Andrew L. McIver

Works (6)

Updated: July 5th, 2023 15:52

2012 journal article

Hydrogen Peroxide Induced Activation of Gene Expression in Mammalian Cells using Boronate Estrone Derivatives

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(36), 9066–9070.

By: J. Govan n, A. McIver n, C. Riggsbee n & A. Deiters n

author keywords: biosensors; estrogen receptor; estrone; gene expression; hydrogen peroxide
TL;DR: Keeping the boron out of the ER: A genetic switch was engineered that activates gene expression in the presence of H(2)O(2). (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 journal article

Heterotaxin: A TGF-beta Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus Embryos

CHEMISTRY & BIOLOGY, 18(2), 252–263.

By: M. Dush n, A. McIver n, M. Parr n, D. Young n, J. Fisher n, D. Newman n, P. Sannes n, M. Hauck n, A. Deiters n, N. Nascone-Yoder n 

MeSH headings : Animals; Cell Line; Drug Evaluation, Preclinical; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Humans; Intracellular Space / drug effects; Intracellular Space / metabolism; Neovascularization, Physiologic / drug effects; Phenotype; Pyridines / chemistry; Pyridines / pharmacology; Signal Transduction / drug effects; Stereoisomerism; Structure-Activity Relationship; Transforming Growth Factor beta / metabolism; Xenopus laevis
TL;DR: A small molecule screen for left-right asymmetry phenotypes in Xenopus embryos is performed and a pyridine analog, heterotaxin, is discovered, which disrupts both cardiovascular and digestive organ laterality and inhibits TGF-β-dependent left- right asymmetric gene expression. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Stabilization and Photochemical Regulation of Antisense Agents through PEGylation

BIOCONJUGATE CHEMISTRY, 22(10), 2136–2142.

By: J. Govan n, A. McIver n & A. Deiters n

MeSH headings : Animals; DNA, Antisense / chemical synthesis; DNA, Antisense / chemistry; DNA, Antisense / genetics; DNA, Antisense / metabolism; Gene Expression Regulation; HEK293 Cells; Humans; Luminescent Proteins / genetics; Mice; NIH 3T3 Cells; Nucleic Acid Denaturation; Photolysis; Polyethylene Glycols / chemistry; Ribonuclease H / metabolism; Ultraviolet Rays
TL;DR: By employing a photocleavable linker between the PEG group and the antisense agent, the paper was able to achieve light-induced deactivation of antisense activity and pave the way for precise regulation of gene expression in biological systems. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 journal article

Photocleavable Polyethylene Glycol for the Light-Regulation of Protein Function

BIOCONJUGATE CHEMISTRY, 21(8), 1404–1407.

By: W. Georgianna n, H. Lusic n, A. Mclver & A. Deiters n

MeSH headings : Crystallography, X-Ray; Models, Molecular; Molecular Structure; Muramidase / chemistry; Muramidase / metabolism; Photochemical Processes; Polyethylene Glycols / chemical synthesis; Polyethylene Glycols / chemistry; Stereoisomerism; Ultraviolet Rays
TL;DR: The synthesis of a photocleavable PEG reagent (PhotoPEG) and its application to the light-regulation of enzyme activity is reported. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 journal article

Tricyclic Alkaloid Core Structures Assembled by a Cyclotrimerization-Coupled Intramolecular Nucleophilic Substitution Reaction

ORGANIC LETTERS, 12(6), 1288–1291.

By: A. McIver n & A. Deiters n

MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Cyclization; Microwaves; Molecular Structure; Pyridines / chemistry; Stereoisomerism
TL;DR: A facile approach to tricyclic alkaloid core structures was developed by sequencing a pyridine-forming [2 + 2 + 2] cyclotrimerization reaction with an intramolecular nucleophilic substitution. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

A general approach to triphenylenes and azatriphenylenes: total synthesis of dehydrotylophorine and tylophorine

CHEMICAL COMMUNICATIONS, (39), 4750–4752.

By: A. McIver n, D. Young n & A. Deiters n

MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Alkaloids / radiation effects; Aza Compounds / chemical synthesis; Aza Compounds / chemistry; Aza Compounds / radiation effects; Chrysenes / chemical synthesis; Chrysenes / chemistry; Chrysenes / radiation effects; Cyclization; Indolizines / chemical synthesis; Indolizines / chemistry; Indolizines / radiation effects; Microwaves; Molecular Structure; Phenanthrenes / chemical synthesis; Phenanthrenes / chemistry; Phenanthrenes / radiation effects; Stereoisomerism
TL;DR: A convergent and flexible synthesis of substituted triphenylenes, azatriphenylene, and the cytotoxic alkaloids dehydrotylophorine and tylophOrine has been developed. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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