Works (171)

Updated: April 3rd, 2024 20:29

2024 journal article

Guided optimization of ToxPi model weights using a Semi-Automated approach

COMPUTATIONAL TOXICOLOGY, 29.

By: J. Fleming n, J. House*, J. Chappel n, A. Motsinger-Reif* & D. Reif*

author keywords: Machine learning; Feature weighting; Exposure assessment; Chemical toxicity; Ordinal regression; Genetic algorithm
Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024

2023 journal article

MKX-AS1 Gene Expression Associated with Variation in Drug Response to Oxaliplatin and Clinical Outcomes in Colorectal Cancer Patients

PHARMACEUTICALS, 16(5).

author keywords: precision medicine; colorectal cancer; pharmacogenomics; oxaliplatin; lncRNA's; antisense
TL;DR: An association between MKX-AS1 and MKX expression status that could be useful as a prognostic marker of response to OXAL and potential patient outcomes in CRC is suggested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 19, 2023

2023 journal article

Pharmacogenomic Analyses Implicate B Cell Developmental Status and MKL1 as Determinants of Sensitivity toward Anti-CD20 Monoclonal Antibody Therapy

CELLS, 12(12).

By: G. Small*, F. Akhtari*, A. Green n, T. Havener*, M. Sikes n, J. Quintanhila, R. Gonzalez*, D. Reif* ...

author keywords: rituximab (Rituxan (R)); ofatumumab (Arzerra (R),& nbsp;Kesimpta (R)); obinutuzumab (Gazyva (R)); CD20 (MS4A1); MKL1 (MRTFA); TGFB1
TL;DR: Results suggest that the efficacy of anti-CD20 mAb therapy may be influenced by B cell developmental status as well as polymorphism in the MKL1 gene. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 8, 2023

2023 journal article

RYK Gene Expression Associated with Drug Response Variation of Temozolomide and Clinical Outcomes in Glioma Patients

PHARMACEUTICALS, 16(5).

By: R. Gonzalez*, G. Small*, A. Green n, F. Akhtari*, T. Havener*, J. Quintanilha, A. Cipriani*, D. Reif* ...

author keywords: GWAS; chemotherapy; sensitivity; resistance; glioma; drug response; temozolomide; knockdown; overexpression; pharmacogenomics; gene expression; RYK
TL;DR: The findings suggest that RYK expression may serve as an important prognostic or predictor of TMZ response and survival for glioma patients and a combination of RyK expression and MGMT status could serve as a additional biomarker for improved survival. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 12, 2023

2022 journal article

Clomifene and Assisted Reproductive Technology in Humans Are Associated with Sex-Specific Offspring Epigenetic Alterations in Imprinted Control Regions

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(18).

By: D. Lloyd n, H. Skinner n, R. Maguire n, S. Murphy*, A. Motsinger-Reif*, C. Hoyo n, J. House n

author keywords: differentially methylated regions; adverse offspring outcomes; infertility
MeSH headings : Child; Clomiphene; DNA Methylation; Female; Genomic Imprinting; Humans; Male; Reproductive Techniques, Assisted / adverse effects; Retrospective Studies
TL;DR: The results suggest that the increased risk of adverse outcomes in offspring conceived through ART may be due in part to altered methylation of ICRs, and larger studies utilizing epigenome-wide interrogation are warranted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 3, 2022

2022 journal article

Comparison of National Vulnerability Indices Used by the Centers for Disease Control and Prevention for the COVID-19 Response

Public Health Reports, 137(4), 803–812.

By: A. Wolkin*, S. Collier*, J. House*, D. Reif n, A. Motsinger-Reif*, L. Duca*, J. Sharpe*

author keywords: COVID-19; vulnerability; social vulnerability index; GIS; geographic information systems
MeSH headings : COVID-19 / epidemiology; COVID-19 / prevention & control; Centers for Disease Control and Prevention, U.S.; Humans; Pandemics / prevention & control; Public Health; United States / epidemiology
TL;DR: The indices can empower local and state public health officials with additional information to focus resources and interventions on disproportionately affected populations to combat the ongoing pandemic and plan for future pandemics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: May 6, 2022

2022 journal article

Correlation Analysis of Variables From the Atherosclerosis Risk in Communities Study

FRONTIERS IN PHARMACOLOGY, 13.

By: M. Mandal*, J. Levy, C. Ives*, S. Hwang*, Y. Zhou n, A. Motsinger-Reif*, H. Pan*, W. Huggins* ...

author keywords: cluster analysis; systems biology; meta-analysis as topic; ARIC; cardiovascular disease
TL;DR: The data-driven approach can facilitate data harmonization and curation efforts by providing human annotators with groups of related variables reflecting the themes present in the data. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Source: Web Of Science
Added: August 8, 2022

2022 article

Genomic map of candidate human imprint control regions: the imprintome

Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). EPIGENETICS, Vol. 6.

By: D. Jima n, D. Skaar n, A. Planchart n, A. Motsinger-Reif n, S. Cevik n, S. Park n, M. Cowley n, F. Wright n ...

author keywords: Epigenetics; genomic imprinting; foetal origins; whole genome; methylation; imprint control regions
MeSH headings : Adult; Humans; Genomic Imprinting; DNA Methylation; Chromosome Mapping; Alleles; Genomics
TL;DR: This draft of the human imprintome will allow for the systematic determination of the role of early-acquired imprinting dysregulation in the pathogenesis of human diseases and developmental and behavioural disorders. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 11, 2022

2022 journal article

The AGMK1-9T7 cell model of neoplasia: Evolution of DNA copy-number aberrations and miRNA expression during transition from normal to metastatic cancer cells

PLOS ONE, 17(10).

By: A. Lewis*, R. Thomas*, M. Breen*, K. Peden*, B. Teferedegne*, G. Foseh*, A. Motsinger-Reif n, D. Rotroff n, G. Lewis

MeSH headings : Animals; Humans; Chlorocebus aethiops; MicroRNAs / genetics; MicroRNAs / metabolism; Neoplasms / genetics; Carcinogenesis / genetics; DNA Copy Number Variations / genetics; Chromosome Aberrations; Neoplasms, Second Primary / genetics; DNA; Gene Expression Regulation, Neoplastic; Gene Expression Profiling
TL;DR: The evolution of chromosomal DNA copy-number aberrations and miRNA expression in this cell line from passage 1 to the acquisition of a tumorigenic phenotype at passage 40 is examined and it is proposed that the evolution of AGMK1-9T7 cells represents a detailed model of neoplasia in vitro. (via Semantic Scholar)
Source: Web Of Science
Added: February 27, 2023

2022 article

ToxPi*GIS Toolkit: creating, viewing, and sharing integrative visualizations for geospatial data using ArcGIS

Fleming, J., Marvel, S. W., Supak, S., Motsinger-Reif, A. A., & Reif, D. M. (2022, April 26). JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, Vol. 4.

By: J. Fleming n, S. Marvel n, S. Supak n, A. Motsinger-Reif* & D. Reif n

author keywords: Visual analytics; Geographic information systems; Data integration
MeSH headings : Humans; Geographic Information Systems; COVID-19
TL;DR: The integration of ToxPi profiles with ArcGIS provides new avenues for geospatial analysis, visualization, and public sharing of multi-factor data that can support decisions that help address issues such as disease prevention, environmental health, natural disaster prevention, chemical risk, and many others. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 10, 2022

2021 journal article

Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome‐Wide Interaction Meta‐Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies

Clinical Pharmacology & Therapeutics, 110(3), 723–732.

By: C. McDonough*, H. Warren*, J. Jack n, A. Motsinger‐Reif*, N. Armstrong*, J. Bis*, J. House*, S. Singh* ...

MeSH headings : Black or African American / genetics; Aged; Antihypertensive Agents / therapeutic use; Blood Pressure / drug effects; Blood Pressure / genetics; Cardiovascular Diseases / chemically induced; Cardiovascular Diseases / genetics; Cardiovascular System / drug effects; Drug-Related Side Effects and Adverse Reactions / etiology; Drug-Related Side Effects and Adverse Reactions / genetics; Female; Genome-Wide Association Study / methods; Humans; Hypertension / drug therapy; Hypertension / genetics; Male; Middle Aged; Pharmacogenomic Testing / methods; Polymorphism, Single Nucleotide / genetics
TL;DR: The NTM region is associated with increased risk for adverse cardiovascular outcomes and less BP reduction in β-blocker treated patients and no SNPs attained genome-wide significance for any other drugs classes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 23, 2021

2021 article

Extending the lymphoblastoid cell line model for drug combination pharmacogenomics

Green, A. J., Anchang, B., Akhtari, F. S., Reif, D. M., & Motsinger-Reif, A. (2021, May 28). PHARMACOGENOMICS, Vol. 5.

By: A. Green n, B. Anchang*, F. Akhtari*, D. Reif n & A. Motsinger-Reif*

author keywords: combination treatment; drug response; LCLs; omics; synergism
MeSH headings : Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cell Line, Tumor / drug effects; Humans; Lymphocytes / drug effects; Pharmacogenomic Testing / methods
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 29, 2021

2021 journal article

High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs

PLOS GENETICS, 17(8).

By: F. Akhtari n, A. Green n, G. Small*, T. Havener*, J. House*, K. Roell n, D. Reif n, H. McLeod, T. Wiltshire*, A. Motsinger-Reif*

Ed(s): F. Vazquez

MeSH headings : Antineoplastic Agents / pharmacology; Biomarkers, Pharmacological / analysis; Cell Line, Tumor; Genome-Wide Association Study / methods; High-Throughput Screening Assays / methods; Humans; NAD(P)H Dehydrogenase (Quinone) / drug effects; NAD(P)H Dehydrogenase (Quinone) / genetics; NAD(P)H Dehydrogenase (Quinone) / metabolism
TL;DR: The NAD(P)H quinone dehydrogenase 1 (NQO1) gene was found to be associated with the dose-response of arsenic trioxide, erlotinib, tramet inib, and a combination treatment of paclitaxel + epirubicin. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 27, 2021

2021 journal article

In vitro iatrogenic hemolysis of canine packed red blood cells during various rapid transfusion techniques

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 31(1), 25–31.

By: J. Weeks, A. Motsinger-Reif n & M. Reems

author keywords: canine; coagulation; hemoglobin; trauma
MeSH headings : Animals; Blood Preservation / veterinary; Blood Transfusion / methods; Blood Transfusion / veterinary; Dogs; Erythrocytes / physiology; Hemolysis; Iatrogenic Disease / veterinary; Prospective Studies
TL;DR: Commonly used rapid infusion techniques in small animal transfusion medicine do not cause significant iatrogenic hemolysis of canine pRBCs in vitro, although a significant risk is present in stored blood. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 16, 2020

2021 journal article

Knockoff boosted tree for model-free variable selection

BIOINFORMATICS, 37(7), 976–983.

By: T. Jiang n, Y. Li* & A. Motsinger-Reif*

MeSH headings : Algorithms; Computer Simulation; Genome; Machine Learning
TL;DR: This work proposes a novel strategy for conducting variable selection without prior model topology knowledge using the knockoff method with boosted tree models and applies this method for tumor purity estimation and tumor classification using Cancer Genome Atlas data. (via Semantic Scholar)
Source: Web Of Science
Added: June 21, 2021

2021 journal article

Prediction of synergistic drug combinations using PCA-initialized deep learning

BIODATA MINING, 14(1).

By: J. Ma n & A. Motsinger-Reif*

author keywords: Deep learning; Cancer treatment; Drug combination treatment; Feedforward neural network; Machine learning; XGBoost; Random Forests; Elastic net
TL;DR: This work presents a new deep learning approach to predict synergistic drug combinations by integrating gene expression profiles from cell lines and chemical structure data using principal component analysis (PCA) to reduce the dimensionality of chemical descriptor data and gene expression data. (via Semantic Scholar)
Source: Web Of Science
Added: November 8, 2021

2021 journal article

Race and smoking status associated with paclitaxel drug response in patient-derived lymphoblastoid cell lines

PHARMACOGENETICS AND GENOMICS, 31(2), 48–52.

By: F. Akhtari n, T. Havener*, D. Hertz*, J. Ash n, A. Larson n, L. Carey*, H. McLeod*, A. Motsinger-Reif*

author keywords: dose-response; lymphoblastoid cell lines; paclitaxel; patient-derived cell lines; pharmacogenomics; smoking
MeSH headings : Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Breast Neoplasms / pathology; Cell Line, Tumor; Cell Survival / drug effects; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm / genetics; Female; Humans; Middle Aged; Paclitaxel / adverse effects; Paclitaxel / pharmacology; Pharmacogenetics; Racial Groups / genetics; Smoking / adverse effects; Smoking / genetics
TL;DR: It is indicated that in-vivo smoking status can influence ex- vivo dose-response in LCLs, and more precise measures of covariates may allow for more precise forecasting of clinical effect. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: May 10, 2021

2021 personal communication

The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning

Marvel, S. W., House, J. S., Wheeler, M., Song, K., Zhou, Y.-H., Wright, F. A., … Reif, D. M. (2021, January).

