Works (25)
Updated: August 29th, 2023 11:25
2011 journal article
Improving Proteome Coverage on a LTQ-Orbitrap Using Design of Experiments
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 22(4), 773–783.
author keywords: LTQ-Orbitrap XL MS/MS instrument parameters; Design of experiments; Fractional-factorial design; Saccharomyces cerevisiae; Proteomics
MeSH headings : Peptide Fragments; Peptide Mapping; Proteome / chemistry; Proteomics / methods; Research Design; Saccharomyces cerevisiae Proteins / chemistry; Tandem Mass Spectrometry / methods; Temperature
TL;DR:
The DOE approach represents a time- and cost-effective method for empirically optimizing MS-based proteomics workflows including sample preparation, LC conditions, and multiple instrument platforms.
(via Semantic Scholar)
link.springer.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
One-year plasma N-linked glycome intra-individual and inter-individual variability in the chicken model of spontaneous ovarian adenocarcinoma
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 305(2-3), 79–86.
author keywords: N-linked glycans; HILIC; FTMS; Longitudinal sampling
TL;DR:
The initial interrogation of longitudinally-procured samples provides evidence that supports the value of this strategy in the search for glycomic biomarkers, and identifies 35 N-linked glycans identified in this study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2010 journal article
Measuring the intra-individual variability of the plasma proteome in the chicken model of spontaneous ovarian adenocarcinoma
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 398(2), 737–749.
Contributors: n, R. Wysocky n, J. Petitte n , K. Anderson n , P. Mozdziak n , O. Fletcher n, J. Horowitz n, D. Muddiman n
author keywords: Genomics/proteomics; Mass spectrometry/ICP-MS; Biological samples; Bioanalytical methods; Clinical/biomedical analysis
MeSH headings : Adenocarcinoma / metabolism; Adenocarcinoma / pathology; Animals; Chickens; Female; Humans; Mass Spectrometry / methods; Ovarian Neoplasms / metabolism; Ovarian Neoplasms / pathology; Plasma / metabolism; Proteome / analysis; Proteome / metabolism; Proteomics / methods
TL;DR:
An experimental strategy for biomarker discovery is reported herein that combines the chicken model of EOC, longitudinal plasma sample collection with matched tissues, advanced mass spectrometry-based proteomics, and concepts derived from the index of individuality in an effort to identify diagnostic protein biomarkers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 article
Measuring the intra-individual variability of the plasma proteome in the chicken model of spontaneous ovarian adenocarcinoma (vol 398, pg 737, 2010)
Hawkridge, A. M., Wysocky, R. B., Petitte, J. N., Anderson, K. E., Mozdziak, P. E., Fletcher, O. J., … Muddiman, D. C. (2010, October). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 398, pp. 1835–1835.
Contributors: n, R. Wysocky n, J. Petitte n , K. Anderson n , P. Mozdziak n , O. Fletcher n, J. Horowitz n, D. Muddiman n
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Utilizing Spectral Counting To Quantitatively Characterize Tandem Removal of Abundant Proteins (TRAP) in Human Plasma
ANALYTICAL CHEMISTRY, 82(24), 10179–10185.
MeSH headings : Biomarkers / analysis; Blood Proteins / analysis; Blood Proteins / isolation & purification; Humans
TL;DR:
The data demonstrate that this method, tandem removal of abundant proteins or TRAP, provides superior removal efficiency compared to traditional applications and improves the depth of proteome coverage in plasma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Coupling of a vented column with splitless nanoRPLC-ESI-MS for the improved separation and detection of brain natriuretic peptide-32 and its proteolytic peptides
Journal of Chromatography B, 877(10), 948–954.
author keywords: Vented column; BNP-32; Splitless nanoLC; Tryptic digestion
MeSH headings : Amino Acid Sequence; Brain Chemistry; Chromatography, Liquid / methods; Molecular Sequence Data; Natriuretic Peptide, Brain / chemistry; Natriuretic Peptide, Brain / isolation & purification; Natriuretic Peptide, Brain / pharmacokinetics; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
It is demonstrated that the use of free cysteine as an alkylation quenching agent and a secondary digestion within the digestion scheme can provide targeted tryptic peptides with increased abundances, which will serve to further augment the detection of BNP-32 by LC-MS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2009 article
Mass Spectrometry-Based Biomarker Discovery: Toward a Global Proteome Index of Individuality
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, Vol. 2, pp. 265–277.
