY, 13.

By: M. Mandal*, J. Levy, C. Ives*, S. Hwang*, Y. Zhou n, A. Motsinger-Reif*, H. Pan*, W. Huggins* ...

co-author countries: United States of America 🇺🇸
author keywords: cluster analysis; systems biology; meta-analysis as topic; ARIC; cardiovascular disease
Source: Web Of Science
Added: August 8, 2022

2022 article

Genomic map of candidate human imprint control regions: the imprintome

Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). EPIGENETICS, Vol. 6.

By: D. Jima n, D. Skaar n, A. Planchart n, A. Motsinger-Reif n, S. Cevik n, S. Park n, M. Cowley n, F. Wright n ...

co-author countries: United States of America 🇺🇸
author keywords: Epigenetics; genomic imprinting; foetal origins; whole genome; methylation; imprint control regions
MeSH headings : Adult; Humans; Genomic Imprinting; DNA Methylation; Chromosome Mapping; Alleles; Genomics
Sources: Web Of Science, ORCID
Added: July 11, 2022

2022 journal article

The AGMK1-9T7 cell model of neoplasia: Evolution of DNA copy-number aberrations and miRNA expression during transition from normal to metastatic cancer cells

PLOS ONE, 17(10).

By: A. Lewis*, R. Thomas*, M. Breen*, K. Peden*, B. Teferedegne*, G. Foseh*, A. Motsinger-Reif n, D. Rotroff n, G. Lewis

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Humans; Chlorocebus aethiops; MicroRNAs / genetics; MicroRNAs / metabolism; Neoplasms / genetics; Carcinogenesis / genetics; DNA Copy Number Variations / genetics; Chromosome Aberrations; Neoplasms, Second Primary / genetics; DNA; Gene Expression Regulation, Neoplastic; Gene Expression Profiling
Source: Web Of Science
Added: February 27, 2023

2022 article

ToxPi*GIS Toolkit: creating, viewing, and sharing integrative visualizations for geospatial data using ArcGIS

Fleming, J., Marvel, S. W., Supak, S., Motsinger-Reif, A. A., & Reif, D. M. (2022, April 26). JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, Vol. 4.

By: J. Fleming n, S. Marvel n, S. Supak n, A. Motsinger-Reif* & D. Reif n

co-author countries: United States of America 🇺🇸
author keywords: Visual analytics; Geographic information systems; Data integration
MeSH headings : Humans; Geographic Information Systems; COVID-19
Sources: Web Of Science, ORCID
Added: May 10, 2022

2021 journal article

Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome‐Wide Interaction Meta‐Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies

Clinical Pharmacology & Therapeutics, 110(3), 723–732.

By: C. McDonough*, H. Warren*, J. Jack n, A. Motsinger‐Reif*, N. Armstrong*, J. Bis*, J. House*, S. Singh* ...

co-author countries: Canada 🇨🇦 Finland 🇫🇮 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Italy 🇮🇹 United States of America 🇺🇸
MeSH headings : Black or African American / genetics; Aged; Antihypertensive Agents / therapeutic use; Blood Pressure / drug effects; Blood Pressure / genetics; Cardiovascular Diseases / chemically induced; Cardiovascular Diseases / genetics; Cardiovascular System / drug effects; Drug-Related Side Effects and Adverse Reactions / etiology; Drug-Related Side Effects and Adverse Reactions / genetics; Female; Genome-Wide Association Study / methods; Humans; Hypertension / drug therapy; Hypertension / genetics; Male; Middle Aged; Pharmacogenomic Testing / methods; Polymorphism, Single Nucleotide / genetics
Sources: Web Of Science, ORCID, Crossref
Added: August 23, 2021

2021 article

Extending the lymphoblastoid cell line model for drug combination pharmacogenomics

Green, A. J., Anchang, B., Akhtari, F. S., Reif, D. M., & Motsinger-Reif, A. (2021, May 28). PHARMACOGENOMICS, Vol. 22.

By: A. Green n, B. Anchang*, F. Akhtari*, D. Reif n & A. Motsinger-Reif*

co-author countries: United States of America 🇺🇸
author keywords: combination treatment; drug response; LCLs; omics; synergism
MeSH headings : Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cell Line, Tumor / drug effects; Humans; Lymphocytes / drug effects; Pharmacogenomic Testing / methods
Sources: Web Of Science, ORCID
Added: May 29, 2021

2021 journal article

High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs

PLOS GENETICS, 17(8).

By: F. Akhtari n, A. Green n, G. Small*, T. Havener*, J. House*, K. Roell n, D. Reif n, H. McLeod, T. Wiltshire*, A. Motsinger-Reif*

co-author countries: United States of America 🇺🇸

Ed(s): F. Vazquez

MeSH headings : Antineoplastic Agents / pharmacology; Biomarkers, Pharmacological / analysis; Cell Line, Tumor; Genome-Wide Association Study / methods; High-Throughput Screening Assays / methods; Humans; NAD(P)H Dehydrogenase (Quinone) / drug effects; NAD(P)H Dehydrogenase (Quinone) / genetics; NAD(P)H Dehydrogenase (Quinone) / metabolism
Sources: Web Of Science, ORCID
Added: August 27, 2021

2021 journal article

In vitro iatrogenic hemolysis of canine packed red blood cells during various rapid transfusion techniques

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 31(1), 25–31.

By: J. Weeks, A. Motsinger-Reif n & M. Reems

co-author countries: United States of America 🇺🇸
author keywords: canine; coagulation; hemoglobin; trauma
MeSH headings : Animals; Blood Preservation / veterinary; Blood Transfusion / methods; Blood Transfusion / veterinary; Dogs; Erythrocytes / physiology; Hemolysis; Iatrogenic Disease / veterinary; Prospective Studies
Source: Web Of Science
Added: November 16, 2020

2021 journal article

Knockoff boosted tree for model-free variable selection

BIOINFORMATICS, 37(7), 976–983.

By: T. Jiang n, Y. Li* & A. Motsinger-Reif*

co-author countries: United States of America 🇺🇸
MeSH headings : Algorithms; Computer Simulation; Genome; Machine Learning
Source: Web Of Science
Added: June 21, 2021

2021 journal article

Prediction of synergistic drug combinations using PCA-initialized deep learning

BIODATA MINING, 14(1).

By: J. Ma n & A. Motsinger-Reif*

co-author countries: United States of America 🇺🇸
author keywords: Deep learning; Cancer treatment; Drug combination treatment; Feedforward neural network; Machine learning; XGBoost; Random Forests; Elastic net
Source: Web Of Science
Added: November 8, 2021

2021 journal article

Race and smoking status associated with paclitaxel drug response in patient-derived lymphoblastoid cell lines

PHARMACOGENETICS AND GENOMICS, 31(2), 48–52.

By: F. Akhtari n, T. Havener*, D. Hertz*, J. Ash n, A. Larson n, L. Carey*, H. McLeod*, A. Motsinger-Reif*

co-author countries: United States of America 🇺🇸
author keywords: dose-response; lymphoblastoid cell lines; paclitaxel; patient-derived cell lines; pharmacogenomics; smoking
MeSH headings : Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Breast Neoplasms / pathology; Cell Line, Tumor; Cell Survival / drug effects; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm / genetics; Female; Humans; Middle Aged; Paclitaxel / adverse effects; Paclitaxel / pharmacology; Pharmacogenetics; Racial Groups / genetics; Smoking / adverse effects; Smoking / genetics
Source: Web Of Science
Added: May 10, 2021

2021 personal communication

The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning

Marvel, S. W., House, J. S., Wheeler, M., Song, K., Zhou, Y.-H., Wright, F. A., … Reif, D. M. (2021, January).

By: S. Marvel n, J. House*, M. Wheeler*, K. Song n, Y. Zhou n, F. Wright n, W. Chiu*, I. Rusyn*, A. Motsinger-Reif*, D. Reif n

co-author countries: United States of America 🇺🇸

Contributors: S. Marvel n, J. House*, M. Wheeler*, K. Song n, Y. Zhou n, F. Wright n, W. Chiu*, I. Rusyn*, A. Motsinger-Reif*, D. Reif n

MeSH headings : COVID-19 / epidemiology; Data Visualization; Health Status Indicators; Humans; Machine Learning; Models, Statistical; Vulnerable Populations
Sources: Web Of Science, ORCID
Added: March 22, 2021

2020 journal article

Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(12), 7409–7419.

By: C. Wise n, S. Hammel*, N. Herkert*, J. Ma n, A. Motsinger-Reif*, H. Stapleton*, M. Breen n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Biomarkers; Dogs; Environmental Monitoring; Humans; Organophosphates; Silicones
Source: Web Of Science
Added: July 13, 2020

2020 journal article

Genetic and environmental risk for lymphoma in boxer dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(5), 2068–2077.

By: K. Craun*, J. Ekena*, J. Sacco*, T. Jiang n, A. Motsinger-Reif n & L. Trepanier*

co-author countries: United States of America 🇺🇸
author keywords: canine; detoxification; exposure; lymphosarcoma
MeSH headings : Animals; Dog Diseases / genetics; Dogs; Genetic Predisposition to Disease; Genotype; Lymphoma / genetics; Lymphoma / veterinary; Risk Factors
Source: Web Of Science
Added: August 3, 2020

2020 journal article

Low-Dose Silver Nanoparticle Surface Chemistry and Temporal Effects on Gene Expression in Human Liver Cells

SMALL, 16(21).

By: J. House n, E. Bouzos*, K. Fahy*, V. Francisco*, D. Lloyd n, F. Wright n, A. Motsinger-Reif*, P. Asuri*, K. Wheeler*

co-author countries: United States of America 🇺🇸

Contributors: J. House n, E. Bouzos*, K. Fahy*, V. Francisco*, D. Lloyd n, F. Wright n, A. Motsinger-Reif*, P. Asuri*, K. Wheeler*

author keywords: nanotoxicity; silver nanoparticles; transcriptomics
MeSH headings : Gene Expression / drug effects; Hepatocytes / drug effects; Humans; Metal Nanoparticles / chemistry; Silver; Surface Properties; Time Factors
Sources: Web Of Science, ORCID
Added: April 14, 2020

2020 journal article

Nonlinear Dose-Response Modeling of High-Throughput Screening Data Using an Evolutionary Algorithm

DOSE-RESPONSE, 18(2).

By: J. Ma n, E. Bair & A. Motsinger-Reif*

co-author countries: United States of America 🇺🇸
author keywords: evolutionary algorithm; hillslope model; parameter estimation; nonlinear regression; model selection
Source: Web Of Science
Added: June 15, 2020

2020 journal article

The influence of packed cell volume versus plasma proteins on thromboelastographic variables in canine blood

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 30(4), 418–425.

By: A. Lynch n, L. Ruterbories n, J. Jack n, A. Motsinger-Reif n & R. Hanel*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Blood Coagulation Tests / veterinary; Blood Proteins / physiology; Cell Size; Dogs / blood; Female; Fibrinogen / metabolism; Hematocrit / veterinary; Male; Thrombelastography / veterinary
Sources: Web Of Science, ORCID
Added: July 13, 2020

2020 journal article

Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(3), 897–906.

By: E. Crestani*, H. Harb*, L. Charbonnier*, J. Leirer n, A. Motsinger-Reif*, R. Rachid*, W. Phipatanakul*, R. Kaddurah-Daouk*, T. Chatila*

co-author countries: United States of America 🇺🇸
author keywords: Asthma; food allergy; invariant natural killer T cells; metabolomics; metabolites; secondary bile acids; sphingolipids; tryptophan
MeSH headings : Asthma / blood; Biomarkers / blood; Child; Child, Preschool; Female; Food Hypersensitivity / blood; Humans; Male; Metabolome; Metabolomics / methods; Pilot Projects
Source: Web Of Science
Added: April 27, 2020

2019 journal article

A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes: Results From the ACCORD and BARI 2D Studies

DIABETES, 68(8), 1649–1662.

By: Y. Tang*, P. Lenzini*, R. Pop-Busui*, P. Ray*, H. Campbell*, B. Perkins*, B. Callaghan*, M. Wagner* ...

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
MeSH headings : Aged; Alleles; Chromosomes, Human, Pair 2; Databases, Genetic; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / epidemiology; Diabetes Mellitus, Type 2 / genetics; Diabetic Neuropathies / genetics; Female; Gene Frequency; Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Incidence; Male; Middle Aged; Polymorphism, Single Nucleotide; Prevalence
Source: Web Of Science
Added: August 12, 2019

2019 journal article

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

Alzheimer's & Dementia, 15(1), 76–92.

