Amy Stieler Stewart
Also known as: A. Stieler; A. Stieler Stewart; A.S. Stewart; A.L. Stieler; A.L. Stieler Stewart
Works (18)
Updated: April 4th, 2024 14:43
2023 journal article
45: Comparison of the Effects of Normothermic Machine Perfusion and Cold Storage Preservation on Porcine Intestinal Allograft Regenerative Potential and Viability
Transplantation, 107(7S), 25–25.
Sources: Web Of Science, ORCID, Crossref
Added: July 31, 2023
2023 journal article
A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease
FASEB JOURNAL, 37(6).
author keywords: APC mutation; colorectal cancer; intestine; Lgr5; porcine; stem cell; transgenic large animal
MeSH headings : Humans; Swine; Animals; Mice; In Situ Hybridization, Fluorescence; Intestines; Stem Cells; Ileum; Colon; Coleoptera; Green Fluorescent Proteins / genetics; Receptors, G-Protein-Coupled / genetics
TL;DR:
This study validates ISC isolation in a new porcine Leucine Rich Repeat Containing G Protein‐Coupled Receptor 5 (LGR5) reporter line and demonstrates the use of these pigs as a novel colorectal cancer model.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: June 12, 2023
2023 journal article
Changes in equine intestinal stem/progenitor cell number at resection margins in cases of small intestinal strangulation
Equine Veterinary Journal, 55(6), 995–1002.
author keywords: horse; immunofluorescence; intestine; Ki67; small intestinal strangulation; stem cell
TL;DR:
Proliferating cell and ISC numbers may be associated with case outcome, and associations between biomarker expression and the number of preoperative risk factors and postoperative complications negatively related to outcome were determined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, Crossref
Added: January 31, 2023
2023 journal article
Comparison of the effects of normothermic machine perfusion and cold storage preservation on porcine intestinal allograft regenerative potential and viability
American Journal of Transplantation, 10.
TL;DR:
Normothermic machine perfusion preservation of kidney and liver allografts minimizes CS-associated ischemia-reperfusion injury and appears to reduce IRI and improve graft regeneration with improved ISC viability and proliferation.
(via Semantic Scholar)
Sources: ORCID, Crossref
Added: December 28, 2023
2022 journal article
Culture of equine intestinal epithelial stem cells after delayed tissue storage for future applications
BMC VETERINARY RESEARCH, 18(1).
author keywords: Horse; Stem cell; 3D culture; Organoid; Enteroid; Intestine; Storage
MeSH headings : Animals; Cryopreservation / veterinary; Epithelial Cells / cytology; Horses; Intestines / cytology; Stem Cells / cytology; Time Factors; Cells, Cultured; Intestinal Diseases / therapy; Intestinal Diseases / veterinary
TL;DR:
Equine ISCs can be isolated and cultured after prolonged tissue storage and this suggests that ISCs could be isolated for several days from samples properly stored after procedures, including surgery or necropsy, and used to create ISC repositories for study or therapy of equine intestinal diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: January 30, 2023
2022 journal article
Orthotopic Transplantation of the Full-length Porcine Intestine After Normothermic Machine Perfusion
Transplantation Direct, 8(11), e1390.
TL;DR:
Development and optimization of machine perfusion preservation of small intestine and successful transplantation of intestinal allografts in a porcine model are reported.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref
Added: October 31, 2022
2021 journal article
HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 321(5), G588–G602.
author keywords: epithelial repair; HOPX; ischemia; large animal models; stem cell
MeSH headings : Animals; Cell Proliferation; Disease Models, Animal; Epithelial Cells / metabolism; Epithelial Cells / pathology; Female; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Male; Mesenteric Ischemia / genetics; Mesenteric Ischemia / metabolism; Mesenteric Ischemia / pathology; Phenotype; Re-Epithelialization; Severity of Illness Index; Stem Cells / metabolism; Stem Cells / pathology; Sus scrofa; Tissue Culture Techniques
TL;DR:
It is demonstrated that during early in vivo recovery, injury-resistant HOPX+cells maintain quiescence, suggesting that HopX may serve a functional role in ISC mediated regeneration after injury and could be a target to control ISC proliferation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: November 3, 2021
2020 journal article
Geographic Disparities in Clinical Characteristics of Duodenitis–Proximal Jejunitis in Horses in the United States
Journal of Equine Veterinary Science, 93, 103192.
