Allyson Mellinger

College of Sciences

Works (8)

Updated: July 23rd, 2023 21:16

2022 journal article

Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance

Cell Metabolism, 34(7), 1042–1053.e6.

By: Y. Wu, C. Wong, E. Chiles, A. Mellinger n, H. Bae *, S. Jung *, T. Peterson*, J. Wang * ...

MeSH headings : Blood Glucose; Diabetes Mellitus, Type 2; Diet, High-Fat / adverse effects; Dietary Fats / pharmacology; Fructose / metabolism; Glucose / metabolism; Glucose Intolerance / metabolism; Humans; Insulin / metabolism; Islets of Langerhans / metabolism
topics (OpenAlex): Diet, Metabolism, and Disease; Liver Disease Diagnosis and Treatment; Diet and metabolism studies
TL;DR: It is reported that dietary fat enhances intestinal fructose metabolism, which releases glycerate into the blood, which provides a link between dietary fructose and diabetes that is modulated by dietary fat. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 8, 2022

2022 article

Highlighting Functional Mass Spectrometry Imaging Methods in Bioanalysis

Mellinger, A. L., Muddiman, D. C., & Gamcsik, M. P. (2022, June 24). Journal of Proteome Research, Vol. 6.

By: A. Mellinger n, D. Muddiman n  & M. Gamcsik n

author keywords: mass spectrometry imaging; kinetics; rate; isotope; metabolism; dynamics
MeSH headings : Magnetic Resonance Imaging; Mass Spectrometry / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Advanced Proteomics Techniques and Applications; Metabolomics and Mass Spectrometry Studies
TL;DR: MSI exceeds some of the classic functional imaging methods, demonstrating the ability to provide functional data from the nanoscale (subcellular) to whole tissue or organ level, and this Perspective highlights several examples of how different MSI ionization and detection technologies can provide unprecedented detailed spatial maps of time-dependent biological processes. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 11, 2022

2022 article

Mapping glycine uptake and its metabolic conversion to glutathione in mouse mammary tumors using functional mass spectrometry imaging

Mellinger, A. L., Kibbe, R. R., Rabbani, Z. N., Meritet, D., Muddiman, D. C., & Gamcsik, M. P. (2022, November 1). Free Radical Biology and Medicine, Vol. 193, pp. 677–684.

By: A. Mellinger n, R. Kibbe n, Z. Rabbani n, D. Meritet n, D. Muddiman n  & M. Gamcsik n

MeSH headings : Mice; Animals; Glycine; Biological Transport; Glutathione; Mammary Neoplasms, Animal; Mass Spectrometry
topics (OpenAlex): Metabolomics and Mass Spectrometry Studies; Mass Spectrometry Techniques and Applications; Sulfur Compounds in Biology
TL;DR: A novel functional mass spectrometry imaging (fMSI) method that can map the variations in the conversion of glycine to glutathione metabolic activity across tumor tissue sections by tracking the fate of three glycine isotopologues administered in a timed sequence to tumor-bearing anesthetized mice is developed. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 23, 2023

2022 article

Novel matrix strategies for improved ionization and spatial resolution using IR‐MALDESI mass spectrometry imaging

Kibbe, R. R., Mellinger, A. L., & Muddiman, D. C. (2022, July 19). Journal of Mass Spectrometry, Vol. 8.

By: R. Kibbe  n, A. Mellinger n & D. Muddiman n 

author keywords: energy-absorbing matrix; glycerol; IR-MALDESI; mass spectrometry imaging
MeSH headings : Animals; Glycerol; Ice; Lipids; Rats; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Metabolomics and Mass Spectrometry Studies
TL;DR: It was observed that utilizing a 50% glycerol matrix without ice provides improved spatial resolution with lipid abundances and annotations comparable to the ice matrix standard, while decreasing the time required to complete an IR‐MALDESI tissue imaging experiment. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 8, 2022

2021 article

Discovery proteomics of human placental tissue

Mellinger, A. L., McCoy, K., Minior, D. A. T., & Williams, T. I. (2021, September 6). Rapid Communications in Mass Spectrometry, Vol. 9.