By: S. MahmoudianDehkordi*, M. Arnold*, K. Nho*, S. Ahmad*, W. Jia*, G. Xie*, G. Louie*, A. Kueider-Paisley* ...

co-author countries: Austria 🇦🇹 China 🇨🇳 Germany 🇩🇪 Netherlands 🇳🇱 United States of America 🇺🇸
author keywords: Metabolomics; Metabolome; Lipidomics; Alzheimer's disease; Gut microbiome; Gut-liver-brain axis; Atlas for Alzheimer; Genetic variants; Immunity; Inflammation
MeSH headings : Aged; Alzheimer Disease / microbiology; Alzheimer Disease / physiopathology; Bile Acids and Salts / blood; Bile Acids and Salts / metabolism; Cognitive Dysfunction / metabolism; Dysbiosis; Female; Gastrointestinal Microbiome; Humans; Liver / metabolism; Male; Metabolome
Source: Crossref
Added: February 21, 2020

2019 article

Bile acids targeted metabolomics and medication classification data in the ADNI1 and ADNIGO/2 cohorts

St John-Williams, L., Mahmoudiandehkordi, S., Arnold, M., Massaro, T., Blach, C., Kastenmueller, G., … Kaddurah-Daouk, R. (2019, October 17). SCIENTIFIC DATA, Vol. 6.

By: L. St John-Williams*, S. Mahmoudiandehkordi*, M. Arnold*, T. Massaro*, C. Blach*, G. Kastenmueller, G. Louie*, A. Kueider-Paisley* ...

co-author countries: Austria 🇦🇹 Germany 🇩🇪 United States of America 🇺🇸
MeSH headings : Aged; Aged, 80 and over; Alzheimer Disease / metabolism; Bile Acids and Salts / blood; Disease Progression; Female; Humans; Male; Metabolomics
Source: Web Of Science
Added: November 11, 2019

2019 journal article

Cheminformatics approach to exploring and modeling trait-associated metabolite profiles

JOURNAL OF CHEMINFORMATICS, 11.

By: J. Ash n, M. Kuenemann n, D. Rotroff n, A. Motsinger-Reif n & D. Fourches n

co-author countries: United States of America 🇺🇸
author keywords: Metabolomics; Data mining; Cheminformatics; Molecular fragmentation; Statistics; Visualization; Chemical structure
Source: Web Of Science
Added: July 15, 2019

2019 journal article

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

NATURE COMMUNICATIONS, 10.

By: M. Menden*, D. Wang*, M. Mason*, B. Szalai*, K. Bulusu*, Y. Guan*, T. Yu*, J. Kang* ...

co-author countries: Germany 🇩🇪 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Hungary 🇭🇺 Korea (Republic of) 🇰🇷 United States of America 🇺🇸
MeSH headings : ADAM17 Protein / antagonists & inhibitors; Antineoplastic Combined Chemotherapy Protocols / pharmacology; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Benchmarking; Biomarkers, Tumor / genetics; Cell Line, Tumor; Computational Biology / methods; Computational Biology / standards; Datasets as Topic; Drug Antagonism; Drug Resistance, Neoplasm / drug effects; Drug Resistance, Neoplasm / genetics; Drug Synergism; Genomics / methods; Humans; Molecular Targeted Therapy / methods; Mutation; Neoplasms / drug therapy; Neoplasms / genetics; Pharmacogenetics / methods; Pharmacogenetics / standards; Phosphatidylinositol 3-Kinases / genetics; Phosphoinositide-3 Kinase Inhibitors; Treatment Outcome
Source: Web Of Science
Added: July 1, 2019

2019 journal article

Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

EPIGENOMICS, 11(13), 1487–1500.

By: S. Sikdar*, R. Joehanes*, B. Joubert*, C. Xu*, M. Vives-Usano*, F. Rezwan*, J. Felix*, J. Ward* ...

co-author countries: Germany 🇩🇪 Spain 🇪🇸 France 🇫🇷 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Mexico 🇲🇽 Netherlands 🇳🇱 Norway 🇳🇴 Sweden 🇸🇪 United States of America 🇺🇸
author keywords: cigarette smoking; epigenetics; infant; maternal exposure; methylation
MeSH headings : Adult; Cohort Studies; CpG Islands; DNA Methylation; Epigenesis, Genetic; Epigenomics / methods; Female; Humans; Infant, Newborn; Maternal Exposure / adverse effects; Pregnancy; Prenatal Exposure Delayed Effects / epidemiology; Prenatal Exposure Delayed Effects / genetics; Tobacco Smoking / epidemiology; Tobacco Smoking / genetics
Source: Web Of Science
Added: December 9, 2019

2019 journal article

Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex

CHROMOSOME RESEARCH, 27(3), 179–202.

By: K. Kennedy n, R. Thomas n, J. Durrant n, T. Jiang n, A. Motsinger-Reif n & M. Breen n

co-author countries: United States of America 🇺🇸
author keywords: Histiocytic sarcoma; Chromothripsis; MMP9; Aurora kinase; Dendritic cell sarcoma
MeSH headings : Animals; Chromosome Disorders; DNA Copy Number Variations / genetics; Dog Diseases / diagnosis; Dog Diseases / genetics; Dogs; Gene Expression Profiling; Genome / genetics; Histiocytic Disorders, Malignant / diagnosis; Histiocytic Disorders, Malignant / genetics; Histiocytic Disorders, Malignant / veterinary; Humans; Immunohistochemistry / methods; Matrix Metalloproteinase 9 / metabolism; Spindle Apparatus / pathology
Source: Web Of Science
Added: September 30, 2019

2019 journal article

Identifying individual risk rare variants using protein structure guided local tests (POINT)

PLOS COMPUTATIONAL BIOLOGY, 15(2).

By: R. West n, W. Lu n, D. Rotroff*, M. Kuenemann n, S. Chang*, M. Wu*, M. Wagner*, J. Buse* ...

co-author countries: Taiwan, Province of China 🇹🇼 United States of America 🇺🇸
MeSH headings : Angiopoietin-Like Protein 4 / genetics; Cholesterol Ester Transfer Proteins / genetics; Computational Biology / methods; Computer Simulation; Genetic Association Studies / methods; Genetic Predisposition to Disease / genetics; Genetic Variation / genetics; Humans; Models, Genetic; Proprotein Convertase 9 / genetics; Protein Structure, Tertiary; Risk Factors; Sequence Analysis, DNA / methods
Source: Web Of Science
Added: March 25, 2019

2019 journal article

Long-term incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy

JOURNAL OF VETERINARY INTERNAL MEDICINE, 33(6), 2572–2586.

By: P. Fox*, B. Keene n, K. Lamb, K. Schober*, V. Chetboul*, V. Fuentes*, J. Payne, G. Wess ...

co-author countries: Brazil 🇧🇷 Canada 🇨🇦 Germany 🇩🇪 Spain 🇪🇸 France 🇫🇷 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Hungary 🇭🇺 Ireland 🇮🇪 Israel 🇮🇱 Italy 🇮🇹 Japan 🇯🇵 Mexico 🇲🇽 Sweden 🇸🇪 Taiwan, Province of China 🇹🇼 United States of America 🇺🇸 South Africa 🇿🇦
author keywords: cancer; chronic kidney disease; epidemiology; mortality; survival
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / mortality; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / mortality; Cats; Female; Incidence; Male; Retrospective Studies; Risk Factors
Source: Web Of Science
Added: October 28, 2019

2019 journal article

Synergistic Chemotherapy Drug Response Is a Genetic Trait in Lymphoblastoid Cell Lines

FRONTIERS IN GENETICS, 10.

By: K. Roell n, T. Havener*, D. Reif n, J. Jack n, H. McLeod*, T. Wiltshire*, A. Motsinger-Reif*

co-author countries: United States of America 🇺🇸

Contributors: K. Roell n, T. Havener*, D. Reif n, J. Jack n, H. McLeod*, T. Wiltshire*, A. Motsinger-Reif*

author keywords: synergy; heritability; chemotherapy; lymphoblastoid cell lines; linkage mapping
Sources: Web Of Science, ORCID
Added: December 2, 2019

2019 article

Untargeted Metabolomic Profiling Identifies Disease-Specific Pathways in Food Allergy and Asthma

Crestani, E., Leirer, J., Motsinger-Reif, A., Phipatanakul, W., Kaddurah-Daouk, R., & Chatila, T. A. (2019, February). JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol. 143, pp. AB255–AB255.

By: E. Crestani*, J. Leirer n, A. Motsinger-Reif n, W. Phipatanakul*, R. Kaddurah-Daouk* & T. Chatila*

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: February 25, 2019

2018 journal article

Gene expression and linkage analysis implicate as a mediator of rituximab resistance

PHARMACOGENOMICS JOURNAL, 18(3), 467–473.

By: J. Jack n, G. Small*, C. Brown*, T. Havener*, H. McLeod*, A. Motsinger-Reif n, K. Richards*

co-author countries: United States of America 🇺🇸
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Antibodies, Monoclonal / administration & dosage; Antibodies, Monoclonal / adverse effects; Antibodies, Monoclonal / genetics; Antigens, CD20 / drug effects; Antigens, CD20 / immunology; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm / drug effects; Drug Resistance, Neoplasm / genetics; Female; Gene Expression Regulation, Neoplastic / drug effects; Genetic Linkage; Genome, Human / genetics; Humans; Leukemia, Lymphocytic, Chronic, B-Cell / complications; Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell / genetics; Male; Proto-Oncogene Proteins c-cbl / genetics; Rituximab / administration & dosage; Rituximab / adverse effects
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Gene set analysis methods: A systematic comparison

Biodata Mining, 11.

By: R. Mathur, D. Rotroff, J. Ma, A. Shojaie & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Genetic Tools for Coronary Risk Assessment in Type 2 Diabetes: A Cohort Study From the ACCORD Clinical Trial

DIABETES CARE, 41(11), 2404–2413.

By: M. Morieri*, H. Gao*, M. Pigeyre*, H. Shah*, J. Sjaarda*, C. Mendonca*, T. Hastings*, P. Buranasupkajorn* ...

co-author countries: Canada 🇨🇦 Thailand 🇹🇭 United States of America 🇺🇸
MeSH headings : Aged; Cohort Studies; Coronary Artery Disease / diagnosis; Coronary Artery Disease / genetics; Coronary Artery Disease / prevention & control; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / diagnosis; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / genetics; Diabetic Angiopathies / diagnosis; Diabetic Angiopathies / genetics; Diabetic Angiopathies / prevention & control; Female; Fenofibrate / administration & dosage; Genetic Association Studies; Genetic Markers; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Molecular Diagnostic Techniques; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Simvastatin / administration & dosage
Source: Web Of Science
Added: November 5, 2018

2018 journal article

Genetic variants in CPA6 and PRPF31 are associated with variation in response to metformin in individuals with type 2 diabetes

Diabetes, 67(7), 1428–1440.

By: D. Rotroff, S. Yee, K. Zhou, S. Marvel, H. Shah, J. Jack, T. Havener, M. Hedderson ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

International collaborative study to assess cardiovascular risk and evaluate long-term health in cats with preclinical hypertrophic cardiomyopathy and apparently healthy cats: The REVEAL Study

Journal of Veterinary Internal Medicine, 32(3), 930–943.

By: P. Fox, B. Keene, K. Lamb, K. Schober, V. Chetboul, V. Fuentes, G. Wess, J. Payne ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Modulation of GLP-1 Levels by a Genetic Variant That Regulates the Cardiovascular Effects of Intensive Glycemic Control in ACCORD

DIABETES CARE, 41(2), 348–355.

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
MeSH headings : Aged; Blood Glucose / genetics; Blood Glucose / metabolism; Diabetes Mellitus, Type 2 / blood; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / genetics; Diabetic Angiopathies / blood; Diabetic Angiopathies / genetics; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Glucagon-Like Peptide 1 / blood; Humans; Hypoglycemic Agents / therapeutic use; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Pharmacogenetic Analysis of the Model-Based Pharmacokinetics of Five Anti-HIV Drugs: How Does This Influence the Effect of Aging?

CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 11(2), 226–236.