By: S. Marvel n, J. House*, M. Wheeler*, K. Song n, Y. Zhou n, F. Wright n, W. Chiu*, I. Rusyn*, A. Motsinger-Reif*, D. Reif n

Contributors: S. Marvel n, J. House*, M. Wheeler*, K. Song n, Y. Zhou n, F. Wright n, W. Chiu*, I. Rusyn*, A. Motsinger-Reif*, D. Reif n

MeSH headings : COVID-19 / epidemiology; Data Visualization; Health Status Indicators; Humans; Machine Learning; Models, Statistical; Vulnerable Populations
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 22, 2021

2020 journal article

Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(12), 7409–7419.

By: C. Wise n, S. Hammel*, N. Herkert*, J. Ma n, A. Motsinger-Reif*, H. Stapleton*, M. Breen n

MeSH headings : Animals; Biomarkers; Dogs; Environmental Monitoring; Humans; Organophosphates; Silicones
TL;DR: Exposures among pet dogs and their owners using silicone dog tags and wristbands were evaluated to determine if contaminant levels were correlated with validated biomarkers and the value of using silicone bands with dogs to investigate health impacts on humans from shared exposures is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: July 13, 2020

2020 journal article

Genetic and environmental risk for lymphoma in boxer dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(5), 2068–2077.

By: K. Craun*, J. Ekena*, J. Sacco*, T. Jiang n, A. Motsinger-Reif n & L. Trepanier*

author keywords: canine; detoxification; exposure; lymphosarcoma
MeSH headings : Animals; Dog Diseases / genetics; Dogs; Genetic Predisposition to Disease; Genotype; Lymphoma / genetics; Lymphoma / veterinary; Risk Factors
TL;DR: Proximity to nuclear power plants, chemical suppliers, and crematoria were significant risk factors for lymphoma in this population of boxers and support the hypothesis that aggregate exposures to environmental chemicals and industrial waste may contribute to lymphoma risk in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 3, 2020

2020 journal article

Low-Dose Silver Nanoparticle Surface Chemistry and Temporal Effects on Gene Expression in Human Liver Cells

SMALL, 16(21).

By: J. House n, E. Bouzos*, K. Fahy*, V. Francisco*, D. Lloyd n, F. Wright n, A. Motsinger-Reif*, P. Asuri*, K. Wheeler*

Contributors: J. House n, E. Bouzos*, K. Fahy*, V. Francisco*, D. Lloyd n, F. Wright n, A. Motsinger-Reif*, P. Asuri*, K. Wheeler*

author keywords: nanotoxicity; silver nanoparticles; transcriptomics
MeSH headings : Gene Expression / drug effects; Hepatocytes / drug effects; Humans; Metal Nanoparticles / chemistry; Silver; Surface Properties; Time Factors
TL;DR: Universal to all surface coatings, AgNP-treated cells responded by inactivating proliferation and enabling cell cycle checkpoints, which provide a foundation for understanding hepatic response to low-dose AgNPs for future risk assessment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 14, 2020

2020 journal article

Nonlinear Dose-Response Modeling of High-Throughput Screening Data Using an Evolutionary Algorithm

DOSE-RESPONSE, 18(2).

By: J. Ma n, E. Bair & A. Motsinger-Reif*

author keywords: evolutionary algorithm; hillslope model; parameter estimation; nonlinear regression; model selection
TL;DR: This work proposes the use of an EA for dose–response modeling for a range of potential response model functional forms that can not only fit the most commonly used nonlinear dose– response models but also select the best model if no model assumption is made, which is especially useful in the case of high-throughput curve fitting. (via Semantic Scholar)
Source: Web Of Science
Added: June 15, 2020

2020 journal article

The influence of packed cell volume versus plasma proteins on thromboelastographic variables in canine blood

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 30(4), 418–425.

By: A. Lynch n, L. Ruterbories n, J. Jack n, A. Motsinger-Reif n & R. Hanel*

MeSH headings : Animals; Blood Coagulation Tests / veterinary; Blood Proteins / physiology; Cell Size; Dogs / blood; Female; Fibrinogen / metabolism; Hematocrit / veterinary; Male; Thrombelastography / veterinary
TL;DR: In an ex vivo model, plasma proteins but not PCV impacted TEG variables, suggesting that TEG changes noted with anemia are imparted by changes in available fibrinogen in a fixed microenvironment rather than artifact of anemia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 13, 2020

2020 journal article

Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 145(3), 897–906.

By: E. Crestani*, H. Harb*, L. Charbonnier*, J. Leirer n, A. Motsinger-Reif*, R. Rachid*, W. Phipatanakul*, R. Kaddurah-Daouk*, T. Chatila*

author keywords: Asthma; food allergy; invariant natural killer T cells; metabolomics; metabolites; secondary bile acids; sphingolipids; tryptophan
MeSH headings : Asthma / blood; Biomarkers / blood; Child; Child, Preschool; Female; Food Hypersensitivity / blood; Humans; Male; Metabolome; Metabolomics / methods; Pilot Projects
TL;DR: Children with FA display a disease-specific metabolomic profile that is informative of disease mechanisms and severity, and which dominates in the presence of asthma. (via Semantic Scholar)
Source: Web Of Science
Added: April 27, 2020

2019 journal article

A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes: Results From the ACCORD and BARI 2D Studies

DIABETES, 68(8), 1649–1662.

By: Y. Tang*, P. Lenzini*, R. Pop-Busui*, P. Ray*, H. Campbell*, B. Perkins*, B. Callaghan*, M. Wagner* ...

MeSH headings : Aged; Alleles; Chromosomes, Human, Pair 2; Databases, Genetic; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / epidemiology; Diabetes Mellitus, Type 2 / genetics; Diabetic Neuropathies / genetics; Female; Gene Frequency; Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Incidence; Male; Middle Aged; Polymorphism, Single Nucleotide; Prevalence
TL;DR: A previously unknown locus with a powerful protective effect on the development of DPN in T2D is identified and successfully validated and may provide novel insights into DPN pathogenesis and point to a potential target for novel interventions. (via Semantic Scholar)
Source: Web Of Science
Added: August 12, 2019

2019 journal article

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

Alzheimer's & Dementia, 15(1), 76–92.

By: S. MahmoudianDehkordi*, M. Arnold*, K. Nho*, S. Ahmad*, W. Jia*, G. Xie*, G. Louie*, A. Kueider-Paisley* ...

author keywords: Metabolomics; Metabolome; Lipidomics; Alzheimer's disease; Gut microbiome; Gut-liver-brain axis; Atlas for Alzheimer; Genetic variants; Immunity; Inflammation
MeSH headings : Aged; Alzheimer Disease / microbiology; Alzheimer Disease / physiopathology; Bile Acids and Salts / blood; Bile Acids and Salts / metabolism; Cognitive Dysfunction / metabolism; Dysbiosis; Female; Gastrointestinal Microbiome; Humans; Liver / metabolism; Male; Metabolome
TL;DR: An association between altered BA profile, genetic variants implicated in AD and cognitive changes in disease is reported using a large multicenter study and warrant further investigation of gut dysbiosis and possible role of gut liver brain axis in the pathogenesis of AD. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: February 21, 2020

2019 article

Bile acids targeted metabolomics and medication classification data in the ADNI1 and ADNIGO/2 cohorts

St John-Williams, L., Mahmoudiandehkordi, S., Arnold, M., Massaro, T., Blach, C., Kastenmueller, G., … Kaddurah-Daouk, R. (2019, October 17). SCIENTIFIC DATA, Vol. 6.

By: L. St John-Williams*, S. Mahmoudiandehkordi*, M. Arnold*, T. Massaro*, C. Blach*, G. Kastenmueller, G. Louie*, A. Kueider-Paisley* ...

MeSH headings : Aged; Aged, 80 and over; Alzheimer Disease / metabolism; Bile Acids and Salts / blood; Disease Progression; Female; Humans; Male; Metabolomics
TL;DR: This data descriptor represents the third in a series of comprehensive metabolomics datasets from the ADMC on the ADNI, and details the quantitative metabolomics data generated on the baseline samples from ADNI1 and ADNIGO/2. (via Semantic Scholar)
Source: Web Of Science
Added: November 11, 2019

2019 journal article

Cheminformatics approach to exploring and modeling trait-associated metabolite profiles

JOURNAL OF CHEMINFORMATICS, 11.

By: J. Ash n, M. Kuenemann n, D. Rotroff n, A. Motsinger-Reif n & D. Fourches n

author keywords: Metabolomics; Data mining; Cheminformatics; Molecular fragmentation; Statistics; Visualization; Chemical structure
TL;DR: A novel cheminformatics-based approach capable of identifying predictive, interpretable, and reproducible trait-metabolite relationships that could ultimately facilitate biological understanding and advance research based on metabolomics data, especially with respect to the identification of novel biomarkers. (via Semantic Scholar)
Source: Web Of Science
Added: July 15, 2019

2019 journal article

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

NATURE COMMUNICATIONS, 10.

By: M. Menden*, D. Wang*, M. Mason*, B. Szalai*, K. Bulusu*, Y. Guan*, T. Yu*, J. Kang* ...

MeSH headings : ADAM17 Protein / antagonists & inhibitors; Antineoplastic Combined Chemotherapy Protocols / pharmacology; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Benchmarking; Biomarkers, Tumor / genetics; Cell Line, Tumor; Computational Biology / methods; Computational Biology / standards; Datasets as Topic; Drug Antagonism; Drug Resistance, Neoplasm / drug effects; Drug Resistance, Neoplasm / genetics; Drug Synergism; Genomics / methods; Humans; Molecular Targeted Therapy / methods; Mutation; Neoplasms / drug therapy; Neoplasms / genetics; Pharmacogenetics / methods; Pharmacogenetics / standards; Phosphatidylinositol 3-Kinases / genetics; Phosphoinositide-3 Kinase Inhibitors; Treatment Outcome
TL;DR: A large drug combination screen across cancer cell lines is provided to benchmark crowdsourced methods and to computationally predict drug synergies, and genomic rationale for synergy predictions are identified. (via Semantic Scholar)
Source: Web Of Science
Added: July 1, 2019

2019 journal article

Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

EPIGENOMICS, 11(13), 1487–1500.

By: S. Sikdar*, R. Joehanes*, B. Joubert*, C. Xu*, M. Vives-Usano*, F. Rezwan*, J. Felix*, J. Ward* ...

author keywords: cigarette smoking; epigenetics; infant; maternal exposure; methylation
MeSH headings : Adult; Cohort Studies; CpG Islands; DNA Methylation; Epigenesis, Genetic; Epigenomics / methods; Female; Humans; Infant, Newborn; Maternal Exposure / adverse effects; Pregnancy; Prenatal Exposure Delayed Effects / epidemiology; Prenatal Exposure Delayed Effects / genetics; Tobacco Smoking / epidemiology; Tobacco Smoking / genetics
TL;DR: Comparing meta-analyses, numerous signatures specific to newborns along with many shared between newborns and adults were identified and unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. (via Semantic Scholar)
Source: Web Of Science
Added: December 9, 2019

2019 journal article

Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex

CHROMOSOME RESEARCH, 27(3), 179–202.

By: K. Kennedy n, R. Thomas n, J. Durrant n, T. Jiang n, A. Motsinger-Reif n & M. Breen n

author keywords: Histiocytic sarcoma; Chromothripsis; MMP9; Aurora kinase; Dendritic cell sarcoma
MeSH headings : Animals; Chromosome Disorders; DNA Copy Number Variations / genetics; Dog Diseases / diagnosis; Dog Diseases / genetics; Dogs; Gene Expression Profiling; Genome / genetics; Histiocytic Disorders, Malignant / diagnosis; Histiocytic Disorders, Malignant / genetics; Histiocytic Disorders, Malignant / veterinary; Humans; Immunohistochemistry / methods; Matrix Metalloproteinase 9 / metabolism; Spindle Apparatus / pathology
TL;DR: Droplet digital PCR evaluation of these regions in numerous cancer specimens effectively discriminated HM from other common round cell tumors, including lymphoma and hemangiosarcoma, resulting in a novel, rapid diagnostic aid for veterinary medicine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: Web Of Science
Added: September 30, 2019

2019 journal article

Identifying individual risk rare variants using protein structure guided local tests (POINT)

PLOS COMPUTATIONAL BIOLOGY, 15(2).

By: R. West n, W. Lu n, D. Rotroff*, M. Kuenemann n, S. Chang*, M. Wu*, M. Wagner*, J. Buse* ...

MeSH headings : Angiopoietin-Like Protein 4 / genetics; Cholesterol Ester Transfer Proteins / genetics; Computational Biology / methods; Computer Simulation; Genetic Association Studies / methods; Genetic Predisposition to Disease / genetics; Genetic Variation / genetics; Humans; Models, Genetic; Proprotein Convertase 9 / genetics; Protein Structure, Tertiary; Risk Factors; Sequence Analysis, DNA / methods
TL;DR: This work proposes a protein structure guided local test (POINT) to provide variant-specific association information using structure-guided aggregation of signal and assess the selection performance of POINT using simulations and illustrates how it can be used to prioritize individual rare variants in PCSK9, ANGPTL4 and CETP in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) clinical trial data. (via Semantic Scholar)
Source: Web Of Science
Added: March 25, 2019

2019 journal article

Long-term incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy

JOURNAL OF VETERINARY INTERNAL MEDICINE, 33(6), 2572–2586.

