Albert Jun Qi Keung
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Works (34)
Updated: September 18th, 2023 08:05
2023 review
A molecular assessment of the practical potential of DNA-based computation
[Review of ]. CURRENT OPINION IN BIOTECHNOLOGY, 81.
Source: Web Of Science
Added: September 11, 2023
2023 journal article
Chaetocin disrupts the SUV39H1-HP1 interaction independent of SUV39H1 methyltransferase activity
BIOCHEMICAL JOURNAL, 480(6), 421–432.
MeSH headings : Humans; Methyltransferases / metabolism; Repressor Proteins / metabolism; Histones / genetics; Histones / metabolism; Chromosomal Proteins, Non-Histone / metabolism
doi.org (publisher)
Source: Web Of Science
Added: April 11, 2023
2023 journal article
Profiling transcriptomic responses of human stem cell-derived medium spiny neuron-like cells to exogenous phasic and tonic neurotransmitters
MOLECULAR AND CELLULAR NEUROSCIENCE, 126.
author keywords: Human pluripotent stem cells; Medium spiny neuron; Tonic neuromodulation; Neurotransmitter; Gene desensitization; Transcriptome
Source: Web Of Science
Added: August 28, 2023
2022 journal article
DINOS: Data INspired Oligo Synthesis for DNA Data Storage
ACM JOURNAL ON EMERGING TECHNOLOGIES IN COMPUTING SYSTEMS, 18(3).
author keywords: DNA information storage; DNA synthesis; DNA assembly algorithms
Sources: Web Of Science, ORCID
Added: April 14, 2022
2022 journal article
Human Pluripotent Stem Cell-Derived Medium Spiny Neuron-like Cells Exhibit Gene Desensitization
CELLS, 11(9).
author keywords: dopamine; gene desensitization; acute and chronic; RNA-seq; human embryonic stem cell; medium spiny neuron
MeSH headings : Dopamine; Humans; Neurites; Neurons / physiology; Pluripotent Stem Cells; Receptors, Dopamine
Source: Web Of Science
Added: May 23, 2022
2022 journal article
Modified Histone Peptides Linked to Magnetic Beads Reduce Binding Specificity
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(3).
author keywords: yeast surface display; histone post-translational modifications; affinity reagents; protein engineering; chromodomain; binder; reader; antibody; epigenome engineering; synthetic biology
MeSH headings : HEK293 Cells; Histone Code; Histones / metabolism; Humans; Jurkat Cells; K562 Cells; Protein Array Analysis; Protein Binding; Protein Engineering; Protein Processing, Post-Translational; Saccharomyces cerevisiae
Source: Web Of Science
Added: February 21, 2022
2021 review
DNA stability: a central design consideration for DNA data storage systems
[Review of ]. NATURE COMMUNICATIONS, 12(1).
MeSH headings : DNA / genetics; Data Systems; Information Storage and Retrieval
Sources: Web Of Science, ORCID
Added: April 19, 2021
2021 journal article
Effects of early geometric confinement on the transcriptomic profile of human cerebral organoids
BMC BIOTECHNOLOGY, 21(1).
author keywords: Human cerebral organoids; Neurodevelopment; Agarose microwells; Microfabrication; RNAseq; Mechanobiology
MeSH headings : Brain; Cell Differentiation; Gene Expression Profiling; Humans; Organoids; Transcriptome
Source: Web Of Science
Added: October 26, 2021
2021 journal article
Evaluation of UBE3A antibodies in mice and human cerebral organoids
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Angelman Syndrome / genetics; Angelman Syndrome / pathology; Animals; Antibodies / genetics; Antibodies / immunology; Autistic Disorder / genetics; Autistic Disorder / pathology; Cerebellum / cytology; Disease Models, Animal; Genomic Imprinting; Humans; Mice; Neural Stem Cells / metabolism; Neurons / metabolism; Neurons / pathology; Organoids / cytology; Pluripotent Stem Cells; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / immunology
Source: Web Of Science
Added: July 19, 2021
2021 journal article
Mapping the dynamic transfer functions of eukaryotic gene regulation
CELL SYSTEMS, 12(11), 1079-+.
