Anna Guiotto

Works (19)

Updated: March 5th, 2026 15:22

2025 article

64779 The impact of UV and diesel damage in cutaneous tissue and the protective role of a topical antioxidant containing vitamin C, E and ferulic acid on biomarkers related to skin aging

Valacchi, G., Ivarsson, J., Percorelli, A., Guiotto, A., Sarandy, M. M., Choudhary, H., & Brieva, P. (2025, September 1). Journal of the American Academy of Dermatology.

By: G. Valacchi n , J. Ivarsson n , A. Percorelli*, A. Guiotto n, M. Sarandy  n, H. Choudhary, P. Brieva

topics (OpenAlex): Skin Protection and Aging
Source: NC State University Libraries
Added: March 4, 2026

2025 article

Abnormal MAMs proteins can disrupt finely tuned signaling between ER and mitochondria in RTT brain

Pecorelli, A., Guiotto, A., Vallese, A., Melija, S., Cordone, V., & Valacchi, G. (2025, May 30). Free Radical Biology and Medicine, Vol. 233.

By: A. Pecorelli n , A. Guiotto n, A. Vallese* , S. Melija*, V. Cordone * & G. Valacchi n 

topics (OpenAlex): Mitochondrial Function and Pathology
Sources: Web Of Science, NC State University Libraries
Added: July 17, 2025

2025 article

Application of Antioxidant Mixture Prevents Cutaneous “Oxinflammaging” in Subjects Exposed to Particulate Matter

Ivarsson, J., Yan, Guiotto, A., Pecorelli, A., Sarandy, M. M., Lynch, S., … Valacchi, G. (2025, July 1). Journal of Cosmetic Dermatology, Vol. 24.

By: J. Ivarsson n , Yan, A. Guiotto n, A. Pecorelli* , M. Sarandy  n, S. Lynch*, S. Anderias*, H. Choudhary* ...

author keywords: air pollution; OxInflammation; skin aging; skin barrier; topical application
MeSH headings : Humans; Female; Antioxidants / administration & dosage; Adult; Particulate Matter / adverse effects; Particulate Matter / toxicity; Skin Aging / drug effects; Young Adult; Ascorbic Acid / administration & dosage; Skin / drug effects; Skin / pathology; Skin / metabolism; Coumaric Acids / administration & dosage; Tocopherols / administration & dosage; Oxidative Stress / drug effects; Air Pollutants / adverse effects; Administration, Cutaneous; Filaggrin Proteins; Drug Combinations
topics (OpenAlex): Skin Protection and Aging; Air Quality and Health Impacts; Thermoregulation and physiological responses
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 15, 2025

2025 article

Comparing UV and Diesel Cutaneous Damage and Evaluating the Protective Role of a Topical Antioxidant Mixture Containing Vitamin C, E and Ferulic Acid

Ivarsson, J., Pecorelli, A., Guiotto, A., Souza, M. M., Choudhary, H., Brieva, P., … Valacchi, G. (2025, March 1). Experimental Dermatology, Vol. 34.

By: J. Ivarsson* , A. Pecorelli* , A. Guiotto*, M. Souza*, H. Choudhary*, P. Brieva *, F. Ferrara*, G. Valacchi* 

author keywords: air pollution; collagen; elastin; oxinflammation; skin ageing; skin barrier
MeSH headings : Antioxidants / administration & dosage; Humans; Coumaric Acids / administration & dosage; Coumaric Acids / pharmacology; Ultraviolet Rays / adverse effects; Filaggrin Proteins; Skin / drug effects; Skin / radiation effects; Oxidative Stress / drug effects; Ascorbic Acid / administration & dosage; Ascorbic Acid / pharmacology; Vehicle Emissions / toxicity; Skin Aging / drug effects; Skin Aging / radiation effects; Particulate Matter
topics (OpenAlex): Skin Protection and Aging; Vitamin C and Antioxidants Research; Bee Products Chemical Analysis
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Sources: Web Of Science, NC State University Libraries
Added: March 17, 2025

2025 article

Evidence of compromised redox homeostasis and ferritinophagy in Rett syndrome

Guiotto, A., Cordone, V., Vallese, A., Hayek, J., Valacchi, G., & Pecorelli, A. (2025, May 30). Free Radical Biology and Medicine.