By: P. Fox*, B. Keene n, K. Lamb, K. Schober*, V. Chetboul*, V. Fuentes*, J. Payne, G. Wess ...

author keywords: cancer; chronic kidney disease; epidemiology; mortality; survival
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / mortality; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / mortality; Cats; Female; Incidence; Male; Retrospective Studies; Risk Factors
TL;DR: All‐cause mortality was significantly greater in pHCM cats due to disease burden contributed by increased cardiovascular death superimposed upon noncardiovascular death. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 28, 2019

2019 journal article

Synergistic Chemotherapy Drug Response Is a Genetic Trait in Lymphoblastoid Cell Lines

FRONTIERS IN GENETICS, 10.

By: K. Roell n, T. Havener*, D. Reif n, J. Jack n, H. McLeod*, T. Wiltshire*, A. Motsinger-Reif*

Contributors: K. Roell n, T. Havener*, D. Reif n, J. Jack n, H. McLeod*, T. Wiltshire*, A. Motsinger-Reif*

author keywords: synergy; heritability; chemotherapy; lymphoblastoid cell lines; linkage mapping
TL;DR: It is demonstrated that synergy occurs and can be quantified in LCLs across a range of clinically important drug combinations, which supports the premise of expanding the use of the LCL model to perform association mapping for combination therapies. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 2, 2019

2019 article

Untargeted Metabolomic Profiling Identifies Disease-Specific Pathways in Food Allergy and Asthma

Crestani, E., Leirer, J., Motsinger-Reif, A., Phipatanakul, W., Kaddurah-Daouk, R., & Chatila, T. A. (2019, February). JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol. 143, pp. AB255–AB255.

By: E. Crestani*, J. Leirer n, A. Motsinger-Reif n, W. Phipatanakul*, R. Kaddurah-Daouk* & T. Chatila*

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 25, 2019

2018 journal article

Gene expression and linkage analysis implicate as a mediator of rituximab resistance

PHARMACOGENOMICS JOURNAL, 18(3), 467–473.

By: J. Jack n, G. Small*, C. Brown*, T. Havener*, H. McLeod*, A. Motsinger-Reif n, K. Richards*

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Antibodies, Monoclonal / administration & dosage; Antibodies, Monoclonal / adverse effects; Antibodies, Monoclonal / genetics; Antigens, CD20 / drug effects; Antigens, CD20 / immunology; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm / drug effects; Drug Resistance, Neoplasm / genetics; Female; Gene Expression Regulation, Neoplastic / drug effects; Genetic Linkage; Genome, Human / genetics; Humans; Leukemia, Lymphocytic, Chronic, B-Cell / complications; Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell / genetics; Male; Proto-Oncogene Proteins c-cbl / genetics; Rituximab / administration & dosage; Rituximab / adverse effects
TL;DR: This study developed a strategy to genetically map in vitro drug sensitivity, identifying genes that alter responsiveness to rituximab, a therapeutic anti-CD20 MAb that provides significant benefit to patients with B-cell malignancies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Gene set analysis methods: A systematic comparison

Biodata Mining, 11.

By: R. Mathur, D. Rotroff, J. Ma, A. Shojaie & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Genetic Tools for Coronary Risk Assessment in Type 2 Diabetes: A Cohort Study From the ACCORD Clinical Trial

DIABETES CARE, 41(11), 2404–2413.

By: M. Morieri*, H. Gao*, M. Pigeyre*, H. Shah*, J. Sjaarda*, C. Mendonca*, T. Hastings*, P. Buranasupkajorn* ...

MeSH headings : Aged; Cohort Studies; Coronary Artery Disease / diagnosis; Coronary Artery Disease / genetics; Coronary Artery Disease / prevention & control; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / diagnosis; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / genetics; Diabetic Angiopathies / diagnosis; Diabetic Angiopathies / genetics; Diabetic Angiopathies / prevention & control; Female; Fenofibrate / administration & dosage; Genetic Association Studies; Genetic Markers; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Molecular Diagnostic Techniques; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Simvastatin / administration & dosage
TL;DR: When combined into a GRS, CAD loci identified in the general population are associated with CAD also in type 2 diabetes, which provides a significant improvement in the ability to correctly predict future MCE. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 5, 2018

2018 journal article

Genetic variants in CPA6 and PRPF31 are associated with variation in response to metformin in individuals with type 2 diabetes

Diabetes, 67(7), 1428–1440.

By: D. Rotroff, S. Yee, K. Zhou, S. Marvel, H. Shah, J. Jack, T. Havener, M. Hedderson ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

International collaborative study to assess cardiovascular risk and evaluate long-term health in cats with preclinical hypertrophic cardiomyopathy and apparently healthy cats: The REVEAL Study

Journal of Veterinary Internal Medicine, 32(3), 930–943.

By: P. Fox, B. Keene, K. Lamb, K. Schober, V. Chetboul, V. Fuentes, G. Wess, J. Payne ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Modulation of GLP-1 Levels by a Genetic Variant That Regulates the Cardiovascular Effects of Intensive Glycemic Control in ACCORD

DIABETES CARE, 41(2), 348–355.

MeSH headings : Aged; Blood Glucose / genetics; Blood Glucose / metabolism; Diabetes Mellitus, Type 2 / blood; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / genetics; Diabetic Angiopathies / blood; Diabetic Angiopathies / genetics; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Glucagon-Like Peptide 1 / blood; Humans; Hypoglycemic Agents / therapeutic use; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors
TL;DR: Differences in GLP-1 axis activation may mediate the modulatory effect of variant rs57922 on the cardiovascular response to intensive glycemic control, and highlight the importance of GLp-1 as a cardioprotective factor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Pharmacogenetic Analysis of the Model-Based Pharmacokinetics of Five Anti-HIV Drugs: How Does This Influence the Effect of Aging?

CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 11(2), 226–236.

By: J. Chen*, F. Akhtari n, M. Wagner*, O. Suzuki*, T. Wiltshire*, A. Motsinger-Reif n, J. Dumond*

MeSH headings : ATP Binding Cassette Transporter, Subfamily B / genetics; Adult; Age Factors; Aged; Aging / genetics; Anti-HIV Agents / administration & dosage; Anti-HIV Agents / pharmacokinetics; Anti-HIV Agents / therapeutic use; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; Cytochrome P-450 CYP2B6 / genetics; Drug Combinations; Drug Therapy, Combination / methods; Female; Frail Elderly; HIV Infections / drug therapy; HIV Infections / genetics; Humans; Male; Middle Aged; Multidrug Resistance-Associated Proteins / genetics; Pharmacogenomic Testing / methods; Prospective Studies; Young Adult
TL;DR: Both age and p16INK4a expression interacted with PGx on ATV and TFV disposition, implying potential dose adjustment based on aging may depend on genetic background. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 7(8), 525–533.

By: R. Kaddurah-Daouk*, T. Hankemeier*, E. Scholl n, R. Baillie*, A. Harms*, C. Stage*, K. Dalhoff*, G. Jurgens* ...

MeSH headings : Adult; Central Nervous System Stimulants / pharmacokinetics; Female; Humans; Male; Methylphenidate / pharmacokinetics; Prospective Studies; Young Adult
TL;DR: In silico analysis suggested that bile acid inhibition of CES1 involved both binding to the active and superficial sites of the enzyme and suggested lipids to regulate or be regulated by this enzyme. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: NC State University Libraries
Added: October 16, 2018

2018 journal article

Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 7(1).

By: M. Shahin*, Y. Gong*, R. Frye*, D. Rotroff n, A. Beitelshees*, R. Baillie*, A. Chapman*, J. Gums* ...

author keywords: blood pressure; lipid metabolites; metabolomics; pharmacogenetics; thiazide diuretics
MeSH headings : Adult; Blood Pressure; Female; Genomics; Humans; Hydrochlorothiazide / therapeutic use; Hypertension / drug therapy; Lipid Metabolism; Male; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Nitriles; Pharmacogenetics; Prognosis; Serine C-Palmitoyltransferase / genetics; Siloxanes; Sodium Chloride Symporter Inhibitors / therapeutic use; Sphingolipids / metabolism; Treatment Outcome
TL;DR: This study provides insight into potential pharmacometabolomic and genetic mechanisms underlying HCTZ BP response and suggests that SPTLC3 is a potential determinant of the BP response to HCTz. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

The influence of Neanderthal alleles on cytotoxic response

PEERJ, 6.

By: F. Akhtari n, T. Havener*, M. Fukudo*, J. Jack n, H. McLeod*, T. Wiltshire*, A. Motsinger-Reif n

author keywords: Neanderthal alleles; Cytotoxic response; Pharmacogenomics; Toxicogenomics; Dose responses; Neanderthal ancestry; Lymphoblastoid cell lines; Anti-cancer drugs; Environmental chemicals; Single nucleotide polymorphisms
TL;DR: The results demonstrate the influence of Neanderthal ancestry-informative markers on cytotoxic response and could be important in identifying biomarkers for personalized medicine or in dissecting the underlying etiology of dose response traits. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 5, 2018

2017 review

An introduction to terminology and methodology of chemical synergy-perspectives from across disciplines

[Review of ]. Frontiers in Pharmacology, 8.

By: K. Roell, D. Reif & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2017 article

Assessment of potential miRNA biomarkers of VERO-cell tumorigenicity in a new line (AGMK1-9T7) of African green monkey kidney cells

Teferedegne, B., Rotroff, D. M., Macauley, J., Foseh, G., Lewis, G., Motsinger-Rief, A., & Lewis, A. M., Jr. (2017, October 4). VACCINE, Vol. 35, pp. 5503–5509.

By: B. Teferedegne*, D. Rotroff n, J. Macauley*, G. Foseh*, G. Lewis, A. Motsinger-Rief n, A. Lewis*

author keywords: African green monkey kidney (AGMK1-9T7) cells; Neoplastic development; Immortalization, transformation; Tumorigenic phenotype microRNA
MeSH headings : Animals; Biomarkers / metabolism; Carcinogenesis / genetics; Carcinogenesis / pathology; Cell Line; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / pathology; Chlorocebus aethiops; Female; Humans; Kidney / pathology; Mice, Nude; MicroRNAs / genetics; Neoplasms / genetics; Neoplasms / pathology; Vero Cells / pathology
TL;DR: The similarities of expression of miRNAs in different AGMK cell lines that were established 50years apart suggest that the process of SPNDT in these non-human primate cells in tissue culture is based upon similar genetic and epigenetic mechanisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Association of breed and histopathological grade in canine mast cell tumours

VETERINARY AND COMPARATIVE ONCOLOGY, 15(3), 829–839.

By: H. Mochizuki n, A. Motsinger-Reif n, C. Bettini, S. Moroff & M. Breen n

author keywords: Boxer; dog; epidemiology; genetics; MCT; Pug
MeSH headings : Age Factors; Animals; Dog Diseases / etiology; Dog Diseases / pathology; Dogs; Female; Male; Mastocytosis, Cutaneous / etiology; Mastocytosis, Cutaneous / pathology; Mastocytosis, Cutaneous / veterinary; Retrospective Studies; Risk Factors; Sex Factors; Skin Neoplasms / etiology; Skin Neoplasms / pathology; Skin Neoplasms / veterinary; Species Specificity
TL;DR: The data indicate that the proportion of high-grade tumours increases with advancing age, and that male and intact dogs have increased odds of developing high- grade tumours, and a genetic association for the development ofhigh-grade MCTs is suggested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Common and rare genetic markers of lipid variation in subjects with type 2 diabetes from the ACCORD clinical trial

PeerJ, 5.

By: S. Marvel, D. Rotroff, M. Wagner, J. Buse, T. Havener, H. McLeod, A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2017 article

Common genetic variants in neurobeachin (nbea) are associated with metformin drug response in individuals with type 2 diabetes in the accord clinical trial

Clinical Pharmacology & Therapeutics, Vol. 101, pp. S9–9.

By: D. Rotroff, S. Marvel, J. Jack, T. Havener, A. Doria, H. Shah, J. Mychaleckyi, H. McLeod ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Data descriptor: Targeted metabolomics and medication classification data from participants in the ADNI1 cohort

Scientific Data, 4.

By: L. St John-Williams, C. Blach, J. Toledo, D. Rotroff, S. Kim, K. Klavins, R. Baillie, X. Han ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

GUT DERIVED BILE ACID METABOLITES CORRELATE WITH STRUCTURAL AND FUNCTIONAL NEUROIMAGING MEASURES IN ALZHEIMER’S DISEASE

Alzheimer's & Dementia, 13(7), P543–P544.

By: K. Nho n, S. Dehkordi, A. Motsinger-Reif*, R. Baillie, S. Bhattacharyya, J. Tenenbaum, J. Thompson, L. St. John Williams ...

