@article{didomenico_jacob_stowe_gruber_2024, title={Diagnostic utility of the total nucleated cell count for differentiation of septic and sterile peritoneal effusions in dogs}, volume={2}, ISSN={["1939-165X"]}, url={https://doi.org/10.1111/vcp.13315}, DOI={10.1111/vcp.13315}, abstractNote={AbstractBackgroundRapid and accurate diagnosis of septic peritonitis is critical for initiating appropriate medical and surgical management.ObjectivesThe aim of this study was to determine the diagnostic utility of the total nucleated cell count (TNCC), absolute neutrophil count, neutrophil percentage, and total protein (TP) to distinguish septic versus non‐septic peritoneal effusions in dogs.MethodsElectronic medical records were retrospectively searched for peritoneal fluid samples from 2008 to 2018 and classified as septic or non‐septic based on bacterial culture and/or cytology results. Receiver operator characteristic curves (ROCs) were used to describe the overall diagnostic utility of each test, with optimal cutpoints analyzed to dichotomize continuous variables. Positive and negative likelihood ratios were calculated at these cutpoints.ResultsA total of 166 unique samples, including 87 septic and 79 non‐septic peritoneal effusions, were included. There were no significant differences in dog sex, age, or days hospitalized between groups. Septic effusions had significantly higher TP, TNCC, absolute neutrophil count, and neutrophil percentage compared with non‐septic effusions. The area under the curve of the ROC curves was TNCC (0.80), absolute neutrophil count (0.80), neutrophil percentage (0.64), and TP (0.63). For TNCC and absolute neutrophil count, optimal cutoffs were 17.13 × 103 cells/μL and 19.88 × 103 cells/μL, resulting in positive and negative likelihood ratios of 2.39 and 0.28 and 2.85 and 0.28, respectively.ConclusionsTotal nucleated cell counts and absolute neutrophil counts aid in the differentiation of septic and non‐septic peritoneal effusions with similar diagnostic utility but are not sufficiently sensitive or specific to use without concurrent microscopic evaluation.}, journal={VETERINARY CLINICAL PATHOLOGY}, author={Didomenico, Amy E. and Jacob, Megan E. and Stowe, Devorah M. and Gruber, Erika J.}, year={2024}, month={Feb} }
 @article{didomenico_fowler_horne_bizikova_schnabel_stowe_2021, title={Pathology in Practice}, volume={258}, ISSN={0003-1488}, url={http://dx.doi.org/10.2460/javma.258.9.961}, DOI={10.2460/javma.258.9.961}, number={9}, journal={Journal of the American Veterinary Medical Association}, publisher={American Veterinary Medical Association (AVMA)}, author={DiDomenico, Amy E. and Fowler, Alexander W. and Horne, Caitlyn R. and Bizikova, Petra and Schnabel, Lauren V. and Stowe, Devorah M.}, year={2021}, month={May}, pages={961–964} }
 @article{didomenico_stowe_lynch_2020, title={What is your diagnosis? Abdominal fluid from a dog}, volume={49}, ISSN={0275-6382 1939-165X}, url={http://dx.doi.org/10.1111/vcp.12815}, DOI={10.1111/vcp.12815}, abstractNote={Veterinary Clinical PathologyVolume 49, Issue 1 p. 164-166 WHAT IS YOUR DIAGNOSIS? What is your diagnosis? Abdominal fluid from a dog Amy E. DiDomenico, Amy E. DiDomenico orcid.org/0000-0001-6818-5599 Department of Public Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USASearch for more papers by this authorDevorah M. Stowe, Corresponding Author Devorah M. Stowe damarks@ncsu.edu Department of Public Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA Correspondence Devorah M. Stowe, Department of Public Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA. Email: damarks@ncsu.eduSearch for more papers by this authorAlex M. Lynch, Alex M. Lynch Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USASearch for more papers by this author Amy E. DiDomenico, Amy E. DiDomenico orcid.org/0000-0001-6818-5599 Department of Public Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USASearch for more papers by this authorDevorah M. Stowe, Corresponding Author Devorah M. Stowe damarks@ncsu.edu Department of Public Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA Correspondence Devorah M. Stowe, Department of Public Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA. Email: damarks@ncsu.eduSearch for more papers by this authorAlex M. Lynch, Alex M. Lynch Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USASearch for more papers by this author First published: 12 January 2020 https://doi.org/10.1111/vcp.12815Citations: 2Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume49, Issue1March 2020Pages 164-166 This article also appears in:What is your diagnosis? Virtual Issue RelatedInformation}, number={1}, journal={Veterinary Clinical Pathology}, publisher={Wiley}, author={DiDomenico, Amy E. and Stowe, Devorah M. and Lynch, Alex M.}, year={2020}, month={Mar}, pages={164–166} }