By: J. Chen*, F. Akhtari n, M. Wagner*, O. Suzuki*, T. Wiltshire*, A. Motsinger-Reif n, J. Dumond*

co-author countries: United States of America 🇺🇸
MeSH headings : ATP Binding Cassette Transporter, Subfamily B / genetics; Adult; Age Factors; Aged; Aging / genetics; Anti-HIV Agents / administration & dosage; Anti-HIV Agents / pharmacokinetics; Anti-HIV Agents / therapeutic use; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; Cytochrome P-450 CYP2B6 / genetics; Drug Combinations; Drug Therapy, Combination / methods; Female; Frail Elderly; HIV Infections / drug therapy; HIV Infections / genetics; Humans; Male; Middle Aged; Multidrug Resistance-Associated Proteins / genetics; Pharmacogenomic Testing / methods; Prospective Studies; Young Adult
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 7(8), 525–533.

By: R. Kaddurah-Daouk*, T. Hankemeier*, E. Scholl n, R. Baillie*, A. Harms*, C. Stage*, K. Dalhoff*, G. Jurgens* ...

co-author countries: Denmark 🇩🇰 France 🇫🇷 Netherlands 🇳🇱 United States of America 🇺🇸
MeSH headings : Adult; Central Nervous System Stimulants / pharmacokinetics; Female; Humans; Male; Methylphenidate / pharmacokinetics; Prospective Studies; Young Adult
Source: NC State University Libraries
Added: October 16, 2018

2018 journal article

Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 7(1).

By: M. Shahin*, Y. Gong*, R. Frye*, D. Rotroff n, A. Beitelshees*, R. Baillie*, A. Chapman*, J. Gums* ...

co-author countries: Saudi Arabia 🇸🇦 United States of America 🇺🇸
author keywords: blood pressure; lipid metabolites; metabolomics; pharmacogenetics; thiazide diuretics
MeSH headings : Adult; Blood Pressure; Female; Genomics; Humans; Hydrochlorothiazide / therapeutic use; Hypertension / drug therapy; Lipid Metabolism; Male; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Nitriles; Pharmacogenetics; Prognosis; Serine C-Palmitoyltransferase / genetics; Siloxanes; Sodium Chloride Symporter Inhibitors / therapeutic use; Sphingolipids / metabolism; Treatment Outcome
Source: Web Of Science
Added: August 6, 2018

2018 journal article

The influence of Neanderthal alleles on cytotoxic response

PEERJ, 6.

By: F. Akhtari n, T. Havener*, M. Fukudo*, J. Jack n, H. McLeod*, T. Wiltshire*, A. Motsinger-Reif n

co-author countries: Japan 🇯🇵 United States of America 🇺🇸
author keywords: Neanderthal alleles; Cytotoxic response; Pharmacogenomics; Toxicogenomics; Dose responses; Neanderthal ancestry; Lymphoblastoid cell lines; Anti-cancer drugs; Environmental chemicals; Single nucleotide polymorphisms
Source: Web Of Science
Added: November 5, 2018

2017 review

An introduction to terminology and methodology of chemical synergy-perspectives from across disciplines

[Review of ]. Frontiers in Pharmacology, 8.

By: K. Roell, D. Reif & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2017 article

Assessment of potential miRNA biomarkers of VERO-cell tumorigenicity in a new line (AGMK1-9T7) of African green monkey kidney cells

Teferedegne, B., Rotroff, D. M., Macauley, J., Foseh, G., Lewis, G., Motsinger-Rief, A., & Lewis, A. M., Jr. (2017, October 4). VACCINE, Vol. 35, pp. 5503–5509.

By: B. Teferedegne*, D. Rotroff n, J. Macauley*, G. Foseh*, G. Lewis, A. Motsinger-Rief n, A. Lewis*

co-author countries: United States of America 🇺🇸
author keywords: African green monkey kidney (AGMK1-9T7) cells; Neoplastic development; Immortalization, transformation; Tumorigenic phenotype microRNA
MeSH headings : Animals; Biomarkers / metabolism; Carcinogenesis / genetics; Carcinogenesis / pathology; Cell Line; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / pathology; Chlorocebus aethiops; Female; Humans; Kidney / pathology; Mice, Nude; MicroRNAs / genetics; Neoplasms / genetics; Neoplasms / pathology; Vero Cells / pathology
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Association of breed and histopathological grade in canine mast cell tumours

VETERINARY AND COMPARATIVE ONCOLOGY, 15(3), 829–839.

By: H. Mochizuki n, A. Motsinger-Reif n, C. Bettini, S. Moroff & M. Breen n

co-author countries: United States of America 🇺🇸
author keywords: Boxer; dog; epidemiology; genetics; MCT; Pug
MeSH headings : Age Factors; Animals; Dog Diseases / etiology; Dog Diseases / pathology; Dogs; Female; Male; Mastocytosis, Cutaneous / etiology; Mastocytosis, Cutaneous / pathology; Mastocytosis, Cutaneous / veterinary; Retrospective Studies; Risk Factors; Sex Factors; Skin Neoplasms / etiology; Skin Neoplasms / pathology; Skin Neoplasms / veterinary; Species Specificity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Common and rare genetic markers of lipid variation in subjects with type 2 diabetes from the ACCORD clinical trial

PeerJ, 5.

By: S. Marvel, D. Rotroff, M. Wagner, J. Buse, T. Havener, H. McLeod, A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2017 article

Common genetic variants in neurobeachin (nbea) are associated with metformin drug response in individuals with type 2 diabetes in the accord clinical trial

Clinical Pharmacology & Therapeutics, Vol. 101, pp. S9–9.

By: D. Rotroff, S. Marvel, J. Jack, T. Havener, A. Doria, H. Shah, J. Mychaleckyi, H. McLeod ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Data descriptor: Targeted metabolomics and medication classification data from participants in the ADNI1 cohort

Scientific Data, 4.

By: L. St John-Williams, C. Blach, J. Toledo, D. Rotroff, S. Kim, K. Klavins, R. Baillie, X. Han ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

GUT DERIVED BILE ACID METABOLITES CORRELATE WITH STRUCTURAL AND FUNCTIONAL NEUROIMAGING MEASURES IN ALZHEIMER’S DISEASE

Alzheimer's & Dementia, 13(7), P543–P544.

By: K. Nho n, S. Dehkordi, A. Motsinger-Reif*, R. Baillie, S. Bhattacharyya, J. Tenenbaum, J. Thompson, L. St. John Williams ...

co-author countries: Austria 🇦🇹 United States of America 🇺🇸
Source: Crossref
Added: February 21, 2020

2017 journal article

Genetic Variants in HSD17B3 , SMAD3 , and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes

Clinical Pharmacology & Therapeutics, 103(4), 712–721.

co-author countries: Spain 🇪🇸 United States of America 🇺🇸
MeSH headings : Aldehyde Reductase / genetics; Animals; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / genetics; Diabetes Mellitus, Type 2 / metabolism; Dyslipidemias / blood; Dyslipidemias / complications; Dyslipidemias / drug therapy; Dyslipidemias / genetics; Female; Fenofibrate / administration & dosage; Fenofibrate / pharmacokinetics; Gene Expression Profiling / methods; Genome-Wide Association Study; Humans; Hypolipidemic Agents / administration & dosage; Hypolipidemic Agents / pharmacokinetics; Lipid Metabolism / drug effects; Lipid Metabolism / genetics; Male; Mice; Middle Aged; Pharmacogenomic Testing / methods; Signal Transduction / drug effects; Smad3 Protein / genetics; beta Karyopherins / genetics
Source: Crossref
Added: February 21, 2020

2017 journal article

Metabolic network failures in Alzheimer's disease: A biochemical road map

Alzheimers & Dementia, 13(9), 965–984.

By: J. Toledo, M. Arnold, G. Kastenmuller, R. Chang, R. Baillie, X. Han, M. Thambisetty, J. Tenenbaum ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Metabolic network failures in Alzheimer's disease: A biochemical road map

Alzheimer's & Dementia, 13(9), 965–984.

By: J. Toledo*, M. Arnold*, G. Kastenmüller*, R. Chang*, R. Baillie*, X. Han*, M. Thambisetty*, J. Tenenbaum* ...

co-author countries: Austria 🇦🇹 Germany 🇩🇪 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Netherlands 🇳🇱 Qatar 🇶🇦 United States of America 🇺🇸
author keywords: Metabolomics; Metabonomics; Pharmacometabolomics; Pharmacometabonomics; Biomarkers; Serum; Metabolism; Systems biology; Biochemical networks; Precision medicine; Alzheimer's disease; Dementia; Branched-chain amino acids; Sphingomyelins; Phospholipids; Acylcarnitines
MeSH headings : Aged; Aged, 80 and over; Aging / blood; Alzheimer Disease / blood; Alzheimer Disease / cerebrospinal fluid; Alzheimer Disease / complications; Alzheimer Disease / diagnostic imaging; Amino Acids / blood; Amyloid beta-Peptides / metabolism; Aniline Compounds / metabolism; Cognitive Dysfunction / blood; Cognitive Dysfunction / diagnostic imaging; Cognitive Dysfunction / etiology; Cohort Studies; Cross-Sectional Studies; Fasting; Female; Humans; Male; Metabolic Diseases / blood; Metabolic Diseases / cerebrospinal fluid; Metabolic Diseases / diagnostic imaging; Metabolic Diseases / etiology; Metabolic Networks and Pathways / physiology; Metabolomics / methods; Peptide Fragments / metabolism; Phosphatidylcholines / blood; Phosphatidylcholines / metabolism; Sphingomyelins / blood; Thiazoles / metabolism; tau Proteins / cerebrospinal fluid
Source: Crossref
Added: February 21, 2020

2017 journal article

Targeted metabolomics and medication classification data from participants in the ADNI1 cohort

Scientific Data, 4(1).

By: L. St John-Williams*, C. Blach*, J. Toledo*, D. Rotroff n, S. Kim*, K. Klavins*, R. Baillie*, X. Han* ...

co-author countries: Austria 🇦🇹 Germany 🇩🇪 United States of America 🇺🇸
MeSH headings : Alzheimer Disease / drug therapy; Alzheimer Disease / genetics; Alzheimer Disease / metabolism; Cognitive Dysfunction; Cohort Studies; Humans; Metabolomics; Neuroimaging
Source: Crossref
Added: February 21, 2020

2017 journal article

The Effect of Heart Disease on Anesthetic Complications During Routine Dental Procedures in Dogs

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 53(4), 206–213.

By: J. Carter n, A. Motsinger-Reif n, W. Krug n & B. Keene n

co-author countries: Australia 🇦🇺 United States of America 🇺🇸
MeSH headings : Anesthesia / adverse effects; Anesthesia / veterinary; Animals; Case-Control Studies; Dental Prophylaxis / veterinary; Dog Diseases / etiology; Dogs; Heart Diseases / complications; Heart Diseases / veterinary; Intraoperative Complications / etiology; Intraoperative Complications / veterinary; Retrospective Studies; Risk Factors
Source: Web Of Science
Added: August 6, 2018

2017 journal article

The steroid metabolome in women with premenstrual dysphoric disorder during GnRH agonist-induced ovarian suppression: effects of estradiol and progesterone addback

Translational Psychiatry, 7(8), e1193–e1193.

By: T. Nguyen, J. Reuter, N. Gaikwad*, D. Rotroff n, H. Kucera*, A. Motsinger-Reif n, C. Smith n, L. Nieman* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Adult; Cross-Over Studies; Desoxycorticosterone / blood; Estradiol / analogs & derivatives; Estradiol / blood; Estradiol / pharmacology; Estrone / blood; Female; Humans; Leuprolide / pharmacology; Metabolome / drug effects; Middle Aged; Pregnanediol / blood; Pregnanolone / blood; Premenstrual Dysphoric Disorder / metabolism; Progesterone / pharmacology; Young Adult
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Thromboelastographic monitoring of the effect of unfractionated heparin in healthy dogs

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 27(1), 71–81.

By: C. McLaughlin n, S. Marks n, D. Dorman n, A. Motsinger-Reif n & R. Hanel n

co-author countries: United States of America 🇺🇸
author keywords: anticoagulation monitoring; anti-Xa; canine; RapidTEG; thrombosis
MeSH headings : Animals; Anticoagulants / administration & dosage; Anticoagulants / pharmacology; Blood Coagulation / drug effects; Dogs; Female; Heparin / administration & dosage; Heparin / pharmacology; Injections, Subcutaneous / veterinary; Male; Partial Thromboplastin Time / veterinary; Prospective Studies; Reference Values; Thrombelastography / veterinary
Source: Web Of Science
Added: August 6, 2018

2016 journal article

A European spectrum of pharmacogenomic biomarkers: Implications for clinical pharmacogenomics

PLoS One, 11(9).