TL;DR: It is discovered that in the pooled-sex network, sphingomyelins and amines correlated with Sex and phosphatidylcholines connects to AD progression (Dx). (via Semantic Scholar)
Source: Crossref
Added: February 21, 2020

2017 journal article

Genetic Variants in HSD17B3 , SMAD3 , and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes

Clinical Pharmacology & Therapeutics, 103(4), 712–721.

MeSH headings : Aldehyde Reductase / genetics; Animals; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / genetics; Diabetes Mellitus, Type 2 / metabolism; Dyslipidemias / blood; Dyslipidemias / complications; Dyslipidemias / drug therapy; Dyslipidemias / genetics; Female; Fenofibrate / administration & dosage; Fenofibrate / pharmacokinetics; Gene Expression Profiling / methods; Genome-Wide Association Study; Humans; Hypolipidemic Agents / administration & dosage; Hypolipidemic Agents / pharmacokinetics; Lipid Metabolism / drug effects; Lipid Metabolism / genetics; Male; Mice; Middle Aged; Pharmacogenomic Testing / methods; Signal Transduction / drug effects; Smad3 Protein / genetics; beta Karyopherins / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: February 21, 2020

2017 journal article

Metabolic network failures in Alzheimer's disease: A biochemical road map

Alzheimers & Dementia, 13(9), 965–984.

By: J. Toledo, M. Arnold, G. Kastenmuller, R. Chang, R. Baillie, X. Han, M. Thambisetty, J. Tenenbaum ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Metabolic network failures in Alzheimer's disease: A biochemical road map

Alzheimer's & Dementia, 13(9), 965–984.

author keywords: Metabolomics; Metabonomics; Pharmacometabolomics; Pharmacometabonomics; Biomarkers; Serum; Metabolism; Systems biology; Biochemical networks; Precision medicine; Alzheimer's disease; Dementia; Branched-chain amino acids; Sphingomyelins; Phospholipids; Acylcarnitines
MeSH headings : Aged; Aged, 80 and over; Aging / blood; Alzheimer Disease / blood; Alzheimer Disease / cerebrospinal fluid; Alzheimer Disease / complications; Alzheimer Disease / diagnostic imaging; Amino Acids / blood; Amyloid beta-Peptides / metabolism; Aniline Compounds / metabolism; Cognitive Dysfunction / blood; Cognitive Dysfunction / diagnostic imaging; Cognitive Dysfunction / etiology; Cohort Studies; Cross-Sectional Studies; Fasting; Female; Humans; Male; Metabolic Diseases / blood; Metabolic Diseases / cerebrospinal fluid; Metabolic Diseases / diagnostic imaging; Metabolic Diseases / etiology; Metabolic Networks and Pathways / physiology; Metabolomics / methods; Peptide Fragments / metabolism; Phosphatidylcholines / blood; Phosphatidylcholines / metabolism; Sphingomyelins / blood; Thiazoles / metabolism; tau Proteins / cerebrospinal fluid
Source: Crossref
Added: February 21, 2020

2017 journal article

Targeted metabolomics and medication classification data from participants in the ADNI1 cohort

Scientific Data, 4(1).

By: L. St John-Williams*, C. Blach*, J. Toledo*, D. Rotroff n, S. Kim*, K. Klavins*, R. Baillie*, X. Han* ...

MeSH headings : Alzheimer Disease / drug therapy; Alzheimer Disease / genetics; Alzheimer Disease / metabolism; Cognitive Dysfunction; Cohort Studies; Humans; Metabolomics; Neuroimaging
TL;DR: This report presents quantitative metabolomics data generated on serum from 199 control, 356 mild cognitive impairment and 175 AD subjects enrolled in ADNI1 using AbsoluteIDQ-p180 platform, along with the pipeline for data preprocessing and medication classification for confound correction. (via Semantic Scholar)
Source: Crossref
Added: February 21, 2020

2017 journal article

The Effect of Heart Disease on Anesthetic Complications During Routine Dental Procedures in Dogs

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 53(4), 206–213.

By: J. Carter n, A. Motsinger-Reif n, W. Krug n & B. Keene n

MeSH headings : Anesthesia / adverse effects; Anesthesia / veterinary; Animals; Case-Control Studies; Dental Prophylaxis / veterinary; Dog Diseases / etiology; Dogs; Heart Diseases / complications; Heart Diseases / veterinary; Intraoperative Complications / etiology; Intraoperative Complications / veterinary; Retrospective Studies; Risk Factors
TL;DR: This study suggests dogs with heart disease, when anesthetized by trained personnel and carefully monitored during routine dental procedures, are not at significantly increased risk for anesthetic complications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

The steroid metabolome in women with premenstrual dysphoric disorder during GnRH agonist-induced ovarian suppression: effects of estradiol and progesterone addback

Translational Psychiatry, 7(8), e1193–e1193.

By: T. Nguyen, J. Reuter, N. Gaikwad*, D. Rotroff n, H. Kucera*, A. Motsinger-Reif n, C. Smith n, L. Nieman* ...

MeSH headings : Adult; Cross-Over Studies; Desoxycorticosterone / blood; Estradiol / analogs & derivatives; Estradiol / blood; Estradiol / pharmacology; Estrone / blood; Female; Humans; Leuprolide / pharmacology; Metabolome / drug effects; Middle Aged; Pregnanediol / blood; Pregnanolone / blood; Premenstrual Dysphoric Disorder / metabolism; Progesterone / pharmacology; Young Adult
TL;DR: No differences in the formation of P4-derived neurosteroids were observed in this otherwise highly selected sample of women studied under controlled hormone exposures in women with prospectively confirmed PMDD and controls without menstrual cycle-related affective symptoms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Thromboelastographic monitoring of the effect of unfractionated heparin in healthy dogs

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 27(1), 71–81.

By: C. McLaughlin n, S. Marks n, D. Dorman n, A. Motsinger-Reif n & R. Hanel n

author keywords: anticoagulation monitoring; anti-Xa; canine; RapidTEG; thrombosis
MeSH headings : Animals; Anticoagulants / administration & dosage; Anticoagulants / pharmacology; Blood Coagulation / drug effects; Dogs; Female; Heparin / administration & dosage; Heparin / pharmacology; Injections, Subcutaneous / veterinary; Male; Partial Thromboplastin Time / veterinary; Prospective Studies; Reference Values; Thrombelastography / veterinary
TL;DR: This study demonstrates that TEG variables derived using robust activation correlate with AXa activity as well as aPTT and have the potential to be used for monitoring UFH therapy in healthy dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

A European spectrum of pharmacogenomic biomarkers: Implications for clinical pharmacogenomics

PLoS One, 11(9).

By: C. Mizzi, E. Dalabira, J. Kumuthini, N. Dzimiri, I. Balogh, N. Basak, R. Bohm, J. Borg ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

A comparison of DMET Plus microarray and genome-wide technologies by assessing population substructure

PHARMACOGENETICS AND GENOMICS, 26(4), 147–153.

By: J. Jackson n, K. Long n, Y. He n, A. Motsinger-Reif n, H. McLeod n & J. Jack n

author keywords: admixture; Affymetrix; cryptic relatedness; DMET Plus; inbreeding coefficients; metabolism; pharmacogenomics; population stratification; principal component analysis; transporters
TL;DR: The DMET Plus pharmacogenomics genotyping chip is effective in quantifying population substructure across the three continental populations and inferring the presence of an admixed population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

A genetic response score for hydrochlorothiazide use insights from genomics and metabolomics integration

Hypertension, 68(3), 621-.

By: M. Shahin, Y. Gong, C. McDonough, D. Rotroff, A. Beitelshees, T. Garrett, J. Gums, A. Motsinger-Reif ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

A genome-wide study of lipid response to fenofibrate in Caucasians: A combined analysis of the GOLDN and ACCORD studies

Pharmacogenetics and Genomics, 26(7), 324–333.

By: M. Irvin, D. Rotroff, S. Aslibekyan, D. Zhi, B. Hidalgo, A. Motsinger-Reif, S. Marvel, V. Srinivasasainagendra ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial

PHARMACOGENOMICS JOURNAL, 16(3), 243–248.

By: Y. He*, S. Winham n, J. Hoskins*, S. Glass*, J. Paul*, R. Brown*, A. Motsinger-Reif n, H. McLeod*

MeSH headings : Adenosine Triphosphatases / genetics; Antineoplastic Combined Chemotherapy Protocols / adverse effects; Carboplatin / adverse effects; Cation Transport Proteins / genetics; Copper-Transporting ATPases; Docetaxel; Female; Gastrointestinal Diseases / chemically induced; Gastrointestinal Diseases / diagnosis; Gastrointestinal Diseases / genetics; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Kaplan-Meier Estimate; NAV1.8 Voltage-Gated Sodium Channel / genetics; Ovarian Neoplasms / drug therapy; Ovarian Neoplasms / mortality; Pharmacogenetics; Pharmacogenomic Variants / genetics; Phenotype; Polymorphism, Single Nucleotide; Proportional Hazards Models; Risk Factors; Scotland; Severity of Illness Index; Taxoids / adverse effects; Time Factors; Treatment Outcome; Vascular Endothelial Growth Factor A / genetics
TL;DR: The SCOTROC1 data provide potential targets for modulation/inhibition of GI toxicity in ovarian cancer patients, and seven single-nucleotide polymorphisms in the ATP7B, GSR, VEGFA and SCN10A genes are identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Comprehensive genomic characterization of five canine lymphoid tumor cell lines

BMC Veterinary Research, 12.

By: S. Roode, D. Rotroff, K. Richards, P. Moore, A. Motsinger-Reif, Y. Okamura, T. Mizuno, H. Tsujimoto, S. Suter, M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Eigenvector metabolite analysis reveals dietary effects on the association among metabolite correlation patterns, gene expression, and phenotypes

METABOLOMICS, 12(11).

By: C. Chialvo*, R. Che n, D. Reif n, A. Motsinger-Reif n & L. Reed*

Contributors: C. Scott Chialvo*, R. Che n, D. Reif n, A. Motsinger-Reif n & L. Reed*

author keywords: Eigenvector metabolite analysis; Linkage analyses; Environment; Enrichment analyses
TL;DR: Eigenvector Metabolite Analysis provides a simple method to identify correlations between metabolites, gene expression, and phenotypes, which can allow us to partition multivariate datasets into meaningful biological modules and identify under-studied metabolites and unannotated gene transcripts that may be central to important biological processes. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 review

Embracing integrative multiomics approaches

[Review of ]. International Journal of Genomics.

By: D. Rotroff & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

GENETIC INFLUENCE ON LEVELS OF TARGETED METABOLITES ASSOCIATED WITH ALZHEIMER’S DISEASE

Alzheimer's & Dementia, 12(7), P164–P165.

By: S. Kim*, J. Toledo*, K. Nho*, S. Risacher*, L. Shen*, J. Thompson*, L. St. John Williams*, J. Tenenbaum* ...

Source: Crossref
Added: August 28, 2020

2016 journal article

Genetic predictors of cardiovascular mortality during intensive glycemic control in type 2 diabetes: Findings from the ACCORD clinical trial

Diabetes Care, 39(11), 1915–1924.

By: H. Shah, H. Gao, M. Morieri, J. Skupien, S. Marvel, G. Pare, G. Mannino, P. Buranasupkajorn ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Genome-wide association study in immunocompetent patients with delayed hypersensitivity to sulfonamide antimicrobials

PLoS One, 11(6).

By: J. Reinhart, A. Motsinger-Reif, A. Dickey, S. Yale & L. Trepanier

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

INDICES OF PLASMALOGEN BIOSYNTHESIS IN ADNI-1 BASELINE SERUM SAMPLES: ASSOCIATION WITH PROGRESSION TO DEMENTIA IN SUBJECTS WITH MILD COGNITIVE IMPAIRMENT

Alzheimer's & Dementia, 12(7), P879–P880.

By: M. Kling*, D. Goodenowe*, J. Toledo*, V. Senanayake*, R. Baillie*, J. Lucas*, J. Tenenbaum*, A. Motsinger-Reif n, X. Han*, R. Kaddurah-Daouk*

TL;DR: The results demonstrate that in patients with AD, T4 levels are about 10 times higher than normal, suggesting that along the development occurs a reduction in expression of isoform of the enzyme D2 or oxidative neurodegeneration cholinergic accompanying this disease, contributes to a reduction of the enzymatic activity D2. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2016 journal article

Incorporating concomitant medications into genome-wide analyses for the study of complex disease and drug response

Frontiers in Genetics, 7.

By: H. Graham, D. Rotroff, S. Marvel, J. Buse, T. Havener, A. Wilson, M. Wagner, A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero

BMC Genomics, 17.

By: D. Rotroff, B. Joubert, S. Marvel, S. Haberg, M. Wu, R. Nilsen, P. Ueland, W. Nystad, S. London, A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants

Translational Psychiatry, 6(9), e894–e894.