author keywords: biological variability; analytical variability; longitudinal sampling
MeSH headings : Animals; Biomarkers / analysis; Humans; Mass Spectrometry / instrumentation; Mass Spectrometry / methods; Proteome / analysis; Proteomics / instrumentation; Proteomics / methods
TL;DR:
The purpose of this review is to discuss the analytical methods and strategies that have been developed for mass spectrometry-based biomarker-discovery platforms and to place them in the context of the many challenges and opportunities yet to be addressed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Proteomics Characterization of Cell Membrane Blebs in Human Retinal Pigment Epithelium Cells
MOLECULAR & CELLULAR PROTEOMICS, 8(10), 2201–2211.
MeSH headings : Aged; Animals; Antioxidants / pharmacology; Basigin / analysis; Cell Line; Cell Membrane / chemistry; Cell Membrane / drug effects; Cell Membrane / ultrastructure; Cell Surface Extensions / chemistry; Cell Surface Extensions / drug effects; Cell Surface Extensions / ultrastructure; Chromatography, Liquid; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Epithelial Cells / chemistry; Epithelial Cells / cytology; Epithelial Cells / drug effects; Extracellular Matrix / chemistry; Extracellular Matrix / metabolism; Eye Proteins / analysis; Humans; Hydroquinones / pharmacology; Macular Degeneration / pathology; Matrix Metalloproteinase 14 / analysis; Matrix Metalloproteinase 2 / analysis; Molecular Sequence Data; Proteomics / methods; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Retinal Pigment Epithelium / chemistry; Retinal Pigment Epithelium / cytology; Smoke; Smoking / adverse effects; Tandem Mass Spectrometry; Tobacco / chemistry
TL;DR:
Basigin and matrix metalloproteinase-14, key proteins involved in extracellular matrix remodeling, were identified in RPE blebs and shown to be more prevalent in AMD patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Ambient aerodynamic ionization source for remote analyte sampling and mass spectrometric analysis
ANALYTICAL CHEMISTRY, 80(13), 5266–5271.
MeSH headings : Acetaminophen / antagonists & inhibitors; Acetaminophen / chemistry; Caffeine / analysis; Caffeine / chemistry; Natriuretic Peptide, Brain / analysis; Natriuretic Peptide, Brain / chemistry; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Ubiquitin / analysis; Ubiquitin / chemistry
TL;DR:
This novel aerodynamic device, herein termed remote analyte sampling, transport, and ionization relay (RASTIR) was used to remotely sample neutral species in the ambient and entrain them into an electrospray plume where they were subsequently ionized and detected using a linear ion trap Fourier transform mass spectrometer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Construction of a versatile high precision ambient Ionization source for direct analysis and imaging
Journal of the American Society for Mass Spectrometry, 19(10), 1527–1534.
MeSH headings : Bradykinin / chemistry; Cations / chemistry; Humans; Lasers; Melitten / chemistry; Muramidase / chemistry; Myoglobin / chemistry; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Ubiquitin / chemistry
TL;DR:
The design and construction of a high precision ambient ionization source matrix-assisted laser desorption electrospray ionization (MALDESI) and the computer controlled high precision motion control system and high repetition rate Explorer laser are demonstrated during MALDESI-FT-ICR analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2008 journal article
Coordination-driven face-directed self-assembly of trigonal prisms. Face-based conformational chirality
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(24), 7620–7628.
MeSH headings : Magnetic Resonance Spectroscopy; Molecular Conformation; Pyridines / chemistry; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Temperature
TL;DR:
NMR data prove that the two edges of the pyridine rings in the triflate salts of 3a-3d are distinct and molecular mechanics results suggest that in the smallest prism 3d collective effects dominate and the all-P and all-M conformers are strongly favored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Development and characterization of an ionization technique for analysis of biological macromolecules: Liquid matrix-assisted laser desorption electrospray ionization
ANALYTICAL CHEMISTRY, 80(17), 6773–6778.
MeSH headings : Organic Chemicals / chemistry; Peptides / analysis; Proteins / analysis; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Surface Properties
TL;DR:
An increase in ion abundance and a concurrent decrease in surface tension with an increase in the applied potential are demonstrated and a singly charged radical cation of an electrochemically active species indicating oxidation occurs for analytes and therefore water is observed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 personal communication
Effect of plasma protein depletion on BNP-32 recovery
Hawkridge, A. M., Muddiman, D. C., Helmlein, D. M., Cataliotti, A., & Burnett, J. C., Jr. (2008, May).
