Antonio Planchart
Also known as: Tony Planchart
Works (34)
Updated: April 8th, 2024 04:56
2024 journal article
Association between F2-isoprostanes and self-reported stressors in pregnant americans of African and European ancestry
HELIYON, 10(3).
author keywords: F2-isoprostane; Psychosocial stress; Pregnant; Depression; Anxiety
www.cell.com (publisher PDF)
Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024
2023 journal article
CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental health
TOXICOLOGICAL SCIENCES, 195(2), 155–168.
author keywords: database tool; chemical-disease pathway; molecular mechanisms; environmental health; knowledge gaps; adverse outcome pathway
Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024
2023 journal article
Developmental cadmium exposure disrupts zebrafish vestibular calcium channels interfering with otolith formation and inner ear function
NEUROTOXICOLOGY, 96, 129–139.
author keywords: Cadmium; Developmental toxicology; Behavior; Vestibular system; P2X receptor; Zebrafish
MeSH headings : Animals; Zebrafish; Cadmium / toxicity; Otolithic Membrane; Vestibule, Labyrinth; Vestibular Diseases
TL;DR:
Cadmium-induced ototoxicity is linked to vestibular-based behavioral abnormalities and auditory sensitivity following developmental exposure, and calcium ion channel function is associated with these defects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 12, 2023
2023 article
The Effects of Long-term, Low-dose & beta;-N-methylamino-l-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish
Weeks, R. D., Banack, S. A., Howell, S., Thunga, P., Green, A. J., Cox, P. A., … Metcalf, J. S. (2023, August 8). The Effects of Long-term, Low-dose & beta;-N-methylamino-l-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish. NEUROTOXICITY RESEARCH, Vol. 8.
author keywords: L-BMAA; D-BMAA; AEG; DAB; ALS; Zebrafish; Neurotoxicity; Neurodegeneration; SOD1
TL;DR:
While the results revealed low concentrations of BMAA in the brains of exposed fish, there was no evidence of decreased swim performance or behavioral differences that might be reflective of neurodegenerative disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023
2023 article
The Effects of Long-term, Low-dose beta-N-methylamino-L-alanine (BMAA) Exposures in Adult SODG93R (Aug, 10.1007/s12640-023-00658-z, 2023)
Weeks, R. D., Banack, S. A., Howell, S., Thunga, P., Metcalf, J. S., Green, A. J., … Planchart, A. (2023, August 24). NEUROTOXICITY RESEARCH, Vol. 8.
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023
2022 article
Genomic map of candidate human imprint control regions: the imprintome
Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). EPIGENETICS, Vol. 6.
author keywords: Epigenetics; genomic imprinting; foetal origins; whole genome; methylation; imprint control regions
MeSH headings : Adult; Humans; Genomic Imprinting; DNA Methylation; Chromosome Mapping; Alleles; Genomics
TL;DR:
This draft of the human imprintome will allow for the systematic determination of the role of early-acquired imprinting dysregulation in the pathogenesis of human diseases and developmental and behavioural disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 11, 2022
2022 journal article
Implementation of Zebrafish Ontologies for Toxicology Screening
Frontiers in Toxicology.
TL;DR:
It is concluded that utilizing a common data standard will not only reduce the heterogeneity of reported terms but increases agreement and repeatability between different laboratories, and advocate for the development of a zebrafish phenotype atlas to help laboratories create interoperable, computable data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: February 16, 2022
2019 journal article
Cadmium exposure and MEG3 methylation differences between Whites and African Americans in the NEST Cohort
Environmental Epigenetics, 5(3).
Contributors: J. House n , J. Hall n, S. Park n, n , E. Money n , R. Maguire n, Z. Huang *, C. Mattingly n
Ed(s): M. Skinner
author keywords: maternal exposures; imprinted genes; offspring epigenetics; cadmium; CpG methylation; racial epigenetic outcome differences
TL;DR:
Data support that prenatal Cd exposure is associated with aberrant methylation of the imprint regulatory element for the MEG3 gene cluster at birth, and neither house-dust nor water are likely exposure sources, and ingestion via contaminated hands is also unlikely to be a significant exposure route in this population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 6, 2019
2019 journal article
Characterizing sources of variability in zebrafish embryo screening protocols
ALTEX, 36(1), 103–120.