By: A. Guiotto n, V. Cordone *, A. Vallese *, J. Hayek *, G. Valacchi * & A. Pecorelli *

topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Advanced Battery Technologies Research
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2. Zero Hunger (OpenAlex)
Source: NC State University Libraries
Added: January 22, 2026

2025 article

Lipid peroxidation-induced cell death in Rett syndrome

Guiotto, A., Vallese, A., Cordone, V., Cervellati, F., Benedusi, M., Hayek, J., … Valacchi, G. (2025, September 22). Free Radical Biology and Medicine, Vol. 241, pp. 243–257.

By: A. Guiotto n, A. Vallese* , V. Cordone *, F. Cervellati *, M. Benedusi *, J. Hayek *, A. Pecorelli n , G. Valacchi* 

author keywords: Ferroptosis; Antioxidant defense; Oxidative stress; Lipid peroxidation; Ferritinophagy; Mitochondria
topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Family and Disability Support Research; Child Nutrition and Feeding Issues
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 7, 2025

2025 article

Role of mitochondrial alterations as upstream triggers of NLRP3 inflammasome response in RETT syndrome

Cordone, V., Bianchi, A., Melija, S., Guiotto, A., Emidio, G. D., Tatone, C., … Valacchi, G. (2025, May 30). Free Radical Biology and Medicine, Vol. 233, pp. S12–S13.

By: V. Cordone *, A. Bianchi *, S. Melija*, A. Guiotto n, G. Emidio *, C. Tatone *, A. Pecorelli n , G. Valacchi n 

topics (OpenAlex): Testicular diseases and treatments; Inflammasome and immune disorders; Congenital Diaphragmatic Hernia Studies
Sources: Web Of Science, NC State University Libraries
Added: July 17, 2025

2025 article

Skin barrier protein responses to oxysterol exposure: from diet to outdoor stressors

Pecorelli, A., Casoni, A., Guiotto, A., Ruzza, M., Beltrami, L., Canepa, B., … Valacchi, G. (2025, May 30). Free Radical Biology and Medicine, Vol. 233.

By: A. Pecorelli n , A. Casoni*, A. Guiotto*, M. Ruzza*, L. Beltrami*, B. Canepa*, F. Biasi *, G. Poli *, G. Valacchi* 

topics (OpenAlex): Exercise and Physiological Responses
Sources: Web Of Science, NC State University Libraries
Added: July 17, 2025

2024 article

Aberrant NLRP3 inflammasome response in Rett syndrome: from ex vivo to in vivo models for investigating pathogenetic mechanisms and new potential therapeutic strategies

Cordone, V., Pecorelli, A., Frescura, F., Vallese, A., Guiotto, A., Ferrara, F., … Valacchi, G. (2024, June 1). Free Radical Biology and Medicine, Vol. 218, pp. 13–14.

By: V. Cordone *, A. Pecorelli n , F. Frescura*, A. Vallese* , A. Guiotto*, F. Ferrara*, J. Hayek *, S. Beggiato *, L. Ferraro *, G. Valacchi n 

topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Family and Disability Support Research
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2024

2024 article

Abnormal Mitochondrion-NLRP3 Inflammasome crosstalk in the pathophysiology of Autism Spectrum Disorder

Vallese, A., Cordone, V., Ferrara, F., Guiotto, A., Gemmo, L., Cervellati, F., … Valacchi, G. (2024, June 1). Free Radical Biology and Medicine, Vol. 218, pp. 50–50.

By: A. Vallese n , V. Cordone *, F. Ferrara*, A. Guiotto n, L. Gemmo*, F. Cervellati *, J. Hayek *, A. Pecorelli n , G. Valacchi n 

topics (OpenAlex): Adenosine and Purinergic Signaling; COVID-19 Impact on Reproduction; Neonatal Respiratory Health Research
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2024

2024 article

Combined exposure to UV and PM affect skin oxinflammatory responses and it is prevented by antioxidant mix topical application: Evidences from clinical study

Ferrara, F., Yan, Pecorelli, A., Guiotto, A., Colella, S., Pasqui, A., … Valacchi, G. (2024, April 8). Journal of Cosmetic Dermatology, Vol. 4.

