@article{durmusoglu_al'abri_collins_cheng_eroglu_beisel_crook_2021, title={In Situ Biomanufacturing of Small Molecules in the Mammalian Gut by Probiotic Saccharomyces boulardii}, volume={5}, DOI={10.1021/acssynbio.0c00562}, journal={ACS SYNTHETIC BIOLOGY}, author={Durmusoglu, Deniz and Al'Abri, Ibrahim S. and Collins, Scott P. and Cheng, Junrui and Eroglu, Abdulkerim and Beisel, Chase L. and Crook, Nathan}, year={2021}, month={May} } @misc{cheng_eroglu_2021, title={The Promising Effects of Astaxanthin on Lung Diseases}, DOI={10.1093/advances/nmaa143}, journal={ADVANCES IN NUTRITION}, author={Cheng, Junrui and Eroglu, Abdulkerim}, year={2021}, month={May} } @article{cheng_balbuena_miller_eroglu_2021, title={The Role of beta-Carotene in Colonic Inflammation and Intestinal Barrier Integrity}, volume={9}, DOI={10.3389/fnut.2021.723480}, journal={FRONTIERS IN NUTRITION}, author={Cheng, Junrui and Balbuena, Emilio and Miller, Baxter and Eroglu, Abdulkerim}, year={2021}, month={Sep} } @article{cheng_miller_balbuena_eroğlu_2020, title={Lycopene Protects against Smoking-Induced Lung Cancer by Inducing Base Excision Repair}, DOI={10.3390/antiox9070643}, journal={Antioxidants}, author={Cheng, Junrui and Miller, Baxter and Balbuena, Emilio and Eroğlu, Abdulkerim}, year={2020}, month={Jul} } @article{eroglu_balbuena_2020, title={Nutrient modulation of DNA repair in lung cancer}, volume={34}, ISBN={1530-6860}, DOI={10.1096/fasebj.2020.34.s1.06866}, journal={FASEB JOURNAL}, author={Eroglu, Abdulkerim and Balbuena, Emilio}, year={2020}, month={Apr} } @article{mejia_zhang_penta_eroglu_lila_2020, series={Annual Review of Food Science and Technology}, title={The Colors of Health: Chemistry, Bioactivity, and Market Demand for Colorful Foods and Natural Food Sources of Colorants}, volume={11}, ISBN={1941-1421}, DOI={10.1146/annurev-food-032519-051729}, journal={ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 11}, author={Mejia, Elvira Gonzalez and Zhang, Qiaozhi and Penta, Kayla and Eroglu, Abdulkerim and Lila, Mary Ann}, year={2020}, pages={145–182}, collection={Annual Review of Food Science and Technology} } @article{investigation into the use of histone deacetylase inhibitor ms-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an skh-1 hairless mouse model._2019, DOI={10.1371/journal.pone.0213095}, journal={PloS one}, year={2019}, month={Mar} } @article{eroglu_schulze_yager_cole_christian_nonyane_lee_wu_khatry_groopman_et al._2018, title={A plasma proteome is associated with carotenoid status and dietary intake of food sources of carotenoids in Nepalese school aged children}, volume={646}, journal={Archives of Biochemistry and Biophysics}, author={Eroglu, A. and Schulze, K.J. and Yager, J. and Cole, R.N. and Christian, P. and Nonyane, B.A.S. and Lee, S.E. and Wu, L.S.F. and Khatry, S. and Groopman, J. and et al.}, year={2018}, pages={153–160} } @article{plasma proteins associated with circulating carotenoids in nepalese school-aged children._2018, DOI={10.1016/j.abb.2018.03.025}, journal={Archives of biochemistry and biophysics}, year={2018}, month={Mar} } @article{lee_schulze_stewart_cole_wu_eroğlu_yager_groopman_christian_west_et al._2018, title={Plasma proteome correlates of lipid and lipoprotein: biomarkers of metabolic diversity and inflammation in children of rural Nepal}, volume={60}, ISSN={0022-2275, 1539-7262}, url={http://www.jlr.org/lookup/doi/10.1194/jlr.P088542}, DOI={10.1194/jlr.P088542}, number={1}, journal={Journal of Lipid Research}, author={Lee, Sun Eun and Schulze, Kerry and Stewart, Christine P. and Cole, Robert N. and Wu, Lee S-F. and Eroğlu, Abdulkerim and Yager, James D. and Groopman, John and Christian, Parul and West, Keith P. and et al.}, year={2018}, month={Nov}, pages={149–160} } @article{kalin_wu_gomez_song_das_hayward_adejola_wu_panova_chung_et al._2018, title={Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors}, volume={9}, ISSN={2041-1723}, DOI={10.1038/s41467-017-02242-4}, abstractNote={Here we report corin, a synthetic hybrid agent derived from the class I HDAC inhibitor (entinostat) and an LSD1 inhibitor (tranylcypromine analog). Enzymologic analysis reveals that corin potently targets the CoREST complex and shows more sustained inhibition of CoREST complex HDAC activity compared with entinostat. Cell-based experiments demonstrate that corin exhibits a superior anti-proliferative profile against several melanoma lines and cutaneous squamous cell carcinoma lines compared to its parent monofunctional inhibitors but is less toxic to melanocytes and keratinocytes. CoREST knockdown, gene expression, and ChIP studies suggest that corin's favorable pharmacologic effects may rely on an intact CoREST complex. Corin was also effective in slowing tumor growth in a melanoma mouse xenograft model. These studies highlight the promise of a new class of two-pronged hybrid agents that may show preferential targeting of particular epigenetic regulatory complexes and offer unique therapeutic opportunities.