Works (1)
Updated: June 14th, 2023 21:36
2021 journal article
Epithelial Regeneration After Doxorubicin Arises Primarily From Early Progeny of Active Intestinal Stem Cells
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 12(1), 119–140.
author keywords: Gastrointestinal; irradiation; LGR5; DNA damage response
MeSH headings : Antibiotics, Antineoplastic / pharmacology; Apoptosis / drug effects; Doxorubicin / pharmacology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / pathology; Humans; Intestines / drug effects; Intestines / metabolism; Regeneration / drug effects; Stem Cells / drug effects; Stem Cells / metabolism; Stem Cells / pathology
TL;DR:
It is shown that DXR effectively depleted aISCs in the small intestine and subsequent epithelial regeneration depended on nonquiescent early progeny cells of a ISCs, which may rely on a dampened DDR in contrast to aISCS’ robust DDR, which facilitates expeditious apoptosis.
(via Semantic Scholar)
www.cmghjournal.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 16, 2021
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.
