Works (34)

Updated: September 18th, 2023 08:05

2023 review

A molecular assessment of the practical potential of DNA-based computation

[Review of ]. CURRENT OPINION IN BIOTECHNOLOGY, 81.

By: R. Polak n & A. Keung n

Source: Web Of Science
Added: September 11, 2023

2023 journal article

Chaetocin disrupts the SUV39H1-HP1 interaction independent of SUV39H1 methyltransferase activity

BIOCHEMICAL JOURNAL, 480(6), 421–432.

By: L. Han n, J. Lee n, E. Indermaur n & A. Keung n

MeSH headings : Humans; Methyltransferases / metabolism; Repressor Proteins / metabolism; Histones / genetics; Histones / metabolism; Chromosomal Proteins, Non-Histone / metabolism
Source: Web Of Science
Added: April 11, 2023

2023 journal article

Profiling transcriptomic responses of human stem cell-derived medium spiny neuron-like cells to exogenous phasic and tonic neurotransmitters

MOLECULAR AND CELLULAR NEUROSCIENCE, 126.

By: R. Tam n & A. Keung n

author keywords: Human pluripotent stem cells; Medium spiny neuron; Tonic neuromodulation; Neurotransmitter; Gene desensitization; Transcriptome
Source: Web Of Science
Added: August 28, 2023

2022 journal article

DINOS: Data INspired Oligo Synthesis for DNA Data Storage

ACM JOURNAL ON EMERGING TECHNOLOGIES IN COMPUTING SYSTEMS, 18(3).

By: K. Volkel n, K. Tomek n, A. Keung n & J. Tuck n

author keywords: DNA information storage; DNA synthesis; DNA assembly algorithms
Sources: Web Of Science, ORCID
Added: April 14, 2022

2022 journal article

Human Pluripotent Stem Cell-Derived Medium Spiny Neuron-like Cells Exhibit Gene Desensitization

CELLS, 11(9).

By: R. Tam n & A. Keung n

author keywords: dopamine; gene desensitization; acute and chronic; RNA-seq; human embryonic stem cell; medium spiny neuron
MeSH headings : Dopamine; Humans; Neurites; Neurons / physiology; Pluripotent Stem Cells; Receptors, Dopamine
Source: Web Of Science
Added: May 23, 2022

2022 journal article

Modified Histone Peptides Linked to Magnetic Beads Reduce Binding Specificity

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(3).

By: J. Meanor n, A. Keung n & B. Rao n

author keywords: yeast surface display; histone post-translational modifications; affinity reagents; protein engineering; chromodomain; binder; reader; antibody; epigenome engineering; synthetic biology
MeSH headings : HEK293 Cells; Histone Code; Histones / metabolism; Humans; Jurkat Cells; K562 Cells; Protein Array Analysis; Protein Binding; Protein Engineering; Protein Processing, Post-Translational; Saccharomyces cerevisiae
Source: Web Of Science
Added: February 21, 2022

2021 review

DNA stability: a central design consideration for DNA data storage systems

[Review of ]. NATURE COMMUNICATIONS, 12(1).

By: K. Matange n, J. Tuck n & A. Keung n

MeSH headings : DNA / genetics; Data Systems; Information Storage and Retrieval
Sources: Web Of Science, ORCID
Added: April 19, 2021

2021 journal article

Effects of early geometric confinement on the transcriptomic profile of human cerebral organoids

BMC BIOTECHNOLOGY, 21(1).

By: D. Sen n, A. Voulgaropoulos n & A. Keung n

author keywords: Human cerebral organoids; Neurodevelopment; Agarose microwells; Microfabrication; RNAseq; Mechanobiology
MeSH headings : Brain; Cell Differentiation; Gene Expression Profiling; Humans; Organoids; Transcriptome
Source: Web Of Science
Added: October 26, 2021

2021 journal article

Evaluation of UBE3A antibodies in mice and human cerebral organoids

SCIENTIFIC REPORTS, 11(1).

By: D. Sen n, Z. Drobna n & A. Keung n

MeSH headings : Angelman Syndrome / genetics; Angelman Syndrome / pathology; Animals; Antibodies / genetics; Antibodies / immunology; Autistic Disorder / genetics; Autistic Disorder / pathology; Cerebellum / cytology; Disease Models, Animal; Genomic Imprinting; Humans; Mice; Neural Stem Cells / metabolism; Neurons / metabolism; Neurons / pathology; Organoids / cytology; Pluripotent Stem Cells; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / immunology
Source: Web Of Science
Added: July 19, 2021

2021 journal article

Mapping the dynamic transfer functions of eukaryotic gene regulation

CELL SYSTEMS, 12(11), 1079-+.