By: C. Mizzi, E. Dalabira, J. Kumuthini, N. Dzimiri, I. Balogh, N. Basak, R. Bohm, J. Borg ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

A comparison of DMET Plus microarray and genome-wide technologies by assessing population substructure

PHARMACOGENETICS AND GENOMICS, 26(4), 147–153.

By: J. Jackson n, K. Long n, Y. He n, A. Motsinger-Reif n, H. McLeod n & J. Jack n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: admixture; Affymetrix; cryptic relatedness; DMET Plus; inbreeding coefficients; metabolism; pharmacogenomics; population stratification; principal component analysis; transporters
Source: Web Of Science
Added: August 6, 2018

2016 journal article

A genetic response score for hydrochlorothiazide use insights from genomics and metabolomics integration

Hypertension, 68(3), 621-.

By: M. Shahin, Y. Gong, C. McDonough, D. Rotroff, A. Beitelshees, T. Garrett, J. Gums, A. Motsinger-Reif ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

A genome-wide study of lipid response to fenofibrate in Caucasians: A combined analysis of the GOLDN and ACCORD studies

Pharmacogenetics and Genomics, 26(7), 324–333.

By: M. Irvin, D. Rotroff, S. Aslibekyan, D. Zhi, B. Hidalgo, A. Motsinger-Reif, S. Marvel, V. Srinivasasainagendra ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial

PHARMACOGENOMICS JOURNAL, 16(3), 243–248.

By: Y. He*, S. Winham n, J. Hoskins*, S. Glass*, J. Paul*, R. Brown*, A. Motsinger-Reif n, H. McLeod*

co-author countries: China 🇨🇳 United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
MeSH headings : Adenosine Triphosphatases / genetics; Antineoplastic Combined Chemotherapy Protocols / adverse effects; Carboplatin / adverse effects; Cation Transport Proteins / genetics; Copper-Transporting ATPases; Docetaxel; Female; Gastrointestinal Diseases / chemically induced; Gastrointestinal Diseases / diagnosis; Gastrointestinal Diseases / genetics; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Kaplan-Meier Estimate; NAV1.8 Voltage-Gated Sodium Channel / genetics; Ovarian Neoplasms / drug therapy; Ovarian Neoplasms / mortality; Pharmacogenetics; Pharmacogenomic Variants / genetics; Phenotype; Polymorphism, Single Nucleotide; Proportional Hazards Models; Risk Factors; Scotland; Severity of Illness Index; Taxoids / adverse effects; Time Factors; Treatment Outcome; Vascular Endothelial Growth Factor A / genetics
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Comprehensive genomic characterization of five canine lymphoid tumor cell lines

BMC Veterinary Research, 12.

By: S. Roode, D. Rotroff, K. Richards, P. Moore, A. Motsinger-Reif, Y. Okamura, T. Mizuno, H. Tsujimoto, S. Suter, M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Eigenvector metabolite analysis reveals dietary effects on the association among metabolite correlation patterns, gene expression, and phenotypes

METABOLOMICS, 12(11).

By: C. Chialvo*, R. Che n, D. Reif n, A. Motsinger-Reif n & L. Reed*

co-author countries: United States of America 🇺🇸

Contributors: C. Scott Chialvo*, R. Che n, D. Reif n, A. Motsinger-Reif n & L. Reed*

author keywords: Eigenvector metabolite analysis; Linkage analyses; Environment; Enrichment analyses
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 review

Embracing integrative multiomics approaches

[Review of ]. International Journal of Genomics.

By: D. Rotroff & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

GENETIC INFLUENCE ON LEVELS OF TARGETED METABOLITES ASSOCIATED WITH ALZHEIMER’S DISEASE

Alzheimer's & Dementia, 12(7), P164–P165.

By: S. Kim*, J. Toledo*, K. Nho*, S. Risacher*, L. Shen*, J. Thompson*, L. St. John Williams*, J. Tenenbaum* ...

co-author countries: Austria 🇦🇹 Germany 🇩🇪 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Qatar 🇶🇦 United States of America 🇺🇸
Source: Crossref
Added: August 28, 2020

2016 journal article

Genetic predictors of cardiovascular mortality during intensive glycemic control in type 2 diabetes: Findings from the ACCORD clinical trial

Diabetes Care, 39(11), 1915–1924.

By: H. Shah, H. Gao, M. Morieri, J. Skupien, S. Marvel, G. Pare, G. Mannino, P. Buranasupkajorn ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Genome-wide association study in immunocompetent patients with delayed hypersensitivity to sulfonamide antimicrobials

PLoS One, 11(6).

By: J. Reinhart, A. Motsinger-Reif, A. Dickey, S. Yale & L. Trepanier

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

INDICES OF PLASMALOGEN BIOSYNTHESIS IN ADNI-1 BASELINE SERUM SAMPLES: ASSOCIATION WITH PROGRESSION TO DEMENTIA IN SUBJECTS WITH MILD COGNITIVE IMPAIRMENT

Alzheimer's & Dementia, 12(7), P879–P880.

By: M. Kling*, D. Goodenowe*, J. Toledo*, V. Senanayake*, R. Baillie*, J. Lucas*, J. Tenenbaum*, A. Motsinger-Reif n, X. Han*, R. Kaddurah-Daouk*

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
Source: Crossref
Added: February 24, 2020

2016 journal article

Incorporating concomitant medications into genome-wide analyses for the study of complex disease and drug response

Frontiers in Genetics, 7.

By: H. Graham, D. Rotroff, S. Marvel, J. Buse, T. Havener, A. Wilson, M. Wagner, A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero

BMC Genomics, 17.

By: D. Rotroff, B. Joubert, S. Marvel, S. Haberg, M. Wu, R. Nilsen, P. Ueland, W. Nystad, S. London, A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants

Translational Psychiatry, 6(9), e894–e894.

By: D. Rotroff n, D. Corum*, A. Motsinger-Reif n, O. Fiehn*, N. Bottrel*, W. Drevets*, J. Singh*, G. Salvadore*, R. Kaddurah-Daouk*

co-author countries: United States of America 🇺🇸
MeSH headings : Adult; Arginine / metabolism; Citrulline / metabolism; Depressive Disorder, Major / drug therapy; Depressive Disorder, Major / metabolism; Depressive Disorder, Treatment-Resistant / drug therapy; Depressive Disorder, Treatment-Resistant / metabolism; Excitatory Amino Acid Antagonists / therapeutic use; Female; Glutamic Acid / metabolism; Humans; Indoleacetic Acids / metabolism; Infusions, Intravenous; Ketamine / therapeutic use; Male; Metabolomics; Methionine / metabolism; Middle Aged; Ornithine / metabolism; Phenotype; Phospholipids / metabolism; Tryptophan / metabolism; Urea / metabolism
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Pharmacometabolomic assessment of metformin in non-diabetic, African Americans

Frontiers in Pharmacology, 7.

By: D. Rotroff, N. Oki, X. Liang, S. Yee, S. Stocker, D. Corum, M. Meisner, O. Fiehn ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

THE ALZHEIMER’S METABOLOME: RELATIONSHIP TO PATHOLOGICAL MARKERS AND COGNITIVE DECLINE IN THE ALZHEIMER’S DISEASE NEUROIMAGING INITIATIVE (ADNI)

Alzheimer's & Dementia, 12(7), P164.

By: J. Toledo*, J. Thompson*, L. St. John Williams*, J. Tenenbaum*, X. Han*, R. Baillie*, M. Thambisetty*, R. Casanova* ...

co-author countries: Austria 🇦🇹 Germany 🇩🇪 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Qatar 🇶🇦 United States of America 🇺🇸
Source: Crossref
Added: August 28, 2020

2016 journal article

Use of RNA-seq to identify cardiac genes and gene pathways differentially expressed between dogs with and without dilated cardiomyopathy

AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(7), 693–699.

By: S. Friedenberg n, L. Chdid n, B. Keene n, B. Sherry n, A. Motsinger-Reif n & K. Meurs n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / metabolism; Cardiomyopathy, Dilated / veterinary; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Down-Regulation; Female; Gene Expression; Heart Ventricles; Male; Myocardium / metabolism; RNA / genetics; Up-Regulation
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

Nature Genetics, 48(9), 1055–1059.

By: K. Zhou*, S. Yee, E. Seiser*, N. van Leeuwen*, R. Tavendale*, A. Bennett*, C. Groves*, R. Coleman* ...

co-author countries: Bosnia and Herzegovina 🇧🇦 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Japan 🇯🇵 Latvia 🇱🇻 Netherlands 🇳🇱 Slovakia 🇸🇰 United States of America 🇺🇸
MeSH headings : Blood Glucose / analysis; Body Mass Index; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / genetics; Genome-Wide Association Study; Glucose Transporter Type 2 / genetics; Glycated Hemoglobin / analysis; Humans; Hypoglycemic Agents / therapeutic use; Metformin / therapeutic use; Polymorphism, Single Nucleotide / genetics; Quantitative Trait, Heritable; White People
Source: Crossref
Added: February 24, 2020

2016 journal article

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

Nature Genetics, 48(9), 1055-.

By: K. Zhou, S. Yee, E. Seiser, N. Leeuwen, R. Tavendalel, A. Bennett, C. Groves, R. Coleman ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

alpha-Hydroxybutyric Acid Is a Selective Metabolite Biomarker of Impaired Glucose Tolerance

DIABETES CARE, 39(6), 988–995.

By: J. Cobb*, A. Eckhart*, A. Motsinger-Reif n, B. Carr*, L. Groop* & E. Ferrannini*

co-author countries: Ireland 🇮🇪 Italy 🇮🇹 Sweden 🇸🇪 United States of America 🇺🇸
MeSH headings : Adult; Biomarkers / metabolism; Blood Glucose / metabolism; Cohort Studies; Fasting; Female; Glucose Intolerance / metabolism; Glucose Tolerance Test; Humans; Hydroxybutyrates / metabolism; Male; Metabolomics; Middle Aged; Multivariate Analysis; Oleic Acid / metabolism; Prediabetic State / metabolism; Prospective Studies
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Accuracy of SNPs to predict risk of HLA alleles associated with drug-induced hypersensitivity events across racial groups

PHARMACOGENOMICS, 16(8), 817–824.

By: Y. He*, J. Hoskins, S. Clark, N. Campbell, K. Wagner, A. Motsinger-Reif n, H. McLeod*

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: drug-induced hypersensitivity; HLA; human leukocyte antigen; pharmacogenetics; pharmacogenomics; risk mitigation
MeSH headings : Black or African American / genetics; Alleles; Asian People / genetics; Drug Hypersensitivity / genetics; Drug Hypersensitivity / pathology; Genotype; HLA-B Antigens / genetics; HLA-DQ alpha-Chains / genetics; Hispanic or Latino / genetics; Humans; Polymorphism, Single Nucleotide / genetics; White People
Source: Web Of Science
Added: August 6, 2018

2015 journal article

An investigation of gene-gene interactions in dose-response studies with Bayesian nonparametrics

Biodata Mining, 8.

By: A. Beam, A. Motsinger-Reif & J. Doyle

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Canine urothelial carcinoma: genomically aberrant and comparatively relevant

Chromosome Research, 23(2), 311–331.

By: S. Shapiro n, S. Raghunath n, C. Williams n, A. Motsinger-Reif n, J. Cullen n, T. Liu*, D. Albertson*, M. Ruvolo* ...

co-author countries: United States of America 🇺🇸
author keywords: Canine; Urothelial carcinoma; Transitional cell carcinoma; Cytogenetics; Chromosome aberration; Array comparative genomic hybridization; Comparative oncology
MeSH headings : Animals; Biopsy; Carcinoma / veterinary; Chromosome Aberrations; Comparative Genomic Hybridization; Computational Biology / methods; DNA Copy Number Variations; Dogs; Female; Genetic Loci; Genomics / methods; Humans; In Situ Hybridization, Fluorescence; Male; Urologic Neoplasms / veterinary
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Comparative cytogenetic characterization of primary canine melanocytic lesions using array CGH and fluorescence in situ hybridization

CHROMOSOME RESEARCH, 23(2), 171–186.