By: D. Rotroff n, D. Corum*, A. Motsinger-Reif n, O. Fiehn*, N. Bottrel*, W. Drevets*, J. Singh*, G. Salvadore*, R. Kaddurah-Daouk*

MeSH headings : Adult; Arginine / metabolism; Citrulline / metabolism; Depressive Disorder, Major / drug therapy; Depressive Disorder, Major / metabolism; Depressive Disorder, Treatment-Resistant / drug therapy; Depressive Disorder, Treatment-Resistant / metabolism; Excitatory Amino Acid Antagonists / therapeutic use; Female; Glutamic Acid / metabolism; Humans; Indoleacetic Acids / metabolism; Infusions, Intravenous; Ketamine / therapeutic use; Male; Metabolomics; Methionine / metabolism; Middle Aged; Ornithine / metabolism; Phenotype; Phospholipids / metabolism; Tryptophan / metabolism; Urea / metabolism
TL;DR: Changes in glutamate and circulating phospholipids that were significantly associated with decreases in depression severity are observed, providing new insights into the mechanism underlying the rapid antidepressant effects of ketamine and esketamine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Pharmacometabolomic assessment of metformin in non-diabetic, African Americans

Frontiers in Pharmacology, 7.

By: D. Rotroff, N. Oki, X. Liang, S. Yee, S. Stocker, D. Corum, M. Meisner, O. Fiehn ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

THE ALZHEIMER’S METABOLOME: RELATIONSHIP TO PATHOLOGICAL MARKERS AND COGNITIVE DECLINE IN THE ALZHEIMER’S DISEASE NEUROIMAGING INITIATIVE (ADNI)

Alzheimer's & Dementia, 12(7), P164.

By: J. Toledo*, J. Thompson*, L. St. John Williams*, J. Tenenbaum*, X. Han*, R. Baillie*, M. Thambisetty*, R. Casanova* ...

TL;DR: The results suggest that both coding and non-coding rare variants influence LOAD susceptibility, and show the continued utility of family-based approaches. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2016 journal article

Use of RNA-seq to identify cardiac genes and gene pathways differentially expressed between dogs with and without dilated cardiomyopathy

AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(7), 693–699.

By: S. Friedenberg n, L. Chdid n, B. Keene n, B. Sherry n, A. Motsinger-Reif n & K. Meurs n

MeSH headings : Animals; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / metabolism; Cardiomyopathy, Dilated / veterinary; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Down-Regulation; Female; Gene Expression; Heart Ventricles; Male; Myocardium / metabolism; RNA / genetics; Up-Regulation
TL;DR: Genes involved in cellular energy metabolism, especially metabolism of carbohydrates and fats, were significantly downregulated in dogs with DCM, and Expression of cardiac structural proteins was also altered in affected dogs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

Nature Genetics, 48(9), 1055–1059.

By: K. Zhou*, S. Yee, E. Seiser*, N. van Leeuwen*, R. Tavendale*, A. Bennett*, C. Groves*, R. Coleman* ...

MeSH headings : Blood Glucose / analysis; Body Mass Index; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / genetics; Genome-Wide Association Study; Glucose Transporter Type 2 / genetics; Glycated Hemoglobin / analysis; Humans; Hypoglycemic Agents / therapeutic use; Metformin / therapeutic use; Polymorphism, Single Nucleotide / genetics; Quantitative Trait, Heritable; White People
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: February 24, 2020

2016 journal article

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

Nature Genetics, 48(9), 1055-.

By: K. Zhou, S. Yee, E. Seiser, N. Leeuwen, R. Tavendalel, A. Bennett, C. Groves, R. Coleman ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

alpha-Hydroxybutyric Acid Is a Selective Metabolite Biomarker of Impaired Glucose Tolerance

DIABETES CARE, 39(6), 988–995.

By: J. Cobb*, A. Eckhart*, A. Motsinger-Reif n, B. Carr*, L. Groop* & E. Ferrannini*

MeSH headings : Adult; Biomarkers / metabolism; Blood Glucose / metabolism; Cohort Studies; Fasting; Female; Glucose Intolerance / metabolism; Glucose Tolerance Test; Humans; Hydroxybutyrates / metabolism; Male; Metabolomics; Middle Aged; Multivariate Analysis; Oleic Acid / metabolism; Prediabetic State / metabolism; Prospective Studies
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Accuracy of SNPs to predict risk of HLA alleles associated with drug-induced hypersensitivity events across racial groups

PHARMACOGENOMICS, 16(8), 817–824.

By: Y. He*, J. Hoskins, S. Clark, N. Campbell, K. Wagner, A. Motsinger-Reif n, H. McLeod*

author keywords: drug-induced hypersensitivity; HLA; human leukocyte antigen; pharmacogenetics; pharmacogenomics; risk mitigation
MeSH headings : Black or African American / genetics; Alleles; Asian People / genetics; Drug Hypersensitivity / genetics; Drug Hypersensitivity / pathology; Genotype; HLA-B Antigens / genetics; HLA-DQ alpha-Chains / genetics; Hispanic or Latino / genetics; Humans; Polymorphism, Single Nucleotide / genetics; White People
TL;DR: This study demonstrates the utility of SNP tagging as a 'real time' approach to predict or exclude the presence of specific HLA alleles of known importance to HSR across diverse ethnic groups. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

An investigation of gene-gene interactions in dose-response studies with Bayesian nonparametrics

Biodata Mining, 8.

By: A. Beam, A. Motsinger-Reif & J. Doyle

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Canine urothelial carcinoma: genomically aberrant and comparatively relevant

Chromosome Research, 23(2), 311–331.

By: S. Shapiro n, S. Raghunath n, C. Williams n, A. Motsinger-Reif n, J. Cullen n, T. Liu*, D. Albertson*, M. Ruvolo* ...

author keywords: Canine; Urothelial carcinoma; Transitional cell carcinoma; Cytogenetics; Chromosome aberration; Array comparative genomic hybridization; Comparative oncology
MeSH headings : Animals; Biopsy; Carcinoma / veterinary; Chromosome Aberrations; Comparative Genomic Hybridization; Computational Biology / methods; DNA Copy Number Variations; Dogs; Female; Genetic Loci; Genomics / methods; Humans; In Situ Hybridization, Fluorescence; Male; Urologic Neoplasms / veterinary
TL;DR: It is proposed that common aberrations found in primary canine UC biopsies are indicative of an evolutionarily conserved mechanism of pathogenesis and harbor genes key to urothelial neoplasia, warranting investigation for diagnostic, prognostic, and therapeutic applications. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Comparative cytogenetic characterization of primary canine melanocytic lesions using array CGH and fluorescence in situ hybridization

CHROMOSOME RESEARCH, 23(2), 171–186.

By: K. Poorman n, L. Borst n, S. Moroff, S. Roy n, P. Labelle, A. Motsinger-Reif n, M. Breen n

author keywords: Canine; Oral melanoma; Cytogenetics; Array; Comparative genomic hybridization
MeSH headings : Animals; Chromosome Aberrations; Cluster Analysis; Comparative Genomic Hybridization; Computational Biology; DNA Copy Number Variations; Dogs; Female; Humans; In Situ Hybridization, Fluorescence; Male; Melanoma / genetics; Melanoma / metabolism; Melanoma / pathology; Mouth Neoplasms / genetics; Mouth Neoplasms / pathology; Penetrance; Skin Neoplasms
TL;DR: This study suggests that in concordance with what is known for human melanomas, canine melanomas of the oral mucosa and cutaneous epithelium are discrete and initiated by different molecular pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Evaluating the role of admixture in cancer therapy via in vitro drug response and multivariate genome-wide associations

PHARMACOGENOMICS, 16(13), 1451–1463.

By: J. Jack n, T. Havener*, H. McLeod*, A. Motsinger-Reif n & M. Foster*

author keywords: admixture; cancer; Caucasian; cytotoxicity; drug; genome-wide association study; GWAS; hispanic; in vitro; lymphoblastoid cell lines
MeSH headings : Black or African American; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cell Line, Tumor; Cohort Studies; Ethnicity; Genetic Variation; Genome-Wide Association Study; Hispanic or Latino; Humans; Multivariate Analysis; Neoplasms / drug therapy; Neoplasms / genetics; Pharmacogenetics; Treatment Outcome; White People
TL;DR: For many drugs, the variability in drug response appears to correlate with self-reported race and estimates of genetic ancestry, and multivariate genome-wide association analyses offered interesting hypotheses governing these differential responses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Genome-wide assessment of recurrent genomic imbalances in canine leukemia identifies evolutionarily conserved regions for subtype differentiation

Chromosome Research, 23(4), 681–708.

By: S. Roode n, D. Rotroff n, A. Avery*, S. Suter n, D. Bienzle*, J. Schiffman*, A. Motsinger-Reif n, M. Breen n

author keywords: Leukemia; Canine; Chromosome; Comparative genomic hybridization; Comparative genomics
MeSH headings : Algorithms; Animals; Cell Transformation, Neoplastic / genetics; Chromosome Aberrations; Chromosome Mapping; Cluster Analysis; Comparative Genomic Hybridization; Conserved Sequence; DNA Copy Number Variations; Disease Models, Animal; Dogs; Evolution, Molecular; Female; Gene Dosage; Genome-Wide Association Study; Genomic Library; Genomics; Humans; In Situ Hybridization, Fluorescence; Leukemia / diagnosis; Leukemia / genetics; Leukemia / metabolism; Male
TL;DR: The use of canine leukemia as a relevant in vivo model for human leukemia is supported and the need to further explore the conserved genomic regions of interest for their clinical impact is justified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain

PeerJ, 3.

By: D. Knazovicky, A. Tomas, A. Motsinger-Reif & B. Lascelles

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Pharmacometabolomic Assessments of Atenolol and Hydrochlorothiazide Treatment Reveal Novel Drug Response Phenotypes

CPT: Pharmacometrics & Systems Pharmacology, 4(11), 669–679.

By: D. Rotroff n, M. Shahin*, S. Gurley*, H. Zhu*, A. Motsinger-Reif n, M. Meisner n, A. Beitelshees*, O. Fiehn* ...

TL;DR: The metabolites identified herein may serve as biomarkers for improving treatment decisions and elucidating mechanisms driving HTN treatment responses as part of a quantitative systems pharmacology approach. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: February 24, 2020

2015 journal article

Population-Based in Vitro Hazard and Concentration-Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study

ENVIRONMENTAL HEALTH PERSPECTIVES, 123(5), 458–466.

By: N. Abdo*, M. Xia*, C. Brown*, O. Kosyk*, R. Huang*, S. Sakamuru*, Y. Zhou n, J. Jack* ...

MeSH headings : Cell Line, Tumor; Genome-Wide Association Study / methods; Genotype; Humans; Risk Assessment; Toxicity Tests / methods
TL;DR: This experimental approach fills critical gaps unaddressed by recent large-scale toxicity testing programs, providing quantitative, experimentally based estimates of human toxicodynamic variability, and also testable hypotheses about mechanisms contributing to interindividual variation. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Relative Quantification and Higher-Order Modeling of the Plasma Glycan Cancer Burden Ratio in Ovarian Cancer Case-Control Samples

JOURNAL OF PROTEOME RESEARCH, 14(10), 4394–4401.

By: E. Hecht*, E. Scholl*, S. Walker*, A. Taylor, W. Cliby*, A. Motsinger-Reif*, D. Muddiman*

author keywords: N-linked glycosylation; INLIGHT; ovarian cancer; relative quantification; cancer biomarker; human plasma
MeSH headings : Biomarkers, Tumor / blood; Carbohydrate Sequence; Case-Control Studies; Chromatography, Liquid / methods; Female; Fucose / blood; Glycosylation; Humans; Hydrazines / chemistry; Molecular Sequence Data; Neoplasm Staging; Ovarian Neoplasms / blood; Ovarian Neoplasms / diagnosis; Ovarian Neoplasms / pathology; Polysaccharides / blood; Sialic Acids / blood; Staining and Labeling / methods; Tandem Mass Spectrometry / methods
TL;DR: For all N-glycans, the vectors of the effects from stages II-IV were sequentially reversed, suggesting potential biological changes in OVC morphology or in host response. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

A novel canine model of immune thrombocytopenia: has immune thrombocytopenia (ITP) gone to the dogs?

British Journal of Haematology, 167(1), 110–120.

By: D. LeVine n, A. Birkenheuer n, M. Brooks*, S. Nordone n, D. Bellinger*, S. Jones n, T. Fischer*, S. Oglesbee* ...

author keywords: immune thrombocytopenia; canine; interleukin-8; animal model
MeSH headings : Animals; Antibodies, Monoclonal / administration & dosage; Antibodies, Monoclonal / adverse effects; Antibodies, Monoclonal / immunology; Blood Platelets / immunology; Blood Platelets / metabolism; Cytokines / blood; Cytokines / metabolism; Disease Models, Animal; Dogs; Hemorrhage / immunology; Phenotype; Platelet Count; Purpura, Thrombocytopenic, Idiopathic / blood; Purpura, Thrombocytopenic, Idiopathic / diagnosis; Purpura, Thrombocytopenic, Idiopathic / immunology
TL;DR: Evaluation of cytokine profiles led to the identification of platelets as a potential source of serum interleukin‐8 (IL8) in dogs, suggesting that platelet IL8 may be a previously unrecognized modulator of platelet‐neutrophil crosstalk in humans with ITP. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

An adaptive permutation approach for genome-wide association study: Evaluation and recommendations for use

Biodata Mining, 7.

