@article{walker_li_nguyen_jauregui_meurs_gagnon_stern_2023, title={Evaluation of autoantibodies to desmoglein-2 in dogs with and without cardiac disease}, volume={13}, ISSN={2045-2322}, url={http://dx.doi.org/10.1038/s41598-023-32081-x}, DOI={10.1038/s41598-023-32081-x}, abstractNote={Abstract}, number={1}, journal={Scientific Reports}, publisher={Springer Science and Business Media LLC}, author={Walker, Ashley L. and Li, Ronald H. L. and Nguyen, Nghi and Jauregui, Carina E. and Meurs, Kathryn M. and Gagnon, Allison L. and Stern, Joshua A.}, year={2023}, month={Mar} } @article{walker_ueda_crofton_harris_stern_2022, title={Ambulatory electrocardiography, heart rate variability, and pharmacologic stress testing in cats with subclinical hypertrophic cardiomyopathy}, volume={12}, ISSN={["2045-2322"]}, url={https://europepmc.org/articles/PMC8817045}, DOI={10.1038/s41598-022-05999-x}, abstractNote={Abstract}, number={1}, journal={SCIENTIFIC REPORTS}, author={Walker, Ashley L. and Ueda, Yu and Crofton, Amanda E. and Harris, Samantha P. and Stern, Joshua A.}, year={2022}, month={Feb} } @article{walker_defrancesco_bonagura_keene_meurs_tou_kurtz_aona_barron_mcmanamey_et al._2022, title={Association of diet with clinical outcomes in dogs with dilated cardiomyopathy and congestive heart failure*}, volume={40}, ISSN={["1875-0834"]}, DOI={10.1016/j.jvc.2021.02.001}, abstractNote={Dilated cardiomyopathy (DCM) in dogs has been associated with feeding of grain-free (GF), legume-rich diets. Some dogs with presumed diet-associated DCM have shown improved myocardial function and clinical outcomes following a change in diet and standard medical therapy. Prior GF (pGF) diet influences reverse cardiac remodeling and clinical outcomes in dogs with DCM and congestive heart failure (CHF). A retrospective study was performed with 67 dogs with DCM and CHF for which diet history was known. Dogs were grouped by diet into pGF and grain-inclusive (GI) groups. Dogs in the pGF group were included if diet change was a component of therapy. Survival was analyzed using Kaplan–Meier curves and the Cox proportional-hazards model. The median survival time was 344 days for pGF dogs vs. 253 days for GI dogs (P = 0.074). Statistically significant differences in median survival were identified when the analysis was limited to dogs surviving longer than one week (P = 0.033). Prior GF dogs had a significantly worse outcome the longer a GF diet was fed prior to diagnosis (P = 0.004) or if they were diagnosed at a younger age (P = 0.017). Prior GF dogs showed significantly greater improvement in normalized left ventricular internal diastolic diameter (P = 0.038) and E-point septal separation (P = 0.031) measurements and significant decreases in their furosemide (P = 0.009) and pimobendan (P < 0.005) dosages over time compared to GI dogs. Prior GF dogs that survived at least one week after diagnosis of DCM, treatment of CHF, and diet change had better clinical outcomes and showed reverse ventricular remodeling compared to GI dogs.}, journal={JOURNAL OF VETERINARY CARDIOLOGY}, author={Walker, A. L. and DeFrancesco, T. C. and Bonagura, J. D. and Keene, B. W. and Meurs, K. M. and Tou, S. P. and Kurtz, K. and Aona, B. and Barron, L. and McManamey, A. and et al.}, year={2022}, month={Apr}, pages={99–109} } @article{grigg_ueda_walker_hart_simas_stern_2021, title={Comparative Assessment of Heart Rate Variability Obtained via Ambulatory ECG and Polar Heart Rate Monitors in Healthy Cats: A Pilot Study}, volume={8}, ISSN={["2297-1769"]}, url={https://europepmc.org/articles/PMC8606523}, DOI={10.3389/fvets.2021.741583}, abstractNote={Chronic exposure to stressful environments can negatively impact cats' health and welfare, affecting behavioral, autonomic, endocrine, and immune function, as with cats in shelters. Low-stress handling practices likely improve shelter cat welfare, but data supporting improved outcomes remain limited. Cardiac activity, particularly heart rate variability (HRV), is an indicator of stress and emotional state in humans and non-human animals, tracking important body functions associated with stress responsiveness, environmental adaptability, mental, and physical health. HRV studies in cats are limited, involving mainly anesthetized or restrained cats. This pilot study tested the feasibility of obtaining HRV data from unrestrained cats, using a commercially available cardiac monitoring system (Polar H10 with chest strap), compared with data from a traditional ambulatory electrocardiogram. Simultaneous data for the two systems were obtained for five adult cats. Overall, the Polar H10 monitor assessments of HRV were lower than the true HRV assessment by ambulatory ECG, except for SDNN. Correlation between the two systems was weak. Possible reasons for the lack of agreement between the two methods are discussed. At this time, our results do not support the use of Polar H10 heart rate monitors for studies of HRV in cats.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Grigg, Emma K. and Ueda, Yu and Walker, Ashley L. and Hart, Lynette A. and Simas, Samany and Stern, Joshua A.}, year={2021}, month={Nov} } @article{gunther-harrington_sharpe_vernau_ueda_montgomery_surmick_fernandez_ontiveros_walker_stern_2021, title={Reference intervals for radiographic, echocardiographic and N-terminal pro B-type natriuretic peptide values in healthy kittens}, volume={23}, ISSN={["1532-2750"]}, url={https://doi.org/10.1177/1098612X20946461}, DOI={10.1177/1098612X20946461}, abstractNote={Objectives Assessment of heart size in kittens is important, and there is a need for reference intervals (RIs) to prevent misinterpretation of cardiomegaly in this patient population. The purpose of this study was to generate RIs for echocardiographic and radiographic quantification of cardiac size in healthy kittens. }, number={4}, journal={JOURNAL OF FELINE MEDICINE AND SURGERY}, publisher={SAGE Publications}, author={Gunther-Harrington, Catherine T. and Sharpe, Ashley N. and Vernau, Karen M. and Ueda, Yu and Montgomery, Elizabeth A. and Surmick, Jennifer D. and Fernandez, Nicole and Ontiveros, Eric and Walker, Ashley L. and Stern, Joshua A.}, year={2021}, month={Apr}, pages={293–301} }