By: K. Poorman n, L. Borst n, S. Moroff, S. Roy n, P. Labelle, A. Motsinger-Reif n, M. Breen n

co-author countries: United States of America 🇺🇸
author keywords: Canine; Oral melanoma; Cytogenetics; Array; Comparative genomic hybridization
MeSH headings : Animals; Chromosome Aberrations; Cluster Analysis; Comparative Genomic Hybridization; Computational Biology; DNA Copy Number Variations; Dogs; Female; Humans; In Situ Hybridization, Fluorescence; Male; Melanoma / genetics; Melanoma / metabolism; Melanoma / pathology; Mouth Neoplasms / genetics; Mouth Neoplasms / pathology; Penetrance; Skin Neoplasms
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Evaluating the role of admixture in cancer therapy via in vitro drug response and multivariate genome-wide associations

PHARMACOGENOMICS, 16(13), 1451–1463.

By: J. Jack n, T. Havener*, H. McLeod*, A. Motsinger-Reif n & M. Foster*

co-author countries: United States of America 🇺🇸
author keywords: admixture; cancer; Caucasian; cytotoxicity; drug; genome-wide association study; GWAS; hispanic; in vitro; lymphoblastoid cell lines
MeSH headings : Black or African American; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cell Line, Tumor; Cohort Studies; Ethnicity; Genetic Variation; Genome-Wide Association Study; Hispanic or Latino; Humans; Multivariate Analysis; Neoplasms / drug therapy; Neoplasms / genetics; Pharmacogenetics; Treatment Outcome; White People
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Genome-wide assessment of recurrent genomic imbalances in canine leukemia identifies evolutionarily conserved regions for subtype differentiation

Chromosome Research, 23(4), 681–708.

By: S. Roode n, D. Rotroff n, A. Avery*, S. Suter n, D. Bienzle*, J. Schiffman*, A. Motsinger-Reif n, M. Breen n

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
author keywords: Leukemia; Canine; Chromosome; Comparative genomic hybridization; Comparative genomics
MeSH headings : Algorithms; Animals; Cell Transformation, Neoplastic / genetics; Chromosome Aberrations; Chromosome Mapping; Cluster Analysis; Comparative Genomic Hybridization; Conserved Sequence; DNA Copy Number Variations; Disease Models, Animal; Dogs; Evolution, Molecular; Female; Gene Dosage; Genome-Wide Association Study; Genomic Library; Genomics; Humans; In Situ Hybridization, Fluorescence; Leukemia / diagnosis; Leukemia / genetics; Leukemia / metabolism; Male
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain

PeerJ, 3.

By: D. Knazovicky, A. Tomas, A. Motsinger-Reif & B. Lascelles

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Pharmacometabolomic Assessments of Atenolol and Hydrochlorothiazide Treatment Reveal Novel Drug Response Phenotypes

CPT: Pharmacometrics & Systems Pharmacology, 4(11), 669–679.

By: D. Rotroff n, M. Shahin*, S. Gurley*, H. Zhu*, A. Motsinger-Reif n, M. Meisner n, A. Beitelshees*, O. Fiehn* ...

co-author countries: Saudi Arabia 🇸🇦 United States of America 🇺🇸
Source: Crossref
Added: February 24, 2020

2015 journal article

Population-Based in Vitro Hazard and Concentration-Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study

ENVIRONMENTAL HEALTH PERSPECTIVES, 123(5), 458–466.

By: N. Abdo*, M. Xia*, C. Brown*, O. Kosyk*, R. Huang*, S. Sakamuru*, Y. Zhou n, J. Jack* ...

co-author countries: Japan 🇯🇵 United States of America 🇺🇸
MeSH headings : Cell Line, Tumor; Genome-Wide Association Study / methods; Genotype; Humans; Risk Assessment; Toxicity Tests / methods
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Relative Quantification and Higher-Order Modeling of the Plasma Glycan Cancer Burden Ratio in Ovarian Cancer Case-Control Samples

JOURNAL OF PROTEOME RESEARCH, 14(10), 4394–4401.

By: E. Hecht*, E. Scholl*, S. Walker*, A. Taylor, W. Cliby*, A. Motsinger-Reif*, D. Muddiman*

co-author countries: United States of America 🇺🇸
author keywords: N-linked glycosylation; INLIGHT; ovarian cancer; relative quantification; cancer biomarker; human plasma
MeSH headings : Biomarkers, Tumor / blood; Carbohydrate Sequence; Case-Control Studies; Chromatography, Liquid / methods; Female; Fucose / blood; Glycosylation; Humans; Hydrazines / chemistry; Molecular Sequence Data; Neoplasm Staging; Ovarian Neoplasms / blood; Ovarian Neoplasms / diagnosis; Ovarian Neoplasms / pathology; Polysaccharides / blood; Sialic Acids / blood; Staining and Labeling / methods; Tandem Mass Spectrometry / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

A novel canine model of immune thrombocytopenia: has immune thrombocytopenia (ITP) gone to the dogs?

British Journal of Haematology, 167(1), 110–120.

By: D. LeVine n, A. Birkenheuer n, M. Brooks*, S. Nordone n, D. Bellinger*, S. Jones n, T. Fischer*, S. Oglesbee* ...

co-author countries: Denmark 🇩🇰 United States of America 🇺🇸
author keywords: immune thrombocytopenia; canine; interleukin-8; animal model
MeSH headings : Animals; Antibodies, Monoclonal / administration & dosage; Antibodies, Monoclonal / adverse effects; Antibodies, Monoclonal / immunology; Blood Platelets / immunology; Blood Platelets / metabolism; Cytokines / blood; Cytokines / metabolism; Disease Models, Animal; Dogs; Hemorrhage / immunology; Phenotype; Platelet Count; Purpura, Thrombocytopenic, Idiopathic / blood; Purpura, Thrombocytopenic, Idiopathic / diagnosis; Purpura, Thrombocytopenic, Idiopathic / immunology
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2014 journal article

An adaptive permutation approach for genome-wide association study: Evaluation and recommendations for use

Biodata Mining, 7.

By: R. Che, J. Jack, A. Motsinger-Reif & C. Brown

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Bayesian neural networks for detecting epistasis in genetic association studies

BMC Bioinformatics, 15.

By: A. Beam, A. Motsinger-Reif & J. Doyle

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Canine hereditary ataxia in Old English Sheepdogs and Gordon Setters is associated with a defect in the autophagy gene encoding RAB24

PLoS Genetics, 10(2).

By: C. Agler, D. Nielsen, G. Urkasemsin, A. Singleton, N. Tonomura, S. Sigurdsson, R. Tang, K. Linder ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Evaluation of thromboelastography for prediction of clinical bleeding in thrombocytopenic dogs after total body irradiation and hematopoietic cell transplantation

AMERICAN JOURNAL OF VETERINARY RESEARCH, 75(5), 425–432.

By: M. Bucknoff, R. Hanel*, S. Marks*, A. Motsinger-Reif* & S. Suter*

MeSH headings : Animals; Bone Marrow Transplantation / veterinary; Cohort Studies; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dogs; Hemorrhage / diagnosis; Hemorrhage / physiopathology; Hemorrhage / veterinary; Hemostasis / physiology; Kaolin; Lymphoma / physiopathology; Lymphoma / veterinary; Male; Platelet Count / veterinary; Prospective Studies; Thrombelastography / methods; Thrombelastography / veterinary; Thrombocytopenia / physiopathology; Thrombocytopenia / veterinary; Whole-Body Irradiation / veterinary
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Genetic heterogeneity beyond CYP2C8*3 does not explain differential sensitivity to paclitaxel-induced neuropathy

BREAST CANCER RESEARCH AND TREATMENT, 145(1), 245–254.

By: D. Hertz*, S. Roy n, J. Jack n, A. Motsinger-Reif n, A. Drobish, L. Clark*, L. Carey*, E. Dees*, H. McLeod*

co-author countries: United States of America 🇺🇸
author keywords: Paclitaxel; Pharmacogenetics; Breast cancer; Chemotherapy-induced peripheral neuropathy; ABCG1; Affymetrix DMET (TM) plus; CYP2C8; Race
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines

PHARMACOGENOMICS, 15(2), 137–146.

By: C. Brown n, T. Havener*, M. Medina, J. Jack n, R. Krauss, H. McLeod*, A. Motsinger-Reif n

co-author countries: United States of America 🇺🇸
author keywords: chemotherapeutics; genome-wide association study; lymphoblastoid cell lines
MeSH headings : Antineoplastic Agents / administration & dosage; Biomarkers, Pharmacological / metabolism; Cell Line, Tumor; Chromosome Mapping; Genome-Wide Association Study; Genotype; Histone Deacetylases / genetics; Humans; Pharmacogenetics; Repressor Proteins / genetics
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

CHROMOSOME RESEARCH, 22(3), 305–319.

By: R. Thomas n, L. Borst n, D. Rotroff n, A. Motsinger-Reif n, K. Lindblad-Toh*, J. Modiano*, M. Breen n

co-author countries: Sweden 🇸🇪 United States of America 🇺🇸
author keywords: canine; chromosome; hemangiosarcoma; comparative genomic hybridization (CGH)
MeSH headings : Animals; Breeding; Comparative Genomic Hybridization; DNA Copy Number Variations / genetics; Dog Diseases / genetics; Dogs; Gene Amplification; Gene Expression Profiling; Genetic Heterogeneity; Genome; Hemangiosarcoma / genetics; Hemangiosarcoma / veterinary; Penetrance; Vascular Endothelial Growth Factor A / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Lymphoblastoid Cell Lines Models of Drug Response: Successes and Lessons from this Pharmacogenomic Model

CURRENT MOLECULAR MEDICINE, 14(7), 833–840.

By: J. Jack*, D. Rotroff* & A. Motsinger-Reif*

author keywords: Cytotoxics; genetic association mapping; genome wide association analysis; lymphoplastoid cell lines; pharmacogenomics
MeSH headings : Cell Line, Transformed; Cost-Benefit Analysis; Genome-Wide Association Study / economics; Genome-Wide Association Study / methods; Humans; Lymphocytes / drug effects; Lymphocytes / metabolism; Models, Biological; Models, Genetic; Pharmacogenetics / economics; Pharmacogenetics / methods; Polymorphism, Single Nucleotide; RNA Interference; Reproducibility of Results; Translational Research, Biomedical / economics; Translational Research, Biomedical / methods
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013

Equine Veterinary Journal, 47(3), 279–284.

By: L. Gonzalez n, C. Fogle n, W. Baker, F. Hughes*, J. Law n, A. Motsinger-Reif n, A. Blikslager n

co-author countries: United States of America 🇺🇸

Contributors: L. Gonzalez n, C. Fogle n, W. Baker, F. Hughes*, J. Law n, A. Motsinger-Reif n, A. Blikslager n

author keywords: horse; large colon volvulus; strangulation; pelvic flexure; surgery
MeSH headings : Animals; Biopsy; Colon / pathology; Hemorrhage / pathology; Hemorrhage / veterinary; Horse Diseases / surgery; Horses; Intestinal Volvulus / pathology; Intestinal Volvulus / surgery; Intestinal Volvulus / veterinary; Logistic Models; Retrospective Studies
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2014 journal article

PGxClean: a quality control GUI for the Affymetrix DMET chip and other candidate gene studies with non-biallelic alleles

Biodata Mining, 7.

By: D. Rotroff, J. Jack, N. Campbell, S. Clark & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Positive association between a glutathione-S-transferase polymorphism and lymphoma in dogs

VETERINARY AND COMPARATIVE ONCOLOGY, 12(3), 227–236.

By: J. Ginn*, J. Sacco*, Y. Wong*, A. Motsinger-Reif n, R. Chun* & L. Trepanier*

co-author countries: United States of America 🇺🇸
author keywords: cancer risk; canine; carcinogens; glutathione; lymphosarcoma; polymorphisms
MeSH headings : Animals; Case-Control Studies; Dog Diseases / enzymology; Dog Diseases / genetics; Dogs; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genotype; Glutathione Transferase / genetics; Glutathione Transferase / metabolism; Lymphoma / enzymology; Lymphoma / genetics; Lymphoma / veterinary; Point Mutation; Polymorphism, Genetic
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Prevalence of onychectomy in cats presented for veterinary care near Raleigh, NC and educational attitudes toward the procedure

Veterinary Anaesthesia and Analgesia, 41(1), 48–53.

By: L. Lockhart n, A. Motsinger-Reif n, W. Simpson* & L. Posner n

co-author countries: United States of America 🇺🇸
author keywords: cat; declaw; education; onychectomy; pain; sterilization
MeSH headings : Animals; Cats / surgery; Education, Veterinary; Female; Hoof and Claw / surgery; Male; North Carolina; Surgical Procedures, Operative / education; Surgical Procedures, Operative / veterinary
Sources: Web Of Science, Crossref
Added: August 6, 2018

2014 journal article

Relationship Between Mechanical Thresholds and Limb Use in Dogs With Coxofemoral Joint OA-Associated Pain and the Modulating Effects of Pain Alleviation From Total Hip Replacement on Mechanical Thresholds

VETERINARY SURGERY, 43(5), 542–548.