MeSH headings : Blood Proteins / metabolism; Humans; Iodine Radioisotopes; Natriuretic Peptide, Brain / blood; Protein Binding
TL;DR:
A targeted biomarker discovery platform for characterizing the circulating forms of B-type natriuretic peptide that includes protein depletion strategies, immunoprecipitation, gel electrophoresis, isotope dilution (absolute quantification), and nanoflow liquid chromatography coupled to high-performance hybrid Fourier transform mass spectrometry is developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Synthesis, characterization, and application of lodoacetamide derivatives utilized for the ALiPHAT strategy
Journal of the American Chemical Society, 130(7), 2122-.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2008 journal article
Temperature-dependent regulation of proteins in Aspergillus flavus: Whole organism stable isotope labeling by amino acids
JOURNAL OF PROTEOME RESEARCH, 7(7), 2973–2979.
author keywords: SILAC; mass spectrometry; proteomics; Aspergillus flavus; aflatoxin
MeSH headings : Aflatoxins / biosynthesis; Amino Acids / metabolism; Arginine / metabolism; Aspergillus flavus / metabolism; Carbon Isotopes; Chromatography, Liquid; Culture Media; Fungal Proteins / biosynthesis; Fungal Proteins / genetics; Gene Expression Regulation, Fungal; Isotope Labeling; Oligonucleotide Array Sequence Analysis; Tandem Mass Spectrometry; Temperature
TL;DR:
The utility of this procedure in quantifying changes in protein expression in response to environmental stimuli is shown, and the first reported labeling of a multicellular free-living prototroph using the SILAC procedure to compare (13)C(6)-arginine-labeled samples to (12)C (6-arginines-labeling samples for quantitative proteomics is reported.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Top-down identification and quantification of stable isotope labeled proteins from Aspergillus flavus using online nano-flow reversed-phase liquid chromatography coupled to a LTQ-FTICR mass spectrometer
ANALYTICAL CHEMISTRY, 80(13), 4994–5001.
MeSH headings : Arginine / chemistry; Arginine / metabolism; Aspergillus flavus / chemistry; Aspergillus flavus / metabolism; Carbon Radioisotopes / chemistry; Chromatography, Liquid / methods; Fourier Analysis; Fungal Proteins / analysis; Fungal Proteins / chemistry; Fungal Proteins / metabolism; Isotope Labeling; Tandem Mass Spectrometry / methods
TL;DR:
The qualitative and quantitative top-down characterization of proteins derived from SILAC-labeled Aspergillus flavus is described using nanoflow reversed-phase liquid chromatography directly coupled to a linear ion trap Fourier transform ion cyclotron resonance mass spectrometer (nLC-LTQ-FTICR-MS).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 journal article
Achieving augmented limits of detection for peptides with hydrophobic alkyl tags
ANALYTICAL CHEMISTRY, 79(11), 3989–3995.
MeSH headings : Acetates / chemistry; Alkylation; Amides / chemical synthesis; Amides / chemistry; Amino Acid Sequence; Chlorides / chemistry; Hydrophobic and Hydrophilic Interactions; Iodine / chemistry; Molecular Sequence Data; Peptides / analysis; Peptides / chemistry; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry
TL;DR:
The results demonstrate the feasibility of the octylcarboxyamidomethyl modification to improve limits of detection for cysteine-containing peptides with hydrophobic alkyl tags.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 journal article
Direct characterization of intact polypeptides by matrix-assisted laser desorption electrospray ionization quadrupole Fourier transform ion cyclotron resonance mass spectrometry
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 21(7), 1150–1154.
MeSH headings : Cyclotrons; Microchemistry / methods; Molecular Weight; Peptides / chemistry; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectroscopy, Fourier Transform Infrared / methods
TL;DR:
The ability of MALDESI-QFT-ICR MS to directly analyze and provide high mass measurement accuracy (approximately 1 part-per-million) of a polypeptide using internal calibration is demonstrated and the potential of this system for the top-down characterization of multiply charged polyPEptide cations is shown.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 article
New cavity rules
Yang, H. B., Hawkridge, A. M., Huang, S. P. D., Das, N., Bunge, S. D., Muddiman, D., & Stang, P. J. (2007, March). NATURE MATERIALS, Vol. 6, pp. 171–171.