By: R. Che, J. Jack, A. Motsinger-Reif & C. Brown

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Bayesian neural networks for detecting epistasis in genetic association studies

BMC Bioinformatics, 15.

By: A. Beam, A. Motsinger-Reif & J. Doyle

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Canine hereditary ataxia in Old English Sheepdogs and Gordon Setters is associated with a defect in the autophagy gene encoding RAB24

PLoS Genetics, 10(2).

By: C. Agler, D. Nielsen, G. Urkasemsin, A. Singleton, N. Tonomura, S. Sigurdsson, R. Tang, K. Linder ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Evaluation of thromboelastography for prediction of clinical bleeding in thrombocytopenic dogs after total body irradiation and hematopoietic cell transplantation

AMERICAN JOURNAL OF VETERINARY RESEARCH, 75(5), 425–432.

By: M. Bucknoff n, R. Hanel n, S. Marks n, A. Motsinger-Reif n & S. Suter n

MeSH headings : Animals; Bone Marrow Transplantation / veterinary; Cohort Studies; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dogs; Hemorrhage / diagnosis; Hemorrhage / physiopathology; Hemorrhage / veterinary; Hemostasis / physiology; Kaolin; Lymphoma / physiopathology; Lymphoma / veterinary; Male; Platelet Count / veterinary; Prospective Studies; Thrombelastography / methods; Thrombelastography / veterinary; Thrombocytopenia / physiopathology; Thrombocytopenia / veterinary; Whole-Body Irradiation / veterinary
TL;DR: Compared with buccal mucosal bleeding time and platelet count, thromboelastography was more reliable at identifying thrombocytopenic dogs with a low risk of bleeding and could be considered to help guide the use of transfusion products in dogs undergoing TBI and BMT. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Genetic heterogeneity beyond CYP2C8*3 does not explain differential sensitivity to paclitaxel-induced neuropathy

BREAST CANCER RESEARCH AND TREATMENT, 145(1), 245–254.

By: D. Hertz*, S. Roy n, J. Jack n, A. Motsinger-Reif n, A. Drobish, L. Clark, L. Carey*, E. Dees*, H. McLeod*

author keywords: Paclitaxel; Pharmacogenetics; Breast cancer; Chemotherapy-induced peripheral neuropathy; ABCG1; Affymetrix DMET (TM) plus; CYP2C8; Race
TL;DR: The pharmacogenetic heterogeneity within a cohort of breast cancer patients is dramatic, though it is not found evidence that this heterogeneity directly influences the risk of PIPN beyond the contribution of CYP2C8*3. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines

PHARMACOGENOMICS, 15(2), 137–146.

By: C. Brown n, T. Havener*, M. Medina, J. Jack n, R. Krauss, H. McLeod*, A. Motsinger-Reif n

author keywords: chemotherapeutics; genome-wide association study; lymphoblastoid cell lines
MeSH headings : Antineoplastic Agents / administration & dosage; Biomarkers, Pharmacological / metabolism; Cell Line, Tumor; Chromosome Mapping; Genome-Wide Association Study; Genotype; Histone Deacetylases / genetics; Humans; Pharmacogenetics; Repressor Proteins / genetics
TL;DR: The utility of LCLs is demonstrated in identifying genes that have clinical importance in drug response and for assigning unclassified agents to specific drug families, and proposes new candidate genes for follow-up in a large number of chemotherapy drugs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

CHROMOSOME RESEARCH, 22(3), 305–319.

By: R. Thomas n, L. Borst n, D. Rotroff n, A. Motsinger-Reif n, K. Lindblad-Toh*, J. Modiano*, M. Breen n

author keywords: canine; chromosome; hemangiosarcoma; comparative genomic hybridization (CGH)
MeSH headings : Animals; Breeding; Comparative Genomic Hybridization; DNA Copy Number Variations / genetics; Dog Diseases / genetics; Dogs; Gene Amplification; Gene Expression Profiling; Genetic Heterogeneity; Genome; Hemangiosarcoma / genetics; Hemangiosarcoma / veterinary; Penetrance; Vascular Endothelial Growth Factor A / genetics
TL;DR: Analysis of genome-wide microarray-based somatic DNA copy number profiling of 75 primary intra-abdominal hemangiosarcomas from five popular dog breeds supports prior transcriptional studies suggesting that the clinical heterogeneity of this cancer may reflect the existence of multiple, molecularly distinct subtypes of canine hemangiusarcoma. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Lymphoblastoid Cell Lines Models of Drug Response: Successes and Lessons from this Pharmacogenomic Model

CURRENT MOLECULAR MEDICINE, 14(7), 833–840.

By: J. Jack*, D. Rotroff* & A. Motsinger-Reif*

author keywords: Cytotoxics; genetic association mapping; genome wide association analysis; lymphoplastoid cell lines; pharmacogenomics
MeSH headings : Cell Line, Transformed; Cost-Benefit Analysis; Genome-Wide Association Study / economics; Genome-Wide Association Study / methods; Humans; Lymphocytes / drug effects; Lymphocytes / metabolism; Models, Biological; Models, Genetic; Pharmacogenetics / economics; Pharmacogenetics / methods; Polymorphism, Single Nucleotide; RNA Interference; Reproducibility of Results; Translational Research, Biomedical / economics; Translational Research, Biomedical / methods
TL;DR: The advantages, limitations, and opportunities for using lymphoblastoid cell lines (LCL) as a model system for human pharmacogenomic studies, including multivariate concentration response modeling, issues with multiple testing, and successful examples of the 'triangle model' to identify candidate variants are reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013

Equine Veterinary Journal, 47(3), 279–284.

By: L. Gonzalez n, C. Fogle n, W. Baker, F. Hughes*, J. Law n, A. Motsinger-Reif n, A. Blikslager n

Contributors: L. Gonzalez n, C. Fogle n, W. Baker, F. Hughes*, J. Law n, A. Motsinger-Reif n, A. Blikslager n

author keywords: horse; large colon volvulus; strangulation; pelvic flexure; surgery
MeSH headings : Animals; Biopsy; Colon / pathology; Hemorrhage / pathology; Hemorrhage / veterinary; Horse Diseases / surgery; Horses; Intestinal Volvulus / pathology; Intestinal Volvulus / surgery; Intestinal Volvulus / veterinary; Logistic Models; Retrospective Studies
TL;DR: Histomorphometric measurements of interstitium-to-crypt ratio and degree of haemorrhage predict short-term outcome in cases of large colon volvulus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

PGxClean: a quality control GUI for the Affymetrix DMET chip and other candidate gene studies with non-biallelic alleles

Biodata Mining, 7.

By: D. Rotroff, J. Jack, N. Campbell, S. Clark & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Positive association between a glutathione-S-transferase polymorphism and lymphoma in dogs

VETERINARY AND COMPARATIVE ONCOLOGY, 12(3), 227–236.

By: J. Ginn*, J. Sacco*, Y. Wong*, A. Motsinger-Reif n, R. Chun* & L. Trepanier*

author keywords: cancer risk; canine; carcinogens; glutathione; lymphosarcoma; polymorphisms
MeSH headings : Animals; Case-Control Studies; Dog Diseases / enzymology; Dog Diseases / genetics; Dogs; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genotype; Glutathione Transferase / genetics; Glutathione Transferase / metabolism; Lymphoma / enzymology; Lymphoma / genetics; Lymphoma / veterinary; Point Mutation; Polymorphism, Genetic
TL;DR: This intronic variant was predicted to perturb GSTT1 mRNA splicing, and may increase lymphoma risk by impairing detoxification of environmental chemicals, and confirmation of this finding in a larger population of dogs may support the inclusion of GSTT 1 genotyping in epidemiologic studies of canine lymph cancer risk. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Prevalence of onychectomy in cats presented for veterinary care near Raleigh, NC and educational attitudes toward the procedure

Veterinary Anaesthesia and Analgesia, 41(1), 48–53.

By: L. Lockhart n, A. Motsinger-Reif n, W. Simpson* & L. Posner n

author keywords: cat; declaw; education; onychectomy; pain; sterilization
MeSH headings : Animals; Cats / surgery; Education, Veterinary; Female; Hoof and Claw / surgery; Male; North Carolina; Surgical Procedures, Operative / education; Surgical Procedures, Operative / veterinary
TL;DR: Almost 21% of cats seen in veterinary hospitals near Raleigh, NC were declawed and there appears to be a discrepancy between the popularity of the onychectomy procedure and the emphasis placed on relevant instruction in veterinary schools in the USA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2014 journal article

Relationship Between Mechanical Thresholds and Limb Use in Dogs With Coxofemoral Joint OA-Associated Pain and the Modulating Effects of Pain Alleviation From Total Hip Replacement on Mechanical Thresholds

VETERINARY SURGERY, 43(5), 542–548.

By: A. Tomas n, D. Marcellin-Little n, S. Roe n, A. Motsinger-Reif n & B. Lascelles n

MeSH headings : Animals; Arthroplasty, Replacement, Hip / veterinary; Coccyx; Dog Diseases / physiopathology; Dog Diseases / surgery; Dogs; Female; Femur; Gait; Hip Joint / physiopathology; Joint Instability / physiopathology; Joint Instability / veterinary; Male; Pain Measurement / veterinary; Prospective Studies; Recovery of Function
TL;DR: Successful unilateral THR results in decreased central sensitization after 12 months in dogs and there were no significant correlations between mQSTvF data and age, bodyweight or the GRF variables. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Single-Nucleotide Polymorphism Data Support the General Unrelatedness of the Males in the Agricultural Health Study

Cancer Epidemiology Biomarkers & Prevention, 23(10), 2192–2195.

By: J. Jack n, A. Motsinger-Reif n, S. Koutros*, M. Alavanja*, L. Beane Freeman* & J. Hoppin n

MeSH headings : Agriculture; Case-Control Studies; Cohort Studies; Consanguinity; Gene-Environment Interaction; Humans; Male; Occupational Exposure; Polymorphism, Single Nucleotide; Principal Component Analysis; Research Design
TL;DR: This analysis rejects the hypothesis that individuals in the case–control study of prostate cancer exhibit cryptic relatedness, and these findings are important for all subsequent analyses of gene–environment interactions in the AHS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

VH1-44 gene usage defines a subset of canine B-cell lymphomas associated with better patient survival

Veterinary Immunology and Immunopathology, 157(3-4), 125–130.

By: H. Chen n, G. Small*, A. Motsinger-Reif n, S. Suter n & K. Richards n

author keywords: Immunoglobulin heavy chain variable region (VH); B-cell lymphoma; Diffuse large B-cell lymphoma; Survival; VH1-44
MeSH headings : Animals; Dog Diseases / genetics; Dog Diseases / immunology; Dog Diseases / mortality; Dogs / immunology; Humans; Immunoglobulin Heavy Chains / genetics; Immunoglobulin Variable Region / genetics; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / immunology; Lymphoma, B-Cell / mortality; Lymphoma, B-Cell / veterinary
TL;DR: It is found that VH1-44 was preferentially expressed in the majority of the 52 cBCLs as well as in themajority of the cDLBCL subset of patients, and may have functional implications for c BCL lymphomagenesis, in addition to being a useful prognostic biomarker. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2013 journal article

Alfaxalone anesthesia in bullfrogs (Lithobates catesbeiana) by injection or immersion

Journal of Zoo and Wildlife Medicine, 44(4), 965–971.

By: L. Posner n, K. Bailey n, E. Richardson n, A. Motsinger-Reif n & C. Harms n

author keywords: Alfaxalone; Alfaxan (R); anesthesia; bullfrogs; immersion; intramuscular
MeSH headings : Anesthetics / administration & dosage; Anesthetics / pharmacology; Animals; Drug Administration Routes; Pregnanediones / administration & dosage; Pregnanediones / pharmacology; Rana catesbeiana
TL;DR: Intramuscular alfaxalone produced immobilization in frogs but did not provide sufficient anesthesia to prevent response to noxious stimuli. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Alterations in metabolic pathways and networks in Alzheimer’s disease

Translational Psychiatry, 3(4), e244–e244.

By: R. Kaddurah-Daouk*, H. Zhu*, S. Sharma*, M. Bogdanov, S. Rozen*, W. Matson*, N. Oki n, A. Motsinger-Reif n ...

author keywords: Alzheimer's disease; metabolomics; partial network reconstruction; pathway analysis
MeSH headings : Aged; Aged, 80 and over; Alzheimer Disease / cerebrospinal fluid; Alzheimer Disease / metabolism; Biomarkers / cerebrospinal fluid; Case-Control Studies; Chromatography, Liquid; Cognitive Dysfunction / cerebrospinal fluid; Cognitive Dysfunction / metabolism; Female; Humans; Male; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Neuropsychological Tests; Prospective Studies
TL;DR: It is indicated that MCI and AD are associated with an overlapping pattern of perturbations in tryptophan, tyrosine, MET and purine pathways, and suggest that profound biochemical alterations are linked to abnormal Ab42 and tau metabolism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2013 journal article

CYP2C8*3 increases risk of neuropathy in breast cancer patients treated with paclitaxel

ANNALS OF ONCOLOGY, 24(6), 1472–1478.

