Andrea Corinne Lantis

Works (4)

Updated: July 5th, 2023 15:49

2015 journal article

Effects of high doses of enalapril and benazepril on the pharmacologically activated renin-angiotensin-aldosterone system in clinically normal dogs

AMERICAN JOURNAL OF VETERINARY RESEARCH, 76(12), 1041–1050.

By: M. Ames*, C. Atkins*, S. Lee, A. Lantis* & J. zumBrunnen

MeSH headings : Aldosterone / blood; Aldosterone / urine; Angiotensin-Converting Enzyme Inhibitors / administration & dosage; Animals; Benzazepines / administration & dosage; Blood Pressure / drug effects; Body Weight / drug effects; Dogs / physiology; Enalapril / administration & dosage; Female; Furosemide / administration & dosage; Heart Rate / drug effects; Male; Peptidyl-Dipeptidase A / blood; Renin-Angiotensin System / drug effects; Time Factors
TL;DR: Administration of high doses of enalapril and benazepril significantly inhibited ACE activity, yet did not prevent increases in mean urine and serum aldosterone concentrations resulting from furosemide activation of RAAS, suggesting that ald testosterone breakthrough from ACE inhibition was a dose-independent effect of ACE inhibitors. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Aldosterone breakthrough with benazepril in furosemide-activated renin-angiotensin-aldosterone system in normal dogs

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 38(1), 65–73.

By: A. Lantis n, M. Ames n, C. Atkins n, T. Defrancesco n , B. Keene n & S. Werre  n

MeSH headings : Aldosterone / metabolism; Aldosterone / urine; Angiotensin-Converting Enzyme Inhibitors / administration & dosage; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Benzazepines / administration & dosage; Benzazepines / pharmacology; Diuretics / administration & dosage; Diuretics / pharmacology; Dogs / physiology; Dogs / urine; Drug Therapy, Combination; Furosemide / administration & dosage; Furosemide / pharmacology; Peptidyl-Dipeptidase A; Renin-Angiotensin System / drug effects; Renin-Angiotensin System / physiology
TL;DR: Benazepril decreased plasma ACE activity but did not prevent furosemide-induced RAAS activation, indicating aldosterone breakthrough (escape), particularly noteworthy in that breakthrough is observed at the time of initiation of RAAS suppression, as opposed to developing after months of therapy. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Effect of furosemide and high-dosage pimobendan administration on the renin-angiotensin-aldosterone system in dogs

American Journal of Veterinary Research, 74(8), 1084–1090.

By: M. Ames n, C. Atkins*, A. Lantis* & S. Were

MeSH headings : Animals; Cardiotonic Agents / pharmacology; Diuretics / pharmacology; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Furosemide / pharmacology; Male; Pyridazines / pharmacology; Renin-Angiotensin System / drug effects; Renin-Angiotensin System / physiology
TL;DR: High-dosage pimobendan administration neither substantially suppressed nor potentiated the RAAS when administered with furosemide in healthy dogs, and this effect was significant only for dogs that received both drugs. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2009 article

ECG of the Month

Lantis, A. C., & Atkins, C. E. (2009, September 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 235, pp. 514–516.

By: A. Lantis n & C. Atkins*

MeSH headings : Animals; Antineoplastic Agents / adverse effects; Bundle-Branch Block / chemically induced; Bundle-Branch Block / veterinary; Dog Diseases / chemically induced; Dogs; Electrocardiography / veterinary; Female; Heart Diseases / chemically induced; Heart Diseases / veterinary; Tachycardia, Sinus / chemically induced; Tachycardia, Sinus / veterinary
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Source: Web Of Science
Added: August 6, 2018

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