By: J. Lee*, L. Caywood*, J. Lo, N. Levering & A. Keung*

MeSH headings : Chromatin / genetics; Eukaryota / genetics; Gene Expression Regulation / genetics; Promoter Regions, Genetic / genetics; Signal Transduction
Sources: Web Of Science, ORCID
Added: January 31, 2022

2021 journal article

Mapping the residue specificities of epigenome enzymes by yeast surface display

CELL CHEMICAL BIOLOGY, 28(12), 1772-+.

By: A. Waldman n, B. Rao n & A. Keung n

MeSH headings : E1A-Associated p300 Protein / genetics; E1A-Associated p300 Protein / metabolism; Epigenome / genetics; Humans; Saccharomyces cerevisiae / metabolism
Source: Web Of Science
Added: January 3, 2022

2021 journal article

Promiscuous molecules for smarter file operations in DNA-based data storage

NATURE COMMUNICATIONS, 12(1).

By: K. Tomek n, K. Volkel n, E. Indermaur n, J. Tuck n & A. Keung n

MeSH headings : Computer Simulation; DNA / chemistry; DNA Primers / chemistry; Databases, Nucleic Acid; High-Throughput Nucleotide Sequencing; Image Processing, Computer-Assisted / methods; Information Storage and Retrieval / methods; Real-Time Polymerase Chain Reaction / methods; Software; Temperature; Thermodynamics
Sources: Web Of Science, ORCID
Added: July 12, 2021

2021 article

Voices of biotech research

Annabi, N., Baker, M., Boettiger, A., Chakraborty, D., Chen, Y., Corbett, K. S., … Wang, J. (2021, March). NATURE BIOTECHNOLOGY, Vol. 39, pp. 281–286.

MeSH headings : Biomedical Research; Biotechnology; Humans; Research Personnel
Source: Web Of Science
Added: April 5, 2021

2020 review

Capturing complex epigenetic phenomena through human multicellular systems

[Review of ]. CURRENT OPINION IN BIOMEDICAL ENGINEERING, 16, 34–41.

By: D. Sen n & A. Keung n

author keywords: Epigenetics; Organoids; Development; Aging; 3D; Multicellular
Source: Web Of Science
Added: June 10, 2021

2020 journal article

Dynamic and scalable DNA-based information storage

NATURE COMMUNICATIONS, 11(1).

By: K. Lin n, K. Volkel n, J. Tuck n & A. Keung n

MeSH headings : Algorithms; Bacteriophage T7 / genetics; DNA / genetics; DNA, Single-Stranded / genetics; Gene Expression Regulation, Viral; Genetic Code; Models, Genetic; Promoter Regions, Genetic / genetics; Transcription, Genetic
Sources: Web Of Science, ORCID
Added: July 13, 2020

2020 journal article

Human Cerebral Organoids Reveal Early Spatiotemporal Dynamics and Pharmacological Responses of UBE3A

STEM CELL REPORTS, 15(4), 845–854.

By: D. Sen n, A. Voulgaropoulos n, Z. Drobna n & A. Keung n

MeSH headings : Angelman Syndrome / pathology; Cell Line; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Cerebrum / metabolism; Genomic Imprinting / drug effects; Humans; Neurons / drug effects; Neurons / metabolism; Organoids / drug effects; Organoids / metabolism; Time Factors; Topoisomerase Inhibitors / pharmacology; Ubiquitin-Protein Ligases / metabolism
Source: Web Of Science
Added: November 9, 2020

2019 journal article

Driving the Scalability of DNA-Based Information Storage Systems

ACS SYNTHETIC BIOLOGY, 8(6), 1241–1248.

By: K. Tomek n, K. Volkel n, A. Simpson n, A. Hass n, E. Indermaur n, J. Tuck n, A. Keung n

author keywords: synthetic biology; DNA storage; information storage; nested architecture; file access; DNA sequencing
MeSH headings : DNA / chemistry; DNA / genetics; Databases, Nucleic Acid; High-Throughput Nucleotide Sequencing; Information Storage and Retrieval / methods; Sequence Analysis, DNA / methods; Synthetic Biology / methods
Source: Web Of Science
Added: July 15, 2019

2019 journal article

Engineering Epigenetic Regulation Using Synthetic Read-Write Modules

CELL, 176(1-2), 227-+.