By: A. Mellinger n, K. McCoy *, D. Minior* & T. Williams n 

Contributors: A. Mellinger n, K. McCoy *, D. Minior* & T. Williams n 

topics (OpenAlex): Advanced Proteomics Techniques and Applications; Pregnancy and preeclampsia studies; Epigenetics and DNA Methylation
TL;DR: A label-free proteomics protocol for the interrogation of the placental proteome is described, which has been applied towards exploring differential protein expression patterns in placentas from women who have been exposed to drugs during pregnancy relative to those who have not. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 8, 2021

2021 article

Multiple Infusion Start Time Mass Spectrometry Imaging of Dynamic SIL-Glutathione Biosynthesis Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization

Mellinger, A. L., Garrard, K. P., Khodjaniyazova, S., Rabbani, Z. N., Gamcsik, M. P., & Muddiman, D. C. (2021, November 22). Journal of Proteome Research, Vol. 3.

By: A. Mellinger n, K. Garrard  n, S. Khodjaniyazova n, Z. Rabbani n, M. Gamcsik n & D. Muddiman n 

author keywords: IR-MALDESI; mass spectrometry imaging; stable isotope labeling; glutathione; kinetic metabolism
MeSH headings : Animals; Glutathione; Glycine; Lasers; Mice; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
topics (OpenAlex): Sulfur Compounds in Biology; Metabolomics and Mass Spectrometry Studies; Mass Spectrometry Techniques and Applications
TL;DR: A study combining a multiple infusion start time protocol, stable isotope labeling technology, infrared matrix-assisted laser desorption electrospray ionization, and high-resolution accurate mass-mass spectrometry imaging to study spatial changes in glutathione kinetics across in sectioned mouse liver tissues is presented. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022

2020 article

Metabolite Profiling Reveals Predictive Biomarkers and the Absence of β-Methyl Amino-l-alanine in Plasma from Individuals Diagnosed with Amyotrophic Lateral Sclerosis

Bereman, M. S., Kirkwood, K. I., Sabaretnam, T., Furlong, S., Rowe, D. B., Guillemin, G. J., … Muddiman, D. C. (2020, May 18). Journal of Proteome Research, Vol. 19, pp. 3276–3285.

By: M. Bereman n, K. Kirkwood n, T. Sabaretnam *, S. Furlong *, D. Rowe *, G. Guillemin *, A. Mellinger n, D. Muddiman n 

author keywords: amyotrophic lateral sclerosis; biomarkers; BMAA; CZE-MS/MS; metabolites; plasma
MeSH headings : Alanine; Amyotrophic Lateral Sclerosis / diagnosis; Biomarkers; Female; Humans; Male; Mass Spectrometry; Metabolome
topics (OpenAlex): Amyotrophic Lateral Sclerosis Research; Cholinesterase and Neurodegenerative Diseases; Neurological diseases and metabolism
TL;DR: The plasma metabolome of 134 patients diagnosed with sporadic amyotrophic lateral sclerosis and 118 individuals deemed healthy was profiled, and two models using the metabolite abundances were developed for the separation of ALS and healthy samples and the prediction of disease progression based on the ALS functional rating score. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: September 14, 2020

2020 article

Peptide variability and signatures associated with disease progression in CSF collected longitudinally from ALS patients

Mellinger, A. L., Griffith, E. H., & Bereman, M. S. (2020, June 26). Analytical and Bioanalytical Chemistry, Vol. 412, pp. 5465–5475.

By: A. Mellinger n, E. Griffith n  & M. Bereman n

author keywords: Amyotrophic lateral sclerosis; Cerebrospinal fluid; Longitudinal modeling; Proteomics; Biomarker
MeSH headings : Aged; Amyotrophic Lateral Sclerosis / cerebrospinal fluid; Chromatography, Liquid / methods; Disease Progression; Female; Humans; Longitudinal Studies; Male; Middle Aged; Peptides / cerebrospinal fluid; Proteomics; Tandem Mass Spectrometry / methods
topics (OpenAlex): Amyotrophic Lateral Sclerosis Research; Alzheimer's disease research and treatments; Cholinesterase and Neurodegenerative Diseases
TL;DR: Overall, the CSF protein abundances are tightly regulated with the intra-individual variability contributing just 4% to the overall variance and the association of inflammation with rate of disease progression is explored. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 13, 2020

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2026) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.