By: D. Hertz*, S. Roy, A. Motsinger-Reif n, A. Drobish, L. Clark, H. McLeod*, L. Carey*, E. Dees*

author keywords: chemotherapy-induced peripheral neuropathy; cytochrome P450 2C8*3; paclitaxel; pharmacogenetics; race
MeSH headings : Adult; Black or African American / genetics; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic / therapeutic use; Aryl Hydrocarbon Hydroxylases / genetics; Breast Neoplasms / drug therapy; Breast Neoplasms / enzymology; Breast Neoplasms / genetics; Cohort Studies; Cytochrome P-450 CYP2C8; Female; Genetic Variation / genetics; Humans; Middle Aged; Paclitaxel / adverse effects; Paraneoplastic Polyneuropathy / chemically induced; Paraneoplastic Polyneuropathy / enzymology; Paraneoplastic Polyneuropathy / genetics; Risk Factors; Treatment Outcome; White People / genetics; Young Adult
TL;DR: The increased risk of paclitaxel-induced neuropathy in patients who carry the CYP2C8*3 variant was replicated in two racially distinct patient cohorts and in direction and magnitude of effect in 107 African-American patients. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Differentially expressed microRNAs and affected biological pathways revealed by modulated modularity clustering (MMC) analysis of human preeclamptic and IUGR placentas

Placenta, 34(7), 599–605.

By: L. Guo n, S. Tsai*, N. Hardison n, A. James*, A. Motsinger-Reif n, B. Thames*, E. Stone n, C. Deng*, J. Piedrahita n

author keywords: Placenta; Preeclampsia; IUGR; MiR-194; MiR-149
MeSH headings : Down-Regulation; Female; Fetal Growth Retardation / genetics; Fetal Growth Retardation / metabolism; Humans; MicroRNAs / biosynthesis; Placenta / metabolism; Pre-Eclampsia / genetics; Pre-Eclampsia / metabolism; Pregnancy; Transcriptome
TL;DR: Modulated modularity clustering (MMC) allowed the elucidation of a molecular signature associated with preeclampsia and a subset of IUGR samples, which allowed the identification of genes, pathways, and microRNAs affected in these diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2013 journal article

Gene Profiling of Canine B-Cell Lymphoma Reveals Germinal Center and Postgerminal Center Subtypes with Different Survival Times, Modeling Human DLBCL

Cancer Research, 73(16), 5029–5039.

By: K. Richards n, A. Motsinger-Reif n, H. Chen n, Y. Fedoriw n, C. Fan n, D. Nielsen n, G. Small n, R. Thomas n ...

MeSH headings : Adolescent; Animals; Child; Child, Preschool; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Disease Models, Animal; Dogs; Female; Gene Expression Profiling / methods; Germinal Center / metabolism; Germinal Center / pathology; Humans; Immunoglobulin Heavy Chains / genetics; Immunoglobulin Heavy Chains / metabolism; Interferon Regulatory Factors / genetics; Interferon Regulatory Factors / metabolism; Lymph Nodes / metabolism; Lymph Nodes / pathology; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / metabolism; Lymphoma, B-Cell / pathology; Lymphoma, Large B-Cell, Diffuse / genetics; Lymphoma, Large B-Cell, Diffuse / metabolism; Lymphoma, Large B-Cell, Diffuse / pathology; Male; Mutation; NF-kappa B / genetics; NF-kappa B / metabolism; Proto-Oncogene Proteins c-bcl-6; Transcriptome
TL;DR: These studies identify molecular similarities to h DLBCL that introduce pet dogs as a representative model of hDLBCL for future studies, including therapeutic clinical trials. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2013 journal article

Gene selection and cancer type classification of diffuse large-B-cell lymphoma using a bivariate mixture model for two-species data

Human Genomics, 7.

By: Y. Su, D. Nielsen, L. Zhu, K. Richards, S. Suter, M. Breen, A. Motsinger-Reif, J. Osborne

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Genome-wide association studies in pharmacogenomics: Successes and lessons

Pharmacogenetics and Genomics, 23(8), 383–394.

By: A. Motsinger-Reif, E. Jorgenson, M. Relling, D. Kroetz, R. Weinshilboum, N. Cox, D. Roden

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Interview A discussion on genome-wide associations in pharmacogenomics

Pharmacogenomics, 14(4), 361–363.

By: S. Jones & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2013 article

Naturally occuring canine cancers: powerful models for stimulating pharmacogenomic advancement in human medicine

Rotroff, D. M., Thomas, R., Breen, M., & Motsinger-Reif, A. A. (2013, December). PHARMACOGENOMICS, Vol. 14, pp. 1929–1931.

By: D. Rotroff n, R. Thomas n, M. Breen n & A. Motsinger-Reif n

author keywords: cancer; canine model; chemotherapy; clinical trials
MeSH headings : Animals; Disease Models, Animal; Dogs; Humans; Neoplasms / drug therapy; Neoplasms / pathology; Pharmacogenetics / methods
TL;DR: Dogs exhibit a wide variety of spontaneous cancers that share extensive clinicopathologic features with those of human patients, offering a unique opportunity for comparative analysis of cancer etiology and pharmacogenomics. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction

Biodata Mining, 6.

By: H. Dai, R. Charnigo, M. Becker, J. Leeder & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT

PHARMACOGENETICS AND GENOMICS, 22(11), 796–802.

By: C. Brown*, T. Havener*, M. Medina, J. Auman*, L. Mangravite*, R. Krauss, H. McLeod*, A. Motsinger-Reif n

author keywords: genome-wide association studies; lymphoblastoid cell lines; MGMT; pharmacogenetics; temozolomide
MeSH headings : Antineoplastic Agents, Alkylating / pharmacology; Cell Line, Tumor; DNA Methylation; DNA Modification Methylases / genetics; DNA Repair Enzymes / genetics; Dacarbazine / analogs & derivatives; Dacarbazine / pharmacology; Gene Expression Regulation, Neoplastic; Genome, Human; Genome-Wide Association Study; Humans; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology; Temozolomide; Tumor Suppressor Proteins / genetics
TL;DR: Genome-wide association analysis using ∼2.1 million quality-controlled single-nucleotide polymorphisms (SNPs) identified a statistically significant association (P<10−8) with SNPs in the O6-methylguanine-DNA methyltransferase (MGMT) gene. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

A predictive model for Efavirenz dosing

Pharmacogenomics, 13(2), 137–138.

By: C. Brown, N. Oki, G. Hariani & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Assessing the utility of whole genome amplified DNA as a template for DMET Plus array

Clinical Chemistry and Laboratory Medicine, 50(8), 1329–1334.

By: Y. He, A. Misher, W. Irvin, A. Motsinger-Reif, H. McLeod & J. Hoskins

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

CYP2C8*3 predicts benefit/risk profile in breast cancer patients receiving neoadjuvant paclitaxel

BREAST CANCER RESEARCH AND TREATMENT, 134(1), 401–410.

By: D. Hertz*, A. Motsinger-Reif n, A. Drobish, S. Winham n, H. McLeod*, L. Carey*, E. Dees*

author keywords: Paclitaxel; CYP2C8*3; Pharmacogenetics; Neoadjuvant breast cancer therapy; Clinical complete response
MeSH headings : ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics; Adult; Aged; Antineoplastic Agents, Phytogenic / adverse effects; Antineoplastic Agents, Phytogenic / pharmacology; Antineoplastic Agents, Phytogenic / therapeutic use; Aryl Hydrocarbon Hydroxylases / genetics; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Breast Neoplasms / pathology; Chemotherapy, Adjuvant; Cytochrome P-450 CYP2C8; Female; Gene Frequency; Genetic Association Studies; Haplotypes; Humans; Middle Aged; Multivariate Analysis; Neoadjuvant Therapy; Paclitaxel / adverse effects; Paclitaxel / pharmacology; Paclitaxel / therapeutic use; Polymorphism, Single Nucleotide; Tumor Burden / drug effects
TL;DR: Patients carrying CYP2C8*3 are more likely to achieve clinical complete response from neoadjuvant paclitaxel treatment, but may also be at increased risk of experiencing severe peripheral neurotoxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 article

Comparison of venous sampling methods for thromboelastography in clinically normal dogs

Walker, J. M., Hanel, R. M., Hansen, B. D., & Motsinger-Reif, A. A. (2012, December). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 73, pp. 1864–1870.

By: J. Walker n, R. Hanel*, B. Hansen* & A. Motsinger-Reif*

MeSH headings : Animals; Blood Platelets / physiology; Dogs / blood; Male; Phlebotomy / methods; Phlebotomy / veterinary; Thrombelastography / methods; Thrombelastography / veterinary
TL;DR: Different sampling methods resulted in small but significant differences in thromboelastographic values, but all of these sampling methods were acceptable for 1-time clinical use. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 article

Effects of acepromazine maleate on platelet function assessed by use of adenosine diphosphate activated- and arachidonic acid-activated modified thromboelastography in healthy dogs

Conner, B. J., Hanel, R. M., Hansen, B. D., Motsinger-Reif, A. A., Asakawa, M., & Swanson, C. R. (2012, May). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 73, pp. 595–601.

By: B. Conner n, R. Hanel n, B. Hansen n, A. Motsinger-Reif n, M. Asakawa n & C. Swanson n

MeSH headings : Acepromazine / administration & dosage; Acepromazine / adverse effects; Adenosine Diphosphate / chemistry; Animals; Arachidonic Acid / chemistry; Blood Platelets / drug effects; Blood Platelets / physiology; Cross-Over Studies; Dogs / physiology; Female; Hemostasis / drug effects; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / adverse effects; Injections, Intravenous / veterinary; Thrombelastography / methods; Thrombelastography / veterinary
TL;DR: Platelet function in dogs, as assessed by use of a modified thromboelastography assay, was not inhibited by acepromazine at doses of 0.05 or 0.1 mg/kg, IV, in contrast to previous reports in which it was suggested that ace Promazine may alter platelet function via inhibition of ADP and AA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Evaluation of Polymorphisms in the Sulfonamide Detoxification Genes CYB5A and CYB5R3 in Dogs with Sulfonamide Hypersensitivity

JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(5), 1126–1133.

By: J. Funk-Keenan*, J. Sacco*, Y. Wong*, S. Rasmussen*, A. Motsinger-Reif n & L. Trepanier*

author keywords: Genotype; Idiosyncratic; Potentiated sulfonamide; Predisposition
MeSH headings : Animals; Cytochrome-B(5) Reductase / genetics; Cytochrome-B(5) Reductase / immunology; Cytochromes b5 / genetics; Cytochromes b5 / immunology; Dog Diseases / genetics; Dog Diseases / immunology; Dogs; Drug Hypersensitivity / etiology; Drug Hypersensitivity / genetics; Drug Hypersensitivity / immunology; Drug Hypersensitivity / veterinary; Female; Genotype; Liver / enzymology; Liver / immunology; Male; Polymorphism, Genetic; RNA / chemistry; RNA / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Sulfonamides / adverse effects
TL;DR: The CYB5R3 729GG variant may contribute to the risk of sulfonamide HS in dogs and functional characterization of this polymorphism, as well as genotyping in a larger number of HS and TOL dogs, is warranted. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity

PHARMACOGENETICS AND GENOMICS, 22(10), 733–740.

By: J. Sacco*, M. Abouraya*, A. Motsinger-Reif n, S. Yale*, C. McCarty* & L. Trepanier*

author keywords: cytochrome b(5); drug hypersensitivity; hydroxylamine; N-acetyltransferase; potentiated sulfonamides; sulfamethoxazole
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Arylamine N-Acetyltransferase / genetics; Child; Child, Preschool; Cytochrome-B(5) Reductase / genetics; Cytochrome-B(5) Reductase / metabolism; Cytochromes b5 / genetics; Drug Hypersensitivity / genetics; Female; Gene Frequency; Genetic Association Studies; Humans; Inactivation, Metabolic / genetics; Infant; Male; Middle Aged; Polymorphism, Genetic; Sulfonamides / pharmacokinetics
TL;DR: No association of NAT2 coding alleles with sulfonamide hypersensitivity (predominantly cutaneous eruptions) in this adult Caucasian population is found. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Loss of Power in Two-Stage Residual-Outcome Regression Analysis in Genetic Association Studies

Genetic Epidemiology, n/a-n/a.

By: R. Che n, A. Motsinger-Reif n & C. Brown

author keywords: loss of power; two-stage regression; degrees of freedom
MeSH headings : Bias; Female; Genetic Association Studies; Humans; Male; Regression Analysis
TL;DR: While there may be some potential advantages with the 2SR approach in both ease of use and computational and data management efficiency, some issues, such as the bias of estimates, power, and type I error, need to be thoroughly investigated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: February 24, 2020

2012 personal communication

Loss of power in two-stage residual-outcome regression analysis in genetic association studies

By: R. Che, A. Motsinger-Reif & C. Brown

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Multivariate methods and software for association mapping in dose-response genome-wide association studies

Biodata Mining, 5.