MeSH headings : Chromatin / genetics; Eukaryota / genetics; Gene Expression Regulation / genetics; Promoter Regions, Genetic / genetics; Signal Transduction
Sources: Web Of Science, ORCID
Added: January 31, 2022
2021 journal article
Mapping the residue specificities of epigenome enzymes by yeast surface display
CELL CHEMICAL BIOLOGY, 28(12), 1772-+.
MeSH headings : E1A-Associated p300 Protein / genetics; E1A-Associated p300 Protein / metabolism; Epigenome / genetics; Humans; Saccharomyces cerevisiae / metabolism
Source: Web Of Science
Added: January 3, 2022
2021 journal article
Promiscuous molecules for smarter file operations in DNA-based data storage
NATURE COMMUNICATIONS, 12(1).
MeSH headings : Computer Simulation; DNA / chemistry; DNA Primers / chemistry; Databases, Nucleic Acid; High-Throughput Nucleotide Sequencing; Image Processing, Computer-Assisted / methods; Information Storage and Retrieval / methods; Real-Time Polymerase Chain Reaction / methods; Software; Temperature; Thermodynamics
Sources: Web Of Science, ORCID
Added: July 12, 2021
2021 article
Voices of biotech research
Annabi, N., Baker, M., Boettiger, A., Chakraborty, D., Chen, Y., Corbett, K. S., … Wang, J. (2021, March). NATURE BIOTECHNOLOGY, Vol. 39, pp. 281–286.
MeSH headings : Biomedical Research; Biotechnology; Humans; Research Personnel
Source: Web Of Science
Added: April 5, 2021
2020 review
Capturing complex epigenetic phenomena through human multicellular systems
[Review of ]. CURRENT OPINION IN BIOMEDICAL ENGINEERING, 16, 34–41.
author keywords: Epigenetics; Organoids; Development; Aging; 3D; Multicellular
Source: Web Of Science
Added: June 10, 2021
2020 journal article
Dynamic and scalable DNA-based information storage
NATURE COMMUNICATIONS, 11(1).
MeSH headings : Algorithms; Bacteriophage T7 / genetics; DNA / genetics; DNA, Single-Stranded / genetics; Gene Expression Regulation, Viral; Genetic Code; Models, Genetic; Promoter Regions, Genetic / genetics; Transcription, Genetic
Sources: Web Of Science, ORCID
Added: July 13, 2020
2020 journal article
Human Cerebral Organoids Reveal Early Spatiotemporal Dynamics and Pharmacological Responses of UBE3A
STEM CELL REPORTS, 15(4), 845–854.
MeSH headings : Angelman Syndrome / pathology; Cell Line; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Cerebrum / metabolism; Genomic Imprinting / drug effects; Humans; Neurons / drug effects; Neurons / metabolism; Organoids / drug effects; Organoids / metabolism; Time Factors; Topoisomerase Inhibitors / pharmacology; Ubiquitin-Protein Ligases / metabolism
Source: Web Of Science
Added: November 9, 2020
2019 journal article
Driving the Scalability of DNA-Based Information Storage Systems
ACS SYNTHETIC BIOLOGY, 8(6), 1241–1248.
author keywords: synthetic biology; DNA storage; information storage; nested architecture; file access; DNA sequencing
MeSH headings : DNA / chemistry; DNA / genetics; Databases, Nucleic Acid; High-Throughput Nucleotide Sequencing; Information Storage and Retrieval / methods; Sequence Analysis, DNA / methods; Synthetic Biology / methods
Source: Web Of Science
Added: July 15, 2019
2019 journal article
Engineering Epigenetic Regulation Using Synthetic Read-Write Modules
CELL, 176(1-2), 227-+.