MeSH headings : Animals; Chorion / metabolism; Drug Evaluation, Preclinical / methods; Embryo, Nonmammalian; Embryonic Development / drug effects; High-Throughput Screening Assays; Toxicity Tests / methods; Zebrafish / embryology
TL;DR:
Initial SEAZIT information-gathering efforts revealed substantial variability across design parameters, data collected, and analysis procedures, which provides a basis for future SEAZit activities to promote more consistent practices among researchers using zebrafish embryos for toxicity evaluation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: January 21, 2019
2019 journal article
Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways
Computational Toxicology, 12, 100094.
Contributors: M. Kosnik n, n , S. Marvel n, D. Reif n & C. Mattingly n
Sources: ORCID, Crossref, NC State University Libraries
Added: August 30, 2019
2018 journal article
Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study
International Journal of Obesity, 42(7), 1285–1295.
Contributors: A. Green n, C. Hoyo n, C. Mattingly n , Y. Luo n, J. Tzeng n, S. Murphy *, D. Buchwalter n, n
MeSH headings : Adipogenesis / drug effects; Animals; Cadmium / adverse effects; Cadmium / analysis; Cadmium / blood; Disease Models, Animal; Environmental Exposure / adverse effects; Environmental Exposure / analysis; Female; Humans; Infant, Newborn; Male; Maternal Exposure / adverse effects; Metals, Heavy / adverse effects; Metals, Heavy / analysis; Pediatric Obesity / blood; Pediatric Obesity / chemically induced; Pediatric Obesity / epidemiology; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects / blood; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / epidemiology; Prospective Studies; Socioeconomic Factors; United States / epidemiology; Zebrafish / metabolism
TL;DR:
The findings identify Cd as a potential human obesogen, suggesting that the underlying mechanisms may be evolutionarily conserved, and that zebrafish may be a valuable model for uncovering pathways leading to Cd-mediated obesity in human populations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 7, 2019
2018 journal article
Heavy Metal Exposure and Metabolic Syndrome: Evidence from Human and Model System Studies
Current Environmental Health Reports, 5(1), 110–124.
author keywords: Metabolic syndrome; Diabetes; Heavy metals; Cadmium; Pb; Mercury
MeSH headings : Animals; Cadmium / adverse effects; Disease Models, Animal; Humans; Lead / adverse effects; Mercury / adverse effects; Metabolic Syndrome / chemically induced; Metals, Heavy / adverse effects
TL;DR:
Assessment of potential causal links between heavy metal exposure and metabolic syndrome remains challenging as epidemiological data are largely cross-sectional; and variation in study design, including samples used for heavy metal measurements, age of subjects at which MS outcomes are measured, and the population demographics vary widely.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 7, 2019
2018 journal article
The neurological toxicity of heavy metals: A fish perspective
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 208, 12–19.
Contributors: A. Green n & n
MeSH headings : Animals; Animals, Genetically Modified; Behavior, Animal / drug effects; Disease Models, Animal; Gene Expression Regulation, Developmental / drug effects; Heavy Metal Poisoning, Nervous System / etiology; Heavy Metal Poisoning, Nervous System / genetics; Heavy Metal Poisoning, Nervous System / metabolism; Heavy Metal Poisoning, Nervous System / pathology; Humans; Metals, Heavy / toxicity; Nerve Degeneration; Nervous System / drug effects; Nervous System / metabolism; Nervous System / pathology; Nervous System / physiopathology; Neurons / drug effects; Neurons / metabolism; Neurons / pathology; Risk Assessment; Water Pollutants, Chemical / toxicity; Zebrafish / genetics; Zebrafish / metabolism
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2017 content posted
Cadmium Disrupts Vestibular Function by Interfering with Otolith Formation
TL;DR:
It is demonstrated that the addition of calcium rescues otolith malformation and reduces circling behavior but has no ameliorating effect on hyperactivity, suggesting that hyperactivity and balance disorders in human populations exposed to Cd are manifestations of separate underlying molecular pathways.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: March 16, 2021
2016 journal article
Advancing toxicology research using in vivo high throughput toxicology with small fish models
ALTEX, 33(4), 435–452.