MeSH headings : Alkynes / chemical synthesis; Alkynes / chemistry; Crystallography, X-Ray; Dendrimers / chemical synthesis; Dendrimers / chemistry; Fourier Analysis; Magnetic Resonance Spectroscopy; Models, Molecular; Organometallic Compounds / chemical synthesis; Organometallic Compounds / chemistry; Organoplatinum Compounds / chemical synthesis; Organoplatinum Compounds / chemistry; Spectrometry, Mass, Electrospray Ionization
TL;DR:
Isotopically resolved mass spectrometry data support the existence of the metallodendrimers with rhomboidal and hexagonal cavities, and NMR data are consistent with the formation of all ensembles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 journal article
Probing the mechanisms of an air amplifier using a LTQ-FT-ICR-MS and fluorescence spectroscopy
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 18(11), 1909–1913.
MeSH headings : Air; Amplifiers, Electronic; Cyclotrons; Fluorescent Dyes / chemistry; Spectrometry, Fluorescence / instrumentation; Spectrometry, Fluorescence / methods; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Spectroscopy, Fourier Transform Infrared / instrumentation; Spectroscopy, Fourier Transform Infrared / methods
TL;DR:
Experimental results provide direct evidence of aerodynamic focusing of electrosprayed droplets/ions enabled by an air amplifier, resulting in improved Electrospray droplet/ion capture efficiency and reduced ion injection time.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 journal article
Remote mass spectrometric sampling of electrospray- and desorption electrospra-generated ions using an air ejector
Journal of the American Society for Mass Spectrometry, 18(10), 1844–1847.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2007 journal article
Sub parts-per-million mass measurement accuracy of intact proteins and product ions achieved using a dual electrospray ionization quadrupole Fourier transform ion cyclotron resonance mass spectrometer
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 18(1), 1–7.
MeSH headings : Amino Acid Sequence; Calibration; Cyclotrons; Ions; Melitten / chemistry; Molecular Sequence Data; Nanotechnology; Polymers / chemistry; Propylene Glycols / chemistry; Proteomics; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Spectroscopy, Fourier Transform Infrared / instrumentation; Spectroscopy, Fourier Transform Infrared / methods; Tandem Mass Spectrometry; Ubiquitin / chemistry
TL;DR:
While external calibration of protein fragments resulted in absolute MMA greater than 16 ppm, internal standardization significantly improved upon the MMA of both the intact proteins and their products ions which ranged from −2.0 ppm to 1.1 ppm.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Generation and detection of multiply-charged peptides and proteins by matrix-assisted laser desorption electrospray ionization (MALDESI) Fourier transform ion cyclotron resonance mass spectrometry
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 17(12), 1712–1716.
MeSH headings : Algorithms; Cyclotrons; Peptide Mapping / methods; Peptides / analysis; Proteins / analysis; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectroscopy, Fourier Transform Infrared / methods; Static Electricity
TL;DR:
Analysis of peptides and proteins resulted in high resolving power single-acquisition FT-ICR mass spectra with average charge-states highly correlated to those obtained by nanoESI, thus, providing strong evidence that the ESI process dictates the observed charge-state distribution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Incorporation of 2,6-di(4,4 '-dipyridyl)-9-thiabicyclo[3.3.1] nonane into discrete 2D supramolecules via coordination-driven self-assembly
JOURNAL OF ORGANIC CHEMISTRY, 71(17), 6644–6647.
MeSH headings : Bridged Bicyclo Compounds / chemistry; Molecular Structure; Platinum / chemistry; Pyridines / chemistry; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared
TL;DR:
The synthesis and characterization of three new supramolecular complexes 6-8 (a rhomboid and two hexagons) via coordination-driven self-assembly are reported in excellent yields (>90%) and the X-ray structure of the 120 degrees tecton 2 is discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Molecular Architecture via Coordination: Self-Assembly of Nanoscale Hexagonal Metallodendrimers with Designed Building Blocks
Journal of the American Chemical Society, 128(31), 10014–10015.
MeSH headings : Dendrimers / chemistry; Metals / chemistry; Models, Molecular; Nanotechnology
TL;DR:
The first self-assembly of nanoscale metallodendrimers that have a hexagonal cavity as a core via the directional-bonding approach is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
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