By: F. Ferrara*, Yan, A. Pecorelli* , A. Guiotto*, S. Colella*, A. Pasqui*, J. Ivarrson* , S. Lynch* ...

author keywords: 4HNE; inflammasome; inflammation; pollution; skin barrier
MeSH headings : Humans; Female; Ultraviolet Rays / adverse effects; Adult; Antioxidants / administration & dosage; Single-Blind Method; Young Adult; Oxidative Stress / drug effects; Oxidative Stress / radiation effects; Particulate Matter / adverse effects; Particulate Matter / administration & dosage; Skin / radiation effects; Skin / drug effects; Skin / metabolism; Adolescent; Skin Aging / drug effects; Skin Aging / radiation effects; Ascorbic Acid / administration & dosage; Ascorbic Acid / pharmacology; Administration, Cutaneous; Lipid Peroxidation / drug effects; Lipid Peroxidation / radiation effects; Coumaric Acids
topics (OpenAlex): Skin Protection and Aging; melanin and skin pigmentation; Psoriasis: Treatment and Pathogenesis
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 15, 2024

2024 article

Comparison of pollutant effects on cutaneous inflammasomes activation.

Ferrara, F., Ivarsson, J., Vallese, A., Guiotto, A., Colella, S., Pecorelli, A., & Valacchi, G. (2024, June 1). Free Radical Biology and Medicine, Vol. 218, pp. 27–27.

By: F. Ferrara*, J. Ivarsson* , A. Vallese* , A. Guiotto*, S. Colella*, A. Pecorelli* , G. Valacchi* 

topics (OpenAlex): Cancer Immunotherapy and Biomarkers; Inflammasome and immune disorders
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 26, 2024

2024 article

Evidence of altered redox homeostasis in trichothiodystrophy

Cordone, V., Guiotto, A., Bucay, V., Pecorelli, A., & Valacchi, G. (2024, January 1). Redox Experimental Medicine, Vol. 2024.

By: V. Cordone *, A. Guiotto n, V. Bucay, A. Pecorelli n  & G. Valacchi n 

author keywords: BACH; mitochondria; NRF2; trichothiodystrophy
topics (OpenAlex): Biochemical effects in animals; Redox biology and oxidative stress; Selenium in Biological Systems
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 23, 2024

2024 article

NLRP3 inflammasome-mitochondrion loop in autism spectrum disorder

Vallese, A., Cordone, V., Ferrara, F., Guiotto, A., Gemmo, L., Cervellati, F., … Valacchi, G. (2024, October 19). Free Radical Biology and Medicine, Vol. 225, pp. 581–594.

By: A. Vallese* , V. Cordone *, F. Ferrara*, A. Guiotto*, L. Gemmo*, F. Cervellati *, J. Hayek *, A. Pecorelli* , G. Valacchi* 

MeSH headings : Autism Spectrum Disorder / metabolism; Autism Spectrum Disorder / pathology; Autism Spectrum Disorder / genetics; Humans; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; Mitochondria / metabolism; Mitochondria / pathology; Inflammasomes / metabolism; Inflammasomes / genetics; Reactive Oxygen Species / metabolism; Interleukin-1beta / metabolism; Interleukin-1beta / genetics; Male; Fibroblasts / metabolism; Fibroblasts / pathology; Lipopolysaccharides / pharmacology; Indenes; Child; Female; Caspase 1 / metabolism; Caspase 1 / genetics; Interleukin-18 / metabolism; Interleukin-18 / genetics; Furans / pharmacology; Cells, Cultured; Adenosine Triphosphate / metabolism; CARD Signaling Adaptor Proteins / metabolism; CARD Signaling Adaptor Proteins / genetics; Organophosphorus Compounds; Piperidines; Sulfonamides
topics (OpenAlex): Inflammasome and immune disorders; Kawasaki Disease and Coronary Complications; Neonatal Respiratory Health Research
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 12, 2024

2023 article

A proteomic approach to investigate the role of the MECP2 gene mutation in Rett syndrome redox regulatory pathways

Pasqui, A., Cicaloni, V., Tinti, L., Guiotto, A., Tinti, C., Mori, A., … Valacchi, G. (2023, December 16). Archives of Biochemistry and Biophysics, Vol. 752.