By: C. Brown, T. Havener, M. Medina, R. Krauss, H. McLeod & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Twice-Daily Application of HIV Microbicides Alters the Vaginal Microbiota

MBIO, 3(6).

By: J. Ravel*, P. Gajer*, L. Fu*, C. Mauck*, S. Koenig*, J. Sakamoto*, A. Motsinger-Reif n, G. Doncel*, S. Zeichner*

MeSH headings : Administration, Intravaginal; Adolescent; Adult; Anti-Infective Agents / administration & dosage; Biota; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; DNA, Ribosomal / chemistry; DNA, Ribosomal / genetics; Female; HIV Infections / prevention & control; Human Experimentation; Humans; Metagenome / drug effects; Middle Aged; Placebos / administration & dosage; RNA, Ribosomal, 16S / genetics; Sequence Analysis, DNA; Vagina / microbiology; Young Adult
TL;DR: The hypothesis that the microbicides negatively affect a critical line of defense against HIV, the vaginal microbiota, is tested, which suggests that molecular evaluation of microbicide effects on vaginal microbiota may be a critical endpoint that should be incorporated in early clinical assessment ofmicrobicide candidates. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

A Comparison of Multifactor Dimensionality Reduction and L-1-Penalized Regression to Identify Gene-Gene Interactions in Genetic Association Studies

STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY, 10(1).

By: S. Winham n, C. Wang n & A. Motsinger-Reif n

author keywords: Multifactor Dimensionality Reduction (MDR); Lasso; gene-gene interactions
MeSH headings : Algorithms; Computer Simulation; Data Mining / methods; Epistasis, Genetic; Genetic Association Studies / statistics & numerical data; Humans; Monte Carlo Method; Multifactor Dimensionality Reduction / methods
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Characterization of Canine Osteosarcoma by Array Comparative Genomic Hybridization and RT-qPCR: Signatures of Genomic Imbalance in Canine Osteosarcoma Parallel the Human Counterpart

GENES CHROMOSOMES & CANCER, 50(11), 859–874.

By: A. Angstadt n, A. Motsinger-Reif n, R. Thomas n, W. Kisseberth*, C. Couto*, D. Duval*, D. Nielsen n, J. Modiano*, M. Breen n

MeSH headings : Animals; Bone Neoplasms / genetics; Bone Neoplasms / veterinary; Comparative Genomic Hybridization; Core Binding Factor Alpha 1 Subunit / genetics; DNA Copy Number Variations; Dog Diseases / genetics; Dogs; Female; Gene Dosage; Genomic Instability; Humans; In Situ Hybridization, Fluorescence; Male; Membrane Proteins / genetics; Osteosarcoma / genetics; Osteosarcoma / veterinary; PTEN Phosphohydrolase / genetics; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Tumor Suppressor Proteins / genetics
TL;DR: Large scale screening of genomic imbalance in canine OS further validates the use of the dog as a suitable model for human cancers, supporting the idea that dysregulation discovered in canine cancers will provide an avenue for complementary study in human counterparts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Genomic Profiling in CEPH Cell Lines Distinguishes between the Camptothecins and Indenoisoquinolines

MOLECULAR CANCER THERAPEUTICS, 10(10), 1839–1845.

By: V. Watson n, N. Hardison n, T. Harris n, A. Motsinger-Reif n & H. McLeod n

MeSH headings : Antineoplastic Agents, Phytogenic / pharmacology; Camptothecin / pharmacology; Cell Line; Drug Evaluation, Preclinical / methods; Gene Expression Profiling; Genomics / methods; Humans; Isoquinolines / pharmacology; Oligonucleotide Array Sequence Analysis; Quantitative Trait Loci; Topoisomerase I Inhibitors / pharmacology
TL;DR: In vitro sensitivity of the same panel of CEPH cell lines to the indenisoquinolones, a structurally distinct class of Top1 inhibitors, is characterized, revealing a pattern of 7 quantitative trait loci (QTL) shared by all of the camptothecins. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Identification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigrees

PLoS One, 6(5).

By: V. Watson, A. Motsinger-Reif, N. Hardison, E. Peters, T. Havener, L. Everitt, J. Auman, D. Comins, H. McLeod

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Insights into the inhibition of platelet activation by omega-3 polyunsaturated fatty acids: Beyond aspirin and clopidogrel

THROMBOSIS RESEARCH, 128(4), 335–340.

By: M. Cohen*, J. Rossi*, J. Garbarino*, R. Bowling, A. Motsinger-Reif n, C. Schuler*, A. Dupont*, D. Gabriel*

MeSH headings : Adult; Aspirin / administration & dosage; Aspirin / adverse effects; Bleeding Time; Blood Platelets / drug effects; Chi-Square Distribution; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fatty Acids, Omega-3 / administration & dosage; Fatty Acids, Omega-3 / adverse effects; Female; Hemorrhage / chemically induced; Humans; Male; Middle Aged; North Carolina; Pilot Projects; Platelet Aggregation / drug effects; Platelet Aggregation Inhibitors / administration & dosage; Platelet Aggregation Inhibitors / adverse effects; Platelet Function Tests; Predictive Value of Tests; Surface Properties; Ticlopidine / administration & dosage; Ticlopidine / adverse effects; Ticlopidine / analogs & derivatives; Time Factors
TL;DR: The results suggest that omega-3 PUFA increase the total platelet surface charge and, therefore, attenuate platelet activation, even among patients taking aspirin or aspirin plus clopidogrel. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer

British Journal of Cancer, 105(11), 1654–1662.

By: F. Thomas*, A. Motsinger-Reif n, J. Hoskins*, A. Dvorak*, S. Roy n, A. Alyasiri*, R. Myerson*, J. Fleshman*, B. Tan*, H. McLeod*

author keywords: MTHFR polymorphisms; 5-FU; mucositis; diarrhoea; rectal cancer; neoadjuvant chemoradiation
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic / administration & dosage; Antimetabolites, Antineoplastic / adverse effects; Antimetabolites, Antineoplastic / therapeutic use; Antineoplastic Combined Chemotherapy Protocols / adverse effects; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Camptothecin / administration & dosage; Camptothecin / adverse effects; Camptothecin / analogs & derivatives; Chemoradiotherapy, Adjuvant / adverse effects; Disease-Free Survival; Fluorouracil / administration & dosage; Fluorouracil / adverse effects; Genotype; Humans; Irinotecan; Methylenetetrahydrofolate Reductase (NADPH2) / genetics; Methylenetetrahydrofolate Reductase (NADPH2) / metabolism; Middle Aged; Pharmacogenetics / methods; Polymorphism, Genetic; Prospective Studies; Radiation-Sensitizing Agents / administration & dosage; Radiation-Sensitizing Agents / adverse effects; Rectal Neoplasms / enzymology; Rectal Neoplasms / genetics; Rectal Neoplasms / therapy; Treatment Outcome; Young Adult
TL;DR: MTHFR polymorphisms can potentially predict toxicity in patients treated with 5-FU as a single chemotherapeutic drug. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: February 24, 2020

2011 journal article

Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior

BMC Cancer, 11.

By: B. Hedan, R. Thomas, A. Motsinger-Reif, J. Abadie, C. Andre, J. Cullen, M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Optimization of nonlinear dose- and concentration-response models utilizing evolutionary computation

Dose-Response, 9(3), 387–409.

By: A. Beam & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Pharmacogenomic characterization of US FDA-approved cytotoxic drugs

PHARMACOGENOMICS, 12(10), 1407–1415.

By: E. Peters*, A. Motsinger-Reif n, T. Havener*, L. Everitt*, N. Hardison n, V. Watson*, M. Wagner*, K. Richards*, M. Province*, H. McLeod*

author keywords: cancer; cell line; chemotherapy; cytotoxicity; pharmacogenetics; pharmacogenomic; QTL
MeSH headings : Antineoplastic Agents / pharmacology; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Approval; Genetic Linkage; Humans; Pharmacogenetics; Quantitative Trait Loci / genetics; United States; United States Food and Drug Administration
TL;DR: The results of this systematic study highlight the variable role that genetics plays in response to cytotoxic drugs, and inform the prioritization of chemotherapeutic drugs with a sizable genetic response component for future investigation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Quality of reporting on randomised controlled trials of auriculotherapy for pain

ACUPUNCTURE IN MEDICINE, 29(2), 122–126.

By: G. Asher*, A. Motsinger-Reif n, D. Jonas* & A. Viera*

MeSH headings : Auriculotherapy; Cluster Analysis; Guidelines as Topic; Humans; Pain Management; Peer Review, Research / standards; Principal Component Analysis; Publishing / standards; Quality Improvement; Randomized Controlled Trials as Topic / standards
TL;DR: Quality of reporting for studies of auriculotherapy for pain appears to have generally improved since the implementation of STRICTA and CONSORT guidelines. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas

Leukemia & Lymphoma, 52(7), 1321–1335.

By: R. Thomas*, E. Seiser*, A. Motsinger-Reif*, L. Borst*, V. Valli, K. Kelley, S. Suter*, D. Argyle ...

author keywords: Comparative genomic hybridization (CGH); canine; lymphoma; chromosome; microarray
MeSH headings : Aneuploidy; Animals; Breeding; Comparative Genomic Hybridization; Cyclin-Dependent Kinase Inhibitor p16 / genetics; DNA Copy Number Variations / genetics; Dogs; Gene Expression Regulation, Neoplastic; Genomics; Immunophenotyping; Lymphoma, Non-Hodgkin / genetics; Lymphoma, Non-Hodgkin / pathology
TL;DR: It is hypothesized that the restricted genetic variation of purebred dogs, combined with the contrasting architecture of the human and canine karyotypes, will increase the penetrance of fundamental NHL-associated chromosomal aberrations in both species. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2011 journal article

Shift work in nurses: Contribution of phenotypes and genotypes to adaptation

PLoS One, 6(4).

By: K. Gamble, A. Motsinger-Reif, A. Hida, H. Borsetti, S. Servick, C. Ciarleglio, S. Robbins, J. Hicks ...

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

The Effect of Retrospective Sampling on Estimates of Prediction Error for Multifactor Dimensionality Reduction

Annals of Human Genetics, 75, 46–61.

By: S. Winham & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways

PLACENTA, 32(2), 175–182.

By: S. Tsai n, N. Hardison n, A. James*, A. Motsinger-Reif n, S. Bischoff n, B. Thames*, J. Piedrahita n

author keywords: Placenta; Preeclampsia; Maternal hypertension; Sialic acid acetylesterase
MeSH headings : Acetylesterase / biosynthesis; Antigens, CD / biosynthesis; Endoglin; Female; Genome-Wide Association Study; Humans; Infant, Newborn; Inhibins / biosynthesis; Male; Pre-Eclampsia / etiology; Pre-Eclampsia / metabolism; Pregnancy; Protein Array Analysis; Receptors, Cell Surface / biosynthesis; Trophoblasts / physiology; Up-Regulation; Vascular Endothelial Growth Factor Receptor-1 / biosynthesis
TL;DR: Evidence is found of preeclampsia-associated placental upregulation of sialic acid acetylesterase (SIAE), a gene functionally associated with autoimmune diseases, and changes in immune-associated signaling pathways, offering a potential upstream explanation for the shallow trophoblast invasion and inadequate uterine remodeling typically observed in pathogenesis of preeClampsia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

A comparison of internal validation techniques for multifactor dimensionality reduction

BMC Bioinformatics, 11.

By: S. Winham, A. Slater & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2010 review

Auriculotherapy for Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

[Review of ]. JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 16(10), 1097–1108.

By: G. Asher*, D. Jonas*, R. Coeytaux*, A. Reilly*, Y. Loh*, A. Motsinger-Reif n, S. Winham n

MeSH headings : Acupuncture, Ear; Analgesia; Humans; Pain Management; Pain Measurement; Perioperative Period; Randomized Controlled Trials as Topic
TL;DR: Auriculotherapy may be effective for the treatment of a variety of types of pain, especially postoperative pain, however, a more accurate estimate of the effect will require further large, well-designed trials. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 article

Discussion of a Genome-Wide Association Approach to Determine HIV-1 Set Point in African Americans

Motsinger-Reif, A. A. (2010, April 15). JOURNAL OF INFECTIOUS DISEASES, Vol. 201, pp. 1118–1120.

By: A. Motsinger-Reif n

MeSH headings : Black or African American / genetics; Disease Susceptibility; Epitopes / genetics; Genome-Wide Association Study; HIV Infections / genetics; HIV-1; Humans; Polymorphism, Single Nucleotide / genetics
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Effect of CYP2B6, ABCB1, and CYP3A5 Polymorphisms on Efavirenz Pharmacokinetics and Treatment Response: An AIDS Clinical Trials Group Study

JOURNAL OF INFECTIOUS DISEASES, 202(5), 717–722.

By: H. Ribaudo*, H. Liu*, M. Schwab*, E. Schaeffeler*, M. Eichelbaum*, A. Motsinger-Reif n, M. Ritchie*, U. Zanger* ...