By: A. Tomas n, D. Marcellin-Little n, S. Roe n, A. Motsinger-Reif n & B. Lascelles n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Arthroplasty, Replacement, Hip / veterinary; Coccyx; Dog Diseases / physiopathology; Dog Diseases / surgery; Dogs; Female; Femur; Gait; Hip Joint / physiopathology; Joint Instability / physiopathology; Joint Instability / veterinary; Male; Pain Measurement / veterinary; Prospective Studies; Recovery of Function
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Single-Nucleotide Polymorphism Data Support the General Unrelatedness of the Males in the Agricultural Health Study

Cancer Epidemiology Biomarkers & Prevention, 23(10), 2192–2195.

By: J. Jack n, A. Motsinger-Reif n, S. Koutros*, M. Alavanja*, L. Beane Freeman* & J. Hoppin n

co-author countries: United States of America 🇺🇸
MeSH headings : Agriculture; Case-Control Studies; Cohort Studies; Consanguinity; Gene-Environment Interaction; Humans; Male; Occupational Exposure; Polymorphism, Single Nucleotide; Principal Component Analysis; Research Design
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2014 journal article

VH1-44 gene usage defines a subset of canine B-cell lymphomas associated with better patient survival

Veterinary Immunology and Immunopathology, 157(3-4), 125–130.

By: H. Chen n, G. Small*, A. Motsinger-Reif n, S. Suter n & K. Richards n

co-author countries: United States of America 🇺🇸
author keywords: Immunoglobulin heavy chain variable region (VH); B-cell lymphoma; Diffuse large B-cell lymphoma; Survival; VH1-44
MeSH headings : Animals; Dog Diseases / genetics; Dog Diseases / immunology; Dog Diseases / mortality; Dogs / immunology; Humans; Immunoglobulin Heavy Chains / genetics; Immunoglobulin Variable Region / genetics; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / immunology; Lymphoma, B-Cell / mortality; Lymphoma, B-Cell / veterinary
Sources: Web Of Science, Crossref
Added: August 6, 2018

2013 journal article

Alfaxalone anesthesia in bullfrogs (Lithobates catesbeiana) by injection or immersion

Journal of Zoo and Wildlife Medicine, 44(4), 965–971.

By: L. Posner n, K. Bailey n, E. Richardson n, A. Motsinger-Reif n & C. Harms n

co-author countries: United States of America 🇺🇸
author keywords: Alfaxalone; Alfaxan (R); anesthesia; bullfrogs; immersion; intramuscular
MeSH headings : Anesthetics / administration & dosage; Anesthetics / pharmacology; Animals; Drug Administration Routes; Pregnanediones / administration & dosage; Pregnanediones / pharmacology; Rana catesbeiana
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2013 journal article

Alterations in metabolic pathways and networks in Alzheimer’s disease

Translational Psychiatry, 3(4), e244–e244.

By: R. Kaddurah-Daouk*, H. Zhu*, S. Sharma*, M. Bogdanov, S. Rozen*, W. Matson*, N. Oki n, A. Motsinger-Reif n ...

co-author countries: Singapore 🇸🇬 United States of America 🇺🇸
author keywords: Alzheimer's disease; metabolomics; partial network reconstruction; pathway analysis
MeSH headings : Aged; Aged, 80 and over; Alzheimer Disease / cerebrospinal fluid; Alzheimer Disease / metabolism; Biomarkers / cerebrospinal fluid; Case-Control Studies; Chromatography, Liquid; Cognitive Dysfunction / cerebrospinal fluid; Cognitive Dysfunction / metabolism; Female; Humans; Male; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Neuropsychological Tests; Prospective Studies
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2013 journal article

CYP2C8*3 increases risk of neuropathy in breast cancer patients treated with paclitaxel

ANNALS OF ONCOLOGY, 24(6), 1472–1478.

By: D. Hertz*, S. Roy, A. Motsinger-Reif n, A. Drobish, L. Clark*, H. McLeod*, L. Carey*, E. Dees*

co-author countries: United States of America 🇺🇸
author keywords: chemotherapy-induced peripheral neuropathy; cytochrome P450 2C8*3; paclitaxel; pharmacogenetics; race
MeSH headings : Adult; Black or African American / genetics; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic / therapeutic use; Aryl Hydrocarbon Hydroxylases / genetics; Breast Neoplasms / drug therapy; Breast Neoplasms / enzymology; Breast Neoplasms / genetics; Cohort Studies; Cytochrome P-450 CYP2C8; Female; Genetic Variation / genetics; Humans; Middle Aged; Paclitaxel / adverse effects; Paraneoplastic Polyneuropathy / chemically induced; Paraneoplastic Polyneuropathy / enzymology; Paraneoplastic Polyneuropathy / genetics; Risk Factors; Treatment Outcome; White People / genetics; Young Adult
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Differentially expressed microRNAs and affected biological pathways revealed by modulated modularity clustering (MMC) analysis of human preeclamptic and IUGR placentas

Placenta, 34(7), 599–605.

By: L. Guo n, S. Tsai*, N. Hardison n, A. James*, A. Motsinger-Reif n, B. Thames*, E. Stone n, C. Deng*, J. Piedrahita n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: Placenta; Preeclampsia; IUGR; MiR-194; MiR-149
MeSH headings : Down-Regulation; Female; Fetal Growth Retardation / genetics; Fetal Growth Retardation / metabolism; Humans; MicroRNAs / biosynthesis; Placenta / metabolism; Pre-Eclampsia / genetics; Pre-Eclampsia / metabolism; Pregnancy; Transcriptome
Sources: Web Of Science, Crossref
Added: August 6, 2018

2013 journal article

Gene Profiling of Canine B-Cell Lymphoma Reveals Germinal Center and Postgerminal Center Subtypes with Different Survival Times, Modeling Human DLBCL

Cancer Research, 73(16), 5029–5039.

By: K. Richards n, A. Motsinger-Reif n, H. Chen n, Y. Fedoriw n, C. Fan n, D. Nielsen n, G. Small n, R. Thomas n ...

co-author countries: Italy 🇮🇹 Japan 🇯🇵 Netherlands 🇳🇱 United States of America 🇺🇸
MeSH headings : Adolescent; Animals; Child; Child, Preschool; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Disease Models, Animal; Dogs; Female; Gene Expression Profiling / methods; Germinal Center / metabolism; Germinal Center / pathology; Humans; Immunoglobulin Heavy Chains / genetics; Immunoglobulin Heavy Chains / metabolism; Interferon Regulatory Factors / genetics; Interferon Regulatory Factors / metabolism; Lymph Nodes / metabolism; Lymph Nodes / pathology; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / metabolism; Lymphoma, B-Cell / pathology; Lymphoma, Large B-Cell, Diffuse / genetics; Lymphoma, Large B-Cell, Diffuse / metabolism; Lymphoma, Large B-Cell, Diffuse / pathology; Male; Mutation; NF-kappa B / genetics; NF-kappa B / metabolism; Proto-Oncogene Proteins c-bcl-6; Transcriptome
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2013 journal article

Gene selection and cancer type classification of diffuse large-B-cell lymphoma using a bivariate mixture model for two-species data

Human Genomics, 7.

By: Y. Su, D. Nielsen, L. Zhu, K. Richards, S. Suter, M. Breen, A. Motsinger-Reif, J. Osborne

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Genome-wide association studies in pharmacogenomics: Successes and lessons

Pharmacogenetics and Genomics, 23(8), 383–394.

By: A. Motsinger-Reif, E. Jorgenson, M. Relling, D. Kroetz, R. Weinshilboum, N. Cox, D. Roden

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Interview A discussion on genome-wide associations in pharmacogenomics

Pharmacogenomics, 14(4), 361–363.

By: S. Jones & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2013 article

Naturally occuring canine cancers: powerful models for stimulating pharmacogenomic advancement in human medicine

Rotroff, D. M., Thomas, R., Breen, M., & Motsinger-Reif, A. A. (2013, December). PHARMACOGENOMICS, Vol. 14, pp. 1929–1931.

By: D. Rotroff n, R. Thomas n, M. Breen n & A. Motsinger-Reif n

co-author countries: United States of America 🇺🇸
author keywords: cancer; canine model; chemotherapy; clinical trials
MeSH headings : Animals; Disease Models, Animal; Dogs; Humans; Neoplasms / drug therapy; Neoplasms / pathology; Pharmacogenetics / methods
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction

Biodata Mining, 6.

By: H. Dai, R. Charnigo, M. Becker, J. Leeder & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT

PHARMACOGENETICS AND GENOMICS, 22(11), 796–802.

By: C. Brown*, T. Havener*, M. Medina, J. Auman*, L. Mangravite*, R. Krauss, H. McLeod*, A. Motsinger-Reif n

co-author countries: United States of America 🇺🇸
author keywords: genome-wide association studies; lymphoblastoid cell lines; MGMT; pharmacogenetics; temozolomide
MeSH headings : Antineoplastic Agents, Alkylating / pharmacology; Cell Line, Tumor; DNA Methylation; DNA Modification Methylases / genetics; DNA Repair Enzymes / genetics; Dacarbazine / analogs & derivatives; Dacarbazine / pharmacology; Gene Expression Regulation, Neoplastic; Genome, Human; Genome-Wide Association Study; Humans; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology; Temozolomide; Tumor Suppressor Proteins / genetics
Source: Web Of Science
Added: August 6, 2018

2012 journal article

A predictive model for Efavirenz dosing

Pharmacogenomics, 13(2), 137–138.

By: C. Brown, N. Oki, G. Hariani & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Assessing the utility of whole genome amplified DNA as a template for DMET Plus array

Clinical Chemistry and Laboratory Medicine, 50(8), 1329–1334.

By: Y. He, A. Misher, W. Irvin, A. Motsinger-Reif, H. McLeod & J. Hoskins

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

CYP2C8*3 predicts benefit/risk profile in breast cancer patients receiving neoadjuvant paclitaxel

BREAST CANCER RESEARCH AND TREATMENT, 134(1), 401–410.

By: D. Hertz*, A. Motsinger-Reif n, A. Drobish, S. Winham n, H. McLeod*, L. Carey*, E. Dees*

co-author countries: United States of America 🇺🇸
author keywords: Paclitaxel; CYP2C8*3; Pharmacogenetics; Neoadjuvant breast cancer therapy; Clinical complete response
MeSH headings : ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics; Adult; Aged; Antineoplastic Agents, Phytogenic / adverse effects; Antineoplastic Agents, Phytogenic / pharmacology; Antineoplastic Agents, Phytogenic / therapeutic use; Aryl Hydrocarbon Hydroxylases / genetics; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Breast Neoplasms / pathology; Chemotherapy, Adjuvant; Cytochrome P-450 CYP2C8; Female; Gene Frequency; Genetic Association Studies; Haplotypes; Humans; Middle Aged; Multivariate Analysis; Neoadjuvant Therapy; Paclitaxel / adverse effects; Paclitaxel / pharmacology; Paclitaxel / therapeutic use; Polymorphism, Single Nucleotide; Tumor Burden / drug effects
Source: Web Of Science
Added: August 6, 2018

2012 article

Comparison of venous sampling methods for thromboelastography in clinically normal dogs

Walker, J. M., Hanel, R. M., Hansen, B. D., & Motsinger-Reif, A. A. (2012, December). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 73, pp. 1864–1870.

By: J. Walker n, R. Hanel*, B. Hansen* & A. Motsinger-Reif*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Blood Platelets / physiology; Dogs / blood; Male; Phlebotomy / methods; Phlebotomy / veterinary; Thrombelastography / methods; Thrombelastography / veterinary
Source: Web Of Science
Added: August 6, 2018

2012 article

Effects of acepromazine maleate on platelet function assessed by use of adenosine diphosphate activated- and arachidonic acid-activated modified thromboelastography in healthy dogs

Conner, B. J., Hanel, R. M., Hansen, B. D., Motsinger-Reif, A. A., Asakawa, M., & Swanson, C. R. (2012, May). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 73, pp. 595–601.