Contributors: n , C. Mattingly n , D. Allen *, P. Ceger *, W. Casey *, D. Hinton *, J. Kanungo *, S. Kullman n
author keywords: aquatic models; 21st century toxicology; alternatives
TL;DR:
The recommendations formulated by workshop participants to enhance the utility of small fish species in toxicology studies are summarized, as well as many of the advances in the field of toxicology that resulted from usingSmall freshwater fish species, including advances in developmental toxicology, cardiovascular toxicologists, neurotoxicology, and immunotoxicology are reviewed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2016 journal article
From the Cover: Embryonic Exposure to TCDD Impacts Osteogenesis of the Axial Skeleton in Japanese medaka,Oryzias latipes
Toxicological Sciences, 155(2), 485–496.
Contributors: A. Watson, n , C. Mattingly n , C. Winkler *, D. Reif n & S. Kullman n
author keywords: receptor, aryl hydrocarbon; gene expression/regulation, bone; transgenic models; methods, developmental/teratology; reproductive and developmental toxicology
MeSH headings : Animals; Calcification, Physiologic / drug effects; Down-Regulation / drug effects; Microscopy, Confocal; Musculoskeletal Diseases / metabolism; Oryzias / embryology; Osteogenesis / drug effects; Polychlorinated Dibenzodioxins / toxicity; Real-Time Polymerase Chain Reaction; Skeleton / drug effects; Skeleton / metabolism; Trans-Activators / drug effects
TL;DR:
It is suggested that TCDD exposure inhibits axial bone formation through dysregulation of osteoblast differentiation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2016 journal article
Impact of Low Dose Oral Exposure to Bisphenol A (BPA) on the Neonatal Rat Hypothalamic and Hippocampal Transcriptome: A CLARITY-BPA Consortium Study
Endocrinology, 157(10), 3856–3872.
Contributors: S. Arambula n, S. Belcher n , n , S. Turner * & H. Patisaul n
MeSH headings : Administration, Oral; Animals; Animals, Newborn; Benzhydryl Compounds / administration & dosage; Benzhydryl Compounds / toxicity; Estrogens, Non-Steroidal / administration & dosage; Estrogens, Non-Steroidal / toxicity; Female; Gene Expression / drug effects; Hippocampus / drug effects; Hippocampus / metabolism; Hypothalamus / drug effects; Hypothalamus / metabolism; Male; Phenols / administration & dosage; Phenols / toxicity; Random Allocation; Rats; Rats, Sprague-Dawley; Sex Characteristics; Transcriptome / drug effects
TL;DR:
Preliminary data demonstrate prenatal BPA exposure, even at doses below the current no-observed-adverse-effect level, can alter gene expression in the developing brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2015 journal article
Machine learning reveals sex-specific 17β-estradiol-responsive expression patterns in white perch (Morone americana ) plasma proteins
PROTEOMICS, 15(15), 2678–2690.
