Adithya Gurumurthy

College of Engineering

Works (3)

Updated: July 5th, 2023 14:29

2021 journal article

Analysis of improved oral drug delivery with different helical stream inhalation modes

COMPUTERS IN BIOLOGY AND MEDICINE, 141.

By: A. Gurumurthy n & C. Kleinstreuer n

author keywords: Pulmonary drug delivery; Polydisperse particle distribution; Subject-specific upper lung airway geometry; Helical drug-aerosol streams; Swirl number; Angled helical injection; Radially positioned helical injection; Lobe-specific drug targeting
MeSH headings : Administration, Inhalation; Aerosols; Drug Delivery Systems; Lung; Metered Dose Inhalers; Particle Size; Rivers
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Source: Web Of Science
Added: February 7, 2022

2021 journal article

Improving Pulmonary Nanotherapeutics Using Helical Aerosol Streams: An In Silico Study

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 143(11).

By: A. Gurumurthy n & C. Kleinstreuer n

author keywords: helical drug-aerosol streams; nanoparticles; human upper respiratory tract; improved drug delivery; CFD; openfoam
MeSH headings : Hydrodynamics
TL;DR: This study numerically analyzes a novel methodology of incorporating helical air-nanoparticle streams for pulmonary nano-therapeutics, using a customized version of the open-source computational fluid dynamics (CFD) toolbox OpenFOAM, and demonstrates the robustness of helical flows in pulmonary drug delivery. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 18, 2021

2020 journal article

Helical fluid-particle flow dynamics for controlling micron-particle deposition in a representative human upper lung-airway model

JOURNAL OF AEROSOL SCIENCE, 151.

By: A. Gurumurthy n & C. Kleinstreuer n

author keywords: Helical air-particle inlet streams; Micron-particle deposition; Human upper respiratory tract; Drug-delivery applications; Open-FOAM software
TL;DR: Helical air-particle flow is introduced, which significantly affects the particle dynamics with applications to targeted drug delivery and a new non-dimensional parameter called the swirl number threshold (Sth) is discussed, which is useful in assessing the impact of helical streams in drug-aerosol delivery. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: December 21, 2020

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