By: M. Park*, N. Patel*, A. Keung n & A. Khalil*

Source: Web Of Science
Added: January 28, 2019

2019 journal article

Modular one-pot assembly of CRISPR arrays enables library generation and reveals factors influencing crRNA biogenesis

NATURE COMMUNICATIONS, 10.

By: C. Liao n, F. Ttofali n, R. Slotkowski n, S. Denny n, T. Cecil n, R. Leenay n, A. Keung n, C. Beisel n

MeSH headings : Base Sequence; CRISPR-Associated Proteins / metabolism; Clustered Regularly Interspaced Short Palindromic Repeats / genetics; DNA / genetics; Endonucleases / metabolism; Gene Library; Genetic Techniques; HEK293 Cells; Humans; Nucleic Acid Conformation; Plasmids / metabolism; RNA / biosynthesis; RNA, Messenger / genetics; RNA, Messenger / metabolism; Saccharomyces cerevisiae / metabolism
Source: Web Of Science
Added: July 22, 2019

2016 article

A unifying model of epigenetic regulation

Keung, A. J., & Khalil, A. S. (2016, February 12). SCIENCE, Vol. 351, pp. 661–662.

By: A. Keung n & A. Khalil*

MeSH headings : Animals; Chromatin / metabolism; DNA Methylation; Gene Silencing; Histones / metabolism; Humans
Source: Web Of Science
Added: August 6, 2018

2016 review

The epigenome: the next substrate for engineering

[Review of ]. GENOME BIOLOGY, 17.

By: M. Park*, A. Keung n & A. Khalil*

MeSH headings : Chromatin / genetics; Epigenesis, Genetic; Epigenomics; Genome, Human; Humans
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Chromatin regulation at the frontier of synthetic biology

Nature Reviews Genetics, 16(3), 159–171.

MeSH headings : Animals; Cell Engineering / methods; Chromatin / chemistry; Chromatin / metabolism; Epigenesis, Genetic; Genome; Histones / chemistry; Histones / metabolism; Humans; Plants / genetics; Plants / metabolism; RNA, Untranslated / chemistry; RNA, Untranslated / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Synthetic Biology; Systems Biology
Source: Crossref
Added: February 24, 2020

2014 journal article

Using Targeted Chromatin Regulators to Engineer Combinatorial and Spatial Transcriptional Regulation

Cell, 158(1), 110–120.

MeSH headings : Chromatin / metabolism; Gene Expression Regulation, Fungal; Gene Regulatory Networks; Genes, Reporter; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / chemistry; Saccharomyces cerevisiae Proteins / metabolism; Transcription, Genetic
Source: Crossref
Added: August 28, 2020

2013 journal article

Pan-neuronal maturation but not neuronal subtype differentiation of adult neural stem cells is mechanosensitive

Scientific Reports, 3(1).

By: A. Keung*, M. Dong*, D. Schaffer* & S. Kumar*

MeSH headings : Adult Stem Cells / cytology; Adult Stem Cells / metabolism; Animals; Brain / metabolism; Cell Differentiation / physiology; Cell Lineage; Cellular Microenvironment / physiology; Female; Gene Expression; Gene Expression Regulation, Developmental; Neural Stem Cells / cytology; Neural Stem Cells / metabolism; Neurons / classification; Neurons / cytology; Neurons / metabolism; Rats; Time Factors; Tubulin / genetics
Source: Crossref
Added: August 28, 2020

2012 journal article

A Genetic Strategy for the Dynamic and Graded Control of Cell Mechanics, Motility, and Matrix Remodeling

Biophysical Journal, 102(3), 434–442.

By: J. MacKay*, A. Keung* & S. Kumar*

MeSH headings : Biomechanical Phenomena; Cell Line; Cell Movement / drug effects; Cell Movement / genetics; Collagen / metabolism; Extracellular Matrix / drug effects; Extracellular Matrix / genetics; Extracellular Matrix / metabolism; Gene Expression Regulation / drug effects; Gene Expression Regulation / genetics; Genetic Engineering / methods; Humans; Mechanical Phenomena; Mechanotransduction, Cellular / drug effects; Mechanotransduction, Cellular / genetics; Mutation; Promoter Regions, Genetic / genetics; Tetracycline / pharmacology
Source: Crossref
Added: August 28, 2020

2012 journal article

Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells

Integrative Biology, 4(9), 1049–1058.