Contributors: J. Schilling n, A. Nepomuceno n, n , J. Yoder n , R. Kelly n , D. Muddiman n , H. Daniels n, N. Hiramatsu*, B. Reading n
author keywords: Animal proteomics; Endocrine disrupting compounds; Machine learning; Plasma; Semiquantitative proteomics; Support vector machines
MeSH headings : Animals; Bass / metabolism; Blood Proteins / metabolism; Blotting, Western; Chromatography, Liquid; Estradiol / pharmacology; Estrogens / pharmacology; Female; Fish Proteins / metabolism; Kininogens / metabolism; Male; Nanotechnology / methods; Proteome / drug effects; Proteome / metabolism; Proteomics / methods; Sex Factors; Support Vector Machine; Tandem Mass Spectrometry; Vitellogenins / metabolism
TL;DR:
This is the first report that Eltd1 and Kng1 may be E2‐responsive proteins in fishes and therefore may be useful indicators of estrogen induction in fishes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2014 journal article
Zebrafish: A Marvel of High-Throughput Biology for 21st Century Toxicology
Current Environmental Health Reports, 1(4), 341–352.
TL;DR:
Advances in automation, high-throughput screening, and analysis that leverage the power of the zebrafish embryo model for unparalleled advances in the authors' understanding of how chemicals in their environment affect their health and wellbeing are highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2013 journal article
Analysis of an intronic promoter within Synj2
Biochemical and Biophysical Research Communications, 440(4), 640–645.
author keywords: Synaptojanin; Inositol polyphosphate phosphatase; Spermatogenesis; Non-canonical promoter; Mouse
MeSH headings : 5' Untranslated Regions; Animals; Introns; Male; Mice; Mice, Inbred BALB C; Nerve Tissue Proteins / genetics; Phosphoric Monoester Hydrolases / genetics; Promoter Regions, Genetic; Spermatogenesis / genetics; Transcription, Genetic
TL;DR:
A novel subset of transcripts appears to derive from a region located within intron 7 of Synj2 that manifest developmental stage specificity and somatic versus gametic differences in expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2012 journal article
Aquatic models, genomics and chemical risk management
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 155(1), 169–173.
Contributors: K. Cheng *, D. Hinton*, C. Mattingly* & *
author keywords: Aquatic toxicology; Phenome project; Zebrafish; Genomics; Atlas
MeSH headings : Animals; Computational Biology / methods; Databases, Factual; Ecotoxicology; Environmental Exposure / analysis; Environmental Monitoring / methods; Fishes / anatomy & histology; Fishes / genetics; Fishes / physiology; Gene-Environment Interaction; Genomics / methods; Internet; Models, Animal; Risk Factors; User-Computer Interface
TL;DR:
It is concluded that automation, database generation, and web-based accessibility, facilitated by genomic/transcriptomic data and high-performance and cloud computing, will potentiate the unique and potentially key roles that aquatic models play in advancing systems biology, drug development, and environmental risk management.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: August 7, 2019
2010 journal article
2,3,7,8-Tetrachlorodibenzo-p-dioxin Upregulates FoxQ1b in Zebrafish Jaw Primordium
Chemical Research in Toxicology, 23(3), 480–487.
Contributors: * & C. Mattingly*
MeSH headings : Animals; Embryo, Nonmammalian / metabolism; Enhancer Elements, Genetic; Environmental Pollutants / pharmacology; Forkhead Transcription Factors / genetics; Gene Expression Regulation, Developmental / drug effects; Jaw / metabolism; Jaw / pathology; Jaw Abnormalities / chemically induced; Polychlorinated Dibenzodioxins / pharmacology; Receptors, Aryl Hydrocarbon / metabolism; Up-Regulation / drug effects; Zebrafish / genetics; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
FoxQ1b is specifically expressed in the jaw primordium where it discretely outlines a developing jaw structure known as Meckel's cartilage--a conserved structure in all jawed vertebrates that develops abnormally in the presence of TCDD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: August 10, 2019
2009 journal article
Oral-aboral axis specification in the sea urchin embryo. III. Role of mitochondrial redox signaling via H<inf>2</inf>O<inf>2</inf>
Developmental Biology, 330(1), 123–130.