By: A. Pasqui*, V. Cicaloni *, L. Tinti *, A. Guiotto n, C. Tinti*, A. Mori *, M. Bruttini *, J. Hayek * ...

author keywords: Rett syndrome; MECP2 mutations; Precision medicine; Proteomics; Oxidative stress
MeSH headings : Humans; Hydrogen Peroxide; Methyl-CpG-Binding Protein 2 / genetics; Mutation; Oxidation-Reduction; Phenotype; Proteins; Proteomics; Rett Syndrome / genetics
topics (OpenAlex): Genetics and Neurodevelopmental Disorders; RNA modifications and cancer; Ubiquitin and proteasome pathways
TL;DR: By employing a multidisciplinary approach encompassing proteomics and bioinformatics analyses, as well as molecular biology assays, the study uncovered phenotypic responses linked to specific MECP2 gene mutations, contributing to a better understanding of the complexity of RTT molecular pathways. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024

2023 article

Comparison of Pollutant Effects on Cutaneous Inflammasomes Activation

Ivarsson, J., Ferrara, F., Vallese, A., Guiotto, A., Colella, S., Pecorelli, A., & Valacchi, G. (2023, November 23). International Journal of Molecular Sciences, Vol. 24.

By: J. Ivarsson* , F. Ferrara*, A. Vallese* , A. Guiotto*, S. Colella*, A. Pecorelli* , G. Valacchi* 

author keywords: oxinflammation; inflammasome; pollutants; skin
MeSH headings : Humans; Inflammasomes / metabolism; Environmental Pollutants / metabolism; Plastics / metabolism; Skin / metabolism; Air Pollutants / toxicity
topics (OpenAlex): Inflammasome and immune disorders; Air Quality and Health Impacts; Heme Oxygenase-1 and Carbon Monoxide
TL;DR: Among all environmental pollutants, O3, MP, and UV represented the main pollutants affecting cutaneous redox homeostasis; of note, the NLRP1 and NLRP6 inflammasomes were the main ones modulated by these outdoor stressors, suggesting their role as possible molecular targets in preventing skin disorders and the inflammaging events associated with environmental pollutants exposure. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 24, 2023

2023 article

Development of Spray Dried Spirulina Protein-Berry Pomace Polyphenol Particles to Attenuate Pollution-Induced Skin Damage: A Convergent Food-Beauty Approach

Hoskin, R. T., Grace, M. H., Guiotto, A., Pecorelli, A., Valacchi, G., & Lila, M. A. (2023, July 15). Antioxidants, Vol. 12.

By: R. Hoskin n , M. Grace n , A. Guiotto n, A. Pecorelli n , G. Valacchi n  & M. Lila n 

author keywords: sustainability; value-added; repurposing; skin health; cosmeceuticals
topics (OpenAlex): Microencapsulation and Drying Processes; Bee Products Chemical Analysis; Phytochemicals and Antioxidant Activities
TL;DR: It is demonstrated that protein-polyphenol complexation is a synergistic strategy to stabilize and deliver residual fruit/algae phytoactives into cosmeceutical products for skin health applications. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 17, 2023

2023 article

Inflammasomes regulation by environmental pollutants in human skin

Ferrara, F., Pecorelli, A., Guiotto, A., Vallese, A., Cordone, V., Benedusi, M., … Valacchi, G. (2023, May 1). Free Radical Biology and Medicine, Vol. 201, pp. 38–39.

By: F. Ferrara*, A. Pecorelli* , A. Guiotto*, A. Vallese* , V. Cordone *, M. Benedusi *, F. Cervellati *, G. Valacchi* 

topics (OpenAlex): Inflammasome and immune disorders; Air Quality and Health Impacts
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2023 article

Topical Application of M89PF Containing Vichy Mineralising Water and Probiotic Fractions Prevents Cutaneous Damage Induced by Exposure to UV and O3

Benedusi, M., Kerob, D., Guiotto, A., Cervellati, F., Ferrara, F., & Pambianchi, E. (2023, July 1). Clinical Cosmetic and Investigational Dermatology.

By: M. Benedusi *, D. Kerob *, A. Guiotto*, F. Cervellati *, F. Ferrara* & E. Pambianchi n

author keywords: ultraviolet radiation; ozone; skin barrier; oxidative stress; inflammation
topics (OpenAlex): Skin Protection and Aging; Dermatology and Skin Diseases; Psoriasis: Treatment and Pathogenesis
TL;DR: M89PF prevents skin barrier damage, as well as oxidative stress and inflammatory markers induced by exposome factors, such as UV, O3, or both combined. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: July 24, 2023

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