By: B. Conner n, R. Hanel*, B. Hansen*, A. Motsinger-Reif*, M. Asakawa* & C. Swanson*

co-author countries: United States of America 🇺🇸
MeSH headings : Acepromazine / administration & dosage; Acepromazine / adverse effects; Adenosine Diphosphate / chemistry; Animals; Arachidonic Acid / chemistry; Blood Platelets / drug effects; Blood Platelets / physiology; Cross-Over Studies; Dogs / physiology; Female; Hemostasis / drug effects; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / adverse effects; Injections, Intravenous / veterinary; Thrombelastography / methods; Thrombelastography / veterinary
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Evaluation of Polymorphisms in the Sulfonamide Detoxification Genes CYB5A and CYB5R3 in Dogs with Sulfonamide Hypersensitivity

JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(5), 1126–1133.

By: J. Funk-Keenan*, J. Sacco*, Y. Wong*, S. Rasmussen*, A. Motsinger-Reif n & L. Trepanier*

co-author countries: United States of America 🇺🇸
author keywords: Genotype; Idiosyncratic; Potentiated sulfonamide; Predisposition
MeSH headings : Animals; Cytochrome-B(5) Reductase / genetics; Cytochrome-B(5) Reductase / immunology; Cytochromes b5 / genetics; Cytochromes b5 / immunology; Dog Diseases / genetics; Dog Diseases / immunology; Dogs; Drug Hypersensitivity / etiology; Drug Hypersensitivity / genetics; Drug Hypersensitivity / immunology; Drug Hypersensitivity / veterinary; Female; Genotype; Liver / enzymology; Liver / immunology; Male; Polymorphism, Genetic; RNA / chemistry; RNA / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Sulfonamides / adverse effects
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity

PHARMACOGENETICS AND GENOMICS, 22(10), 733–740.

By: J. Sacco*, M. Abouraya*, A. Motsinger-Reif n, S. Yale*, C. McCarty* & L. Trepanier*

co-author countries: United States of America 🇺🇸
author keywords: cytochrome b(5); drug hypersensitivity; hydroxylamine; N-acetyltransferase; potentiated sulfonamides; sulfamethoxazole
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Arylamine N-Acetyltransferase / genetics; Child; Child, Preschool; Cytochrome-B(5) Reductase / genetics; Cytochrome-B(5) Reductase / metabolism; Cytochromes b5 / genetics; Drug Hypersensitivity / genetics; Female; Gene Frequency; Genetic Association Studies; Humans; Inactivation, Metabolic / genetics; Infant; Male; Middle Aged; Polymorphism, Genetic; Sulfonamides / pharmacokinetics
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Loss of Power in Two-Stage Residual-Outcome Regression Analysis in Genetic Association Studies

Genetic Epidemiology, n/a-n/a.

By: R. Che n, A. Motsinger-Reif n & C. Brown

co-author countries: United States of America 🇺🇸
author keywords: loss of power; two-stage regression; degrees of freedom
MeSH headings : Bias; Female; Genetic Association Studies; Humans; Male; Regression Analysis
Source: Crossref
Added: February 24, 2020

2012 personal communication

Loss of power in two-stage residual-outcome regression analysis in genetic association studies

By: R. Che, A. Motsinger-Reif & C. Brown

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Multivariate methods and software for association mapping in dose-response genome-wide association studies

Biodata Mining, 5.

By: C. Brown, T. Havener, M. Medina, R. Krauss, H. McLeod & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Twice-Daily Application of HIV Microbicides Alters the Vaginal Microbiota

MBIO, 3(6).

By: J. Ravel*, P. Gajer*, L. Fu*, C. Mauck*, S. Koenig*, J. Sakamoto*, A. Motsinger-Reif n, G. Doncel*, S. Zeichner*

co-author countries: United States of America 🇺🇸
MeSH headings : Administration, Intravaginal; Adolescent; Adult; Anti-Infective Agents / administration & dosage; Biota; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; DNA, Ribosomal / chemistry; DNA, Ribosomal / genetics; Female; HIV Infections / prevention & control; Human Experimentation; Humans; Metagenome / drug effects; Middle Aged; Placebos / administration & dosage; RNA, Ribosomal, 16S / genetics; Sequence Analysis, DNA; Vagina / microbiology; Young Adult
Source: Web Of Science
Added: August 6, 2018

2011 journal article

A Comparison of Multifactor Dimensionality Reduction and L-1-Penalized Regression to Identify Gene-Gene Interactions in Genetic Association Studies

STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY, 10(1).

By: S. Winham n, C. Wang n & A. Motsinger-Reif n

co-author countries: United States of America 🇺🇸
author keywords: Multifactor Dimensionality Reduction (MDR); Lasso; gene-gene interactions
MeSH headings : Algorithms; Computer Simulation; Data Mining / methods; Epistasis, Genetic; Genetic Association Studies / statistics & numerical data; Humans; Monte Carlo Method; Multifactor Dimensionality Reduction / methods
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Characterization of Canine Osteosarcoma by Array Comparative Genomic Hybridization and RT-qPCR: Signatures of Genomic Imbalance in Canine Osteosarcoma Parallel the Human Counterpart

GENES CHROMOSOMES & CANCER, 50(11), 859–874.

By: A. Angstadt n, A. Motsinger-Reif n, R. Thomas n, W. Kisseberth*, C. Couto*, D. Duval*, D. Nielsen n, J. Modiano*, M. Breen n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Bone Neoplasms / genetics; Bone Neoplasms / veterinary; Comparative Genomic Hybridization; Core Binding Factor Alpha 1 Subunit / genetics; DNA Copy Number Variations; Dog Diseases / genetics; Dogs; Female; Gene Dosage; Genomic Instability; Humans; In Situ Hybridization, Fluorescence; Male; Membrane Proteins / genetics; Osteosarcoma / genetics; Osteosarcoma / veterinary; PTEN Phosphohydrolase / genetics; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Tumor Suppressor Proteins / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Genomic Profiling in CEPH Cell Lines Distinguishes between the Camptothecins and Indenoisoquinolines

MOLECULAR CANCER THERAPEUTICS, 10(10), 1839–1845.

By: V. Watson n, N. Hardison n, T. Harris n, A. Motsinger-Reif n & H. McLeod n

co-author countries: United States of America 🇺🇸
MeSH headings : Antineoplastic Agents, Phytogenic / pharmacology; Camptothecin / pharmacology; Cell Line; Drug Evaluation, Preclinical / methods; Gene Expression Profiling; Genomics / methods; Humans; Isoquinolines / pharmacology; Oligonucleotide Array Sequence Analysis; Quantitative Trait Loci; Topoisomerase I Inhibitors / pharmacology
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Identification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigrees

PLoS One, 6(5).

By: V. Watson, A. Motsinger-Reif, N. Hardison, E. Peters, T. Havener, L. Everitt, J. Auman, D. Comins, H. McLeod

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Insights into the inhibition of platelet activation by omega-3 polyunsaturated fatty acids: Beyond aspirin and clopidogrel

THROMBOSIS RESEARCH, 128(4), 335–340.

By: M. Cohen*, J. Rossi*, J. Garbarino*, R. Bowling, A. Motsinger-Reif n, C. Schuler*, A. Dupont*, D. Gabriel*

co-author countries: United States of America 🇺🇸
MeSH headings : Adult; Aspirin / administration & dosage; Aspirin / adverse effects; Bleeding Time; Blood Platelets / drug effects; Chi-Square Distribution; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fatty Acids, Omega-3 / administration & dosage; Fatty Acids, Omega-3 / adverse effects; Female; Hemorrhage / chemically induced; Humans; Male; Middle Aged; North Carolina; Pilot Projects; Platelet Aggregation / drug effects; Platelet Aggregation Inhibitors / administration & dosage; Platelet Aggregation Inhibitors / adverse effects; Platelet Function Tests; Predictive Value of Tests; Surface Properties; Ticlopidine / administration & dosage; Ticlopidine / adverse effects; Ticlopidine / analogs & derivatives; Time Factors
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer

British Journal of Cancer, 105(11), 1654–1662.

By: F. Thomas*, A. Motsinger-Reif n, J. Hoskins*, A. Dvorak*, S. Roy n, A. Alyasiri*, R. Myerson*, J. Fleshman*, B. Tan*, H. McLeod*

co-author countries: France 🇫🇷 United States of America 🇺🇸
author keywords: MTHFR polymorphisms; 5-FU; mucositis; diarrhoea; rectal cancer; neoadjuvant chemoradiation
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic / administration & dosage; Antimetabolites, Antineoplastic / adverse effects; Antimetabolites, Antineoplastic / therapeutic use; Antineoplastic Combined Chemotherapy Protocols / adverse effects; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Camptothecin / administration & dosage; Camptothecin / adverse effects; Camptothecin / analogs & derivatives; Chemoradiotherapy, Adjuvant / adverse effects; Disease-Free Survival; Fluorouracil / administration & dosage; Fluorouracil / adverse effects; Genotype; Humans; Irinotecan; Methylenetetrahydrofolate Reductase (NADPH2) / genetics; Methylenetetrahydrofolate Reductase (NADPH2) / metabolism; Middle Aged; Pharmacogenetics / methods; Polymorphism, Genetic; Prospective Studies; Radiation-Sensitizing Agents / administration & dosage; Radiation-Sensitizing Agents / adverse effects; Rectal Neoplasms / enzymology; Rectal Neoplasms / genetics; Rectal Neoplasms / therapy; Treatment Outcome; Young Adult
Source: Crossref
Added: February 24, 2020

2011 journal article

Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior

BMC Cancer, 11.

By: B. Hedan, R. Thomas, A. Motsinger-Reif, J. Abadie, C. Andre, J. Cullen, M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Optimization of nonlinear dose- and concentration-response models utilizing evolutionary computation

Dose-Response, 9(3), 387–409.

By: A. Beam & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Pharmacogenomic characterization of US FDA-approved cytotoxic drugs

PHARMACOGENOMICS, 12(10), 1407–1415.

By: E. Peters*, A. Motsinger-Reif n, T. Havener*, L. Everitt*, N. Hardison n, V. Watson*, M. Wagner*, K. Richards*, M. Province*, H. McLeod*

co-author countries: United States of America 🇺🇸
author keywords: cancer; cell line; chemotherapy; cytotoxicity; pharmacogenetics; pharmacogenomic; QTL
MeSH headings : Antineoplastic Agents / pharmacology; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Approval; Genetic Linkage; Humans; Pharmacogenetics; Quantitative Trait Loci / genetics; United States; United States Food and Drug Administration
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Quality of reporting on randomised controlled trials of auriculotherapy for pain

ACUPUNCTURE IN MEDICINE, 29(2), 122–126.

By: G. Asher*, A. Motsinger-Reif n, D. Jonas* & A. Viera*

co-author countries: United States of America 🇺🇸
MeSH headings : Auriculotherapy; Cluster Analysis; Guidelines as Topic; Humans; Pain Management; Peer Review, Research / standards; Principal Component Analysis; Publishing / standards; Quality Improvement; Randomized Controlled Trials as Topic / standards
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas

Leukemia & Lymphoma, 52(7), 1321–1335.

By: R. Thomas*, E. Seiser*, A. Motsinger-Reif*, L. Borst*, V. Valli, K. Kelley, S. Suter*, D. Argyle ...

author keywords: Comparative genomic hybridization (CGH); canine; lymphoma; chromosome; microarray
MeSH headings : Aneuploidy; Animals; Breeding; Comparative Genomic Hybridization; Cyclin-Dependent Kinase Inhibitor p16 / genetics; DNA Copy Number Variations / genetics; Dogs; Gene Expression Regulation, Neoplastic; Genomics; Immunophenotyping; Lymphoma, Non-Hodgkin / genetics; Lymphoma, Non-Hodgkin / pathology
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2011 journal article

Shift work in nurses: Contribution of phenotypes and genotypes to adaptation

PLoS One, 6(4).

By: K. Gamble, A. Motsinger-Reif, A. Hida, H. Borsetti, S. Servick, C. Ciarleglio, S. Robbins, J. Hicks ...

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

The Effect of Retrospective Sampling on Estimates of Prediction Error for Multifactor Dimensionality Reduction

Annals of Human Genetics, 75, 46–61.

By: S. Winham & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways

PLACENTA, 32(2), 175–182.