Contributors: J. Coffman*, A. Coluccio*, * & A. Robertson *
author keywords: Axis specification; Nodal; Redox; ROS; Hydrogen peroxide; Mitochondria
MeSH headings : Animals; Body Patterning / genetics; Body Patterning / physiology; Catalase / metabolism; Embryo, Nonmammalian / metabolism; Female; Hydrogen Peroxide / metabolism; Mitochondria / metabolism; Mouth / embryology; Mouth / metabolism; Nodal Protein / genetics; Nodal Protein / metabolism; Reactive Oxygen Species / metabolism; Signal Transduction; Strongylocentrotus purpuratus / embryology; Strongylocentrotus purpuratus / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
It is shown that the spatial pattern of nodal activity also correlates with the mitochondrial gradient, and that the latter correlates with inhomogeneous levels of intracellular reactive oxygen species, and it is concluded that mitochondrial H(2)O(2), which functions as a redox signal to activate nodal, is rate-limiting for the initial activation of nodsal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: March 16, 2021
2009 journal article
Perturbation of Defense Pathways by Low-Dose Arsenic Exposure in Zebrafish Embryos
Environmental Health Perspectives, 117(6), 981–987.
Contributors: C. Mattingly* , T. Hampton, K. Brothers, N. Griffin & *
author keywords: arsenic; Comparative Toxicogenomics Database; embryonic development; gene regulatory networks; immunity; microarray; toxicogenomics; transcriptional profiling; zebrafish
MeSH headings : Animals; Arsenic / toxicity; Embryo, Nonmammalian; Gene Expression / drug effects; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Water Pollutants, Chemical / toxicity; Zebrafish / metabolism
TL;DR:
It is demonstrated that arsenic significantly down-regulates expression levels of multiple genes potentially critical for regulating the establishment of an immune response, and provides molecular evidence consistent with phenotypic observations reported in other model systems.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: August 10, 2019
2007 journal article
Degradation of the encephalomyocarditis virus and hepatitis A virus 3C proteases by the ubiquitin/26S proteasome system in vivo
Virology, 360(2), 350–363.
Contributors: P. Schlax*, J. Zhang *, E. Lewis*, * & T. Lawson*
author keywords: 3C protease; encephalornyocarditis; hepatitis A; picornavirus; proteasome; proteolysis; ubiquitin
MeSH headings : 3C Viral Proteases; Animals; Cell Line; Cell Nucleus / chemistry; Cell Survival; Cysteine Endopeptidases / biosynthesis; Cysteine Endopeptidases / genetics; Cysteine Endopeptidases / metabolism; Cytoplasm / chemistry; Encephalomyocarditis virus / enzymology; Fibroblasts / virology; Hepatitis A virus / enzymology; Humans; Mice; Proteasome Endopeptidase Complex / metabolism; Protein Processing, Post-Translational; Ubiquitin / metabolism; Viral Proteins / biosynthesis; Viral Proteins / genetics; Viral Proteins / metabolism
TL;DR:
The absence of polyubiquitinated EMCV 3C protease conjugates in nuclear fraction preparations suggests that localization to the nucleus can protect this protein from ubiquitination.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2005 journal article
Mutations in Serac1 or Synj2 cause proximal t haplotype-mediated male mouse sterility but not transmission ratio distortion
Proceedings of the National Academy of Sciences, 102(9), 3342–3347.
Contributors: J. Schimenti *, J. Reynolds * & *
MeSH headings : Animals; Base Sequence; Chromosomes, Artificial, Bacterial; DNA; Haplotypes; Infertility, Male / genetics; Male; Mice; Molecular Sequence Data; Mutation; Nerve Tissue Proteins / genetics; Phosphoric Monoester Hydrolases / genetics; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
Results uncouple the proximal t haplotype sterility locus, S1, from TRD, demonstrating that S1 and the proximate distorter loci, D1, are not the same gene.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2003 journal article
MGD: the Mouse Genome Database
Nucleic Acids Research, 31(1), 193–195.