author keywords: Gastrointestinal; Small intestine; Duodenitis-proximal jejunitis; Colic
MeSH headings : Animals; Case-Control Studies; Duodenitis / epidemiology; Duodenitis / veterinary; Horse Diseases / epidemiology; Horses; Jejunal Diseases / veterinary; Prospective Studies; Southeastern United States; United States / epidemiology
TL;DR:
Differences in clinical parameters of horses with DPJ between geographic regions were identified to corroborate anecdotal reports and support theories of differing etiologies and identify risk factors contributing toward regional differences in this disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: July 16, 2020
2019 journal article
Preservation of reserve intestinal epithelial stem cells following severe ischemic injury
American Journal of Physiology-Gastrointestinal and Liver Physiology, 316(4), G482–G494.
author keywords: intestine; ischemia reperfusion injury; large animal model; reserve stem cells; stem cell
MeSH headings : Animals; Apoptosis; Cell Proliferation / physiology; Cell Self Renewal / physiology; Cell Survival / physiology; Disease Models, Animal; Homeodomain Proteins / metabolism; Intestinal Mucosa / blood supply; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Ischemia / metabolism; Receptors, G-Protein-Coupled / metabolism; Reperfusion Injury / metabolism; Swine
TL;DR:
Data indicate that Hopx+ cells are resistant to injury and are the likely source of epithelial renewal following prolonged ischemic injury, and it is therefore possible that targeting reserve stem cells will lead to new therapies for patients with severe intestinal injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Crossref
Added: March 16, 2019
2018 journal article
Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
Journal of Visualized Experiments, 5(135).
author keywords: Medicine; Issue 135; Porcine; intestine; ischemia-reperfusion; stem cell; enteroid; organoid
MeSH headings : Animals; Cell Culture Techniques / methods; Disease Models, Animal; Humans; Intestine, Small / cytology; Intestine, Small / metabolism; Intestine, Small / pathology; Ischemia / etiology; Mice; Stem Cells / metabolism; Swine
TL;DR:
By utilizing a porcine model, a protocol is established in which segmental loops of intestinal ischemia can be created within a single animal, enabling the study of differing time points of ischemic injury and repair in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: October 16, 2018
2017 journal article
Advanced three-dimensional culture of equine intestinal epithelial stem cells
Equine Veterinary Journal, 50(2), 241–248.
author keywords: horse; stem cell; 3D culture; intestine; enteroid; organoid
MeSH headings : Animals; Cell Culture Techniques / veterinary; Cell Differentiation; Female; Horses; Intestinal Mucosa / cytology; Male; Models, Biological; Stem Cells / physiology
TL;DR:
The successful culture of equine intestinal crypts into 3D "mini-guts" allows for in vitro studies of the equine intestine and has relevance to future development of novel therapies that harness the regenerative potential ofequine intestine in horses with gastrointestinal disease (colic).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2017 review
Alterations in Intestinal Permeability: The Role of the "Leaky Gut" in Health and Disease
[Review of ]. JOURNAL OF EQUINE VETERINARY SCIENCE, 52, 10–22.
author keywords: Horse; Intestinal permeability; Leaky gut; Barrier function; Decreased performance
TL;DR:
The normal intestinal barrier, measurement of barrier permeability, pathogenesis and main causes of altered permeability are reviewed, and potential alternative therapies of leaky gut in horses are highlighted while relating what has been studied in other species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Effects of clarithromycin, azithromycin and rifampicin on terbutaline-induced sweating in foals
Equine Veterinary Journal, 3.
author keywords: horse; foal; anhidrosis; rifampicin; macrolide; Rhodococcus equi
MeSH headings : Animals; Azithromycin / pharmacology; Clarithromycin / pharmacology; Horses; Rifampin / pharmacology; Sweating / drug effects; Terbutaline
TL;DR:
The potent anti-sudorific effect of ERY is delayed, but not substantially affected by concurrent RIF administration, and effects of RIF on ERY-induced anhidrosis could not definitively be ascribed to altered ERY bioavailability.