Source: Web Of Science
Added: January 28, 2019
2019 journal article
Modular one-pot assembly of CRISPR arrays enables library generation and reveals factors influencing crRNA biogenesis
NATURE COMMUNICATIONS, 10.
MeSH headings : Base Sequence; CRISPR-Associated Proteins / metabolism; Clustered Regularly Interspaced Short Palindromic Repeats / genetics; DNA / genetics; Endonucleases / metabolism; Gene Library; Genetic Techniques; HEK293 Cells; Humans; Nucleic Acid Conformation; Plasmids / metabolism; RNA / biosynthesis; RNA, Messenger / genetics; RNA, Messenger / metabolism; Saccharomyces cerevisiae / metabolism
Source: Web Of Science
Added: July 22, 2019
2016 article
A unifying model of epigenetic regulation
Keung, A. J., & Khalil, A. S. (2016, February 12). SCIENCE, Vol. 351, pp. 661–662.
MeSH headings : Animals; Chromatin / metabolism; DNA Methylation; Gene Silencing; Histones / metabolism; Humans
Source: Web Of Science
Added: August 6, 2018
2016 review
The epigenome: the next substrate for engineering
[Review of ]. GENOME BIOLOGY, 17.
MeSH headings : Chromatin / genetics; Epigenesis, Genetic; Epigenomics; Genome, Human; Humans
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Chromatin regulation at the frontier of synthetic biology
Nature Reviews Genetics, 16(3), 159–171.
MeSH headings : Animals; Cell Engineering / methods; Chromatin / chemistry; Chromatin / metabolism; Epigenesis, Genetic; Genome; Histones / chemistry; Histones / metabolism; Humans; Plants / genetics; Plants / metabolism; RNA, Untranslated / chemistry; RNA, Untranslated / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Synthetic Biology; Systems Biology
Source: Crossref
Added: February 24, 2020
2014 journal article
Using Targeted Chromatin Regulators to Engineer Combinatorial and Spatial Transcriptional Regulation
Cell, 158(1), 110–120.
MeSH headings : Chromatin / metabolism; Gene Expression Regulation, Fungal; Gene Regulatory Networks; Genes, Reporter; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / chemistry; Saccharomyces cerevisiae Proteins / metabolism; Transcription, Genetic
Source: Crossref
Added: August 28, 2020
2013 journal article
Pan-neuronal maturation but not neuronal subtype differentiation of adult neural stem cells is mechanosensitive
Scientific Reports, 3(1).
MeSH headings : Adult Stem Cells / cytology; Adult Stem Cells / metabolism; Animals; Brain / metabolism; Cell Differentiation / physiology; Cell Lineage; Cellular Microenvironment / physiology; Female; Gene Expression; Gene Expression Regulation, Developmental; Neural Stem Cells / cytology; Neural Stem Cells / metabolism; Neurons / classification; Neurons / cytology; Neurons / metabolism; Rats; Time Factors; Tubulin / genetics
Source: Crossref
Added: August 28, 2020
2012 journal article
A Genetic Strategy for the Dynamic and Graded Control of Cell Mechanics, Motility, and Matrix Remodeling
Biophysical Journal, 102(3), 434–442.
MeSH headings : Biomechanical Phenomena; Cell Line; Cell Movement / drug effects; Cell Movement / genetics; Collagen / metabolism; Extracellular Matrix / drug effects; Extracellular Matrix / genetics; Extracellular Matrix / metabolism; Gene Expression Regulation / drug effects; Gene Expression Regulation / genetics; Genetic Engineering / methods; Humans; Mechanical Phenomena; Mechanotransduction, Cellular / drug effects; Mechanotransduction, Cellular / genetics; Mutation; Promoter Regions, Genetic / genetics; Tetracycline / pharmacology
Source: Crossref
Added: August 28, 2020
2012 journal article
Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells
Integrative Biology, 4(9), 1049–1058.