Contributors: J. Blake *, J. Richardson*, C. Bult *, J. Kadin*, J. Eppig*, R. Baldarelli, J. Beal, D. Bradt
MeSH headings : Alleles; Animals; Chromosome Mapping; Databases, Genetic; Genome; Genotype; Internet; Mice / genetics; Mice, Mutant Strains; Phenotype; Terminology as Topic
TL;DR:
The Mouse Genome Database strives to provide an extensively integrated information resource with experimental details annotated from both literature and on-line genomic data sources to curate a definitive set of information about the laboratory mouse.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: March 16, 2021
2002 journal article
The Mouse Genome Database (MGD): the model organism database for the laboratory mouse
Nucleic Acids Research, 30(1), 113–115.
Contributors: J. Blake*, J. Richardson*, C. Bult *, J. Kadin*, J. Eppig*, R. Baldarelli, M. Baya, J. Beal
MeSH headings : Alleles; Animals; Chromosome Mapping; Data Collection; Database Management Systems; Databases, Genetic; Genome; Genotype; Humans; Information Storage and Retrieval; Internet; Mice / genetics; Mutation; Phenotype; Radiation Hybrid Mapping; Rats; Sequence Homology; User-Computer Interface; Vocabulary, Controlled
TL;DR:
Recent integration of large datasets of mouse full-length cDNAs and radiation-hybrid mapped ESTs, the continued development and use of extensive structured vocabularies and the expansion of the representation of phenotypes highlight this year's developments.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: March 16, 2021
2001 journal article
Experimental and computational approaches yield a high-resolution, 1-Mb physical map of the region harboring the mouse t haplotype sterility factor, tcs1
Mammalian Genome, 12(8), 668–670.
Contributors: * & J. Schimenti *
MeSH headings : Animals; Chromosomes / genetics; Chromosomes, Artificial, Bacterial; Computational Biology / methods; Contig Mapping; DNA-Binding Proteins; Databases, Nucleic Acid; Genome; Haplotypes / genetics; Mice / genetics; Physical Chromosome Mapping / methods; Software; Telomerase / genetics
TL;DR:
The loci responsible for the phenomena of t haplotype-specific male sterility and high transmission ratio distortion (TRD) map to the inversions that characterize the mouse t complex of Chromosome (Chr) 17, with results suggesting that during spermatogenesis in a t/+ mouse, the mutant TCD/TCS factors negatively affect the wild-type TCR1, thus inactivating wild- type sperm.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: March 16, 2021
2001 journal article
Mutations of the Mouse Twist and sy (Fibrillin 2) Genes Induced by Chemical Mutagenesis of ES Cells
Genomics, 73(3), 291–298.
Contributors: V. Browning*, S. Chaudhry*, * , M. Dixon * & J. Schimenti *
MeSH headings : Alleles; Amino Acid Sequence; Animals; Base Sequence; DNA Mutational Analysis; Ethyl Methanesulfonate / pharmacology; Exons / genetics; Fibrillin-2; Fibrillins; Genes, Lethal / genetics; Genetic Complementation Test; Genotype; Long Interspersed Nucleotide Elements / genetics; Mice; Microfilament Proteins / genetics; Molecular Sequence Data; Mutagenesis / drug effects; Mutagenesis / genetics; Mutation / drug effects; Mutation / genetics; Nuclear Proteins / chemistry; Nuclear Proteins / genetics; Phenotype; Physical Chromosome Mapping; Polydactyly / genetics; Sequence Alignment; Sequence Deletion / genetics; Stem Cells / drug effects; Stem Cells / metabolism; Syndactyly / genetics; Transcription Factors; Twist-Related Protein 1
TL;DR:
Sne is a new fused phalanges (fp) allele of the shaker-with-syndactylism deletion complex (sy), and it is shown that the genomic lesion is a small deletion removing an entire exon, coincident with the insertion of the 3' end of a LINE element belonging to the TF subfamily.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: March 16, 2021
2000 journal article
Physical mapping of male fertility and meiotic drive quantitative trait loci in the mouse t complex using chromosome deficiencies
Genetics, 155(2), 803–812. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034084813&partnerID=MN8TOARS
Source: ORCID
Added: March 16, 2021
1998 journal article
Caspar Carboxylates: The Structural Basis of Tobamovirus Disassembly
Biophysical Journal, 74(1), 633–638.
