Works (6)
Updated: July 5th, 2023 15:52
2012 journal article
Hydrogen Peroxide Induced Activation of Gene Expression in Mammalian Cells using Boronate Estrone Derivatives
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(36), 9066–9070.
author keywords: biosensors; estrogen receptor; estrone; gene expression; hydrogen peroxide
TL;DR:
Keeping the boron out of the ER: A genetic switch was engineered that activates gene expression in the presence of H(2)O(2).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Heterotaxin: A TGF-beta Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus Embryos
CHEMISTRY & BIOLOGY, 18(2), 252–263.
MeSH headings : Animals; Cell Line; Drug Evaluation, Preclinical; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Humans; Intracellular Space / drug effects; Intracellular Space / metabolism; Neovascularization, Physiologic / drug effects; Phenotype; Pyridines / chemistry; Pyridines / pharmacology; Signal Transduction / drug effects; Stereoisomerism; Structure-Activity Relationship; Transforming Growth Factor beta / metabolism; Xenopus laevis
TL;DR:
A small molecule screen for left-right asymmetry phenotypes in Xenopus embryos is performed and a pyridine analog, heterotaxin, is discovered, which disrupts both cardiovascular and digestive organ laterality and inhibits TGF-β-dependent left- right asymmetric gene expression.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Stabilization and Photochemical Regulation of Antisense Agents through PEGylation
BIOCONJUGATE CHEMISTRY, 22(10), 2136–2142.
MeSH headings : Animals; DNA, Antisense / chemical synthesis; DNA, Antisense / chemistry; DNA, Antisense / genetics; DNA, Antisense / metabolism; Gene Expression Regulation; HEK293 Cells; Humans; Luminescent Proteins / genetics; Mice; NIH 3T3 Cells; Nucleic Acid Denaturation; Photolysis; Polyethylene Glycols / chemistry; Ribonuclease H / metabolism; Ultraviolet Rays
TL;DR:
By employing a photocleavable linker between the PEG group and the antisense agent, the paper was able to achieve light-induced deactivation of antisense activity and pave the way for precise regulation of gene expression in biological systems.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Photocleavable Polyethylene Glycol for the Light-Regulation of Protein Function
BIOCONJUGATE CHEMISTRY, 21(8), 1404–1407.
MeSH headings : Crystallography, X-Ray; Models, Molecular; Molecular Structure; Muramidase / chemistry; Muramidase / metabolism; Photochemical Processes; Polyethylene Glycols / chemical synthesis; Polyethylene Glycols / chemistry; Stereoisomerism; Ultraviolet Rays
TL;DR:
The synthesis of a photocleavable PEG reagent (PhotoPEG) and its application to the light-regulation of enzyme activity is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Tricyclic Alkaloid Core Structures Assembled by a Cyclotrimerization-Coupled Intramolecular Nucleophilic Substitution Reaction
ORGANIC LETTERS, 12(6), 1288–1291.
MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Cyclization; Microwaves; Molecular Structure; Pyridines / chemistry; Stereoisomerism
TL;DR:
A facile approach to tricyclic alkaloid core structures was developed by sequencing a pyridine-forming [2 + 2 + 2] cyclotrimerization reaction with an intramolecular nucleophilic substitution.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
A general approach to triphenylenes and azatriphenylenes: total synthesis of dehydrotylophorine and tylophorine
CHEMICAL COMMUNICATIONS, (39), 4750–4752.
MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Alkaloids / radiation effects; Aza Compounds / chemical synthesis; Aza Compounds / chemistry; Aza Compounds / radiation effects; Chrysenes / chemical synthesis; Chrysenes / chemistry; Chrysenes / radiation effects; Cyclization; Indolizines / chemical synthesis; Indolizines / chemistry; Indolizines / radiation effects; Microwaves; Molecular Structure; Phenanthrenes / chemical synthesis; Phenanthrenes / chemistry; Phenanthrenes / radiation effects; Stereoisomerism
TL;DR:
A convergent and flexible synthesis of substituted triphenylenes, azatriphenylene, and the cytotoxic alkaloids dehydrotylophorine and tylophOrine has been developed.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
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