MeSH headings : Cell Culture Techniques / methods; Cell Differentiation / physiology; Dopaminergic Neurons / cytology; Extracellular Matrix / physiology; Flow Cytometry; Humans; Microscopy, Atomic Force; Microscopy, Phase-Contrast; Neurogenesis / physiology; Pluripotent Stem Cells / cytology; Stress, Mechanical
Source: Crossref
Added: August 28, 2020

2011 journal article

An Evolved Adeno-associated Viral Variant Enhances Gene Delivery and Gene Targeting in Neural Stem Cells

Molecular Therapy, 19(4), 667–675.

By: J. Jang*, J. Koerber*, J. Kim*, P. Asuri*, T. Vazin*, M. Bartel*, A. Keung*, I. Kwon*, K. Park*, D. Schaffer*

MeSH headings : Animals; Cells, Cultured; Chromatography; Dependovirus / genetics; Female; Fluorescent Antibody Technique; Gene Transfer Techniques; Neural Stem Cells / virology; Polymerase Chain Reaction; Rats; Rats, Inbred F344
Source: Crossref
Added: August 28, 2020

2011 journal article

Rho GTPases Mediate the Mechanosensitive Lineage Commitment of Neural Stem Cells

STEM CELLS, 29(11), 1886–1897.

By: A. Keung*, E. de Juan-Pardo*, D. Schaffer* & S. Kumar*

author keywords: Neural stem cells; Cellular mechanotransduction; Rho GTP-binding proteins; Adipose stem cells; Extracellular matrix; Elastic modulus
MeSH headings : Animals; Apoptosis / genetics; Apoptosis / physiology; Cell Differentiation / genetics; Cell Differentiation / physiology; Cell Proliferation; Cells, Cultured; Extracellular Matrix / metabolism; Female; Fluorescent Antibody Technique; Mechanotransduction, Cellular / genetics; Mechanotransduction, Cellular / physiology; Microscopy, Atomic Force; Neural Stem Cells / cytology; Neural Stem Cells / metabolism; Neurogenesis / genetics; Neurogenesis / physiology; Rats; Rats, Inbred F344; cdc42 GTP-Binding Protein / genetics; cdc42 GTP-Binding Protein / metabolism; rho GTP-Binding Proteins / genetics; rho GTP-Binding Proteins / metabolism; rhoA GTP-Binding Protein / genetics; rhoA GTP-Binding Protein / metabolism
Source: Crossref
Added: August 28, 2020

2010 journal article

A Genetic Strategy for Graded and Dynamic Control of Cell-Matrix Mechanobiology

Biophysical Journal, 98(3), 730a.

By: J. MacKay*, A. Keung* & S. Kumar*

Source: Crossref
Added: August 28, 2020

2010 journal article

Biophysics and dynamics of natural and engineered stem cell microenvironments

Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2(1), 49–64.

MeSH headings : Adult; Animals; Biomechanical Phenomena / physiology; Biophysics / methods; Biophysics / trends; Cell Culture Techniques / methods; Environment; Humans; Kinetics; Models, Biological; Stem Cells / cytology; Stem Cells / metabolism; Stem Cells / physiology; Tissue Engineering / methods
Source: Crossref
Added: August 28, 2020

2010 journal article

Mechanotransductive Engineering of Neural Stem Cell Behavior

Biophysical Journal, 98(3), 404a–405a.

By: A. Keung*, E. de Juan-Pardo*, D. Schaffer* & S. Kumar*

Source: Crossref
Added: August 28, 2020

2007 journal article

Thermal Control of Amide Product Distributions at the Ge(100)-2×1 Surface

The Journal of Physical Chemistry C, 111(1), 411–419.

By: A. Keung*, M. Filler* & S. Bent*

Source: Crossref
Added: August 28, 2020

2006 journal article

Carboxylic Acid Chemistry at the Ge(100)-2 × 1 Interface:  Bidentate Bridging Structure Formation on a Semiconductor Surface

Journal of the American Chemical Society, 128(3), 770–779.

Source: Crossref
Added: August 28, 2020

2005 journal article

Tertiary amide chemistry at the Ge(100)-2×1 surface

Surface Science, 599(1-3), 41–54.

author keywords: density functional calculations; vibrational spectroscopies; germanium; organic molecules; organo-functionalization of surfaces; desorption; amide; Ge(100)
Source: Crossref
Added: August 28, 2020