(via Semantic Scholar)
Source: ORCID
Added: February 11, 2019
2016 journal article
Spinal Cord Hamartomatous Myelodysplasia in 2 Horses With Clinical Neurologic Deficits
Veterinary Pathology, 53(4), 844–846.
author keywords: ataxia; hamartoma; horse; hydromyelia; muscle spasm; myelodysplasia; spinal cord
MeSH headings : Animals; Ataxia / pathology; Ataxia / veterinary; Hamartoma / diagnosis; Hamartoma / pathology; Hamartoma / veterinary; Hindlimb / pathology; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Neural Tube Defects / diagnosis; Neural Tube Defects / pathology; Neural Tube Defects / veterinary; Spasm / pathology; Spasm / veterinary; Spinal Cord / pathology
TL;DR:
Two horses euthanized for neurologic deficits were diagnosed with hamartomatous myelodysplasia of the spinal cord, which had focal disorganization of the white and gray matter of the cerebral spinal cord forming a mass interspersed with neurons, glial cells, and disoriented axon bundles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2015 journal article
Macrolide-induced hyperthermia in foals: Role of impaired sweat responses
Equine Veterinary Journal, 48(5), 590–594.
author keywords: horse; anhidrosis; erythromycin; hyperthermia; foal; sweat
MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Erythromycin / adverse effects; Female; Fever / chemically induced; Fever / veterinary; Horse Diseases / chemically induced; Horses; Injections, Intradermal; Intradermal Tests; Male; Sweating / drug effects; Sympathomimetics / administration & dosage; Sympathomimetics / pharmacology; Terbutaline / administration & dosage; Terbutaline / pharmacology
TL;DR:
Drug-induced anhidrosis is the likely cause of hyperthermia in some foals treated with erythromycin, and terbutaline-induced sweating was significantly reduced from baseline in eryhromycin-treated foals at all subsequent days.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2014 journal article
Non-Surgical management of vaginal prolapse in a late gestation alpaca (Lamos pacos)
Clinical Theriogenology, 6(4), 489–493.
Source: NC State University Libraries
Added: February 18, 2019
2013 journal article
What Is Your Neurologic Diagnosis?
Journal of the American Veterinary Medical Association, 243(6), 779–781.
MeSH headings : Animals; Female; Horse Diseases / diagnosis; Horse Diseases / parasitology; Horse Diseases / pathology; Horses; Radiography; Sarcocystis / immunology; Sarcocystosis / diagnosis; Sarcocystosis / diagnostic imaging; Sarcocystosis / pathology; Sarcocystosis / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 11, 2019
2012 journal article
Neutrophil and monocyte function in neonatal dairy calves fed fresh or frozen colostrum
International Journal of Applied Research in Veterinary Medicine, 10(4), 328–334.
Source: NC State University Libraries
Added: February 18, 2019
Employment
Updated: April 4th, 2020 13:10
2019 - present
North Carolina State University Raleigh, NC, US
Assistant Research Professor
Department of Clinical Sciences
Education
Updated: April 4th, 2020 13:09
2015 - 2019
North Carolina State University Raleigh, NC, US
PhD
Comparative Biomedical Sciences
2012 - 2015
University of Florida College of Veterinary Medicine Gainesville, FL, US
Resident, Large Animal Internal Medicine (DACVIM)
2011 - 2012
University of Georgia College of Veterinary Medicine Athens, GA, US
Internship, Large Animal Medicine and Surgery
2007 - 2011
University of Florida College of Veterinary Medicine Gainesville, FL, US
DVM
2003 - 2007
University of Florida Gainesville, FL, US
BS/Animal Biology
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