}, number={1}, journal={Nature Communications}, author={Kalin, Jay H. and Wu, Muzhou and Gomez, Andrea V. and Song, Yun and Das, Jayanta and Hayward, Dawn and Adejola, Nkosi and Wu, Mingxuan and Panova, Izabela and Chung, Hye Jin and et al.}, year={2018}, month={Apr}, pages={53} } @article{narayanasamy_sun_pavlovicz_eroglu_rush_sunkel_li_harrison_curley_2017, title={Synthesis of apo-13- and apo-15-lycopenoids, cleavage products of lycopene that are retinoic acid antagonists}, volume={58}, ISSN={0022-2275}, url={https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408601/}, DOI={10.1194/jlr.D073148}, abstractNote={Consumption of the tomato carotenoid, lycopene, has been associated with favorable health benefits. Some of lycopene’s biological activity may be due to metabolites resulting from cleavage of the lycopene molecule. Because of their structural similarity to the retinoic acid receptor (RAR) antagonist, β-apo-13-carotenone, the “first half” putative oxidative cleavage products of the symmetrical lycopene have been synthesized. All transformations proceed in moderate to good yield and some with high stereochemical integrity allowing ready access to these otherwise difficult to obtain terpenoids. In particular, the methods described allow ready access to the trans isomers of citral (geranial) and pseudoionone, important flavor and fragrance compounds that are not readily available isomerically pure and are building blocks for many of the longer apolycopenoids. In addition, all of the apo-11, apo-13, and apo-15 lycopenals/lycopenones/lycopenoic acids have been prepared. These compounds have been evaluated for their effect on RAR-induced genes in cultured hepatoma cells and, much like β-apo-13-carotenone, the comparable apo-13-lycopenone and the apo-15-lycopenal behave as RAR antagonists. Furthermore, molecular modeling studies demonstrate that the apo-13-lycopenone efficiently docked into the ligand binding site of RARα. Finally, isothermal titration calorimetry studies reveal that apo-13-lycopenone acts as an antagonist of RAR by inhibiting coactivator recruitment to the receptor.}, number={5}, journal={Journal of Lipid Research}, author={Narayanasamy, Sureshbabu and Sun, Jian and Pavlovicz, Ryan E. and Eroglu, Abdulkerim and Rush, Cassandra E. and Sunkel, Benjamin D. and Li, Chenglong and Harrison, Earl H. and Curley, Robert W.}, year={2017}, month={May}, pages={1021–1029} } @article{eroglu_gentleman_poliakov_redmond_2016, title={Inhibition of RPE65 retinol isomerase activity by inhibitors of lipid metabolism}, volume={291}, DOI={10.1074/jbc.m115.685651}, journal={Journal of Biological Chemistry}, author={Eroglu, A. and Gentleman, S. and Poliakov, E. and Redmond, T.M.}, year={2016}, pages={4966–4973} } @article{eroglu_harrison_2013, title={Carotenoid metabolism in mammals, including man; formation, occurrence, and function of apocarotenoids}, volume={54}, DOI={10.1194/jlr.r039537}, journal={Journal of Lipid Research}, author={Eroglu, A. and Harrison, E.H.}, year={2013}, pages={1719–1730} } @article{eroglu_hruszkewycz_sena_narayanasamy_riedl_kopec_schwartz_harrison_curley_2012, title={Naturally-occurring eccentric cleavage products of provitamin A carotene b-carotene function as antagonists of retinoic acid receptors}, volume={287}, DOI={10.1074/jbc.m111.325142}, journal={Journal of Biological Chemistry}, author={Eroglu, A. and Hruszkewycz, D.P. and Sena, C. and Narayanasamy, S. and Riedl, K.M. and Kopec, R.E. and Schwartz, S.J. and Harrison, E.H. and Curley, R.W.}, year={2012}, pages={15886–158995} } @article{harrison_sena_eroglu_fleshman_2012, title={The formation, occurrence and function of b-apocarotenoids: b-Carotene metabolites that may modulate nuclear receptor signaling}, volume={96}, DOI={10.3945/ajcn.112.034843}, journal={American Journal of Clinical Nutrition}, author={Harrison, E.H. and Sena, C. and Eroglu, A. and Fleshman, M.}, year={2012}, pages={1189–1192} } @article{eroglu_hruszkewycz_curley_harrison_2010, title={The eccentric cleavage product of b- carotene, b-apo-13-carotenone, functions as an antagonist of RXRa}, volume={504}, DOI={10.1016/j.abb.2010.07.025}, journal={Archives of Biochemistry and Biophysics}, author={Eroglu, A. and Hruszkewycz, D.P. and Curley, R.W. and Harrison, E.H.}, year={2010}, pages={11–16} }