Works (4)
Updated: July 5th, 2023 15:49
2015 journal article
Effects of high doses of enalapril and benazepril on the pharmacologically activated renin-angiotensin-aldosterone system in clinically normal dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 76(12), 1041–1050.
MeSH headings : Aldosterone / blood; Aldosterone / urine; Angiotensin-Converting Enzyme Inhibitors / administration & dosage; Animals; Benzazepines / administration & dosage; Blood Pressure / drug effects; Body Weight / drug effects; Dogs / physiology; Enalapril / administration & dosage; Female; Furosemide / administration & dosage; Heart Rate / drug effects; Male; Peptidyl-Dipeptidase A / blood; Renin-Angiotensin System / drug effects; Time Factors
TL;DR:
Administration of high doses of enalapril and benazepril significantly inhibited ACE activity, yet did not prevent increases in mean urine and serum aldosterone concentrations resulting from furosemide activation of RAAS, suggesting that ald testosterone breakthrough from ACE inhibition was a dose-independent effect of ACE inhibitors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Aldosterone breakthrough with benazepril in furosemide-activated renin-angiotensin-aldosterone system in normal dogs
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 38(1), 65–73.
MeSH headings : Aldosterone / metabolism; Aldosterone / urine; Angiotensin-Converting Enzyme Inhibitors / administration & dosage; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Benzazepines / administration & dosage; Benzazepines / pharmacology; Diuretics / administration & dosage; Diuretics / pharmacology; Dogs / physiology; Dogs / urine; Drug Therapy, Combination; Furosemide / administration & dosage; Furosemide / pharmacology; Peptidyl-Dipeptidase A; Renin-Angiotensin System / drug effects; Renin-Angiotensin System / physiology
TL;DR:
Benazepril decreased plasma ACE activity but did not prevent furosemide-induced RAAS activation, indicating aldosterone breakthrough (escape), particularly noteworthy in that breakthrough is observed at the time of initiation of RAAS suppression, as opposed to developing after months of therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Effect of furosemide and high-dosage pimobendan administration on the renin-angiotensin-aldosterone system in dogs
American Journal of Veterinary Research, 74(8), 1084–1090.
MeSH headings : Animals; Cardiotonic Agents / pharmacology; Diuretics / pharmacology; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Furosemide / pharmacology; Male; Pyridazines / pharmacology; Renin-Angiotensin System / drug effects; Renin-Angiotensin System / physiology
TL;DR:
High-dosage pimobendan administration neither substantially suppressed nor potentiated the RAAS when administered with furosemide in healthy dogs, and this effect was significant only for dogs that received both drugs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
2009 article
ECG of the Month
Lantis, A. C., & Atkins, C. E. (2009, September 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 235, pp. 514–516.
MeSH headings : Animals; Antineoplastic Agents / adverse effects; Bundle-Branch Block / chemically induced; Bundle-Branch Block / veterinary; Dog Diseases / chemically induced; Dogs; Electrocardiography / veterinary; Female; Heart Diseases / chemically induced; Heart Diseases / veterinary; Tachycardia, Sinus / chemically induced; Tachycardia, Sinus / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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