Angelito Inocencio Nepomuceno

Works (7)

Updated: July 5th, 2023 15:44

2015 journal article

Global Proteomic Analysis of Functional Compartments in Immature Avian Follicles Using Laser Microdissection Coupled to LC-MS/MS

JOURNAL OF PROTEOME RESEARCH, 14(9), 3912–3923.

By: A. Nepomuceno n, D. Muddiman n  & J. Petitte n 

author keywords: microdissection; proteomics; ovary; follicle; avian; chicken; yolk; steroidogenesis; vitellogenin
MeSH headings : Animals; Avian Proteins / analysis; Avian Proteins / chemistry; Chickens; Chromatography, Liquid; Female; Laser Capture Microdissection / methods; Ovarian Follicle / chemistry; Proteome / analysis; Proteome / chemistry; Proteomics / methods; Tandem Mass Spectrometry
TL;DR: A global proteome for SWF, white yolk, and ovarian stroma of the avian ovary is provided that can be used as a baseline for future studies and verifies that the coupling of LMD with proteomic analysis can be use to evaluate proteins from small, physiologically functional compartments of complex tissue. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

In-depth LC-MS/MS analysis of the chicken ovarian cancer proteome reveals conserved and novel differentially regulated proteins in humans

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407(22), 6851–6863.

By: A. Nepomuceno n, H. Shao *, K. Jing*, Y. Ma *, J. Petitte n , M. Idowu *, D. Muddiman n , X. Fang *, A. Hawkridge *

author keywords: Mass spectrometry; Proteomics; Ovarian Cancer; Chicken; Ovostatin 2; OVOS2
MeSH headings : Amino Acid Sequence; Animals; Chickens; Chromatography, Liquid / methods; Conserved Sequence; Female; Gene Expression Regulation, Neoplastic; Humans; Mass Spectrometry / methods; Molecular Sequence Data; Neoplasm Proteins / metabolism; Ovarian Neoplasms / metabolism; Proteome / chemistry; Proteome / metabolism; Species Specificity
TL;DR: Analysis of the ovarian cancer proteome of the chicken provides the first evidence for involvement of OVOS2 in the pathogenesis of both chicken and human ovarian cancer. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Machine learning reveals sex-specific 17β-estradiol-responsive expression patterns in white perch (Morone americana) plasma proteins

PROTEOMICS, 15(15), 2678–2690.

By: J. Schilling n, A. Nepomuceno n, A. Planchart n , J. Yoder n , R. Kelly n , D. Muddiman n , H. Daniels n, N. Hiramatsu*, B. Reading n 

Contributors: J. Schilling n, A. Nepomuceno n, A. Planchart n , J. Yoder n , R. Kelly n , D. Muddiman n , H. Daniels n, N. Hiramatsu*, B. Reading n 

author keywords: Animal proteomics; Endocrine disrupting compounds; Machine learning; Plasma; Semiquantitative proteomics; Support vector machines
MeSH headings : Animals; Bass / metabolism; Blood Proteins / metabolism; Blotting, Western; Chromatography, Liquid; Estradiol / pharmacology; Estrogens / pharmacology; Female; Fish Proteins / metabolism; Kininogens / metabolism; Male; Nanotechnology / methods; Proteome / drug effects; Proteome / metabolism; Proteomics / methods; Sex Factors; Support Vector Machine; Tandem Mass Spectrometry; Vitellogenins / metabolism
TL;DR: This is the first report that Eltd1 and Kng1 may be E2‐responsive proteins in fishes and therefore may be useful indicators of estrogen induction in fishes. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

C/EBPα regulates CRL4Cdt2-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint

Cell Cycle, 13(22), 3602–3610.

By: J. Hall n , M. Bereman n, A. Nepomuceno n, E. Thompson n, D. Muddiman n  & R. Smart n 

author keywords: C/EBP alpha; CRL4(Cdt2); G(1)/S DNA damage checkpoint; keratinocytes; p21
MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / genetics; CCAAT-Enhancer-Binding Protein-alpha / metabolism; Cell Cycle Checkpoints / genetics; Cell Cycle Checkpoints / radiation effects; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; DNA Damage / genetics; DNA Damage / radiation effects; G1 Phase Cell Cycle Checkpoints / genetics; Keratinocytes / metabolism; Keratinocytes / radiation effects; Mice; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Proteolysis; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Ultraviolet Rays; p21-Activated Kinases / genetics; p21-Activated Kinases / metabolism
TL;DR: Findings reveal C/EBPα regulates G1/S cell cycle arrest in response to DNA damage via the control of CRL4Cdt2 mediated degradation of p21. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2014 journal article

Compartment Proteomics Analysis of White Perch (Morone americana) Ovary Using Support Vector Machines

JOURNAL OF PROTEOME RESEARCH, 13(3), 1515–1526.

By: J. Schilling n, A. Nepomuceno n, J. Schaff n, D. Muddiman n , H. Daniels n & B. Reading n 

author keywords: compartment proteomics; support vector machines; modulated modularity clustering; ovary; oocytes; vitellogenin; transcriptome; mitochondria; alternatively spliced variants
MeSH headings : Animals; Bass / metabolism; Chemical Fractionation; Female; Fish Proteins / analysis; Membrane Proteins / analysis; Mitochondrial Proteins / analysis; Molecular Sequence Annotation; Ovary / chemistry; Ovary / metabolism; Proteomics / methods; Support Vector Machine; Tandem Mass Spectrometry
TL;DR: The white perch ovary cytosolic and membrane proteomes and transcriptome presented in this study can support future investigations into oogenesis and early embryogenesis ofwhite perch and other members of the genus Morone. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Accurate Identification of Deamidated Peptides in Global Proteomics Using a Quadrupole Orbitrap Mass Spectrometer

JOURNAL OF PROTEOME RESEARCH, 13(2), 777–785.

By: A. Nepomuceno n, R. Gibson n, S. Randall n & D. Muddiman n 

author keywords: deamidation; post-translational modification; quadrupole orbitrap mass spectrometry
MeSH headings : Amides / chemistry; Chromatography, Liquid; Peptides / chemistry; Proteomics; Tandem Mass Spectrometry / instrumentation
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Comparative Proteomic Analysis and IgE Binding Properties of Peanut Seed and Testa (Skin)

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 61(16), 3957–3968.

By: B. White*, E. Goekce, A. Nepomuceno n, D. Muddiman n , T. Sanders* & J. Davis*

author keywords: IgE binding; LC-MS/MS; peanut; proteomics; skins; testae
MeSH headings : Allergens / immunology; Antigens, Plant / immunology; Arachis / chemistry; Arachis / immunology; Humans; Immunoglobulin E / metabolism; Peanut Hypersensitivity / immunology; Plant Proteins / analysis; Plant Proteins / chemistry; Plant Proteins / immunology; Proteomics; Seeds / chemistry; Seeds / immunology
TL;DR: Findings indicate that peanut skins contain potentially allergenic proteins; however, the presence of phenolic compounds may attenuate this effect. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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