Works (2)

Updated: July 5th, 2023 15:48

2013 journal article

Quantitation of Hydrogen Peroxide Fluctuations and Their Modulation of Dopamine Dynamics in the Rat Dorsal Striatum Using Fast-Scan Cyclic Voltammetry

ACS CHEMICAL NEUROSCIENCE, 4(5), 782–789.

By: M. Spanos n, J. Gras-Najjar n, J. Letchworth n, A. Sanford n, J. Toups n & L. Sombers n

author keywords: oxidative stress; reactive oxygen species; H2O2; FSCV; Parkinson's disease; basal dopamine concentrations
MeSH headings : Animals; Dopamine / metabolism; Electric Stimulation; Electrochemical Techniques; Hydrogen Peroxide / metabolism; Male; Neostriatum / drug effects; Neostriatum / metabolism; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species / metabolism; Rotenone / pharmacology; Uncoupling Agents / pharmacology
TL;DR: Increases in endogenous H2O2 in the dorsal striatum attenuated electrically evoked DA release, and also decreased basal DA levels in this brain region will help to disambiguate the chemical mechanisms underlying the progression of neurodegenerative disease states, such as Parkinson's disease, that involve oxidative stress. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Voltammetric Detection of Hydrogen Peroxide at Carbon Fiber Microelectrodes

ANALYTICAL CHEMISTRY, 82(12), 5205–5210.

By: A. Sanford n, S. Morton n, K. Whitehouse n, H. Oara n, L. Lugo-Morales n, J. Roberts n, L. Sombers n

MeSH headings : Animals; Biosensing Techniques / instrumentation; Biosensing Techniques / methods; Brain Chemistry; Carbon / chemistry; Carbon Fiber; Electrochemistry / instrumentation; Electrochemistry / methods; Hydrogen Peroxide / analysis; Hydrogen Peroxide / metabolism; Limit of Detection; Male; Microelectrodes; Rats; Rats, Sprague-Dawley
TL;DR: The first voltammetric characterization of rapid hydrogen peroxide fluctuations at an uncoated carbon fiber microelectrode is presented, demonstrating unprecedented chemical and spatial resolution. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

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