Adithya Gurumurthy

College of Engineering

Works (3)

Updated: July 5th, 2023 14:29

2022 journal article

Analysis of improved oral drug delivery with different helical stream inhalation modes

COMPUTERS IN BIOLOGY AND MEDICINE, 141.

By: A. Gurumurthy n & C. Kleinstreuer n

author keywords: Pulmonary drug delivery; Polydisperse particle distribution; Subject-specific upper lung airway geometry; Helical drug-aerosol streams; Swirl number; Angled helical injection; Radially positioned helical injection; Lobe-specific drug targeting
MeSH headings : Administration, Inhalation; Aerosols; Drug Delivery Systems; Lung; Metered Dose Inhalers; Particle Size; Rivers
topics (OpenAlex): Inhalation and Respiratory Drug Delivery; Particle Dynamics in Fluid Flows; Aerosol Filtration and Electrostatic Precipitation
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: February 7, 2022

2021 journal article

Helical fluid-particle flow dynamics for controlling micron-particle deposition in a representative human upper lung-airway model

JOURNAL OF AEROSOL SCIENCE, 151.

By: A. Gurumurthy n & C. Kleinstreuer n

author keywords: Helical air-particle inlet streams; Micron-particle deposition; Human upper respiratory tract; Drug-delivery applications; Open-FOAM software
topics (OpenAlex): Inhalation and Respiratory Drug Delivery; Aerosol Filtration and Electrostatic Precipitation; Particle Dynamics in Fluid Flows
TL;DR: Helical air-particle flow is introduced, which significantly affects the particle dynamics with applications to targeted drug delivery and a new non-dimensional parameter called the swirl number threshold (Sth) is discussed, which is useful in assessing the impact of helical streams in drug-aerosol delivery. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: December 21, 2020

2021 journal article

Improving Pulmonary Nanotherapeutics Using Helical Aerosol Streams: An In Silico Study

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 143(11).

By: A. Gurumurthy n & C. Kleinstreuer n

author keywords: helical drug-aerosol streams; nanoparticles; human upper respiratory tract; improved drug delivery; CFD; openfoam
MeSH headings : Hydrodynamics
topics (OpenAlex): Inhalation and Respiratory Drug Delivery; Aerosol Filtration and Electrostatic Precipitation; Particle Dynamics in Fluid Flows
TL;DR: This study numerically analyzes a novel methodology of incorporating helical air-nanoparticle streams for pulmonary nano-therapeutics, using a customized version of the open-source computational fluid dynamics (CFD) toolbox OpenFOAM, and demonstrates the robustness of helical flows in pulmonary drug delivery. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 18, 2021

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