MeSH headings : Cell Culture Techniques / methods; Cell Differentiation / physiology; Dopaminergic Neurons / cytology; Extracellular Matrix / physiology; Flow Cytometry; Humans; Microscopy, Atomic Force; Microscopy, Phase-Contrast; Neurogenesis / physiology; Pluripotent Stem Cells / cytology; Stress, Mechanical
Source: Crossref
Added: August 28, 2020
2011 journal article
An Evolved Adeno-associated Viral Variant Enhances Gene Delivery and Gene Targeting in Neural Stem Cells
Molecular Therapy, 19(4), 667–675.
MeSH headings : Animals; Cells, Cultured; Chromatography; Dependovirus / genetics; Female; Fluorescent Antibody Technique; Gene Transfer Techniques; Neural Stem Cells / virology; Polymerase Chain Reaction; Rats; Rats, Inbred F344
Source: Crossref
Added: August 28, 2020
2011 journal article
Rho GTPases Mediate the Mechanosensitive Lineage Commitment of Neural Stem Cells
STEM CELLS, 29(11), 1886–1897.
author keywords: Neural stem cells; Cellular mechanotransduction; Rho GTP-binding proteins; Adipose stem cells; Extracellular matrix; Elastic modulus
MeSH headings : Animals; Apoptosis / genetics; Apoptosis / physiology; Cell Differentiation / genetics; Cell Differentiation / physiology; Cell Proliferation; Cells, Cultured; Extracellular Matrix / metabolism; Female; Fluorescent Antibody Technique; Mechanotransduction, Cellular / genetics; Mechanotransduction, Cellular / physiology; Microscopy, Atomic Force; Neural Stem Cells / cytology; Neural Stem Cells / metabolism; Neurogenesis / genetics; Neurogenesis / physiology; Rats; Rats, Inbred F344; cdc42 GTP-Binding Protein / genetics; cdc42 GTP-Binding Protein / metabolism; rho GTP-Binding Proteins / genetics; rho GTP-Binding Proteins / metabolism; rhoA GTP-Binding Protein / genetics; rhoA GTP-Binding Protein / metabolism
Source: Crossref
Added: August 28, 2020
2010 journal article
A Genetic Strategy for Graded and Dynamic Control of Cell-Matrix Mechanobiology
Biophysical Journal, 98(3), 730a.
Source: Crossref
Added: August 28, 2020
2010 journal article
Biophysics and dynamics of natural and engineered stem cell microenvironments
Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2(1), 49–64.
MeSH headings : Adult; Animals; Biomechanical Phenomena / physiology; Biophysics / methods; Biophysics / trends; Cell Culture Techniques / methods; Environment; Humans; Kinetics; Models, Biological; Stem Cells / cytology; Stem Cells / metabolism; Stem Cells / physiology; Tissue Engineering / methods
Source: Crossref
Added: August 28, 2020
2010 journal article
Mechanotransductive Engineering of Neural Stem Cell Behavior
Biophysical Journal, 98(3), 404a–405a.
Source: Crossref
Added: August 28, 2020
2007 journal article
Thermal Control of Amide Product Distributions at the Ge(100)-2×1 Surface
The Journal of Physical Chemistry C, 111(1), 411–419.
Source: Crossref
Added: August 28, 2020
2006 journal article
Carboxylic Acid Chemistry at the Ge(100)-2 × 1 Interface: Bidentate Bridging Structure Formation on a Semiconductor Surface
Journal of the American Chemical Society, 128(3), 770–779.
Source: Crossref
Added: August 28, 2020
2005 journal article
Tertiary amide chemistry at the Ge(100)-2×1 surface
Surface Science, 599(1-3), 41–54.
author keywords: density functional calculations; vibrational spectroscopies; germanium; organic molecules; organo-functionalization of surfaces; desorption; amide; Ge(100)
Source: Crossref
Added: August 28, 2020
