Ariel Dianne Hickey

Works (1)

Updated: July 5th, 2023 15:45

2012 journal article

WNT7B in fibroblastic foci of idiopathic pulmonary fibrosis

Respiratory Research, 13(1), 62.

By: T. Meuten n, A. Hickey n, K. Franklin n, B. Grossi n, J. Tobias  n, D. Newman n, S. Jennings n, M. Correa n, P. Sannes n

author keywords: Myofibroblasts; Alveolar epithelium; Interstitial lung disease
MeSH headings : Aged; Aged, 80 and over; Basement Membrane / pathology; Female; Fibroblasts / pathology; Humans; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Macrophages / pathology; Male; Middle Aged; Muscle, Smooth / pathology; Respiratory Mucosa / pathology; Respiratory System / blood supply; Respiratory System / pathology; Severity of Illness Index; Wnt Proteins / analysis; Wnt Proteins / metabolism
TL;DR: Tissue samples from the Lung Tissue Research Consortium of 39 patients diagnosed with mild to severe IPF/usual interstitial pneumonia and 19 normal patients were examined for the immunolocalization of Wnt7B, demonstrating Wnt 7B to be expressed at high concentrations in regions of active hyperplasia, metaplasia and fibrotic change in IPF patients. (via Semantic Scholar)
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