Ali Schubert

College of Veterinary Medicine

Works (4)

Updated: July 5th, 2023 14:54

2022 journal article

A Platelet-Rich Plasma-Derived Biologic Clears Staphylococcus aureus Biofilms While Mitigating Cartilage Degeneration and Joint Inflammation in a Clinically Relevant Large Animal Infectious Arthritis Model

Frontiers in Cellular and Infection Microbiology, 12.

By: J. Gilbertie n, T. Schaer *, J. Engiles *, G. Seiler n, B. Deddens n, A. Schubert n, M. Jacob n, D. Stefanovski * ...

author keywords: infectious arthritis; S; aureus; biofilm; antimicrobial; platelets; cartilage; synovium; synovial fluid
MeSH headings : Amikacin; Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Arthritis, Infectious / drug therapy; Biofilms; Biological Products; Disease Models, Animal; Horses; Inflammation; Platelet-Rich Plasma; Staphylococcal Infections / drug therapy; Staphylococcal Infections / veterinary; Staphylococcus aureus
TL;DR: The results demonstrate the in vivo efficacy of AMK+BIO-PLY and represents a new approach to restore and potentiate antimicrobial activity against synovial fluid biofilms. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: June 20, 2022

2022 article

Identification of redundancy between human Fc epsilon RI beta and MS4A6A proteins points toward additional complex mechanisms for Fc epsilon RI trafficking and signaling

Bitting, K., Hedgespeth, B., Ehrhardt-Humbert, L. C., Arthur, G. K., Schubert, A. G., Bradding, P., … Cruse, G. (2022, December 7). ALLERGY, Vol. 12.

By: K. Bitting n, B. Hedgespeth n, L. Ehrhardt-Humbert n, G. Arthur n, A. Schubert n, P. Bradding *, S. Tilley*, G. Cruse n 

Contributors: K. Bitting n, B. Hedgespeth n, L. Ehrhardt-Humbert n, G. Arthur n, A. Schubert n, P. Bradding *, S. Tilley*, G. Cruse n 

author keywords: asthma; IgE; mast cells
MeSH headings : Animals; Humans; Mice; Basophils / metabolism; Cell Degranulation; Exons; Hypersensitivity / metabolism; Mast Cells / metabolism; Receptors, IgE / genetics; Receptors, IgE / metabolism; Signal Transduction
TL;DR: It is reported that targeting FcεRIβ with exon‐skipping oligonucleotides eliminates IgE‐mediated degranulation in mouse MCs, but equivalent targeting in human MCs was not effective at reducing degranulations. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 25, 2022

2020 journal article

Ecological level analysis of primary lung tumors in dogs and cats and environmental radon activity

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(6), 2660–2670.

By: B. Fowler *, C. Johannes *, A. O'Connor *, D. Collins*, J. Lustgarten*, C. Yuan*, K. Weishaar *, K. Sullivan* ...

author keywords: canine; epidemiology; feline; incidence; pulmonary neoplasia
MeSH headings : Animals; Cat Diseases / epidemiology; Cat Diseases / etiology; Cats; Dog Diseases / epidemiology; Dog Diseases / etiology; Dogs; Environmental Exposure / adverse effects; Lung Neoplasms / epidemiology; Lung Neoplasms / etiology; Lung Neoplasms / veterinary; Radon / analysis; Radon / toxicity; Retrospective Studies
TL;DR: Exposure to household radon might play a role in development of PPN in dogs and cats, and county level PPN rates were calculated using the average annual county cat and dog populations. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 24, 2020

2020 journal article

Platelet-rich plasma lysate displays antibiofilm properties and restores antimicrobial activity against synovial fluid biofilms in vitro

JOURNAL OF ORTHOPAEDIC RESEARCH, 38(6), 1365–1374.

By: J. Gilbertie n, T. Schaer *, A. Schubert n, M. Jacob n, S. Menegatti n , R. Lavoie  n, L. Schnabel n

author keywords: biofilms; equine model; infectious arthritis; platelet-rich plasma; Staphylococcus aureus
MeSH headings : Aminoglycosides / pharmacology; Animals; Anti-Bacterial Agents / pharmacology; Arthritis, Infectious / drug therapy; Biofilms / drug effects; Female; Horses; Male; Molecular Weight; Platelet-Rich Plasma; Synovial Fluid / microbiology
TL;DR: Overall, PRP‐L exhibited synergism with amikacin against aminoglycoside tolerant biofilm aggregates with greater activity against gram‐positive bacteria, which could lead to a decrease in morbidity and mortality associated with infectious arthritis. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 27, 2020

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