By: S. Tsai n, N. Hardison n, A. James*, A. Motsinger-Reif n, S. Bischoff n, B. Thames*, J. Piedrahita n

co-author countries: United States of America 🇺🇸
author keywords: Placenta; Preeclampsia; Maternal hypertension; Sialic acid acetylesterase
MeSH headings : Acetylesterase / biosynthesis; Antigens, CD / biosynthesis; Endoglin; Female; Genome-Wide Association Study; Humans; Infant, Newborn; Inhibins / biosynthesis; Male; Pre-Eclampsia / etiology; Pre-Eclampsia / metabolism; Pregnancy; Protein Array Analysis; Receptors, Cell Surface / biosynthesis; Trophoblasts / physiology; Up-Regulation; Vascular Endothelial Growth Factor Receptor-1 / biosynthesis
Source: Web Of Science
Added: August 6, 2018

2010 journal article

A comparison of internal validation techniques for multifactor dimensionality reduction

BMC Bioinformatics, 11.

By: S. Winham, A. Slater & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2010 review

Auriculotherapy for Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

[Review of ]. JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 16(10), 1097–1108.

By: G. Asher*, D. Jonas*, R. Coeytaux*, A. Reilly*, Y. Loh*, A. Motsinger-Reif n, S. Winham n

co-author countries: United States of America 🇺🇸
MeSH headings : Acupuncture, Ear; Analgesia; Humans; Pain Management; Pain Measurement; Perioperative Period; Randomized Controlled Trials as Topic
Source: Web Of Science
Added: August 6, 2018

2010 article

Discussion of a Genome-Wide Association Approach to Determine HIV-1 Set Point in African Americans

Motsinger-Reif, A. A. (2010, April 15). JOURNAL OF INFECTIOUS DISEASES, Vol. 201, pp. 1118–1120.

By: A. Motsinger-Reif n

co-author countries: United States of America 🇺🇸
MeSH headings : Black or African American / genetics; Disease Susceptibility; Epitopes / genetics; Genome-Wide Association Study; HIV Infections / genetics; HIV-1; Humans; Polymorphism, Single Nucleotide / genetics
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Effect of CYP2B6, ABCB1, and CYP3A5 Polymorphisms on Efavirenz Pharmacokinetics and Treatment Response: An AIDS Clinical Trials Group Study

JOURNAL OF INFECTIOUS DISEASES, 202(5), 717–722.

By: H. Ribaudo*, H. Liu*, M. Schwab*, E. Schaeffeler*, M. Eichelbaum*, A. Motsinger-Reif n, M. Ritchie*, U. Zanger* ...

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
MeSH headings : ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics; Alkynes; Anti-HIV Agents / pharmacokinetics; Anti-HIV Agents / therapeutic use; Aryl Hydrocarbon Hydroxylases / genetics; Benzoxazines / pharmacokinetics; Benzoxazines / therapeutic use; Black People; Cyclopropanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A / genetics; Female; HIV Infections / drug therapy; HIV Infections / ethnology; HIV Infections / genetics; Hispanic or Latino; Humans; Male; Oxidoreductases, N-Demethylating / genetics; Pharmacogenetics; Polymorphism, Single Nucleotide; Reverse Transcriptase Inhibitors / pharmacokinetics; Reverse Transcriptase Inhibitors / therapeutic use; Treatment Outcome; White People
Source: Web Of Science
Added: August 6, 2018

2010 chapter

Grammatical Evolution Decision Trees for Detecting Gene-Gene Interactions

In Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics (pp. 98–109).

By: S. Deodhar n & A. Motsinger-Reif n

co-author countries: United States of America 🇺🇸
Source: Crossref
Added: February 24, 2020

2010 conference paper

Grammatical evolution decision trees for detecting gene-gene interactions

Evolutionary computation, machine learning and data mining in bioinformatics, proceedings, 6023, 98–109.

By: S. Deodhar & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Polymorphisms in IL-1 beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis

BMC Medical Genetics, 11.

By: A. Motsinger-Reif, P. Antas, N. Oki, S. Levy, S. Holland & T. Sterling

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups

BLOOD, 115(18), 3827–3834.

co-author countries: Brazil 🇧🇷 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Korea (Republic of) 🇰🇷 Sweden 🇸🇪 Taiwan, Province of China 🇹🇼 United States of America 🇺🇸
MeSH headings : Adult; Aged; Aged, 80 and over; Algorithms; Anticoagulants / administration & dosage; Asian People / genetics; Black People / genetics; Dose-Response Relationship, Drug; Female; Genotype; Haplotypes; Humans; Linkage Disequilibrium; Male; Middle Aged; Mixed Function Oxygenases / genetics; Pharmacogenetics; Polymorphism, Single Nucleotide / genetics; Racial Groups / genetics; Risk Factors; Vitamin K Epoxide Reductases; Warfarin / administration & dosage; White People / genetics
Source: Web Of Science
Added: August 6, 2018

2009 article

A Comparison of Analytical Methods for Genetic Association Studies (vol 32, pg 767, 2008)

Motsinger-Reif, A. A., Reif, D. M., Fanelli, T. J., & Ritchie, M. D. (2009, December). GENETIC EPIDEMIOLOGY, Vol. 33, pp. 751–751.

By: A. Motsinger-Reif n, D. Reif*, T. Fanelli* & M. Ritchie*

co-author countries: United States of America 🇺🇸

Contributors: A. Motsinger-Reif n, D. Reif*, T. Fanelli* & M. Ritchie*

Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Characterization of Conserved and Nonconserved Imprinted Genes in Swine

BIOLOGY OF REPRODUCTION, 81(5), 906–920.

By: S. Bischoff n, S. Tsai n, N. Hardison n, A. Motsinger-Reif n, B. Freking*, D. Nonneman*, G. Rohrer*, J. Piedrahita n

co-author countries: United States of America 🇺🇸
author keywords: assisted reproductive technology; comparative genomic imprinting; epigenetics; gene regulation; genomic imprinting; parthenogenesis; placenta; swine parthenote
MeSH headings : Animals; Female; Fetus / anatomy & histology; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genomic Imprinting / genetics; Oligonucleotide Array Sequence Analysis; Organ Size; Parthenogenesis / genetics; Placenta / anatomy & histology; Polymorphism, Single Nucleotide; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; Staining and Labeling; Swine / genetics
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination

GENES AND IMMUNITY, 10(2), 112–119.

By: D. Reif*, A. Motsinger-Reif n, B. McKinney*, M. Rock*, J. Crowe* & J. Moore*

co-author countries: United States of America 🇺🇸

Contributors: D. Reif*, A. Motsinger-Reif n, B. McKinney*, M. Rock*, J. Crowe Jr. & J. Moore*

author keywords: smallpox; Random Forests; integrated analysis; genetic; proteomic; interactions
MeSH headings : Biomarkers / blood; Cytokines / blood; Cytokines / genetics; Decision Making, Computer-Assisted; Female; Humans; Inflammation / blood; Inflammation / chemically induced; Inflammation / genetics; Intercellular Adhesion Molecule-1 / blood; Intercellular Adhesion Molecule-1 / genetics; Male; Models, Biological; Polymorphism, Single Nucleotide; Proteomics / methods; Smallpox Vaccine / administration & dosage; Smallpox Vaccine / adverse effects; Vaccination
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

262: Molecular signatures of preeclampsia in human term placentas

American Journal of Obstetrics and Gynecology, 199(6), S84.

By: S. Tsai n, N. Hardison n, S. Bischoff n, B. Thames*, A. Jamessd*, A. Motsinger-Reif n, J. Piedrahita n

co-author countries: United States of America 🇺🇸
Source: Crossref
Added: February 24, 2020

2008 journal article

A Comparison of Analytical Methods for Genetic Association Studies

GENETIC EPIDEMIOLOGY, 32(8), 767–778.

By: A. Motsinger-Reif n, D. Reif*, T. Fanelli* & M. Ritchie*

co-author countries: United States of America 🇺🇸

Contributors: A. Motsinger-Reif n, D. Reif*, T. Fanelli* & M. Ritchie*

author keywords: genetic association study; epistasis; multifactor dimensionality reduction; grammatical evolution neural networks; focused interaction testing framework
MeSH headings : Data Interpretation, Statistical; Epistasis, Genetic; Genetic Linkage; Genetic Techniques; Genome; Humans; Models, Genetic; Models, Statistical; Models, Theoretical; Neural Networks, Computer; Phenotype; Probability; Regression Analysis; Software
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

Comparison of approaches for machine-learning optimization of neural networks for detecting gene-gene interactions in genetic epidemiology

GENETIC EPIDEMIOLOGY, 32(4), 325–340.

By: A. Motsinger-Reif n, S. Dudek*, L. Hahn* & M. Ritchie*

co-author countries: United States of America 🇺🇸
author keywords: grammatical evolution neural networks; epistasis; genetic programming neural networks
MeSH headings : Artificial Intelligence; Data Interpretation, Statistical; Databases, Genetic; Epidemiologic Methods; Epistasis, Genetic; Genetic Predisposition to Disease; HIV Infections / epidemiology; HIV Infections / genetics; HIV Infections / immunology; Humans; Immunogenetics; Models, Genetic; Neural Networks, Computer; Pattern Recognition, Automated; Polymorphism, Single Nucleotide
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Genetic Basis for Adverse Events after Smallpox Vaccination

The Journal of Infectious Diseases, 198(1), 16–22.

By: D. Reif*, B. McKinney*, A. Motsinger*, S. Chanock*, K. Edwards*, M. Rock*, J. Moore, J. Crowe, Jr.

co-author countries: United States of America 🇺🇸

Contributors: D. Reif*, B. McKinney*, A. Motsinger*, S. Chanock*, K. Edwards*, M. Rock*, J. Moore, J. Crowe Jr.

MeSH headings : Adult; Female; Genetic Predisposition to Disease; Genotype; Humans; Interferon Regulatory Factor-1 / genetics; Interleukin-4 / genetics; Male; Methylenetetrahydrofolate Reductase (NADPH2) / genetics; Polymorphism, Single Nucleotide; Smallpox Vaccine / adverse effects; Vaccination / adverse effects
Sources: Crossref, ORCID
Added: May 14, 2019

2008 journal article

Hemochromatosis Gene Polymorphisms, Mitochondrial Haplogroups, and Peripheral Lipoatrophy during Antiretroviral Therapy

The Journal of Infectious Diseases, 197(6), 858–866.

By: T. Hulgan, P. Tebas, J. Canter, K. Mulligan, D. Haas, M. Dubé, S. Grinspoon, G. Robbins, A. Motsinger, A. Kallianpur

Source: Crossref
Added: October 29, 2021

2007 journal article

A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction

Genetic Epidemiology, 31(4), 306–315.

By: D. Velez*, B. White, A. Motsinger*, W. Bush*, M. Ritchie*, S. Williams*, J. Moore*

co-author countries: United States of America 🇺🇸
MeSH headings : Algorithms; Epistasis, Genetic; Gene Frequency; Humans; Models, Genetic; Polymorphism, Single Nucleotide; Sample Size; Software
Source: Crossref
Added: October 29, 2021

2007 journal article

Complex gene–gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes

Neurogenetics, 8(1), 11–20.

By: A. Motsinger*, D. Brassat*, S. Caillier*, H. Erlich*, K. Walker*, L. Steiner*, L. Barcellos*, M. Pericak-Vance* ...

co-author countries: United States of America 🇺🇸
author keywords: multiple sclerosis; multifactor dimensionality reduction; epistasis
MeSH headings : Case-Control Studies; Genotype; Humans; Inflammation / genetics; Models, Genetic; Multiple Sclerosis / genetics; Multiple Sclerosis / pathology; Proteins / genetics
Source: Crossref
Added: October 29, 2021

2007 journal article

Genetic heterogeneity is not as threatening as you might think

Genetic Epidemiology, 31(7), 797–800.

By: M. Ritchie*, T. Edwards*, T. Fanelli* & A. Motsinger*

co-author countries: United States of America 🇺🇸
MeSH headings : Genetic Variation; Humans; Models, Genetic; Quantitative Trait Loci / genetics
Source: Crossref
Added: October 29, 2021

2007 journal article

Genetic programming neural networks: A powerful bioinformatics tool for human genetics

Applied Soft Computing, 7(1), 471–479.

By: M. Ritchie*, A. Motsinger*, W. Bush*, C. Coffey* & J. Moore*

co-author countries: United States of America 🇺🇸
author keywords: nueral networks; genetic programming; bioinformatics; epistasis; gene-gene interactions
Source: Crossref
Added: October 29, 2021

2007 journal article

Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: A validated genetic association study

Mitochondrion, 7(3), 204–210.

By: J. Canter*, M. Summar*, H. Smith*, G. Rice*, L. Hall*, M. Ritchie*, A. Motsinger*, K. Christian* ...

co-author countries: United States of America 🇺🇸