Allyson Mellinger

College of Sciences

Works (8)

Updated: July 23rd, 2023 21:16

2022 journal article

Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance

CELL METABOLISM, 34(7), 1042-+.

By: Y. Wu *, C. Wong *, E. Chiles *, A. Mellinger n, H. Bae *, S. Jung *, T. Peterson*, J. Wang * ...

MeSH headings : Blood Glucose; Diabetes Mellitus, Type 2; Diet, High-Fat / adverse effects; Dietary Fats / pharmacology; Fructose / metabolism; Glucose / metabolism; Glucose Intolerance / metabolism; Humans; Insulin / metabolism; Islets of Langerhans / metabolism
TL;DR: It is reported that dietary fat enhances intestinal fructose metabolism, which releases glycerate into the blood, which provides a link between dietary fructose and diabetes that is modulated by dietary fat. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 8, 2022

2022 article

Highlighting Functional Mass Spectrometry Imaging Methods in Bioanalysis

Mellinger, A. L., Muddiman, D. C., & Gamcsik, M. P. (2022, June 27). JOURNAL OF PROTEOME RESEARCH, Vol. 6.

By: A. Mellinger n, D. Muddiman n  & M. Gamcsik n

author keywords: mass spectrometry imaging; kinetics; rate; isotope; metabolism; dynamics
MeSH headings : Magnetic Resonance Imaging; Mass Spectrometry / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: MSI exceeds some of the classic functional imaging methods, demonstrating the ability to provide functional data from the nanoscale (subcellular) to whole tissue or organ level, and this Perspective highlights several examples of how different MSI ionization and detection technologies can provide unprecedented detailed spatial maps of time-dependent biological processes. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 11, 2022

2022 journal article

Mapping glycine uptake and its metabolic conversion to glutathione in mouse mammary tumors using functional mass spectrometry imaging

FREE RADICAL BIOLOGY AND MEDICINE, 193, 677–684.

By: A. Mellinger n, R. Kibbe n, Z. Rabbani n, D. Meritet n, D. Muddiman n  & M. Gamcsik n

MeSH headings : Mice; Animals; Glycine; Biological Transport; Glutathione; Mammary Neoplasms, Animal; Mass Spectrometry
TL;DR: A novel functional mass spectrometry imaging (fMSI) method that can map the variations in the conversion of glycine to glutathione metabolic activity across tumor tissue sections by tracking the fate of three glycine isotopologues administered in a timed sequence to tumor-bearing anesthetized mice is developed. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 23, 2023

2022 journal article

Novel matrix strategies for improved ionization and spatial resolution using IR-MALDESI mass spectrometry imaging

JOURNAL OF MASS SPECTROMETRY, 57(8).

By: R. Kibbe  n, A. Mellinger n & D. Muddiman n 

author keywords: energy-absorbing matrix; glycerol; IR-MALDESI; mass spectrometry imaging
MeSH headings : Animals; Glycerol; Ice; Lipids; Rats; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: It was observed that utilizing a 50% glycerol matrix without ice provides improved spatial resolution with lipid abundances and annotations comparable to the ice matrix standard, while decreasing the time required to complete an IR‐MALDESI tissue imaging experiment. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 8, 2022

2021 article

Discovery proteomics of human placental tissue

Mellinger, A. L., McCoy, K., Minior, D. A. T., & Williams, T. I. (2021, December 23). RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol. 9.

By: A. Mellinger n, K. McCoy *, D. Minior* & T. Williams n 

Contributors: A. Mellinger n, K. McCoy *, D. Minior* & T. Williams n 

TL;DR: A label-free proteomics protocol for the interrogation of the placental proteome is described, which has been applied towards exploring differential protein expression patterns in placentas from women who have been exposed to drugs during pregnancy relative to those who have not. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 8, 2021

2021 journal article

Multiple Infusion Start Time Mass Spectrometry Imaging of Dynamic SIL-Glutathione Biosynthesis Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization

JOURNAL OF PROTEOME RESEARCH, 21(3), 747–757.

By: A. Mellinger n, K. Garrard  n, S. Khodjaniyazova n, Z. Rabbani n, M. Gamcsik n & D. Muddiman n 

author keywords: IR-MALDESI; mass spectrometry imaging; stable isotope labeling; glutathione; kinetic metabolism
MeSH headings : Animals; Glutathione; Glycine; Lasers; Mice; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: A study combining a multiple infusion start time protocol, stable isotope labeling technology, infrared matrix-assisted laser desorption electrospray ionization, and high-resolution accurate mass-mass spectrometry imaging to study spatial changes in glutathione kinetics across in sectioned mouse liver tissues is presented. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022

2020 journal article

Metabolite Profiling Reveals Predictive Biomarkers and the Absence of beta-Methyl Amino-L-alanine in Plasma from Individuals Diagnosed with Amyotrophic Lateral Sclerosis

JOURNAL OF PROTEOME RESEARCH, 19(8), 3276–3285.

By: M. Bereman n, K. Kirkwood n, T. Sabaretnam *, S. Furlong *, D. Rowe *, G. Guillemin *, A. Mellinger n, D. Muddiman n 

author keywords: amyotrophic lateral sclerosis; biomarkers; BMAA; CZE-MS/MS; metabolites; plasma
MeSH headings : Alanine; Amyotrophic Lateral Sclerosis / diagnosis; Biomarkers; Female; Humans; Male; Mass Spectrometry; Metabolome
TL;DR: The plasma metabolome of 134 patients diagnosed with sporadic amyotrophic lateral sclerosis and 118 individuals deemed healthy was profiled, and two models using the metabolite abundances were developed for the separation of ALS and healthy samples and the prediction of disease progression based on the ALS functional rating score. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 14, 2020

2020 journal article

Peptide variability and signatures associated with disease progression in CSF collected longitudinally from ALS patients

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 412(22), 5465–5475.

By: A. Mellinger n, E. Griffith n  & M. Bereman n

author keywords: Amyotrophic lateral sclerosis; Cerebrospinal fluid; Longitudinal modeling; Proteomics; Biomarker
MeSH headings : Aged; Amyotrophic Lateral Sclerosis / cerebrospinal fluid; Chromatography, Liquid / methods; Disease Progression; Female; Humans; Longitudinal Studies; Male; Middle Aged; Peptides / cerebrospinal fluid; Proteomics; Tandem Mass Spectrometry / methods
TL;DR: Overall, the CSF protein abundances are tightly regulated with the intra-individual variability contributing just 4% to the overall variance and the association of inflammation with rate of disease progression is explored. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 13, 2020

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