Contributors: H. Wang *, * & G. Stubbs*
MeSH headings : Binding Sites; Capsid / chemistry; Carboxylic Acids; Macromolecular Substances; Models, Molecular; Protein Structure, Secondary; Static Electricity; Tobacco Mosaic Virus / physiology; Tobacco Mosaic Virus / ultrastructure; Tobamovirus / physiology; Tobamovirus / ultrastructure; Virus Assembly
TL;DR:
Comparison of the stabilities of the various mutant viruses shows that disassembly is driven by a much more complex set of carboxylate interactions than had previously been postulated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: March 16, 2021
1993 journal article
Preliminary X-ray Diffraction Studies of Ribgrass Mosaic Virus
Journal of Molecular Biology, 234(3), 902–904.
Contributors: H. Wang *, * , D. Allen*, R. Pattanayek* & G. Stubbs*
author keywords: VIRUS; RIBGRASS MOSAIC VIRUS; TOBACCO MOSAIC VIRUS; FIBER DIFFRACTION; CARBOXYL-CARBOXYLATE PAIRS
MeSH headings : Amino Acid Sequence; Binding Sites; Capsid / chemistry; Lead / metabolism; Macromolecular Substances; Models, Structural; Mosaic Viruses / chemistry; Mosaic Viruses / ultrastructure; Poaceae; Protein Conformation; X-Ray Diffraction / methods
TL;DR:
Two intersubunit carboxyl-carboxylate pairs, different from those in other tobamoviruses, are predicted to control viral assembly and disassembly in ribgrass mosaic virus.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: March 16, 2021
journal article
Characterization of a Novel DNA Motif in the Tctex1 and TCP10 Gene Complexes and its Prevalence in the Mouse Genome.
Advances in Biological Research (Rennes).
Source: ORCID
Added: March 16, 2021
Employment
Updated: November 14th, 2018 16:15
2018 - present
North Carolina State University Raleigh, NC, US
Associate Professor
Biological Sciences
2012 - 2018
North Carolina State University Raleigh, NC, US
Assistant Professor
Biological Sciences
2005 - 2011
Mount Desert Island Biological Laboratory Salsbury Cove, ME, US
Investigator
Education
Updated: December 1st, 2016 13:16
1989 - 1995
Vanderbilt University Nashville, TN, US
PhD
Molecular Biology
1987 - 1989
Texas A&M University Corpus Christi Corpus Christi, TX, US
BSc
Biology
Funding History
Funding history based on the linked ORCID record. Updated: November 14th, 2018 16:01
award
July 1, 2017 - June 1, 2018
Elucidating the Connection Between Cadmium Mediated Hyperactivity and Down regulation of the E3 Ubiquitin Ligase, RNF2
National Institute of Environmental Health Sciences
award
December 1, 2016 - November 1, 2017
Investigating the Interplay between Genetic and Environmental Mechanisms Underlying Amyotrophic Lateral Sclerosis Etiology
National Institute of Environmental Health Sciences
grant
March 25, 2014 - January 1, 2016
ZRC-NCSU: A Zebrafish Research Core at NCSU to Advance Basic, Environmental and Biomedical Research
North Carolina Biotechnology Center
grant
January 1, 2010 - December 31, 2011
The role of FOXQ1 in TCDD-induced jaw malformations
National Institute of Environmental Health Sciences
grant
August 1, 2007 - July 31, 2009
MRI: Acquisition of a Phosphorimager for Research in Marine Functional Genomics
Directorate for Biological Sciences
grant
July 15, 2003 - June 30, 2006
Acquisition of a Multifunctional Imaging System for Research and Teaching in an Undergraduate Environment
Directorate for Biological Sciences
grant
February 1, 1999 - January 1, 2000
FUNCTIONAL ANALYSIS OF THE T COMPLEX
National Institute of Child Health and Human Development
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